Core Viewpoint - Crystal Technology (晶泰科技) announced a significant milestone in clinical research for the next-generation PRMT5 inhibitor PEP08, which has received clinical trial approvals from regulatory bodies in Australia and Taiwan, marking the initiation of Phase I clinical trials [1][3]. Group 1: Clinical Development - PEP08 has been approved for clinical trials by the Human Research Ethics Committee (HREC) in Australia, the Therapeutic Goods Administration (TGA), and the Taiwan Food and Drug Administration (TFDA) [1]. - The approval signifies a major step forward in the collaboration between Crystal Technology and PharmaEngine, leading to milestone payments for Crystal Technology [1][3]. Group 2: Drug Characteristics - PRMT5 is a key enzyme overexpressed in various cancers, and inhibiting its activity can lead to a "synthetic lethality" effect in tumors with homozygous deletion of MTAP, which accounts for approximately 10-15% of human cancers [1]. - PEP08, as a second-generation PRMT5 inhibitor, exhibits high activity and selectivity, forming a stable ternary complex with PRMT5, specifically targeting MTAP-deficient tumor cells while minimizing effects on normal cells [2][3]. Group 3: Preclinical Research - Preclinical data indicate that PEP08 shows significant advantages in toxicity and safety compared to first-generation non-selective PRMT5 inhibitors, with good blood-brain barrier penetration and ideal overall drug-like properties [3]. - PEP08 demonstrates strong in vivo efficacy at lower doses in multiple animal efficacy models, suggesting potential best-in-class effects and broad potential for combination with other therapies [3].

Core Viewpoint - JingTai Technology (02228) announced a significant clinical development milestone for the next-generation PRMT5 inhibitor PEP08, which has received clinical trial approvals from regulatory bodies in Australia and Taiwan, marking the initiation of Phase I clinical trials [1][3]. Group 1: Clinical Development - PEP08 has achieved important clinical research milestones, receiving approvals from the Human Research Ethics Committee (HREC) and the Therapeutic Goods Administration (TGA) in Australia, as well as the Taiwan Food and Drug Administration (TFDA) [1]. - The project has led to milestone payments for JingTai Technology, confirming the progress made in collaboration with PharmaEngine, Inc. [1][3]. Group 2: Drug Characteristics - PRMT5 is a key enzyme overexpressed in various cancers, and inhibiting its activity can lead to a "synthetic lethality" effect in tumors with homozygous deletion of MTAP, which accounts for approximately 10-15% of human cancers [1]. - PEP08, as a second-generation PRMT5 inhibitor, exhibits high activity and selectivity, forming a stable ternary complex with PRMT5 through an MTA cooperative binding mode, specifically targeting MTAP-deficient tumor cells while minimizing effects on normal cells [2]. Group 3: Preclinical Research and Efficacy - Preclinical data indicate that PEP08 shows significant advantages in toxicity and safety compared to first-generation non-selective PRMT5 inhibitors, with good blood-brain barrier penetration and ideal overall drug-like properties [3]. - PEP08 demonstrates strong in vivo efficacy at lower doses in multiple animal efficacy models, showcasing potential best-in-class effects and broad potential for combination with other therapies [3].

Group 1 - The top three companies with the highest short positions as of August 29 are ZTE Corporation (00763) at 16.47%, COSCO Shipping Holdings (01919) at 13.94%, and CATL (03750) at 13.88% [1][2] - The company with the largest increase in short positions is Ganfeng Lithium (01772), which rose by 2.85% to 12.46% [2][3] - The companies with the largest decrease in short positions include Hisense Home Appliances (00921), which decreased by 3.57% to 4.72%, and WuXi AppTec (02359), which decreased by 2.44% to 11.64% [3][4] Group 2 - The latest short position data shows that the top ten companies with the highest short ratios include China Ping An (02318) at 12.58% and Zijin Mining (02899) at 11.91% [2] - The companies with the most significant increases in short positions also include Huahong Semiconductor (01347) with an increase of 2.56% to 9.73% and Meitu (01357) with an increase of 1.80% to 4.85% [2] - The companies with the most significant decreases in short positions also include Weimob (02013) with a decrease of 1.66% to 9.40% and Linklogis Technology (09959) with a decrease of 1.43% to 2.76% [3][4]

Market Overview - On September 4, the Hang Seng Index fell by 1.12%, with total southbound trading amounting to HKD 1,470.86 billion, including buy transactions of HKD 738.96 billion and sell transactions of HKD 731.90 billion, resulting in a net buying amount of HKD 7.06 billion [1] Southbound Trading Details - Southbound trading through the Stock Connect (Shenzhen) recorded a total trading amount of HKD 569.41 billion, with buy transactions of HKD 281.30 billion and sell transactions of HKD 288.11 billion, leading to a net selling amount of HKD 6.80 billion [1] - Southbound trading through the Stock Connect (Shanghai) had a total trading amount of HKD 901.45 billion, with buy transactions of HKD 457.66 billion and sell transactions of HKD 443.79 billion, resulting in a net buying amount of HKD 13.86 billion [1] Active Stocks - The most actively traded stock by southbound funds was Alibaba-W, with a total trading amount of HKD 120.58 billion, followed by SMIC and Tencent Holdings with trading amounts of HKD 99.57 billion and HKD 49.79 billion, respectively [1] - In terms of net buying, the top stocks included UBTECH with a net buying amount of HKD 8.28 billion, Xiaomi Group-W with HKD 7.03 billion, and Alibaba-W with HKD 5.50 billion [1] - The stock with the highest net selling was SMIC, with a net selling amount of HKD 11.58 billion, followed by Hua Hong Semiconductor and Kuaishou-W with net selling amounts of HKD 6.88 billion and HKD 5.41 billion, respectively [1] Continuous Net Buying and Selling - Two stocks, Alibaba-W and Yangtze Optical Fibre and Cable, experienced continuous net buying for more than three days, with Alibaba-W having a total net buying amount of HKD 173.78 billion over ten days [2] - The stocks with the highest continuous net selling were SMIC and Hua Hong Semiconductor, with total net selling amounts of HKD 23.06 billion and HKD 21.09 billion, respectively [2]

Core Insights - The Hong Kong stock market saw a net inflow of 706 million HKD from Northbound trading on September 4, with a net buy of 1.386 billion HKD from the Shanghai Stock Connect and a net sell of 680 million HKD from the Shenzhen Stock Connect [1] Group 1: Stock Performance - The top net bought stocks included UBTECH (09880), Xiaomi Group-W (01810), and Alibaba-W (09988) [1] - The most sold stocks were SMIC (00981), Hua Hong Semiconductor (01347), and Tencent Holdings (00700) [1] Group 2: Detailed Stock Transactions - Alibaba-W had a net buy of 4.042 billion HKD and a sell of 3.633 billion HKD, resulting in a net inflow of 409 million HKD [2] - UBTECH received a net buy of 1.437 billion HKD and a sell of 860 million HKD, leading to a net inflow of 577 million HKD [2] - Xiaomi Group-W had a net buy of 1.057 billion HKD and a sell of 911 million HKD, resulting in a net inflow of 146 million HKD [2] Group 3: Company Announcements - UBTECH announced a procurement contract worth 250 million RMB for humanoid robots, expected to start delivery within the year [6] - Xiaomi reported over 30,000 vehicle deliveries in August and plans to open 32 new stores in September to meet demand [6] - Alibaba's cloud business revenue reached 33.398 billion RMB, with significant increases in capital expenditure and cloud revenue exceeding expectations [7] Group 4: Market Sentiment - SMIC and Hua Hong Semiconductor faced significant net sells of 11.58 billion HKD and 6.88 billion HKD, respectively, amid a positive outlook for the semiconductor industry driven by AI and domestic substitution [9] - Meituan-W and Changfei Optical Cable received net buys of 5.27 billion HKD and 1.06 billion HKD, while Tencent faced a net sell of 3.37 billion HKD [10]

Group 1 - The company, Crystal Tech Holdings (02228), announced that all conditions of the placement agreement have been met, with the placement completed on September 4, 2025 [1] - According to the terms and conditions of the placement agreement, the placement agent successfully placed a total of 285.9 million new shares at a placement price of HKD 9.28 per share to no less than six subscribers [1] - The newly placed shares represent approximately 6.64% of the company's enlarged issued share capital immediately following the completion of the placement [1]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 晶泰控股有限公司 呈交日期： 2025年9月4日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 02228 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括庫存股 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 本公告僅供參考用途，並不構成收購、購買或認購本公司證券的邀請或要約。 本公告或其任何副本概不得直接或間接在美國，或在刊發或派發本公告屬違法的任何其他司 法權區內刊發或派發。 本公告並非構成或組成於美國境內購買或認購證券的任何要約或購買或認購證券的招攬的 一部分。本公告所述證券並未亦不會根據證券法登記，亦不得在美國境內提呈發售或出售， 惟根據證券法的登記規定獲豁免或不受證券法登記規定規限的交易除外。本公司無意根據證 券法登記本公告所指之任何證券，或在美國進行證券的公開發售。 XtalPi Holdings Limited （ 於 開 曼 群 島 註 冊 成 立 之 有 限 公 司 ） 晶泰控股有限公司 （股份代號：2228） 完成根據一般授權配售新股份 聯席整體協調人 （按英文字母順序排序） 聯席賬簿管理人 （排名不分先後） 完成配售 董事會欣然宣佈，配售協議所載全部條件均獲達成，配售於2025年9月4日 ...

Core Insights - The report highlights significant changes in the Hong Kong Stock Connect holdings, with notable increases and decreases in ownership percentages for various companies [1][2][3] Group 1: Increased Holdings - Haotian International Investment (01341) saw the largest increase in holdings, up by 2.83%, bringing its total to 58.85% [2] - Chifeng Jilong Gold Mining (06693) and Shandong Gold (01787) also experienced notable increases of 1.81% and 1.44%, respectively, with holdings of 43.83% and 54.55% [2] - Other companies with significant increases include Yimai Sunshine (02522) at +1.43% (41.36%) and Changfei Optical Fiber Cable (06869) at +1.01% (55.00%) [2] Group 2: Decreased Holdings - Kinglong Magnetics (06680) had the largest decrease in holdings, down by 1.67% to 25.77% [2] - Other notable decreases include Chunli Medical (01858) at -1.41% (46.64%) and Longpan Technology (02465) at -1.17% (50.37%) [2] - Additional companies with reduced holdings include Chongqing Steel (01053) at -0.76% (30.19%) and Tianqi Lithium (09696) at -0.66% (37.65%) [3] Group 3: Five-Day Changes - In the last five trading days, Jingtai Holdings (02228) had the highest increase at +3.39%, with a total holding of 42.87% [3] - Anjiu Food (02648) also saw a significant increase of 3.31% (17.38%) [3] - Shandong Gold (01787) increased by 2.83% (54.55%) during this period [3] Group 4: Twenty-Day Changes - Over the past twenty days, Anjiu Food (02648) experienced the largest increase of 13.05%, bringing its holding to 17.38% [4] - Lens Technology (06613) and Yimai Sunshine (02522) also saw substantial increases of 12.03% (12.56%) and 10.48% (41.36%), respectively [4]

Summary of Key Points Core Viewpoint - The Hong Kong stock market experienced significant net inflows from northbound capital, totaling HKD 55.08 billion on September 3, with notable net purchases in stocks like Alibaba, Xiaomi, and Meituan, while Tencent and Huahong Semiconductor faced substantial net sell-offs [1][4]. Group 1: Northbound Capital Inflows - Northbound capital recorded a net purchase of HKD 55.08 billion, with HKD 32.02 billion from the Shanghai Stock Connect and HKD 23.07 billion from the Shenzhen Stock Connect [1]. - Alibaba (09988) was the top net buyer, with a net inflow of HKD 17.95 billion, followed by Xiaomi (01810) and Meituan (03690) [2][4]. Group 2: Individual Stock Performance - Alibaba-W (09988) saw a net purchase of HKD 24.88 billion, driven by positive earnings expectations and management's optimistic outlook on core business growth [4][5]. - Xiaomi Group-W (01810) received a net inflow of HKD 6.98 billion, attributed to exceeding delivery targets and strong order demand [5]. - Meituan-W (03690) had a net inflow of HKD 5.7 billion, reflecting ongoing investor interest [8]. Group 3: Notable Sell-offs - Tencent (00700) faced a net sell-off of HKD 4.71 billion, with analysts expressing concerns over its recent performance despite a significant stock price increase [7][8]. - Huahong Semiconductor (01347) experienced a net outflow of HKD 4.05 billion, indicating a shift in investor sentiment [6][8]. Group 4: Market Insights - The market is witnessing a trend where companies like Alibaba and Xiaomi are gaining traction due to strong operational performance and growth prospects, while others like Tencent are facing scrutiny due to overvaluation concerns [6][7].