FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 和譽開曼有限責任公司 呈交日期： 2025年8月28日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02256 | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | 事件 | | 已發行股份（不包括庫存股份）數 目 | 佔有關事件前的現有已發 行股份（不包括庫存 ...

Core Viewpoint - The company is expanding its product portfolio from small molecule innovation in oncology to non-oncology treatments, with significant advancements in drug commercialization and clinical trials [1][2]. Group 1: Product Development - The company has received acceptance for the new drug application (NDA) of Pimicotinib for treating adult tenosynovial giant cell tumors (TGCT) by the National Medical Products Administration (NMPA) in China, with a target date of June 10, 2025 [1]. - Pimicotinib has also been granted breakthrough therapy designation (BTD) by the FDA and priority medicine (PRIME) designation by the EMA, indicating its potential for global commercialization [1]. - The company has initiated the first patient dosing in a registration study for Epaglutide in patients with FGF19 overexpressing hepatocellular carcinoma (HCC), with promising data from ongoing clinical trials [1]. Group 2: Clinical Trials and Collaborations - The company is exploring the combination of ABSK043 (an oral PD-L1 inhibitor) with other therapies for treating KRAS-G12C mutated non-small cell lung cancer (NSCLC) and is conducting a Phase II clinical study for ABSK043 combined with other agents for EGFR mutated NSCLC [2]. - The latest Phase II study results for Epaglutide combined with Atezolizumab showed an overall response rate (ORR) of ≥50% and progression-free survival (PFS) of ≥7 months [1]. Group 3: Financial Projections - Revenue forecasts for the company are projected at 612.1 million, 678.8 million, and 627.2 million yuan for 2025-2027, reflecting year-on-year growth rates of 21.5%, 10.9%, and -7.6% respectively [2]. - The current stock price corresponds to price-to-sales (PS) ratios of 17, 15, and 17 for the years 2025, 2026, and 2027, respectively, indicating potential investment opportunities as the company approaches product commercialization [2].

Summary of Key Points Core Viewpoint - On August 27, 17 Hong Kong-listed companies conducted share buybacks, totaling 7.876 million shares and an amount of 614 million HKD [1]. Group 1: Buyback Details - Tencent Holdings repurchased 909,000 shares for 550 million HKD, with a highest price of 614.50 HKD and a lowest price of 596.00 HKD, accumulating a total buyback amount of 44.448 billion HKD for the year [1][2]. - Hang Seng Bank repurchased 210,000 shares for 23.49 million HKD, with a highest price of 112.20 HKD and a lowest price of 111.50 HKD, totaling 432.12 million HKD in buybacks for the year [1][2]. - MGM China repurchased 1 million shares for 16.018 million HKD, with a highest price of 16.13 HKD and a lowest price of 15.92 HKD, accumulating 134.98 million HKD in buybacks for the year [1][2]. Group 2: Buyback Rankings - The highest buyback amount on August 27 was from Tencent Holdings at 550 million HKD, followed by Hang Seng Bank at 23.49 million HKD [1]. - In terms of share quantity, Maple Leaf Education had the highest buyback with 4.492 million shares, followed by MGM China and Tencent Holdings with 1 million and 909,000 shares respectively [1][2]. Group 3: Additional Insights - The buyback by Bruker was its first for the year, while Tencent has conducted multiple buybacks totaling 44.448 billion HKD [2].

Summary of Key Points Core Viewpoint - Multiple companies, including Tencent Holdings and Hang Seng Bank, conducted share buybacks on August 27, 2025, with Tencent leading in both volume and monetary value [1]. Group 1: Buyback Details - Tencent Holdings (00700) repurchased 909,000 shares for a total of 550 million [2]. - Hang Seng Bank (00011) repurchased 210,000 shares amounting to 23.49 million [2]. - MGM China (02282) repurchased 1 million shares for 16.02 million [2]. Group 2: Cumulative Buyback Data - Tencent's cumulative buyback for the year reached 44.82 million shares, representing 0.488% of its total share capital [2]. - Maple Leaf Education (01317) has the highest cumulative buyback at 55.19 million shares, accounting for 1.860% of its total [2]. - Other notable cumulative buybacks include Guichuang Tongqiao-B (02190) at 175,250 shares (0.536%) and Beisen Holdings (09669) at 777,520 shares (1.107%) [2].

和誉-B(02256)发布公告，于2025年8月27日斥资320.12万港元回购20万股股份。 ...

格隆汇8月27日丨和誉-B(02256.HK)公告，8月27日耗资320.1万港元回购20万股。 ...

智通财经APP讯，和誉-B(02256)发布公告，于2025年8月27日斥资320.12万港元回购20万股股份。 ...

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 和譽開曼有限責任公司 呈交日期： 2025年8月27日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02256 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | | 庫存股份變動 | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | | 佔有關 ...

Investment Rating - The report assigns a "Buy" rating for the company [3][17]. Core Insights - The company, He Yu-B (2256.HK), is a small molecule innovative drug company focusing on oncology and expanding into non-oncology treatment pipelines. Since its establishment in 2016, it has concentrated on precision oncology and immunotherapy while exploring non-oncology indications [1][6]. - Pimicotinib has initiated its global commercialization process, with its New Drug Application (NDA) for treating adult tenosynovial giant cell tumors (TGCT) accepted by the National Medical Products Administration (NMPA) in China on June 10, 2025. The product has also received breakthrough therapy designation (BTD) from the FDA and priority medicine (PRIME) designation from the EMA [1][40]. - The company has a robust pipeline with 22 candidate drugs, 12 of which are in clinical development, focusing on small molecules for precision oncology and immunotherapy [32]. Financial Projections - Revenue projections for 2025-2027 are estimated at 612.1 million, 678.8 million, and 627.2 million yuan, reflecting year-on-year growth rates of 21.5%, 10.9%, and -7.6% respectively. The current stock price corresponds to price-to-sales (PS) ratios of 17, 15, and 17 for the respective years [3][17]. - The company achieved total revenue of 657.1 million yuan in the first half of 2025, primarily from Merck's licensing income of 612.1 million yuan (85 million USD), with a net profit of 328.5 million yuan [35]. Key Assumptions - The report highlights that the successful commercialization of Pimicotinib and the clinical data readouts for Ipagoatinib are critical catalysts for stock price appreciation. The company expects significant milestone revenues from Merck's licensing agreements and sales shares from Pimicotinib [15][17]. Pipeline Overview - The company has a diverse pipeline, including Pimicotinib for TGCT and Ipagoatinib for FGF19 overexpressing HCC, with promising clinical data indicating high objective response rates (ORR) and progression-free survival (PFS) [2][3][39].

Investment Rating - The report assigns a "Buy-A" investment rating to the company, with a target price of HKD 19.43 over the next six months [3][6]. Core Insights - The company reported a revenue of CNY 612 million and a net profit of CNY 328 million for the first half of 2025. Merck exercised its global commercialization option for Pimitinib, with an expected NDA submission to the FDA in the second half of 2025. The company could receive up to USD 605.5 million from this collaboration, including an upfront payment and milestone payments [1][3]. - Multiple innovative pipelines are advancing rapidly, including the FGFR4 inhibitor ABSK011 for previously treated FGF19+ liver cancer patients, and various clinical trials for other inhibitors targeting different cancers [2]. Financial Projections - Revenue projections for 2025, 2026, and 2027 are CNY 612 million, CNY 650 million, and CNY 680 million, respectively. Net profit estimates for the same years are CNY 88.47 million, CNY 117.36 million, and CNY 89.75 million [3][8]. - The company is expected to achieve a gross margin of 90% and a net profit margin of 14.46% in 2025, with a projected return on equity (ROE) of 4.32% [13]. Market Performance - The company's stock has shown significant performance, with a relative return of 55.4% over the past month and 410.4% over the past year [7]. - The stock price as of August 22, 2025, was HKD 16.82, with a 12-month price range of HKD 2.86 to HKD 17.09 [6][7]. Financial Statements Overview - The company reported total assets of CNY 3.85 billion for 2025, with current assets of CNY 3.78 billion and total liabilities of CNY 1.81 billion [10]. - The cash flow from operating activities is projected to be CNY 1.25 billion in 2025, indicating a strong recovery from previous years [11]. Valuation Model - The DCF model indicates a market capitalization of CNY 12 billion, with a projected share price of HKD 19.43 based on future cash flows [9].