股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年6月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 北京昭衍新藥研究中心股份有限公司 呈交日期: 2025年7月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06127 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 118,995,206 | RMB | | 1 | RMB | | 118,995,206 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 118,995,206 | RMB | | 1 | RMB | | 118,995,206 | | 2. 股份分類 ...

Group 1 - The stock price of Zhaoyan New Drug (603127) reached a new high of 19.49 HKD, surpassing the previous high in March and marking the highest price since September 2023 [1] - The stock experienced significant volatility, with a nearly 30% drop in April due to market turbulence and regulatory changes, followed by a recovery of over 40% in May [1][4] - After peaking on June 17, the stock faced a three-day decline, dropping to a low of 13.89 HKD, a decrease of 28.73% from the peak [1] Group 2 - The Hang Seng Healthcare Index also rebounded after a five-day decline, indicating continued upward momentum in the Hong Kong pharmaceutical sector [2] - Investors are closely watching whether Zhaoyan New Drug can achieve new highs amid ongoing market fluctuations [2] Group 3 - Since the beginning of the year, southbound funds have accumulated a net purchase of nearly 700 billion HKD in Hong Kong stocks, with the healthcare sector showing significant gains [4] - The holding ratio of southbound funds in Zhaoyan New Drug increased from 37.58% to 40.64% in 2025, indicating a trend of increased investment [4][6] - The investment behavior of northbound funds shifted from "buying on dips" to "buying on rises" and back to "buying on dips" again, reflecting changing market dynamics [6] Group 4 - The recent surge in the Hong Kong innovative drug sector is driven by improved performance, policy optimization, and low valuations [4] - The financing environment for the domestic biopharmaceutical sector has improved, with a notable increase in investment cases and amounts in Q1 2025 [7] - The number of clinical approvals for new drugs in China has significantly increased, with 186 first-class new drugs receiving clinical approval in Q1 2025 [8][10] Group 5 - Zhaoyan New Drug reported a 115.11% year-on-year increase in net profit for Q1 2025, indicating strong financial performance despite market fluctuations [10] - The National Medical Products Administration's recent announcement aims to optimize the clinical trial review process, potentially accelerating the approval timeline for innovative drugs [10][12] - The average duration for new drug IND tasks in China is currently 71 days, with plans to reduce this to 30 working days, which could stimulate demand for Zhaoyan New Drug's services [12]

Core Viewpoint - The company, Zhaoyan New Drug, has experienced a decline in stock price and revenue, while showing significant growth in net profit, indicating mixed performance in the current market environment [1]. Company Summary - Zhaoyan New Drug's closing stock price on July 2 was 21.95 yuan, down 1.57%, with a rolling PE ratio of 42.46 times and a total market capitalization of 16.451 billion yuan [1]. - The company operates primarily in non-clinical safety evaluation services for drugs, clinical research services, and sales of experimental animals and related products [1]. - For the first quarter of 2025, Zhaoyan New Drug reported revenue of 287 million yuan, a year-on-year decrease of 11.54%, while net profit reached 41.1195 million yuan, reflecting a year-on-year increase of 115.11%, with a gross profit margin of 28.61% [1]. Industry Summary - The average PE ratio for the medical services industry is 41.66 times, with a median of 43.69 times, placing Zhaoyan New Drug at the 29th position within the industry [1]. - As of the first quarter of 2025, 22 institutions held shares in Zhaoyan New Drug, including 20 funds, with a total holding of 72.9482 million shares valued at 1.484 billion yuan [1]. - The industry comparison shows that Zhaoyan New Drug's PE ratio is higher than the industry average but lower than the median, indicating a competitive yet challenging market position [2].

Overview of Investment Fund Collaboration - The company, Beijing Zhaoyan New Drug Research Center Co., Ltd., has approved an investment of up to 20 million RMB to participate in the establishment of the Huaxia Zhiyuan Venture Capital Fund [2][3] - The fund aims to engage in investment activities primarily in unlisted companies within the full industry chain of molecular diagnostics and targeted therapies [4][5] Partnership Agreement Details - A partnership agreement has been signed with Huaxia Equity Investment Fund Management (Beijing) Co., Ltd., which will act as the general partner and fund manager [2][4] - The partnership has a term of 20 years, with an investment operation period of 7 years, extendable by up to 2 years under certain conditions [3][4] Fund Structure and Financials - The target total subscription amount for the fund is 35 million RMB, with a minimum contribution of 10 million RMB for each limited partner [3][5] - The management fee is set at 1% per year of the total paid-in capital, calculated daily [5] Investment Focus - The fund will focus on investments in the full industry chain of biomedicine for molecular diagnostics and targeted therapies, particularly in the development of Alpha-targeted therapies [4][5]

Core Insights - The National Healthcare Security Administration and the National Health Commission issued measures to support the high-quality development of innovative drugs, focusing on the entire chain from research and development to payment systems [1] - The inclusion of innovative drug directories in commercial health insurance is expected to enhance the multi-tiered medical security system and provide economic support for the development of innovative drugs [1][2] - The stock market reacted positively, with significant gains in innovative drug concept stocks and ETFs, indicating strong investor interest and liquidity in this sector [1][2] Industry Developments - The establishment of a commercial insurance innovative drug directory marks a significant step in enhancing the role of commercial insurance in the multi-tiered medical security system, providing payment support for high-priced innovative drugs and medical devices [2] - The "18A" policy has catalyzed a wave of medical companies listing in Hong Kong, focusing on cutting-edge medical industry directions, which has attracted market attention and investment [2] Market Performance - The Hong Kong innovative drug ETF (513120) saw a rise of over 2%, with a trading volume of 4.1 billion yuan, leading the market in the pharmaceutical ETF category [1] - The latest scale of the Hong Kong innovative drug ETF reached 13.4 billion yuan, indicating its leading position in the market [1] - The innovative drug ETF (515120) also performed well, with a trading volume of 145 million yuan and a net inflow of nearly 200 million yuan over five consecutive days [1]

Core Viewpoint - The A-share pharmaceutical sector experienced a significant rally, with notable stocks such as Saily Medical hitting the daily limit, Rongchang Bio rising over 7%, and Shutai Shen increasing by more than 6% due to supportive government measures for innovative drug development [1] Group 1 - The National Healthcare Security Administration and the National Health Commission issued measures to support the high-quality development of innovative drugs [1] - The new measures include the use of medical insurance data to facilitate the research and development of innovative drugs [1]

司股份数量为101,714股，占公司股份总数的0.02%，最高成交价为人民币79.3元/ 股，最低成交价为人民币75.5元/股，成交总金额为人民币7,997,727.28元（不含 交易费用）。回购方案实际执行与已披露的方案不存在差异，公司已按照披露的 方案完成回购。具体内容详见公司于2022年9月2日在上海证券交易所网站 （www.sse.com.cn）及公司指定信息披露媒体《上海证券报》披露的《昭衍新药 关于回购股份方案实施完成暨股份变动的公告》（公告编号：2022-076）。 证券代码：603127 证券简称：昭衍新药 公告编号：2025-025 北京昭衍新药研究中心股份有限公司 关于减少注册资本暨通知债权人的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 一、通知债权人的原因 北京昭衍新药研究中心股份有限公司（以下简称"公司"）于2023年3月30 日召开的第四届董事会第二次会议及第四届监事会第二次会议审议通过了《关于 公司终止实施2021年A股员工持股计划的议案》，于2023年10月30日召开的第四 届董事 ...

北京市天元律师事务所 关于北京昭衍新药研究中心股份有限公司 2024 年年度股东大会、2025 年第二次 A 股类别股东会议及 2025 年第二次 H 股类别股东会议的法律意见 京天股字（2025）第 401 号 致：北京昭衍新药研究中心股份有限公司 北京昭衍新药研究中心股份有限公司（以下简称"公司"）2024 年年度股东大 会（以下简称"本次年度股东大会"）、2025 年第二次 A 股类别股东会（以下简称 "本次 A 股类别股东会"）及 2025 年第二次 H 股类别股东会（以下简称"本次 H 股类别股东会"，与"本次年度股东大会"、"本次 A 股类别股东会"以下合称"本 次股东大会"）采取现场投票与网络投票相结合的方式召开，现场会议于 2025 年 6 月 18 日在北京市经济技术开发区瑞合西一路 7 号院会议室召开。北京市天元律师 事务所（以下简称"本所"）接受公司聘任，指派本所律师参加本次股东大会现场 会议，并根据《中华人民共和国公司法》（以下简称"《公司法》"）、《中华人民共 和国证券法》（以下简称"《证券法》"）、《上市公司股东会规则》及《北京昭衍新 药研究中心股份有限公司章程》（以下简称"《公司 ...

以下文章来源于解码LP ，作者余梦莹 解码LP . 投资界（PEdaily.cn）旗下，专注募资动态 欢迎加入投资界读者群 LP阵容浮现。 作者 I 余梦莹 报道 I 投资界-解码LP 这始于一纸公告。 投资界-解码LP获悉，近日锦波生物和昭衍新药公告，公司已与招商局资本管理（北京） 有限公司、其他合伙人签署《合伙协议》，共同发起成立服务贸易创新发展引导基金二 期（有限合伙）（简称"服贸基金二期"）。 根据公告信息，服贸基金二期的认缴出资额为10 0亿元，其中财政部出资20亿元，深圳市 招服投资有限责任公司出资1 9亿元，杭州产业投资有限公司出资15亿元；上市企业锦波 生物、昭衍新药均出资1亿，占比均为1%。 进一步看，基金主要经营场所位于杭州市萧山区，存续期限最长为15年，招商局资本管 理（北京）有限公司作为基金管理人向合伙企业提供投资管理服务，同时也为执行事务 合伙人。 | 序号 | 合伙人名称 | 合伙人类别 | 实际认缴出资额 | 早报 | | --- | --- | --- | --- | --- | | | | | (万元) | | | 1 | 中华人民共和国财政部 | 有限合伙人 | 200, ...

日前，小商品城、昭衍新药等多家上市公司发布公告披露参与设立产业基金的进展。 小商品城在公告中指出：近日，公司与招商局资本管理（北京）有限公司及参与本基金的其他合伙 人共同签署了《合伙协议》，协议主要内容如下： 1、合伙目的 围绕创新服务贸易发展机制、发展数字贸易，加强与社会资本的协同配合，有效发挥 财政资金的政策引导和杠杆放大效应，带动社会资本支持服务贸易创新发展，推动数字贸易改革创 新发展，培育外贸新业态新模式，激发服务贸易发展新动能，推进贸易强国建设。 2、合伙期限 本合伙企业工商登记的合伙期限最长为十五（15）年，自《营业执照》载明的成立日 期起算。虽有前述约定，普通合伙人可根据全体合伙人的一致意见，报请商务部、财政部按程序研 究确定延长或提前终止本合伙企业的合伙期限。 3、出资方式 （1）所有合伙人之出资方式均为以人民币现金出资。 （2）全体合伙人同意，本合伙企业的各合伙人应于普通合伙人根据本合伙企业项目投资的具体资 金需求情况签发的各期缴付出资通知书分期进行缴付，每期的缴付出资由全体合伙人按实际认缴出 资比例缴付。为各期出资缴付之目的，普通合伙人将提前向各合伙人发出该期缴付出资通知书，列 明该合伙人 ...