Core Viewpoint - The flu season in China has begun, leading to an increase in demand for antiviral medications, which has positively impacted the stock prices of flu-related companies [1] Group 1: Market Overview - The flu activity level has significantly risen, with historical data indicating that the flu season typically starts in October to November, peaking around late December to early January [1] - E-commerce platforms report an increase in sales of antiviral medications for flu, reflecting heightened consumer demand [1] Group 2: Key Players and Supply Chain - Dongyang Sunshine Pharmaceutical holds a significant market share in the supply of Oseltamivir, a neuraminidase inhibitor, and has established a robust supply chain to ensure stable drug availability during peak flu seasons [2] - The company has comprehensive coverage across hospitals, chain pharmacies, and online platforms, maintaining sufficient inventory to meet market demands [2] Group 3: Antiviral Drug Developments - In the RNA polymerase inhibitor category, Marbofloxacin has gained traction due to its convenience as a single oral dose, marketed as "Xufuda" by Roche [3] - Roche has initiated local production of Xufuda in Shanghai to shorten supply chain times and enhance responsiveness to market needs [4] Group 4: Supply Assurance and New Entries - Roche has increased the supply of Xufuda to over three times that of the previous year, with contingency plans in place to respond quickly to sudden surges in flu cases [5] - Three new RNA polymerase inhibitors have been launched by domestic companies, including Qingfeng Pharmaceutical's Mabulosavir, which is similar to Roche's Xufuda, and is currently approved for adult treatment [5][6] - Zhongsheng Pharmaceutical's Angladiwe has been recognized as the world's first PB2 protein inhibitor for treating influenza A in adults, with a stable supply chain established for its distribution [6]

Core Viewpoint - The flu vaccine market in China is underperforming compared to the flu treatment drug market, with low vaccination rates and sales figures for vaccine companies [2][3]. Group 1: Vaccine Market Performance - The main flu vaccine companies in A-shares and Hong Kong include Hualan Biological (10.73 billion), Gendik (808.03 million), and Zhonghui Biological (2.6 billion) for 2024 sales [3]. - The total sales of these four companies (Hualan, Gendik, Zhonghui, and Baike) do not exceed 1.6 billion, which is significantly lower than the 2.6 billion sales of Dongyang Sunshine Pharmaceutical's flu treatment drug Oseltamivir [3]. Group 2: Economic Burden of Influenza - A study cited in the article indicates that the economic burden of outpatient flu patients ranges from 801 to 1,320 yuan, while hospitalized patients face a burden between 9,832 and 23,833 yuan [4]. - Vaccination can effectively reduce the number of flu-related hospitalizations and deaths, leading to significant economic benefits [4]. Group 3: Challenges in Vaccine Promotion - Public misconceptions about the necessity and effectiveness of flu vaccines hinder vaccination rates, with many believing they do not need the vaccine or underestimating the severity of flu [5]. - Vaccine hesitancy is a significant issue, with the World Health Organization identifying it as a global health threat since 2019 [5]. Group 4: Recommendations for Improvement - To improve vaccination rates, it is essential to conduct public education to dispel misconceptions, enhance accessibility to vaccination services, and integrate prevention and treatment efforts [6]. - Exploring flexible funding mechanisms for vaccine costs and expanding coverage of beneficial policies are also recommended [6].

Core Viewpoint - The performance of four major flu vaccine companies in China is significantly lagging behind that of a single antiviral drug, Oseltamivir, highlighting challenges in flu vaccine promotion and public perception [1] Group 1: Company Performance - The main flu vaccine companies in A-shares include Hualan Biological (301207.SZ), Jindike (688670.SH), and Baike Biological (688276.SH), while the primary company in Hong Kong is Zhonghui Biological (02627.HK) [1] - From 2021 to 2024, Hualan Biological has maintained its leading position in the domestic flu vaccine market with consistent batch approvals [1] - The total sales revenue of the four flu vaccine companies in 2024 is projected to be less than 1.6 billion yuan [1] Group 2: Market Comparison - In contrast, Dongyang Sunshine Pharmaceutical (06887.HK), which holds the largest market share in China's antiviral drug market, is expected to achieve sales of approximately 2.6 billion yuan for Oseltamivir in 2024 [1] Group 3: Promotion Challenges - The promotion of flu vaccines faces significant hurdles due to public perceptions of necessity, concerns about vaccine efficacy, and fears of side effects [1] - Industry insiders indicate that the public has higher safety expectations for vaccines compared to antiviral drugs, leading to lower tolerance for potential side effects [1]

本文字数：1767，阅读时长大约3分钟 作者 | 第一财经 林志吟 每年的流感流行季，流感病例短时间迅速增加可能会给医疗机构带来巨大压力。接种流感疫苗，被视 为防控流感的"第一道防线"，可以显著降低接种者罹患流感和发生严重并发症的风险。 2025.11. 26 不过，长期以来，国内流感疫苗的接种率并不理想，仍在个位数徘徊。相比流感治疗药物市场，流感 疫苗市场销售表现得较为逊色。 流感疫苗销售干不过流感治疗药物 第一财经记者统计了A股以及港股的流感疫苗企业2024年销售额情况。 A股的流感疫苗企业主要是华兰疫苗（301207.SZ）、金迪克（688670.SH）、百克生物 （688276.SH）；港股的流感疫苗企业主要是中慧生物（02627.HK）。2021年至2024年，华兰 疫苗流感疫苗批签发批次数量持续保持国内龙头地位。 华兰疫苗、金迪克、中慧生物当前的收入主要依靠流感疫苗销售，这三家企业2024年流感疫苗销售 额分别为10.73亿元、8080.27万元、2.6亿元。 百克生物旗下有多款疫苗产品在售中。2024年，该公司的流感疫苗销售占比低于15%，即不超过 1.85亿元。 总体看，前述这四家流感疫苗企业 ...

流感疫苗是防控流感的"第一道防线"。 每年的流感流行季，流感病例短时间迅速增加可能会给医疗机构带来巨大压力。接种流感疫苗，被视为 防控流感的"第一道防线"，可以显著降低接种者罹患流感和发生严重并发症的风险。 不过，长期以来，国内流感疫苗的接种率并不理想，仍在个位数徘徊。相比流感治疗药物市场，流感疫 苗市场销售表现得较为逊色。 流感疫苗销售干不过流感治疗药物 第一财经记者统计了A股以及港股的流感疫苗企业2024年销售额情况。 A股的流感疫苗企业主要是华兰疫苗（301207.SZ）、金迪克（688670.SH）、百克生物 （688276.SH）；港股的流感疫苗企业主要是中慧生物（02627.HK）。2021年至2024年，华兰疫苗流感 疫苗批签发批次数量持续保持国内龙头地位。 华兰疫苗、金迪克、中慧生物当前的收入主要依靠流感疫苗销售，这三家企业2024年流感疫苗销售额分 别为10.73亿元、8080.27万元、2.6亿元。 百克生物旗下有多款疫苗产品在售中。2024年，该公司的流感疫苗销售占比低于15%，即不超过1.85亿 元。 换言之，华兰疫苗、金迪克、中慧生物、百克生物这4家流感疫苗企业年销售额累计抵不过东阳 ...

东阳光药(06887.HK)发布公告，公司有意于公开市场上购回自身股份。公司管理层对集团前景充满信 心，而建议回购体现了董事会及管理层团队对公司长远业务前景及发展的信心。董事会认为建议回购符 合公司与公司股东的整体最佳利益。 ...

Core Viewpoint - The article discusses the rising demand for influenza antiviral medications as the flu season begins in China, highlighting the market dynamics and supply chain responses from key pharmaceutical companies [3][4]. Group 1: Influenza Season and Market Dynamics - The flu season in China typically starts in October to November, with peaks in late December and early January [3]. - Increased sales of antiviral medications have been observed on e-commerce platforms, leading to a rise in stock prices of related companies in the A-share market [3]. Group 2: Key Pharmaceutical Companies and Their Responses - Dongyang Sunshine Pharmaceutical holds a significant market share in the supply of Oseltamivir, stating that they have a robust supply chain and emergency plans to ensure stable drug supply during peak demand [4]. - Roche, the manufacturer of the antiviral drug Baloxavir marboxil (brand name "Xofluza"), has initiated local production in Shanghai to shorten supply chain times and enhance responsiveness to market demands [6]. - Roche has reported that the supply of Xofluza this year is over three times that of the previous year, with plans for flexible supply adjustments based on regional demand [7]. Group 3: New Drug Developments - Three new RNA polymerase inhibitors have been launched in China, produced by local companies, which include Qingfeng Pharmaceutical's Marbofloxacin, Zhongsheng Pharmaceutical's Anladiwei, and Jichuan Pharmaceutical's Maxilovirin [8][9]. - Zhongsheng Pharmaceutical's Anladiwei is noted as the world's first PB2 protein inhibitor for influenza treatment, specifically for adult patients [8].

流感特效药厂家众多。 当前，全国进入流感流行季，流感活动水平明显上升。 近日，中国疾病预防控制中心病毒病所研究员王大燕表示，监测数据显示，往年开始进入流感流行季的 时间一般都是在10—11月，个别年度也有9月份开始，流行高峰的时间一般出现在12月中下旬和1月初。 伴随着流感流行，流感药物需求增加。一些电商平台数据显示，流感抗病毒药物销量在增加。近两日， A股资本市场中的一些流感概念股股价也在上涨。抗流感特效药供应情况如何？ 我国目前上市的对流感病毒敏感的药物有神经氨酸酶抑制剂、RNA聚合酶抑制剂和血凝素抑制剂三 种，前两者应用较广，且对应的生产厂家较多。 在神经氨酸酶抑制剂方面，代表性药物是奥司他韦，主要有颗粒、胶囊、干悬混剂三大规格，可以覆盖 儿童以及成人患者。 长期以来，在奥司他韦供应上，东阳光药（06887.HK）占据较高的市场份额。 东阳光药物方面回复第一财经记者表示，流感由于需求的突发性，过往常出现市场供应短缺，终端价格 短期大幅波动的现象。作为国内该品类的主要供应商之一，公司已构建了成熟、完善的供应链体系与应 急预案，有能力在疫情高峰期确保药品的稳定供应，为满足市场需求、维护终端价格稳定提供坚实保 ...

每经AI快讯，东阳光药(06887.HK)早盘涨超3%，截至发稿，涨3.43%，报45.88港元，成交额454.31万港 元。 ...

消息面上，据央广网消息，当前正值流感等呼吸道传染病高发季节，奥司他韦、玛巴洛沙韦等流感药物 的需求量不断增加。数据显示，奥司他韦近七天销量增长率达237%，玛巴洛沙韦上涨达180%。公开资 料显示，东阳光药有着"流感药物之王"称号，旗下的流感药物奥司他韦(商品名：可威)长期占据着国内 主要市场份额。 此外，11月25日晚，东阳光药发布公告称，公司有意于公开市场上购回自身股份。公司管理层对集团前 景充满信心，而建议回购体现了董事会及管理层团队对公司长远业务前景及发展的信心。董事会认为建 议回购符合公司与公司股东的整体最佳利益。 东阳光（600673）药(06887)早盘涨超4%，截至发稿，涨3.43%，报45.88港元，成交额454.31万港元。 ...