Group 1: Macro Strategy and Tariff Impact - The report highlights the significant changes in the U.S. non-farm data as a reflection of the post-pandemic "K-shaped economy" differentiation, raising doubts about the effectiveness of current economic statistics [3][23] - It discusses the evolving framework of the U.S. "reciprocal tariffs" policy, which is becoming clearer with three tiers based on country agreements, affecting various industries [23][24] - The report suggests that the impact of tariffs on consumer prices in the U.S. is just beginning to manifest, with potential inflation risks remaining due to the ongoing tariff framework and domestic demand stimulation from tax cuts [25][26] Group 2: Chemical Industry - Soda Ash Investment Opportunities - The soda ash industry has about 30% of its capacity being outdated, with 10% of the capacity having energy consumption and emissions below benchmark levels [4] - The report emphasizes the importance of focusing on companies with cost advantages, particularly those using natural soda ash methods, which are more energy-efficient and cost-effective compared to synthetic methods [4] - Recommended companies include Boyuan Chemical, which is the largest domestic soda ash producer with a capacity of 6.8 million tons, and Zhongyan Chemical, which is expanding its capacity through new mining rights [4] Group 3: Pharmaceutical Industry - Kolun Biotechnology - Kolun Biotechnology's SKB264, a TROP2 ADC drug, is in the global phase III clinical trials and is considered to have blockbuster potential, with significant data expected in 2027 [5][36] - The drug has shown promising results in various indications, particularly in NSCLC, outperforming competitors in terms of progression-free survival [37][38] - The report indicates that SKB264 is positioned in the first tier of global competition, with a strong focus on its unique molecular design contributing to its efficacy and safety profile [37][38] Group 4: Electronics Industry - Lian De Equipment - Lian De Equipment has been awarded a contract for the 8.6 generation AMOLED production line, indicating its leading position in the OLED equipment market [18][27] - The company is expected to benefit from the growing demand for flexible AMOLED displays, particularly in foldable smartphones and high-end IT devices [28][29] - The report projects significant growth in the solid-state battery market, with Lian De Equipment actively developing equipment for this sector, indicating a strong future market potential [30][31] Group 5: Electronics Industry - Sunrock Electronics - Sunrock Electronics reported a sales revenue of 3.224 billion yuan in the first half of 2025, marking a year-on-year increase of 19.80% [32][33] - The company is experiencing growth in its automotive electronics and data center business, with significant contributions to its revenue from these sectors [34] - The report maintains a positive outlook on the company's profitability, projecting net profits of 1.05 billion yuan for 2025 and 1.28 billion yuan for 2026 [35]

Core Insights - The collaboration between the company and Merck focuses on the global development of TROP2 ADC, specifically the drug SKB264, which is recognized for its potential as a blockbuster product [1] - SKB264 is currently in the phase III global multi-center registration clinical trials for over ten solid tumor indications, with significant data expected to be disclosed in 2027 [1] - SKB264 has demonstrated superior efficacy in various patient populations, particularly in NSCLC, outperforming competitors in terms of median progression-free survival (mPFS) [2][3] Group 1: Product Development and Clinical Trials - SKB264 has entered the phase III clinical trial stage for multiple solid tumors, with Merck planning to disclose nine clinical trial data points in 2027 [1] - The drug has shown promising results in the first-line wild-type NSCLC population, achieving an mPFS of 15.0 months when combined with PD-1 monoclonal antibody KL-A167, surpassing other TROP2 ADCs [2] - In the PD-L1 TPS≥1% population, SKB264 achieved an mPFS of 17.8 months, and in the PD-L1 TPS<1% group, it reached 12.4 months, indicating its efficacy across different expression levels [2] Group 2: Competitive Landscape - SKB264 is positioned in the first tier of the global TROP2 ADC competition, alongside Gilead's Trodelvy and AstraZeneca/Daiichi Sankyo's Dato-DXd [1] - The molecular design of SKB264 provides it with better plasma stability and a longer half-life compared to Trodelvy, while being slightly shorter than Dato-DXd [1] Group 3: Future Directions and Market Potential - The rise of next-generation immunotherapy drugs suggests that IO+ADC combination therapies may become a key focus in the treatment of solid tumors [3] - The collaboration between BMS and BioNTech to develop a dual-specific antibody candidate highlights the commercial potential of combining IO with ADC therapies [3] Group 4: Financial Projections - The company forecasts revenues of 2.084 billion, 2.876 billion, and 4.663 billion yuan for the years 2025 to 2027, respectively, with net profits expected to improve significantly by 2027 [4]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 四川科倫博泰生物醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6990） 董事會會議通告 四 川 科 倫 博 泰 生 物 醫 藥 股 份 有 限 公 司（「本公司」）董 事 會（「董事會」）茲 通 告 謹 定 於2025年8月18日（星 期 一）舉 行 董 事 會 會 議，以（其 中 包 括）考 慮 及 批 准 本 公 司 及 其附屬公司截至2025年6月30日 止 六 個 月 之 中 期 業 績 及 其 發 佈，以 及 處 理 其 他 事 項。 中 期 業 績 發 佈 後，本 公 司 的 管 理 層 將 於 香 港╱北 京 時 間2025年8月18日（星 期 一） 下 午 八 時 正（即 格 林 威 治 標 準 時 間2 ...

Investment Rating - The report maintains a "Buy" rating for the company [5][7]. Core Insights - The company's core product, SKB264, is positioned as a promising ADC targeting TROP2, with significant clinical trial progress and potential for commercialization [1][14]. - SKB264 has shown superior efficacy in various clinical settings, particularly in NSCLC, outperforming competitors in terms of mPFS [2][24]. - The collaboration with Merck enhances the global development strategy for SKB264, indicating strong commercial potential [1][15]. Summary by Sections Section 1: Collaboration and Clinical Development - The company has partnered with Merck to develop SKB264, which is currently in multiple Phase III clinical trials for various indications, including NSCLC and triple-negative breast cancer [14][15]. - SKB264 is recognized as a candidate with "blockbuster potential" by Merck, reflecting confidence in its market value [16]. Section 2: Efficacy in NSCLC - In the first-line treatment of wild-type NSCLC, SKB264 demonstrated a median progression-free survival (mPFS) of 15.0 months, significantly better than other TROP2 ADCs [2][24]. - In patients with PD-L1 TPS ≥1%, the mPFS reached 17.8 months, showcasing its effectiveness in this subgroup [2][24]. - SKB264 also exhibited promising results in EGFR-mutated NSCLC patients, with a notable reduction in tumor size compared to standard treatments [3][36]. Section 3: Future Potential and Market Position - The report highlights the potential of combining next-generation immunotherapy with ADCs, positioning SKB264 as a key player in this evolving treatment landscape [4][19]. - The competitive landscape for TROP2 ADCs is intensifying, with SKB264 among the leading candidates, necessitating close monitoring of upcoming clinical data [19][21]. Section 4: Financial Projections - Revenue forecasts for the company are optimistic, with projected revenues of 2.084 billion, 2.876 billion, and 4.663 billion CNY for 2025, 2026, and 2027 respectively [5][7]. - The company is expected to achieve profitability by 2027, with a projected net profit of 561 million CNY [5].

Core Insights - Adidas reported a 7% year-on-year revenue growth for FY2025H1, reaching €12.105 billion, with a net profit increase of 121% to €798 million [4] - The brand's revenue growth was 14% on a currency-neutral basis, with all regional markets achieving double-digit growth [4] - The company maintains its full-year guidance, expecting high single-digit revenue growth on a currency-neutral basis for FY2025, with double-digit growth for the Adidas brand [4] Market Trends - The domestic market indices showed positive performance, with the Shanghai Composite Index closing at 3,617.60, up 0.96% [3] - The textile and apparel sector experienced a decline of 2.14% this week, underperforming the broader market [5] - Retail sales of sports and entertainment products grew significantly, with a 22.2% year-on-year increase in the first half of 2025 [5] Industry Dynamics - The Chinese gold consumption in the first half of 2025 was 505.205 tons, a decrease of 3.54% year-on-year, with jewelry consumption dropping by 26% [5] - The pharmaceutical industry is seeing advancements in innovative drugs, particularly in obesity treatments with GLP-1 and Amylin therapies showing promising results in clinical trials [8][11] - In the biopharmaceutical sector, ADC drugs for lung cancer are demonstrating significant efficacy, with several products showing improved outcomes in clinical trials [10][12]

Core Viewpoint - The Hong Kong innovative drug company, Keren Biotechnology, has reached a market capitalization of HKD 101 billion, marking its entry into the exclusive club of companies valued over HKD 100 billion in the innovative drug sector [1][4]. Group 1: Market Performance - As of August 5, Keren Biotechnology's stock closed at HKD 433 per share, reflecting a sevenfold increase from its IPO price in July 2023 [4]. - The innovative drug sector in Hong Kong has seen multiple stocks reaching new highs, with seven companies now having market capitalizations exceeding HKD 100 billion, including Keren Biotechnology, Hengrui Medicine, and Innovent Biologics [1][2]. Group 2: Business Development (BD) and Collaborations - Hengrui Medicine announced a collaboration with GlaxoSmithKline (GSK) on a PDE3/4 inhibitor and up to 11 other projects, indicating a trend of active business development in the sector [2]. - The recent announcement by CSPC Pharmaceutical regarding a licensing agreement with Madrigal for a GLP-1 receptor agonist also highlights the growing BD activities among innovative drug companies [2]. Group 3: Policy and Market Sentiment - Recent policy adjustments, such as the initiation of a commercial health insurance innovative drug directory, are expected to enhance the payment landscape for innovative drugs, contributing to positive market sentiment [2]. - The overall optimistic sentiment in the Hong Kong innovative drug market is driving the continuous rise in stock prices [2]. Group 4: Company-Specific Developments - Keren Biotechnology is evolving into a comprehensive biopharmaceutical platform, with its lead product, sac-TMT, showing significant progress in clinical trials for various cancer treatments [4][5]. - The company has multiple differentiated ADC pipelines and is advancing its HER2 ADC, A166, with two applications currently under review in China [5]. - Keren Biotechnology is expected to reach operational breakeven within two years, reflecting its strategic growth trajectory [5].

Market Overview - US stock indices rebounded, influenced positively by Trump's market support, leading to a 0.68% rise in Hong Kong stocks [1] - San Francisco Fed President Daly indicated that the timing for interest rate cuts is approaching, with expectations for two 25 basis point cuts this year [1] - Goldman Sachs predicts three consecutive 25 basis point cuts starting in September, with a potential 50 basis point cut if unemployment rises further [1] Domestic Market Sentiment - A-share new account openings in July reached 1.96 million, a 71% year-on-year increase, indicating rising domestic confidence [2] - The stock of Upwind New Materials surged 20% after resuming trading, reigniting market enthusiasm [2] - The steel sector saw a significant rise, with Maanshan Iron & Steel's stock increasing over 15% due to improved loss forecasts and supportive policies [2] Industry Trends - The paper industry is experiencing a price increase, with major companies like Nine Dragons Paper and Lee & Man Paper announcing price hikes [2] - The eleventh batch of centralized drug procurement in China saw a record 45 companies applying for the same drug, intensifying competition in the generic drug market [3] - Investment is shifting towards innovative drugs, with companies like Junshi Biosciences seeing stock increases of nearly 34% due to promising clinical trials [3] Financial Support for Key Industries - A joint guideline from the central bank and seven departments aims to support financing for key manufacturing sectors, including integrated circuits and medical equipment [4] - AI-related companies like Longi Green Energy and Lenovo's server business are seeing stock increases due to new orders and market interest [4] Gaming Industry Performance - The domestic gaming market is projected to reach RMB 168 billion in sales by the first half of 2025, a 14.08% year-on-year increase [4] - Heartbeat Games anticipates a revenue increase of approximately 37% for the first half of 2025, driven by strong performance from self-developed games [4] Individual Company Highlights - Tencent's mobile game "Valorant: Source Action" is set to launch on August 19, with projected annual revenue exceeding RMB 6 billion [5] - Oriental Selection's stock surged nearly 17% ahead of its upcoming financial report, reflecting strong market performance [6] - The Macau gaming sector is experiencing a positive trend, with Morgan Stanley raising its revenue growth forecast for the year from 5% to 10% [6] Technological Advancements - Apple's breakthrough in brain-computer interface (BCI) technology allows users to control devices through thought, indicating a significant market opportunity [7] - The Chinese BCI market is expected to exceed RMB 3.8 billion by 2025, with a CAGR of approximately 20% [7] Investment Opportunities - Kelun-Bio has become a top holding in a major fund, indicating strong market confidence in its innovative drug pipeline [8] - The company has established multiple technology platforms and is expected to accelerate commercialization in 2025 [8]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 四川科倫博泰生物醫藥股份有限公司 (於中華人民共和國註冊成立的股份有限公司) 呈交日期: 2025年8月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06990 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 162,769,979 | RMB | | 1 RMB | | 162,769,979 | | 增加 / 減少 (-) | | | | | | RMB | | | | 本月底結存 | | | 162,769,979 | RMB | | 1 RMB | | 162,769,979 | | 2. 股份分類 ...

Core Insights - The innovative drug sector has seen significant growth this year, with the China Securities Hong Kong Stock Connect Innovative Drug Index rising over 124% since the beginning of the year, and the Shanghai Stock Exchange Sci-Tech Innovation Board Innovative Drug Index increasing over 80% [2][3] - There is a growing divergence in opinions among fund managers regarding the valuation of innovative drugs, with some expressing caution and suggesting profit-taking, while others remain optimistic about future growth [2][11] Fund Performance - As of July 29, 2023, 16 funds have reported returns exceeding 100%, all heavily invested in the innovative drug sector [5] - The fund managed by Zhang Wei, Huatai-PineBridge Hong Kong Advantage Selection, leads with a 139% return [5] - The total scale of funds focused on innovative drugs has increased from 111 billion yuan to 366 billion yuan this year, marking a growth of over 200% [5] Market Dynamics - The innovative drug sector has attracted significant investor interest, with the scale of the Huatai-PineBridge National Index Hong Kong Stock Connect Innovative Drug ETF rising from less than 700 million yuan to nearly 8 billion yuan in the first half of the year [5] - The innovative drug index has seen a net inflow of 172 billion yuan, making it one of the highest net buying sectors this year [5][6] Valuation Concerns - Some fund managers, like Wan Minyuan from Rongtong Fund, have raised concerns about the high valuations of A-share innovative drug stocks, suggesting that many companies may have reached their peak valuations [11][12] - There is a belief that the current market is experiencing a bubble, with excessive speculation on early-stage clinical drugs [11][12] Long-term Outlook - The innovative drug sector is viewed as a critical area for investment, with expectations of continued growth driven by technological advancements and supportive policies [10][14] - Fund managers emphasize the importance of selecting companies with strong technological capabilities and sustainable clinical value to navigate potential market volatility [2][14]

Group 1 - The overall market has seen significant growth in 2023, with 23 funds achieving over 100% returns year-to-date, predominantly in the pharmaceutical sector [1][3] - Among these, 17 funds are focused on innovative drugs, making up over 70% of the "doubling funds," with the top performers including 汇添富香港优势精选混合 (QDII) C at 139.12% [4][6] - Over the past year, a total of 134 funds have doubled their returns, with the top fund, 中信建投北交所两年定开混合 A, achieving a remarkable 207.48% return [4][5] Group 2 - The pharmaceutical sector remains a focal point for investment, with analysts optimistic about the innovative drug market and its potential for continued growth [6][7] - Key stocks in high-performing funds include 三生制药 and 科伦博泰生物-B, which have seen substantial price increases of 428.9% and 138% respectively [6][7] - The outlook for the third quarter suggests ongoing opportunities in the innovative drug space, driven by global collaborations and significant clinical data releases [6][7]