Summary of Conference Call Industry Overview - The conference focused on updates and developments in the Chinese biopharmaceutical industry, particularly highlighting companies such as BeiGene, 3SBio, and Kelun-Biotech [1][10]. Key Company Insights BeiGene - BeiGene's BCL-2 inhibitor has been approved for sale in China and is expected to receive accelerated approval in the U.S. within the year [1]. - BCL-2 is viewed as a second growth driver for BeiGene, complementing its existing BTK inhibitors, which have shown rapid sales growth in the U.S. market [2]. - The company has a robust pipeline for solid tumors, with several candidates entering late-stage development, including treatments for breast cancer and other indications [3]. - BeiGene is anticipated to report its first annual profit, with expectations that its annual report may exceed forecasts [3]. 3SBio - Pfizer has outlined a global development plan for its drug 707, with five global Phase III trials expected to start by 2026, targeting various cancers [4]. - The trials include first-line treatments for colorectal cancer and non-small cell lung cancer [4]. Kelun-Biotech - Kelun-Biotech is expected to have a significant year with five products anticipated to be commercialized, three of which have already been included in the national medical insurance [5]. - The company has successfully commercialized its top two ADC products and is expected to see explosive growth following their inclusion in insurance [5]. Innovent Biologics - Innovent's Ivosidenib is expected to receive final approval from the FDA in Q4 of this year, with ongoing clinical trials for various cancers [6][7]. - The company is also preparing for the commercialization of its CAR-T product, which has already been approved domestically [8]. Rongchang - Rongchang has announced plans for three Phase III trials, including one for non-small cell lung cancer, which has received FDA approval [7][8]. Other Notable Mentions - Merck has initiated 16 global Phase III trials for its drug targeting various major indications, with data expected in the second half of the year [5]. - The conference highlighted the importance of clinical trial data releases for several companies, which are crucial for their long-term valuations [3][10]. Market Dynamics - The overall market for innovative drugs is currently experiencing a downturn, primarily due to internal funding shifts within the pharmaceutical sector [10]. - The high percentage of holdings in innovative and traditional pharmaceuticals (around 75%) has led to a reallocation of funds towards other sectors like AI healthcare and CROs [11]. - Despite the market's performance, the fundamental aspects of many companies remain strong, with ongoing clinical advancements and positive earnings expectations [11]. - The total amount of business development (BD) transactions in recent weeks has already reached 25% of last year's total, indicating a robust pace of international expansion [11]. Conclusion - The conference provided a comprehensive overview of the current state of the biopharmaceutical industry in China, highlighting significant advancements and the potential for growth among key players. The market dynamics suggest a temporary disconnect between stock performance and fundamental company health, indicating potential investment opportunities.

Group 1 - The QDII funds have shown impressive performance since 2025, with an average net value increase of 27.9%, particularly driven by funds heavily invested in Hong Kong innovative pharmaceuticals [2] - Notable funds such as Huatai-PB Korea Semiconductor ETF and E Fund Global Growth Select Mixed A have seen net value increases of 127.55% and 102.91% respectively, with several other funds also exceeding 80% growth [2] - The top holdings of these high-performing funds predominantly include Hong Kong innovative pharmaceutical stocks, with examples like Kelun-Botai Biotech and Innovent Biologics among the top five holdings of Huatai-PB Hong Kong Advantage Select Mixed A [2] Group 2 - The technology sector is also a key focus for many high-performing products, with E Fund Global Growth Select Mixed A holding major global tech stocks such as TSMC and Google-A among its top ten holdings [3] - Fund managers express optimism for the future of the innovative pharmaceutical and technology sectors, citing a recent phase of adjustment in the innovative drug industry as a temporary market sentiment issue rather than a fundamental change [4][5] - The innovative drug sector's valuation has become attractive, with expectations of upward potential, and the industry is anticipated to show resilience and technological attributes over the next 2 to 3 years [5] Group 3 - The pharmaceutical industry is expected to see positive changes in 2026, with contract development organizations (CXO) gaining confidence from solid data, and new technologies like artificial intelligence and brain-machine interfaces opening new application scenarios [5] - The semiconductor sector, particularly in storage, is projected to continue its cycle, with local market trends favoring leading storage manufacturers and potential IPOs supporting capacity expansion [6]

茲提述本公司日期為2026年1月16日 的 公 告，內 容 有 關2026年研發相關物 資 框 架 協 議 的 持 續 關 連 交 易（「該公告」）。除 另 有 界 定 外，本 公 告 所 用 詞 彙 與 該 公 告 所 界 定 者 具 有 相 同 涵 義。董 事 會 謹 此 知 會，於2026年1月1日 至 16日（包 括 首 尾 兩 日）期 間，概 無 根 據2026年研發相關物資框架協議進行 交 易，並 謹 此 提 供 根 據2026年研發相關物資框架協議擬向華潤科倫及╱或 其 附 屬 公 司 採 購 研 發 相 關 物 資 的 定 價 政 策 的 補 充 資 料。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的 任 何 損 失 承 擔 任 何 責 任。 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 四川科倫博泰生物醫藥股份有限公司 （於 中 華 人 民 共 和 國 ...

Group 1 - The 2025 Hurun China Unicorn Graduation List identifies 796 companies that have graduated as unicorns, valued at over $1 billion, established after 2000 [1][3] - Chengdu ranks seventh in the number of listed companies, with 18 enterprises making the list [1][4] - The total value of these unicorn graduates across China reaches 24 trillion RMB, with an average establishment year of 2006 and an average age of 19 years [2][3] Group 2 - The top five industries by the number of listed companies are semiconductors, industrial equipment, biotechnology, new energy, and software services, accounting for 46% of the total [3] - The highest valued industries are semiconductors, new energy, industrial equipment, consumer electronics, and biotechnology [3] - Among the 796 unicorn graduates, 33 companies are valued over 100 billion RMB, with 3 exceeding 1 trillion RMB [3][4] Group 3 - Chengdu's notable companies include: - Xinyi Technology (New Easy Win) ranked 44th with a valuation of 82 billion RMB in telecommunications [2][5] - Kelong Botai Biotechnology ranked 55th with a valuation of 11 billion RMB in biotechnology [2][5] - Zhonghang Unmanned Aerial Vehicle ranked 149th with a valuation of 30 billion RMB in robotics [2][5] - Chengdu Huami and Jiachitech both ranked 236th with valuations of 21 billion RMB in semiconductors and new materials respectively [2][5] - Other notable companies include Dekang Agriculture Technology, Huatuo Shanding, and Tea Hundred Road, with valuations ranging from 13 billion to 19 billion RMB [2][5]

格隆汇1月16日丨科伦博泰生物-B(06990.HK)公告，有关2023年研发相关药物及消耗品框架协议，该协 议已于2025年12月31日届满。鉴于上述情况，于2026年1月16日，公司订立了2026年研发相关物资框架 协议，期限由2026年1月16日起至2028年12月31日止，据此，公司同意于2026年研发相关物资框架协议 期限内，不时向华润科伦及╱或其附属公司采购研发相关药物、消耗品及固定资产。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的 任 何 損 失 承 擔 任 何 責 任。 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 四川科倫博泰生物醫藥股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6990） 持續關連交易 2026年研發相關 物 資 框架協議 茲提述本公司日期為2023年6月29日 之 招 股 章 程，內 容 有 關2023年研發 相 關 藥 物 及 消 耗 品 框 架 協 議，該 協 議 已 於2025年12月31日 屆 滿。 華 潤 科 倫 為 本 公 司 董 事 劉 思 川 先 生 的 聯 繫 人。因 此，根 據 上 市 規 則 第 十 四A章，華 潤 科 倫 為 本 公 司 的 關 連 人 士。因 此，根 據 上 市 規 則 第 十 四 A章，2026年研發相關 物 資 框架協 ...

Summary of Sichuan Kelun-Biotech Biopharmaceutical FY Conference Company Overview - **Company Name**: Sichuan Kelun-Biotech Biopharmaceutical (SEHK:06990) - **Industry**: Biopharmaceuticals - **Focus Areas**: Research, development, manufacturing, and commercialization of novel drugs in oncology, immunology, metabolism, and other therapeutic areas [2][3] Key Points Pipeline and Product Development - **Pipeline Programs**: Over 30 pipeline programs, including four approved products with seven indications, two products at NDA stage, and over 10 in clinical development [3] - **Employee Count**: Approximately 2,000 employees, with 900 in R&D, 500 in manufacturing and quality control, and 500 in sales and marketing [3] - **Approved Products**: - TROP2 ADC (SAC-TMT) approved for three indications in China, including lung cancer [4] - HER2-ADC (trastuzumab botidotecan) approved for HER2-positive breast cancer [4] - Cetuximab N01 for RAS wild-type colorectal cancer and PD-L1 for nasopharyngeal carcinoma [4] Clinical Studies and Results - **Clinical Trials**: Five pivotal studies initiated for breast cancer, six for lung cancer, and one for gastrointestinal cancer [5] - **Study Presentations**: Clinical data presented at major conferences, including ESMO and published in journals like the New England Journal of Medicine [6] - **Efficacy Data**: SAC-TMT demonstrated significant improvements in progression-free survival (PFS) and overall survival (OS) in various cancer types [10] Strategic Collaborations - **Partnerships**: Collaborations with MSD, Ellipses Pharma, and others to enhance pipeline value and global market reach [7][8] - **Out-License Agreements**: Entered into agreements to develop and commercialize novel oncology therapies [8] Market Position and Future Plans - **Market Access**: Three core products included in the National Reimbursement Drug List (NRDL) effective January 2026 [7] - **Commercialization Strategy**: Full-fledged commercialization team established, focusing on Class III hospitals and key opinion leaders [6] - **Growth Plans**: Focus on advancing differentiated pipeline programs, optimizing ADC platform, and expanding capabilities for drug development and commercialization [15][16] Innovation and Technology - **OptiDC Platform**: A world-class drug-conjugate technology platform aimed at optimizing drug design for better efficacy and safety [2][13] - **Non-Oncology Applications**: Exploring ADCs for autoimmune and metabolic diseases, combining biologicals and small molecules [14][15] Additional Insights - **Market Trends**: The company is positioned to leverage its innovative drug development capabilities in a rapidly evolving biopharmaceutical landscape, particularly in oncology [2][15] - **Regulatory Environment**: The inclusion of products in the NRDL indicates a supportive regulatory environment for biopharmaceuticals in China [7] This summary encapsulates the key aspects of the conference, highlighting the company's strategic direction, product pipeline, and market positioning within the biopharmaceutical industry.

Core Insights - The 44th J.P. Morgan Healthcare Conference has highlighted significant industry developments, including a $1 billion investment by NVIDIA and Eli Lilly to establish a joint research lab in the San Francisco Bay Area to accelerate AI applications in the pharmaceutical sector [1] - The conference serves as a critical platform for domestic pharmaceutical companies to showcase core molecular product capabilities and advance overseas business development collaborations, indicating a return to global value validation for products [2] - The participation of over 8,000 global attendees and more than 500 listed companies underscores the strengthening global competitiveness of Chinese companies in the pharmaceutical sector [2] Group 1: Innovative Drugs - BeiGene focuses on oncology drug development and global commercialization, presenting progress on core products like CDK4 at the conference [2] - Rongchang Biologics has entered an exclusive licensing agreement with AbbVie for the novel PD-1/VEGF bispecific antibody drug RC148, granting AbbVie rights outside Greater China for development, production, and commercialization [2] - Hengrui Medicine, involved in the R&D, production, and sales of innovative and generic drugs, reported that over 50% of its revenue now comes from innovative drugs, with multiple self-developed products receiving approvals [2] Group 2: CRO/CMO - WuXi AppTec provides integrated CXO services covering the entire drug development and manufacturing process, projecting a 32.56% year-on-year growth in net profit for 2025 [3] - WuXi Biologics, specializing in biopharmaceutical CRDMO services, announced 209 new projects, bringing the total to 945, with potential milestone payments exceeding $4 billion from new research contracts [3] - Tigermed offers clinical trial CRO services and participated in the Asia-Pacific session of the conference, providing outsourcing services related to clinical trials for global pharmaceutical companies [3] Group 3: AI in Healthcare - NVIDIA and Eli Lilly's collaboration aims to build AI models to enhance new drug development, with a planned investment of $1 billion over the next five years [4] - RunDa Medical focuses on comprehensive medical testing services and is developing an automated testing interpretation system based on large models [4] - Anbiping has launched a digital pathology AI system and is exploring the registration and commercialization of AI medical devices in cervical cytology [4]

Core Viewpoint - The article discusses the evolving landscape of the Chinese healthcare sector, particularly in the context of the upcoming JP Morgan Healthcare Conference, highlighting the diversification of Chinese companies and their strategic positioning in the global market [4][29]. Group 1: Conference Overview - The JP Morgan Healthcare Conference is the largest and most informative international healthcare investment and business development meeting, scheduled for January 12-15, 2026, in San Francisco [4]. - Approximately 22 Chinese companies are participating, categorized into four distinct roles: transaction-oriented innovative drug companies, disclosure companies at commercialization or regulatory milestones, supply-side platforms for global R&D and production outsourcing, and device companies focusing on efficiency and international expansion [4]. Group 2: Supply-Side Platforms - Supply-side platform companies are becoming essential in the global innovation chain, as they focus on delivering stable and efficient R&D and production capabilities, especially during periods of increased volatility in innovative drug companies [6][8]. - WuXi Biologics is shifting its focus from project quantity to project quality, emphasizing capacity utilization and long-term contract stability as key indicators of its value in the global biopharmaceutical supply chain [8]. Group 3: Cross-Border Licensing and Outbound Companies - The pricing logic for Chinese innovative drugs in cross-border licensing has evolved, with a focus on the overall deliverable capabilities rather than just the individual molecules [14]. - Companies like Kelun-Blotech and BaiLi Tianheng are exemplifying this trend by integrating their platforms into global R&D systems and establishing long-term collaborations with multinational pharmaceutical companies [16][18]. Group 4: Regulatory and Commercialization Companies - Companies that have accumulated clinical data and registration progress are transitioning towards verifiable sales and profit curves, shifting their valuation logic from future expectations to tangible cash flows [19]. - Zai Lab and Antengene are in the early commercialization stages, with their success hinging on their products' acceptance in clinical settings and the speed of prescription growth [21][23]. Group 5: Medical Device Companies - Mindray Medical is recognized for its comprehensive coverage of hospital workflows, with a focus on multi-product synergy rather than single-device performance, which is crucial for establishing long-term customer relationships [26]. - MicroPort Scientific is navigating a challenging environment where operational efficiency and cash flow management are critical for sustaining long-term clinical validation and international expansion [28]. Group 6: Industry Trends and Insights - The Chinese healthcare sector is transitioning from a phase of visibility to one of selection, where companies must clearly define their positions and deliverables in a high-intensity global exchange [29]. - The differentiation among Chinese companies in the global system is accelerating, with a clear divide between transaction-oriented innovative drug companies and those that have crossed critical regulatory milestones, focusing on verifiable growth [31].

Core Viewpoint - Recently, Kelong Botai Biopharmaceutical (Shanghai) Co., Ltd. was established with a registered capital of 5 million RMB, fully owned by Sichuan Kelong Botai Biopharmaceutical Co., Ltd. [1] Company Summary - The legal representative of Kelong Botai Biopharmaceutical (Shanghai) Co., Ltd. is Ding Nanchao [1] - The company operates in the field of scientific research and technical services, specifically in research and experimental development [1] - The registered address is located at 500 Lane 500, Furonghua Road, Pudong New District, Shanghai [1] - The company type is a limited liability company, wholly owned by a natural person [1] - The business scope includes medical research and experimental development (excluding human stem cells, gene diagnosis, and treatment technology development and application), import and export of goods, and technology import and export [1] Business Activities - The company is involved in various activities such as technical services, technical development, technical consulting, technical communication, technical transfer, and technical promotion [1] - It also organizes cultural and artistic exchange activities, conference and exhibition services (with overseas exhibitions subject to approval), marketing planning, corporate management consulting, and information technology consulting services [1]