Group 1 - The Hong Kong innovative drug sector is undergoing an unprecedented wave of value reassessment, with around 12 innovative drug concept stocks rising over 50% year-to-date, including Rongchang Biopharma and Sanofi Biotech, which have surged over 200% [1] - The ASCO annual meeting served as a key catalyst, showcasing over 70 research results from Chinese pharmaceutical companies, with Innovent Biologics' IBI363 clinical data generating significant attention due to its breakthrough efficacy in treating advanced non-small cell lung cancer [2] - License-out transactions have become a core engine for valuation reshaping, with 41 outbound transactions totaling $36.93 billion in Q1 2025, nearing the total for the entire year of 2023 [3] Group 2 - Domestic drug approvals are accelerating, with the National Medical Products Administration approving 11 innovative drugs from 8 companies, including 9 domestically developed drugs, indicating a robust pipeline for commercialization [4] - The policy environment is favorable, with the National Healthcare Security Administration constructing a multi-tiered payment system to support innovative drugs throughout their lifecycle, enhancing the attractiveness of the sector [5] - The pharmaceutical sector is expected to see strong performance in H1 2025, driven by favorable external conditions and the ongoing trend of self-sufficiency in drug development [6]

Core Insights - Bristol-Myers Squibb (BMS) acquired BioNTech's PD-L1/VEGF dual antibody BNT327 for $9 billion, highlighting the increasing interest in Chinese biotech firms and their innovative drug pipelines [1][2] - The rapid financial success of BioNTech, which earned over $8 billion from the initial $55 million licensing deal with Chinese firm Pumice Biologics, raises questions about the pricing strategies of Chinese pharmaceutical companies in the global market [1][2][3] - The trend of multinational corporations (MNCs) aggressively acquiring Chinese dual antibodies is reshaping the global landscape of innovative drugs, with significant deals such as the $6.05 billion agreement between 3SBio and Pfizer [1][4] Group 1: Major Transactions - BMS's deal with BioNTech includes a $1.5 billion upfront payment, a record for oncology licensing agreements, along with additional milestone payments totaling $76 billion [2] - 3SBio's licensing of its PD-1/VEGF dual antibody SSGJ-707 to Pfizer for $6.05 billion, with an upfront payment of $1.25 billion, sets a new record for domestic innovative drug licensing [4][5] - Other notable transactions include Merck's $3.3 billion investment in LianBio and the anticipated $5 billion deal involving Shijiazhuang Yiling Pharmaceutical [5][6] Group 2: Market Dynamics - The surge in MNCs acquiring Chinese dual antibodies is driven by the expiration of patents for existing blockbuster drugs and the need for new products [6][7] - Chinese innovative drug companies benefit from lower development costs and a large patient pool, making them attractive targets for MNCs seeking to enhance their product pipelines [6][7] - The total value of outbound licensing deals for Chinese innovative drugs reached $45.5 billion since early 2025, with 42% of high-value projects coming from China [5][6] Group 3: Future Outlook - The ongoing trend of MNCs partnering with Chinese biotech firms is expected to bolster the confidence of domestic companies in pursuing research and development [7][8] - The ability of Chinese innovative drug companies to negotiate higher prices in licensing deals will depend on their negotiation skills and market positioning [8] - The need for a "pricing power revolution" in the Chinese pharmaceutical industry is emphasized, as companies face challenges from rising R&D costs and stringent domestic pricing policies [9]

Core Viewpoint - The cell immunotherapy sector has shown significant growth, with a 3.87% increase, ranking second among concept sectors, driven by strong performances from several stocks [1][2]. Group 1: Sector Performance - As of June 3, the cell immunotherapy concept saw 51 stocks rise, with notable gainers including Shutaishen and Guanhao Biological, both reaching a 20% limit up [1]. - Other top performers in the sector included Hainan Haiyao, Rui Zhi Pharmaceutical, and Zuo Li Pharmaceutical, with increases of 9.97%, 13.15%, and 10.66% respectively [1][2]. - Conversely, stocks like Xue Rong Biological, *ST Biological, and Fosun Pharmaceutical experienced declines of 1.76%, 1.14%, and 0.39% respectively [1]. Group 2: Capital Flow - The cell immunotherapy sector attracted a net inflow of 269 million yuan, with 34 stocks receiving significant capital inflows [2]. - Leading the net inflow was Huahai Pharmaceutical, which saw 266 million yuan enter, followed by Guanhao Biological and Hainan Haiyao with inflows of 159 million yuan and 64.85 million yuan respectively [2][3]. - The highest net inflow ratios were recorded for ST Zhongzhu, Hainan Haiyao, and Huahai Pharmaceutical, at 15.16%, 13.79%, and 12.53% respectively [3]. Group 3: Stock Specifics - Huahai Pharmaceutical had a daily increase of 7.63% with a turnover rate of 7.71% and a net capital flow of 266.08 million yuan [3]. - Guanhao Biological surged by 19.97% with a turnover rate of 28.68% and a net capital flow of 159.24 million yuan [3]. - Hainan Haiyao also performed well, increasing by 9.97% with a turnover rate of 6.18% and a net capital flow of 64.85 million yuan [3].

Investment Rating - The report assigns an "Overweight" rating to the pharmaceutical and biotechnology industry, indicating that the industry index is expected to outperform the CSI 300 index by 10% or more over the next six months [2][37]. Core Insights - The pharmaceutical and biotechnology sector saw an overall increase of 2.21% in the week from May 26 to May 30, ranking second among 31 industries in the Shenwan index and outperforming the CSI 300 index by 3.29 percentage points. Year-to-date, the sector has risen by 6.61%, ranking sixth among the 31 industries and outperforming the CSI 300 index by 9.02 percentage points [4][13][15]. - The current PE valuation for the pharmaceutical and biotechnology sector is 27.98 times, which is at the historical median level, with a valuation premium of 137% compared to the CSI 300 index. The top three sub-sectors in terms of growth are chemical pharmaceuticals, biological products, and medical services, with increases of 3.83%, 3.14%, and 2.46% respectively [4][22][15]. - A total of 373 stocks (77.9%) in the sector rose last week, while 97 stocks (20.3%) declined. The top five gainers were Shuyou Shen (60.41%), Huason Pharmaceutical (41.97%), Changshan Pharmaceutical (35.91%), Huana Pharmaceutical (32.62%), and Yifang Biological (30.51%) [4][27]. Market Performance - The pharmaceutical and biotechnology sector's performance is highlighted by the approval of 11 innovative drugs by the National Medical Products Administration (NMPA) on May 29, which enhances treatment options for patients and showcases the increasing innovation capability of China's pharmaceutical industry [5][29]. - The 2025 American Society of Clinical Oncology (ASCO) annual meeting showcased several domestic innovative drug projects, indicating that local companies are gaining international recognition for their innovative capabilities [5][32]. Investment Recommendations - The report suggests focusing on the innovative drug sector as it is the most certain and leading sub-sector within the pharmaceutical and biotechnology industry. Additionally, it recommends exploring investment opportunities in medical devices, traditional Chinese medicine, chain pharmacies, and medical services [6][35]. - Recommended stocks include Beida Pharmaceutical, Te Bao Biological, Qianhong Pharmaceutical, Ling Rui Pharmaceutical, and Lao Bai Xing. Stocks to watch include Kelong Pharmaceutical, Rongchang Biological, Kaili Medical, Huaxia Eye Hospital, and Baipu Sais [6][35].

Group 1 - The core viewpoint highlights the positive market reaction to the collaboration between Bristol-Myers Squibb and BioNTech regarding the new cancer drug BNT327, with milestone payments potentially reaching $11.1 billion, which has boosted the performance of innovative drug concept stocks [1] - The performance of the Kexin Biopharmaceutical ETF (588250.SH) increased by 1.23%, with its associated index Kexin Biopharmaceutical (000683.SH) rising by 0.96%, indicating a favorable market sentiment towards the biopharmaceutical sector [1] - Notable increases in major component stocks include Microchip Biotech rising by 9.44%, Huaxi Biotech by 7.63%, and Rongchang Biotech by 4.92%, reflecting strong investor interest in innovative drug companies [1] Group 2 - Guosen Securities reported significant advancements in domestic innovative drugs, particularly focusing on bispecific antibodies and ADC technologies, with promising clinical data from Innovent Biologics and Mingji Biotech in pancreatic cancer treatments [2] - Shenwan Hongyuan highlighted Huaxi Biotech as a key player in the recombinant collagen market, benefiting from the domestic beauty trend and strong brand recognition, suggesting potential for consumer recovery [2] - Both research institutions' insights align with the performance of innovative drug and medical beauty leading companies within the Kexin Biopharmaceutical ETF [2]

作者 | 黄绎达 编辑 | 郑怀舟 在A股市场，鲜有连续熊市超过三年的行业板块，而医药板块是其中的典型。从2021年7月到去年924行情启动之前，该板块经历了连续3年的下行调整， 申万医药生物指数在此期间的跌幅高达54%，板块市值近乎腰斩，众多医药龙头股亦同步陷入估值与业绩的双重回调。 在医药板块持续低迷的周期中，曾经风光无两的医药主题基金（以下简称：医药基金）也褪去了往日的光彩。根据wind统计，受医药板块长期熊市的拖 累，即便有去年924行情的提振，今年医药板块有所反弹，目前存续的600余只医药基金中，截至今年5月28日，大约2/3的基金净值目前还在1以下，最低 者甚至只有0.35。 但是从短期来看，进入2025年后，半数以上的医药基金在今年（截至5月28日）取得了正收益，表现优异者如长城医药产业精选、永赢医药创新智选、华 安医药生物、中银大健康等基金的同期收益在47%~56%区间，同类基金同期排名亦均位于前列，似乎医药基金的春天回来了。 那么，驱动医药基金在今年回暖的核心因素都有哪些？医药基金现在还能买吗？ 01 医药大盘反弹在beta层面支撑医药基金走强 医药基金近年来长期表现相对颓势，在不发生风格漂 ...

| 证券代码：688331 | 证券简称：荣昌生物 公告编号：2025-032 | | --- | --- | | 港股代码：09995 | 港股简称：榮昌生物 | 荣昌生物制药（烟台）股份有限公司 关于完成发行 H 股的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 荣昌生物制药（烟台）股份有限公司（以下简称"本公司"）于2025年5月22 日发布了《荣昌生物制药（烟台）股份有限公司关于根据一般授权发行H股的公告》 （公告编号：2025-025），内容有关配售本公司19,000,000股新H股（以下简称"本 次配售"）。除另有界定外，本公告所用词汇与该公告所定义者具有相同含义。 二、配售事项完成后的股本变动 因发行配售股份，本公司已发行股份总数由544,608,243股增加至563,608,243 股。本次配售完成后，本公司已发行H股总数由189,581,239股H股增加至 208,581,239股H股，而A股数目维持不变，仍为355,027,004股A股。 董事会欣然宣布，配售协议中规定的所有先决条件均已达成（包括取 ...

Core Viewpoint - Rongchang Biologics (688331.SH) successfully issued a total of 19 million new H-shares at a placement price of HKD 42.44 per share, raising approximately HKD 806.36 million in total proceeds [1] Group 1 - The new H-shares represent about 9.11% of the enlarged total issued H-shares after the placement [1] - The total issued shares after the placement will increase by approximately 3.37% [1] - The net proceeds from the placement, after deducting commissions and estimated expenses, will amount to approximately HKD 796 million [1]

Group 1: Market Performance - Major indices experienced a strong rebound, with the Shanghai Composite Index rising by 0.7%, Shenzhen Component Index by 1.24%, and ChiNext Index by 1.37% [2] - Over 4,200 stocks in the two markets saw gains, with a total trading volume of approximately 1.19 trillion yuan [2] Group 2: Digital Currency and Software Sector - The digital currency and software sectors led the market rally, with notable stocks like Lakala (300773.SZ) and Sifang Jingchuang (300468.SZ) hitting the daily limit with a 20% surge [2] - New Guodu (300130.SZ) rose over 14%, while Feitian Chengxin (300386.SZ) and Shenzhou Information (000555.SZ) also saw significant increases of 12.84% and 10%, respectively [2] Group 3: Autonomous Driving and Intelligent Connected Vehicles - Stocks related to autonomous driving and intelligent connected vehicles surged, with companies like Fulongma (603686.SH) and Jintour Environment (001230.SZ) hitting the daily limit [3] - A strategic cooperation agreement was signed between Xiaoma Zhixing and Guangzhou Public Transport Group, focusing on autonomous vehicle services [3] Group 4: Innovative Pharmaceuticals - The innovative pharmaceutical sector remains active, with companies like Sanofi Guojian (688336.SH) rising over 12% [4][3] - The sector is supported by policy backing, global competitiveness, and improving fundamentals, with a focus on "innovation + internationalization" [4] Group 5: Automotive Sector - The automotive sector showed strong performance, with Jinlong Automobile (600686.SH) and Dongfeng Co. (600006.SH) both increasing by 10% [5] - The launch of new models by XPeng and supportive government policies in Fujian province are contributing factors to the sector's growth [5] Group 6: Weak Sectors - The precious metals and food processing sectors experienced declines, with companies like Western Gold (601069.SH) and Laiyifen (603777.SH) seeing significant drops [5]

Core Viewpoint - RemeGen Co., Ltd. has received approval from the National Medical Products Administration (NMPA) in China for the marketing of Taitizumab (brand name: Tai'ai®) for the treatment of generalized myasthenia gravis (gMG) in adult patients who are positive for acetylcholine receptor (AChR) antibodies [1][2]. Group 1: Product Approval and Clinical Benefits - Taitizumab has shown significant clinical benefits in gMG patients, with 98.1% of patients in the Taitizumab group improving their Myasthenia Gravis Activities of Daily Living (MG-ADL) score by at least 3 points after 24 weeks, compared to only 12.0% in the placebo group [2]. - The Taitizumab group experienced a reduction in MG-ADL scores by 5.74 points from baseline, while the placebo group saw a reduction of only 0.91 points [2]. - In terms of Quantitative Myasthenia Gravis (QMG) scores, 87.0% of patients in the Taitizumab group improved by at least 5 points, compared to 16.0% in the placebo group, with a reduction of 8.66 points from baseline in the Taitizumab group versus 2.27 points in the placebo group [2]. Group 2: Market Potential and Unmet Needs - There is a significant unmet clinical need for gMG treatments, with approximately 120 million patients globally, including around 220,000 patients in China, of which 80%-85% are AChR antibody positive [3]. - The approval of Taitizumab in China is expected to benefit a larger population of gMG patients and help achieve better treatment outcomes in long-term disease management [2][3]. - Taitizumab is also being investigated in global multicenter Phase III trials for its efficacy and safety in a broader patient population [2]. Group 3: Mechanism of Action - Taitizumab targets the pathogenic antibody production at the source by simultaneously acting on B-cell activating factor (BLyS) and proliferation-inducing ligand (APRIL), which are crucial in the activation of B cells and plasma cells [3]. - In addition to gMG, Taitizumab has also been approved for the treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in China [3].