Regulatory Actions - Haosai is under investigation by the China Securities Regulatory Commission for suspected violations of information disclosure, but the company states that its operations remain normal and the investigation will not significantly impact management [2] - Central Plaza and its executives received a warning letter from the Jiangsu Securities Regulatory Bureau for failing to timely disclose significant litigation progress, which led to inaccurate financial reporting [3] - Guolian Aquatic received a warning letter from the Guangdong Securities Regulatory Bureau for non-operating fund occupation by its controlling shareholder, which was not disclosed in a timely manner [9] Corporate Actions - Jiarong Technology is planning a major asset restructuring and has suspended trading of its shares, expected to last no more than 10 trading days [4] - Maiwei Co. announced a debt restructuring totaling 371 million yuan, with an expected loss of 85.465 million yuan, aimed at improving cash flow and reducing receivables risk [5] - New World plans to use up to 850 million yuan of idle fundraising to purchase financial products or deposits, with a total of 575 million yuan already invested in such products [6] Legal Matters - Sunshine Nuohuo's lawsuit against Hengsheng Pharmaceutical has entered the second instance, with the original claim amounting to 20 million yuan and a counterclaim of 7.4073 million yuan [8] Product Development - Huyou Pharmaceutical's HYP-6589 tablet has received acceptance for clinical trial applications for treating advanced non-small cell lung cancer [7] - Renfu Pharmaceutical's application for the marketing license of a new ADHD treatment has been accepted, with no similar products currently available in the domestic market [10] Strategic Partnerships - Jindi Co. signed a strategic cooperation letter of intent with Dongpei Co. to explore collaboration on humanoid robot harmonic reducer assemblies and key components [11] Share Buybacks and Holdings - Yuyuan Co. has repurchased 1 million A-shares for a total of approximately 5.3864 million yuan as part of a buyback plan [12] - Yuheng Pharmaceutical's executives increased their holdings by 1.12%, acquiring a total of 25 million shares [13] Major Contracts - Huayou Huibo has been awarded a contract worth 225 million USD for the Iraq NaftKhana oilfield project, which is expected to significantly impact future earnings [16] - Dajin Heavy Industry's subsidiary signed a contract worth approximately 1.339 billion yuan for a European offshore wind farm project, representing 35.41% of the company's expected annual revenue [17]

证券代码：688553 证券简称：汇宇制药 公告编号：2025-091 四川汇宇制药股份有限公司 自愿披露 HYP-6589 片联合用药获得药物临床试验申请 受理通知书的公告 受理号：CXHL2501288；CXHL2501289； 适应症：拟用于与奥希替尼联合治疗靶点驱动基因阳性的晚期非小细胞肺癌。 申请人：四川汇宇海玥医药科技有限公司 审批结论：根据《中华人民共和国行政许可法》第三十二条的规定，经审查， 决定予以受理。 二、本次药品新增联合用药的情况 HYP-6589 片是公司全资子公司汇宇海玥开发的高选择性 SOS1 小分子抑制 剂，其注册分类为化学药 1 类创新药。根据国家药品监督管理局发布的《化学药 品注册分类及申报资料要求》（2020 年第 44 号），HYP-6589 为新的结构明确 的，具有药理作用的化合物，公司已获批并正在中国开展单药治疗晚期实体瘤的 临床研究。具体详见公司于 2024 年 11 月 8 日刊登在上海证券交易所网站 （www.sse.com.cn）上的《关于自愿披露 HYP-6589 片获得药物临床试验批准通 知书的公告》（公告编号：2024-105）。 本公司董事会及全体董 ...

Core Viewpoint - Huiyu Pharmaceutical (688553) announced that its wholly-owned subsidiary, Huiyu Haiyue, received a notice of acceptance from the National Medical Products Administration for the clinical trial application of HYP-6589 tablets in combination with Osimertinib for the treatment of advanced non-small cell lung cancer with target-driven gene positivity, marking a significant step in the development of this innovative drug [1] Company Summary - Huiyu Pharmaceutical's HYP-6589 is classified as a Category 1 innovative chemical drug, indicating its novel nature in the pharmaceutical market [1] - There are currently no similar products approved for sale domestically or internationally, highlighting the potential market opportunity for HYP-6589 [1]

Core Insights - HYP-6589, a selective SOS1 small molecule inhibitor developed by the company's subsidiary, has received acceptance for clinical trial application in combination with Osimertinib for treating advanced non-small cell lung cancer with target-driven gene positivity [1][2] - The drug is classified as a Class 1 innovative chemical drug and is currently undergoing clinical research for monotherapy in advanced solid tumors in China [1] - There are no similar products approved for market in both domestic and international markets as of the announcement date [1] Group 1 - HYP-6589 has received the acceptance notice from the National Medical Products Administration for clinical trials [1] - The drug is designed to enhance the efficacy of Osimertinib and potentially overcome resistance mechanisms associated with it [2] - Preclinical studies indicate that the combination of SOS1 inhibitors and Osimertinib can achieve deeper and more sustained inhibition of MAPK and PI3K signaling pathways [2] Group 2 - SOS1 is a crucial regulator in the RTK-RAS signaling pathway, which is activated by receptor tyrosine kinases [2] - The activation of SOS1 leads to the formation of RAS-GTP, which is essential for downstream signaling pathways [2] - Inhibition of SOS1 has shown potential to address unmet clinical needs in the context of Osimertinib resistance [2]

Core Viewpoint - The company Huayu Pharmaceutical (688553.SH) announced that its wholly-owned subsidiary Sichuan Huayu Haiyue Pharmaceutical Technology Co., Ltd. received a notice from the National Medical Products Administration for the clinical trial application of HYP-6589 tablets in combination with Osimertinib for the treatment of advanced non-small cell lung cancer with target-driven gene positivity [1] Group 1 - HYP-6589 tablets are a highly selective SOS1 small molecule inhibitor developed by the company's subsidiary, classified as a Class 1 innovative chemical drug [1] - The drug has been approved for clinical research in China for monotherapy in advanced solid tumors [1] - The new application for clinical trials in combination with Osimertinib for advanced non-small cell lung cancer has been accepted, with no similar products approved for marketing domestically or internationally as of the announcement date [1]

Core Viewpoint - The announcement indicates that Huiyu Pharmaceutical's wholly-owned subsidiary, Huiyu Haiyue, has received approval from the National Medical Products Administration for a clinical trial application involving HYP-6589 tablets in combination with Osimertinib for treating advanced non-small cell lung cancer with target-driven gene positivity [1] Group 1 - Huiyu Haiyue received the acceptance notice for the clinical trial application on November 21, 2025 [1] - The drug HYP-6589, also known by its research and development code "HY-0006," is intended for use in conjunction with Osimertinib [1] - The focus of the clinical trial is on advanced non-small cell lung cancer that is positive for target-driven genes [1]

Group 1 - Kanglongda's shareholder plans to reduce holdings by up to 3% of the company's shares, totaling no more than 4.83 million shares [1] - The company specializes in the research, production, and sales of special and ordinary labor protection gloves [1] Group 2 - Haizheng Pharmaceutical's subsidiary plans to collaborate with East China Institute on a biological method for synthesizing heparin, with a project contract amount not exceeding 120 million yuan [2] - The company focuses on the research, production, and sales of chemical raw materials and formulations [3] Group 3 - Tianyin Holdings received approval from the China Securities Regulatory Commission for a stock issuance to specific investors [4] - The company is engaged in the sales of smart terminals, e-commerce, lottery, mobile resale, and mobile internet businesses [4] Group 4 - Shanghai Yashi plans to use up to 200 million yuan of temporarily idle raised funds for cash management in high-security, liquid deposit products [5] - The company specializes in supply chain logistics and execution trade [6] Group 5 - Parker New Materials intends to use 130 million yuan of idle raised funds to purchase structured deposits with expected annual yields between 0.59% and 2.9001% [7] - The company focuses on the research, production, and sales of various types of ring forgings, free forgings, and die forgings [7] Group 6 - Huayang New Materials appointed Jing Hongsheng as the new general manager [8] Group 7 - Liyuan Technology's shareholder plans to reduce holdings by up to 2.03% of the company's shares, totaling no more than 3.04 million shares [9] - The company specializes in the research, design, and integration of environmental water treatment systems and hydrogen fuel cell engine systems [9] Group 8 - Shengnuo Biopharmaceutical's subsidiary received approval for the listing application of Visepegenatide raw materials, a GLP-1 receptor agonist for treating type 2 diabetes and obesity [10][11] - The company focuses on the research, production, and sales of peptide raw materials and formulations [10] Group 9 - Puluo Pharmaceutical plans to repurchase shares worth between 180 million and 360 million yuan, with a maximum price of 23 yuan per share [12] - The company specializes in the research, production, and sales of raw material intermediates and innovative drugs [12] Group 10 - Dongfang Electric's subsidiary plans to establish a joint venture with Anhui Waneng Energy, with a registered capital of approximately 1.857 billion yuan [13] - The company is involved in the development, design, manufacturing, and sales of advanced power generation equipment [13] Group 11 - Hefei China announced that its stock will resume trading on November 20 after completing a review of abnormal trading fluctuations [14] - The company focuses on international trade and after-sales services related to in vitro diagnostic medical devices [14] Group 12 - Dafeng Industrial won a bid for the stage equipment project of the Shenzhen International Performing Arts Center, with a contract amount of 165 million yuan [15] - The company specializes in cultural sports equipment, digital art technology, and operation services [15] Group 13 - Baiyunshan's subsidiary received a drug registration certificate for An Gong Niu Huang Wan in Vietnam [16] - The company is engaged in the research, manufacturing, and sales of traditional Chinese and Western medicines [16] Group 14 - Neusoft Group received a notification to supply intelligent cockpit domain controllers for multiple models from a well-known domestic automobile manufacturer, with an estimated total amount of about 4.2 billion yuan [17] - The company focuses on providing industry solutions and software products [17] Group 15 - Huayu Pharmaceutical's product received overseas marketing approval [18] - The company specializes in the research, production, and sales of innovative and high-quality generic drugs in the oncology field [18] Group 16 - Yao Pi Glass received approval from the CSRC for its stock issuance to specific investors [19] - The company specializes in the production and sales of float glass and processed glass [19] Group 17 - Guangyu Yuan's vice president Wang Junbo resigned due to work adjustments [20] - The company focuses on the production and sales of traditional Chinese medicine products [20] Group 18 - Biyi Co. received approval from the CSRC for its stock issuance to specific investors [21] - The company specializes in the design, manufacturing, and sales of smart small household appliances [21] Group 19 - Sunshine Nuohe's application for acquiring 100% equity of Jiangsu Langyan Life Science Technology Co., Ltd. through share issuance and convertible bonds has been accepted by the Shanghai Stock Exchange [22] - The company provides comprehensive drug research and development services for domestic pharmaceutical enterprises and research institutions [22] Group 20 - Longxin General plans to increase capital in its wholly-owned subsidiary by no more than 1.65 billion yuan [23] - The company specializes in the research, production, and sales of motorcycles and engines [23] Group 21 - Jiekang Equipment received a corrective order from the Tianjin Securities Regulatory Bureau due to internal control deficiencies [24] - The company specializes in the research, production, and sales of nuclear biochemical safety equipment [24] Group 22 - Wantong Technology plans to raise no more than 920 million yuan through a private placement to supplement working capital [25] - The company focuses on information technology services for highways and ports [25] Group 23 - Dongshan Precision has submitted an application for H-share listing to the Hong Kong Stock Exchange [26] - The company specializes in the research, production, and sales of electronic circuit products and precision components [26] Group 24 - Yonghe Intelligent Control plans to publicly transfer 100% equity of its wholly-owned subsidiary Kunming Medical Oncology Hospital [27] - The company specializes in water and heating valve fittings, tumor precision radiation therapy, and photovoltaic battery businesses [27] Group 25 - Aok Shares signed a strategic cooperation framework agreement with Suzhou Qitian New Materials Co., Ltd. [28] - The company focuses on the research and production of high-end new materials derived from ethylene oxide and ethylene [28] Group 26 - Hongquan Technology's shareholder plans to reduce holdings by up to 3% of the company's shares, totaling no more than 299,440 shares [29] - The company specializes in the research, production, and sales of intelligent connected products and software platform development [29] Group 27 - Shilong Industrial's controlling shareholder plans to reduce holdings by up to 3% of the company's shares, totaling no more than 7.2 million shares [30] - The company specializes in the research, production, and sales of chemical products [30] Group 28 - Tangrenshen decided to terminate the investment in the "Dongchong Phase III Pig Breeding Base Construction Project," reallocating the remaining funds of 78.9587 million yuan to supplement working capital [31] - The company specializes in the research, production, and sales of feed, pigs, meat products, and animal health products [31] Group 29 - Gaode Infrared's actual controller plans to reduce holdings by up to 3% of the company's shares, totaling no more than 12.8 million shares [32] - The company specializes in infrared focal plane detector chips and infrared thermal imaging systems [32] Group 30 - Kangyuan Pharmaceutical's actual controller recently increased holdings by 20,000 shares [33] - The company specializes in the research, production, and sales of pharmaceuticals [33] Group 31 - Haida Group plans to repurchase shares worth between 1 billion and 1.6 billion yuan, with a maximum price of 62.00 yuan per share [34] - The company provides overall solutions for animal husbandry [34] Group 32 - Qizhong Technology's 850 million yuan convertible bonds have been approved for listing [35] - The company specializes in advanced packaging and testing of integrated circuits [35] Group 33 - Dingyang Technology launched the new SNA5000B series vector network analyzer [36] - The company specializes in the research, production, and sales of general electronic testing and measuring instruments [36] Group 34 - Airo Energy plans to distribute a cash dividend of 0.9375 yuan per share to all shareholders [37] - The company specializes in photovoltaic energy storage systems and products [37] Group 35 - Hechuan Technology's actual controller and some directors plan to reduce holdings by up to 6% of the company's shares [38] - The company specializes in the research, production, and sales of industrial automation products [38] Group 36 - China First Heavy Industries' chairman was arrested for suspected bribery [39] - The company specializes in heavy machinery manufacturing for various industries [39] Group 37 - Lianhuan Pharmaceutical plans to invest 15 million yuan in joint research with Nanjing University for anti-thrombotic small nucleic acid drugs [40] - The company specializes in the manufacturing and sales of chemical raw materials [40] Group 38 - Anxu Biotech's shareholder plans to reduce holdings by up to 0.94% of the company's shares, totaling no more than 120,000 shares [41] - The company specializes in the research, production, and sales of POCT reagents and instruments [41] Group 39 - Yaxiang Integration's shareholder reduced holdings by 130,000 shares [42] - The company specializes in providing cleanroom engineering and related services for high-tech electronic industries [42] Group 40 - Zhongwen Media plans to use up to 9.5 billion yuan of idle funds to purchase financial products [43] - The company specializes in traditional publishing and various new media businesses [43]

中国经济网北京11月19日讯 汇宇制药(688553.SH)今日收报20.60元，跌幅5.24%。目前该股处于破 发状态。 2021年10月26日，汇宇制药在上交所科创板上市，公开发行股票6360.00万股，发行价格为38.87元/ 股，保荐机构、主承销商为中信建投证券，保荐代表人为杨泉、田斌，联席主承销商为国都证券。 汇宇制药发行费用合计1.11亿元，其中中信建投证券、国都证券获得承销费9887.48万元。 （责任编辑：何潇） 上市当日，汇宇制药盘中最高报42.59元，创上市以来股价最高点。 汇宇制药发行募集资金总额为24.72亿元，扣除发行费用后，募集资金净额为23.61亿元。汇宇制药 最终募集资金净额比原计划多4.53亿元。汇宇制药于2021年10月18日披露的招股书显示，公司拟募集资 金19.07亿元，分别用于汇宇欧盟标准注射剂产业化基地（二期）项目、汇宇创新药物研究院建设项 目、补充流动资金。 ...

格隆汇11月19日｜有投资者在互动平台向汇宇制药提问：相关媒体报道，公司在前段时间的进博会上， 与阿斯利康签订了战略合作框架协议。但公司在业绩说明会上表示，公司尚未与阿斯利康达成任何药物 研究合作。公司能具体说说双方之间的关系吗？ 汇宇制药回复称，公司与阿斯利康已签署战略合作框 架协议，该协议不涉及具体药物研究合作内容，不会对公司经营产生重大影响，该事项未达披露标准， 因此公司未进行披露。未来，公司期待与阿斯利康进行药物研究等更多合作，如后续合作预计将对公司 经营产生重大影响，公司将严格按照监管规定，及时履行信息披露义务并发布公告。 ...

中国经济网北京11月19日讯汇宇制药(688553.SH)今日收报20.60元，跌幅5.24%。目前该股处于破发状 态。 2021年10月26日，汇宇制药在上交所科创板上市，公开发行股票6360.00万股，发行价格为38.87元/股， 保荐机构、主承销商为中信建投（601066）证券，保荐代表人为杨泉、田斌，联席主承销商为国都证 券。 汇宇制药发行募集资金总额为24.72亿元，扣除发行费用后，募集资金净额为23.61亿元。汇宇制药最终 募集资金净额比原计划多4.53亿元。汇宇制药于2021年10月18日披露的招股书显示，公司拟募集资金 19.07亿元，分别用于汇宇欧盟标准注射剂产业化基地(二期)项目、汇宇创新药物研究院建设项目、补充 流动资金。 汇宇制药发行费用合计1.11亿元，其中中信建投证券、国都证券获得承销费9887.48万元。 上市当日，汇宇制药盘中最高报42.59元，创上市以来股价最高点。 ...