上海益诺思生物技术股份有限公司 关于国药集团财务有限公司2025年半年度风险持续评 估的报告 通过查验国药集团财务有限公司（以下简称国药财务公司）《金 融许可证》《企业法人营业执照》等证件资料，并审阅了国药财务公 司截至2025年6月的财务报告以及风险指标等必要信息，对国药财务 公司的经营资质、业务和风险状况进行了评估，具体情况报告如下： 一、国药财务公司基本情况 国药财务公司成立于2012年2月，是经原中国银行业监督管理委 员会批准成立的非银行金融机构。 企业名称：国药集团财务有限公司 注册地址：北京市海淀区知春路20号中国医药大厦7层 法定代表人：王鹏 金融许可证机构编码：L0145H211000001 统一社会信用代码：9111000071783212X7 目前国药财务公司注册资本金为人民币220,000万元，股权结构 如下表所示： （一）控制环境 国药财务公司已经建立了内部控制制度体系。包括：公司章程、 各项管理制度和业务操作流程等。《公司章程》确定了成立公司的基 本原则，明确股东的出资方式，确定了公司的经营范围，对股东的权 利和义务进行界定，规范了股东会、董事会的职权和议事规则，对经 营管理机构管理 ...

为真实、准确和公允地反映公司财务状况、资产价值，公司根据《企业会计 准则》及会计政策的相关规定，基于谨慎性原则对截至2025年6月30日的各项资 产进行了减值迹象识别和测试，并根据测试结果对存在减值迹象的资产相应计提 了减值准备。经测试，2025年1-6月公司计提信用减值准备和资产减值准备合计 35,952,734.18元，对公司合并报表利润总额影响数为35,952,734.18元（不包含所 得税影响）。具体情况如下： 证券代码：688710 证券简称：益诺思 公告编号：2025-030 单位：人民币 元 上海益诺思生物技术股份有限公司 关于计提信用减值损失和资产减值准备的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 根据《企业会计准则》和相关会计政策等规定，上海益诺思生物技术股份有 限公司（以下简称"公司"）对截至2025年6月30日的各项资产进行了减值测试， 并根据结果对其中存在减值迹象的资产计提了减值准备。现将具体情况公告如下： 一、概述 （三）资产减值损失-合同资产减值损失 合同资产无论是否存在重大融资成分 ...

证券代码：688710 证券简称：益诺思 公告编号：2025-025 根据中国证券监督管理委员会出具的《关于同意上海益诺思生物技术股份有 限公司首次公开发行股票注册的批复》（证监许可〔2024〕762 号），并经上海证 券交易所同意，公司首次向社会公开发行人民币普通股（A 股）35,244,904 股，并 于 2024 年 9 月 3 日在上海证券交易所科创板挂牌上市，发行后公司总股本为 140,979,615 股，其中有限售条件流通股 114,476,841 股，无限售条件流通股 26,502,774 股 。 具 体 详 见 公 司 2024 年 9 月 2 日 在 上 海 证 券 交 易 所 网 站 （www.sse.com.cn）上披露的《上海益诺思生物技术股份有限公司公开发行股票科 创板上市公告书》。有限售条件流通股中，首次公开发行网下配售限售股 1,693,150 股，已于 2025 年 3 月 3 日起上市流通。 本次上市流通的限售股为公司首次公开发行前已发行的部分股份及首次公开 发行战略配售股，限售股股东数量为 11 名，限售期为自公司首次公开发行股票并 上市之日起 12 个月，该部分限售股股东 ...

国泰海通证券股份有限公司 关于上海益诺思生物技术股份有限公司 首次公开发行前已发行股份及首次公开发行战略配售股份 上市流通的核查意见 国泰海通证券股份有限公司（以下简称"国泰海通"或"保荐机构"）作为上海 益诺思生物技术股份有限公司（以下简称"益诺思"或"公司"）首次公开发行股票 并在科创板上市及持续督导的保荐机构，根据《证券发行上市保荐业务管理办法》 《上海证券交易所科创板股票上市规则》《上海证券交易所科创板上市公司自律 监管指引第 1 号——规范运作》等法律法规的相关规定，对益诺思首次公开发行 前已发行股份及首次公开发行战略配售股份上市流通事项进行了核查，核查情况 及核查意见如下: 一、本次上市流通的限售股类型 二、本次上市流通的限售股形成后至今公司股本数量变化情况 根据中国证券监督管理委员会出具的《关于同意上海益诺思生物技术股份有 限公司首次公开发行股票注册的批复》（证监许可〔2024〕762 号），并经上海证 券交易所同意，公司首次向社会公开发行人民币普通股（A 股）35,244,904 股， 并于 2024 年 9 月 3 日在上海证券交易所科创板挂牌上市，发行后公司总股本为 140,979,615 ...

证券代码：688710 证券简称：益诺思 公告编号：2025-025 上海益诺思生物技术股份有限公司 关于首次公开发行前已发行股份及首次公开发行战略 配售股份上市流通的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： ? 本次股票上市类型为首发战略配售股份（限售期 12 月）；股票认购方式 为网下，上市股数为3,524,490股。 ? 除首发配售股份外，其他股票上市类型为首发限售股份；股票认购方式为 网下，上市股数为58,973,550股。 三、 本次上市流通的限售股的有关承诺 （一）股东上海张江生物医药基地开发有限公司、上海翱鹏企业管理中心（有 限合伙）作出限售安排、自愿锁定、持股及减持意向的承诺如下： ? 本次股票上市流通总数为62,498,040股。 ? 本次股票上市流通日期为2025 年 9 月 3 日。 一、 本次上市流通的限售股类型 二、 本次上市流通的限售股形成后至今公司股本数量变化情况 本次上市流通的限售股属于首次公开发行前已发行的部分股份及首次公开发 行战略配售股，自公司首次公开发行至 ...

上海益诺思生物技术股份有限公司 关于召开 2025 年半年度业绩说明会的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 证券代码：688710 证券简称：益诺思 公告编号：2025-024 重要内容提示： 会议问题征集：投资者可于 2025 年 9 月 1 日(星期一)16:00 前登录 上证路演中心网站首页点击"提问预征集"栏目或通过公司邮箱 bo@innostar.cn 进行会前提问，公司将在本次说明会上对投资者普遍 关注的问题进行回答。 上海益诺思生物技术股份有限公司（以下简称"公司"）拟于 2025 年 8 月 29 日发布公司 2025 年半年度报告，为便于广大投资者更全面 深入地了解公司 2025 年半年度经营成果、财务状况，公司计划于 2025 年 9 月 2 日（星期二）16:00-17:00 举行 2025 年半年度业绩说明会， 就投资者关心的问题进行交流。 一、 说明会类型 本次投资者说明会以网络互动形式召开，公司将针对 2025 年半 年度的经营成果及财务指标的具体情况与投资者进行互动交流和沟 ...

Core Insights - Yinosh experienced a slight decline of 0.31% on August 22, with a trading volume of 55.43 million yuan [1] - The company reported a financing buy-in amount of 10.08 million yuan and a net financing buy of 0.61 million yuan on the same day [1] - As of August 22, the total financing and securities lending balance for Yinosh was 92.67 million yuan, accounting for 7.84% of its market capitalization [1] Financing and Securities Lending - On August 22, Yinosh had a financing buy-in of 10.08 million yuan, with a financing balance of 92.67 million yuan [1] - The company had no securities lending transactions on that day, with a remaining balance of 0.00 shares [1] Company Overview - Shanghai Yinosh Biotechnology Co., Ltd. was established on May 12, 2010, and is located in the China (Shanghai) Pilot Free Trade Zone [1] - The company specializes in providing comprehensive research and development services (CRO) primarily focused on non-clinical research in biomedicine, with 95.42% of its revenue coming from non-clinical services [1] - As of March 31, the number of shareholders was 5,435, a decrease of 46.05%, while the average circulating shares per person increased by 97.22% to 5,187 shares [1] Financial Performance - For the period from January to March 2025, Yinosh reported a revenue of 209 million yuan and a net profit attributable to shareholders of 5.52 million yuan, reflecting a year-on-year decrease of 90.30% [1] - Since its A-share listing, Yinosh has distributed a total of 45.11 million yuan in dividends [2] Institutional Holdings - As of March 31, 2025, the top ten circulating shareholders included notable institutional investors such as Agricultural Bank of China Medical Health Stock and China Europe Medical Health Mixed Fund, with varying increases in their holdings [2]

Summary of the Conference Call for Yinos Company Overview - Yinos is positioned as the innovation technology source for China National Pharmaceutical Group, benefiting from internal business cooperation within the group [2][7] - The company has a strategic reserve of experimental monkey resources, ensuring stable supply of core materials [2][8] - Yinos is one of the few companies in China with GLP certifications from China, OECD, and FDA, indicating strong international service capabilities [2][10] Key Points and Arguments - **Growth from National Pharmaceutical Group**: New orders from clients within the group are expected to grow by 26.3% year-on-year in 2024, highlighting Yinos's strategic position and growth potential [2][7] - **Market Position in Ampoules**: Yinos is a leading player in the domestic ampoule market, with a market share of 6.8% in non-clinical safety evaluation, ranking third [3] - **Revenue from Innovative Drugs**: Over 90% of Yinos's revenue comes from innovative drugs, having assisted in nearly 200 first-in-class drug research services [4] - **CRO Industry Growth**: The global CRO market is expected to grow at a compound annual growth rate (CAGR) of nearly 11% in the coming years, driven by rising R&D costs and the need for cost-effective solutions [12][14] Financial Performance - Despite a challenging CXO industry leading to price wars, Yinos has maintained growth in business volume, with clinical CRO revenue expected to grow by 27.2% in 2024, reaching nearly 50 million yuan [6] Strategic Initiatives - **Resource Stability**: Yinos has established a breeding and feeding facility for experimental monkeys, with a book value of approximately 25 million yuan by the end of 2024 [2][8] - **Management Team**: The management team consists of experienced drug evaluation experts, enhancing the company's service quality [9] Industry Trends - **Impact of Patent Cliffs**: The upcoming patent cliffs are expected to lead to significant revenue losses for multinational pharmaceutical companies, prompting them to seek new innovations through mergers and licensing [13] - **Support for Innovation**: The Chinese government has implemented policies to support the development of innovative drugs, including the reactivation of the STAR Market for unprofitable biotech companies [17][19] Future Outlook - **Market Potential**: The domestic innovative drug market is projected to grow significantly, with the proportion of approved innovative drugs increasing from 0.2% in 2018 to 10.4% in 2024 [16] - **Valuation and Risks**: Yinos is projected to achieve a target price of 51.45 yuan based on a 52x P/E ratio, with risks including industry slowdown, regulatory changes, and raw material price fluctuations [25] Conclusion Yinos is well-positioned for future growth within the pharmaceutical industry, leveraging its strategic partnerships, innovative capabilities, and supportive government policies to capitalize on emerging market opportunities.

Investment Rating - The report gives a "Buy" rating for the company for the first time, with a target price of 51.48 CNY based on a 52x P/E ratio for 2025 [5][8]. Core Insights - The company is a leading player in non-clinical safety evaluation in China, backed by strong resources from its parent company, China National Pharmaceutical Group [12][16]. - The CRO (Contract Research Organization) market is expected to see growth driven by increasing demand for innovative drug development and favorable policies [12][44]. - The company has a comprehensive range of GLP (Good Laboratory Practice) certifications, enabling it to provide international standard services [21][22]. Financial Forecast and Investment Recommendations - The projected EPS for 2025-2027 is 0.99, 1.16, and 1.42 CNY respectively, indicating significant growth potential due to the company's competitive advantages [5]. - Revenue is expected to grow from 1,038 million CNY in 2023 to 1,490 million CNY in 2027, with a CAGR of approximately 14.8% [7]. - The company's net profit is forecasted to increase from 194 million CNY in 2023 to 200 million CNY in 2027, reflecting a strong growth trajectory [7]. Company Overview - The company specializes in innovative drug research outsourcing services and ranks third in the domestic preclinical safety evaluation sector [12][29]. - It has successfully assisted in the research services of nearly 200 innovative drugs, covering a wide range of drug types including small molecules and ADCs (Antibody-Drug Conjugates) [12][31]. Market Trends - The CRO market is anticipated to maintain a double-digit growth rate, with global market size projected to reach 126 billion USD by 2028 [44][47]. - The report highlights a rebound in overseas demand for CRO services and an upward cycle in the domestic market, driven by improved financing conditions and increased willingness of domestic pharmaceutical companies to invest in innovative drug development [12][44].

Core Viewpoint - The article highlights the recent financial activities and market performance of Shanghai Yinos Biotech Co., Ltd., including its financing activities and stock performance trends [1]. Financing Activities - Yinos received a net financing inflow of 18.91 million yuan last week, ranking 412th in the market [1]. - The total financing amount for the week was 123 million yuan, while the repayment amount was 104 million yuan [1]. Market Performance - Over the past 5 days, the main capital outflow from Yinos was 3.33 million yuan, with a price decline of 0.43% [1]. - In the last 10 days, the main capital inflow was 27.64 million yuan, resulting in a price increase of 1.88% [1]. Company Overview - Shanghai Yinos Biotech Co., Ltd. was established in 2010 and is located in Shanghai, primarily engaged in technology promotion and application services [1]. - The company has a registered capital of 1.41 billion yuan and a paid-in capital of 1.06 billion yuan [1]. - The legal representative of the company is Chang Yan [1]. Investment and Intellectual Property - Yinos has invested in 3 external companies and participated in 68 bidding projects [1]. - The company holds 15 trademark registrations and 79 patents, along with 223 administrative licenses [1].