一、 股权分置改革方案的相关情况 根据国务院《关于推进资本市场改革开放和稳定发展的若干意见》、中国证 监会、国资委、财政部、中国人民银行和商务部联合发布的《关于上市公司股权 分置改革的指导意见》以及中国证监会《上市公司股权分置改革管理办法》等文 件的精神及要求，派林生物股权分置改革方案经 2007 年 12 月 24 日现场召开的 三九宜工生化股份有限公司（即派斯双林生物制药股份有限公司）2007 年第二 次临时股东大会暨相关股东会议表决通过。派林生物本次股权分置改革以 2013 年 1 月 8 日为股权分置改革方案实施的股权登记日，具体方案为：以公司资本公 积中的 6,089.4108 万元向本次股权分置改革股权登记日登记在册的流通股股东 定向转增股本，每 10 股流通股股东获得转增 6 股，相当于流通股股东每 10 股获 非流通股股东付出 2.426 股。非流通股股东由此获得所持非流通股份的流通权。 西南证券股份有限公司关于派斯双林生物制药股份 有限公司解除部分股份限售的核查意见 深圳证券交易所： 作为派斯双林生物制药股份有限公司（以下简称"派林生物"、"上市公 司"、"公司"）股权分置改革的保荐机构，西 ...

证券代码：000403 证券简称：派林生物 公告编号：2025-031 派斯双林生物制药股份有限公司 解除股份限售的提示性公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或者重大遗漏。 特别提示： 1、本次解除限售股份股东数量为3名，解除限售股份的数量为991,607股，占公 司总股本比例0.1043%； 2、本次限售股份可上市流通日期：2025年6月25日。 一、股权分置改革方案概述 1、股权分置改革对价方案概述 以公司资本公积中的6,089.4108万元向股权分置改革股权登记日登记在册的流 通股股东定向转增股本，每10股流通股股东获得转增6股，相当于流通股股东每10股 获非流通股股东付出2.426股。 2、通过股权分置改革方案的股东大会日期、届次 派斯双林生物制药股份有限公司股权分置改革方案经2007年12月24日召开的 三九宜工生化股份有限公司（即派斯双林生物制药股份有限公司）2007年第二次临 时股东大会暨相关股东会议审议通过。 2012年12月17日，公司召开2012年第二次临时股东大会审议通过了《关于公司 股权分置改革特别承诺事项优化履行暨关联交易方案的议 ...

Core Viewpoint - The blood products industry is experiencing significant consolidation, highlighted by China National Pharmaceutical Group's acquisition of a 21.03% stake in Palin Bio for 4.6 billion yuan, which is a high premium acquisition that will reshape the industry landscape [1][5]. Company Summary - China National Pharmaceutical Group's acquisition will increase its control over the blood products market, consolidating its position as the leading player with a total of 154 plasma stations across its subsidiaries, including Tian Tan Biological and Wei Guang Biological [6][9]. - Palin Bio has undergone multiple ownership changes, with its history marked by internal conflicts that have hindered its growth. The company has changed hands six times, with the latest acquisition by China National Pharmaceutical Group marking a potential end to its tumultuous ownership history [3][4]. Industry Summary - The blood products industry is characterized by a high degree of concentration, with major players like Tian Tan Biological, Shanghai Laishi, and Palin Bio dominating the market. The industry is moving towards an oligopolistic structure, with the number of companies decreasing significantly over the years [8][11]. - The global blood products market is projected to exceed $50 billion in 2024 and reach over $90 billion by 2030, indicating substantial growth potential driven by increasing demand for blood products due to aging populations and the need for critical medical supplies [8][10]. - China's blood products market is expected to grow significantly, with projections of reaching 60 billion yuan in 2024 and 95 billion yuan by 2030. The industry faces challenges such as limited raw material supply and strict regulations on blood plasma collection [11][12].

Core Viewpoint - The acquisition of a 21.03% stake in Pailin Biopharmaceuticals by China National Pharmaceutical Group is a strategic move to reshape the competitive landscape in the blood products industry, potentially enhancing market share and resource integration [2][5][13]. Group 1: Acquisition Details - Pailin Biopharmaceuticals announced a framework agreement for the acquisition, with a transaction value of approximately 4.6 billion yuan, calculated based on the principal of 3.844 billion yuan and an annualized interest of 9% [2]. - If the acquisition is completed, the actual controller of Pailin Biopharmaceuticals will change from the Shaanxi Provincial State-owned Assets Supervision and Administration Commission to China National Pharmaceutical Group [2][5]. Group 2: Industry Context - The blood products industry is experiencing a wave of mergers and acquisitions, with major players like China National Pharmaceutical Group and China Biotech aiming to increase market concentration [5][14]. - The industry is characterized by high barriers to entry, scarcity of plasma collection resources, and strict regulatory oversight, making the acquisition of existing companies a strategic necessity for growth [13][14]. Group 3: Historical Control Changes - Pailin Biopharmaceuticals has undergone five changes in control since its listing, reflecting the intense capital competition in the blood products sector over the past two decades [6][7]. - The company was previously embroiled in ownership disputes, which affected its strategic direction until a stable control was established in 2019 [6][7]. Group 4: Financial Performance - Pailin Biopharmaceuticals reported a revenue of 10.5 billion yuan in 2020, with a year-on-year growth of 14.67%, and net profit of 1.86 billion yuan, marking a 15.90% increase [9]. - The company achieved a revenue of 24.05 billion yuan in 2022, with a net profit of 5.87 billion yuan, benefiting from continuous investment in product development and market expansion [9][10]. - However, in 2023, the company faced a slight revenue decline of 3.18% to 23.29 billion yuan, although net profit increased to 6.12 billion yuan [9][10]. Group 5: Future Outlook - In 2024, Pailin Biopharmaceuticals is projected to achieve a revenue of 26.55 billion yuan, a 14% increase, driven by rising demand for blood products and increased plasma collection [10]. - The company anticipates challenges in 2025, with expected declines in revenue and net profit due to production capacity expansion and supply issues [11][12].

Group 1 - Xiaofang Pharmaceutical announced a collaboration with Shanghai Skin Disease Hospital to develop a new traditional Chinese medicine for hair loss, Compound Cèbǎi Tincture, which is expected to be the first TCM formulation for hair loss in China [1] - Guizhou Sanli plans to invest 150 million RMB in a patent transfer and technical cooperation contract with Guangdong Pharmaceutical University for the development of a new TCM drug [1] - The technical cooperation will involve a total development cost of 100 million RMB for the research and development of SL&GDPU-001, a new TCM drug [2] Group 2 - Jichuan Pharmaceutical's actual controller, Cao Longxiang, transferred part of his equity in Jichuan Holdings to his son, Cao Fei, which is an internal family equity adjustment and will not affect the company's independence [2] - Junshi Biosciences received acceptance for the clinical trial application of JT118 injection, a vaccine aimed at preventing monkeypox virus infection, marking a significant step as no such vaccine has been approved in China [3] - Palin Bio announced that its controlling shareholder, Shengbang Yinghao, intends to transfer 21.03% of its shares to China National Pharmaceutical Group, which will result in a change of control [3] Group 3 - East China Pharmaceutical's subsidiary received FDA approval for the clinical trial of HDM1010 tablets, aimed at treating type 2 diabetes, enhancing the company's competitiveness in the endocrine field [4]

Group 1 - China National Pharmaceutical Group (Sinopharm) announced the acquisition of 21.03% stake in Palin Bio for over 4.5 billion yuan, representing a premium of 32% [1][2] - The acquisition aims to create a blood product giant with an annual plasma collection capacity of nearly 4,000 tons, reshaping the competitive landscape of the industry [1][4] - The blood product industry has seen intense competition for scarce licenses since the freeze on new approvals in 2001, leading to a wave of consolidations among major players [1][4] Group 2 - Palin Bio has undergone three ownership changes in seven years, reflecting the challenges and conflicts in the blood product sector [2][4] - The company has 38 plasma stations and an annual plasma collection capacity of over 1,400 tons, positioning it among the top players in the industry [4][5] - Despite its resources, Palin Bio has faced internal management issues, leading to governance challenges and regulatory penalties [5] Group 3 - The entry of Sinopharm is expected to bring stability and leverage its complete industry chain from research to distribution, potentially ending the cycle of ownership changes for Palin Bio [5] - Balancing capital demands with industry regulations remains a critical challenge for the newly formed entity post-acquisition [5]

Core Viewpoint - The control of blood product company Palin Bio (000403.SZ) has been transferred to China National Pharmaceutical Group (Sinopharm), which may lead to the integration of Palin Bio and Tian Tan Bio (600161.SH), potentially reshaping the competitive landscape in the blood product industry [1][5][9]. Group 1: Company Control and Financials - On June 10, Palin Bio announced that its controlling shareholder, Qiongcheng Shengbang Yinghao Investment Partnership, plans to transfer its entire 21.03% stake to China National Biotechnology Co., Ltd. [1] - The transaction is valued at 38.44 billion yuan, with a share price of 24.96 yuan, representing a 47% premium over the closing price of 16.96 yuan on June 6 [3]. - The estimated price-to-earnings ratio for this transaction is close to 32 times, based on a projected net profit of 7.45 billion yuan for 2024 [3][4]. Group 2: Industry Competition and Market Position - The integration of Tian Tan Bio and Palin Bio could lead to a combined revenue of approximately 86.87 billion yuan, surpassing Shanghai Lai Shi's (002252.SZ) projected revenue of 81.76 billion yuan for 2024 [7][15]. - If the integration occurs, the combined entity would control at least 123 plasma collection stations and have a total plasma collection volume of 4,181 tons, significantly increasing market share to nearly 30% [7][16]. - The blood product industry is experiencing consolidation due to limited new entrants since 2001, with companies increasingly acquiring others to expand market share [16][17]. Group 3: Challenges and Future Outlook - The integration process may face challenges, particularly regarding the internal conflicts within Palin Bio, especially with its second-largest shareholder, Harbin Tongzhi Cheng Technology Development Co., Ltd. [10][11][14]. - The future of the blood product industry may depend on how effectively China National Pharmaceutical Group can manage these internal dynamics while pursuing further consolidation [9][14]. - The industry is also exploring innovative solutions to reduce reliance on human plasma, with several companies making progress in developing recombinant products [21][22].

生物制品板块短线拉升，派林生物（000403）涨停，荣昌生物、长春高新（000661）、君实生物、百普 赛斯（301080）、诺诚健华等跟涨。 暗盘资金正涌入这些股票，点击速看>>> ...

近日，派林生物发布关于控股股东签署《收购框架协议》暨公司控制权拟发生变更的提示性公告。披露 中国生物技术股份有限公司与公司控股股东共青城胜帮英豪投资合伙企业（有限合伙）签署了《收购框 架协议》，胜帮英豪拟将所持派斯双林生物制药股份有限公司21.03%股份转让给中国生物。 为免疑义，本协议签署前派林生物已向乙方派发的现金分红以及标的股份对应的派林生物 2024 年度现 金分红（即每 10 股派发现金红利 3.5 元（含税））归乙方所有。 （企业公告） 标的股份的转让价格拟按照以下标准计算：乙方 2023 年 3 月 20 日收购派林生物控制权交易本金 384,382.03 万元，加上该等本金于利息期间（指 2023 年 3 月 20 日起算至本次交易正式交易文件签署 日，不足一年的按日计算，每年按照 365日计算）按照年化单利 9%计算的利息。 鉴于甲方未完成对派林生物的全面尽调、交易方案及交易条款尚未达成，本次交易最终成交金额及付款 安排将以本次交易相关方签署的正式股份转让协议及其他相关交易文件为准，具体定价需符合法律、法 规、规章和国资监管部门的规范性文件的相关规定。 若本次交易顺利推进并实施完成，公司控股 ...

Core Viewpoint - The acquisition of 21.03% of shares in Palin Biotech by China National Pharmaceutical Group (Sinopharm) marks a significant shift in control, with the company expected to become part of the national team in the blood products industry [1][4][12]. Group 1: Acquisition Details - Palin Biotech's controlling shareholder will change from Shengbang Yinghao to China National Pharmaceutical Group, with the actual controller shifting from the Shaanxi Provincial State-owned Assets Supervision and Administration Commission to Sinopharm [1][4]. - The transaction price for the share transfer is approximately 38.44 billion yuan, which includes interest calculated at an annual rate of 9% from March 20, 2023, until the signing of the transaction documents [8][10]. - The share transfer price represents a premium of about 47.40% over the closing price of 16.96 yuan per share on the day before the agreement was signed [6][8]. Group 2: Financial Performance and Growth - Palin Biotech has shown steady revenue growth, with reported revenues of 19.72 billion yuan, 24.05 billion yuan, 23.29 billion yuan, and 26.55 billion yuan from 2021 to 2024, respectively [14]. - The net profit attributable to the parent company has also increased, with figures of 3.91 billion yuan, 5.87 billion yuan, 6.12 billion yuan, and 7.45 billion yuan for the same years [14]. - The company is expected to distribute a total of 5.12 billion yuan in cash dividends in 2023 and 2024, with Shengbang Yinghao projected to receive over 1 billion yuan in dividends [10]. Group 3: Industry Context and Competition - The acquisition raises potential concerns regarding competition, as both Palin Biotech and Tian Tan Biological Products, a subsidiary of Sinopharm, operate in the same blood products sector [2][15]. - The integration of Palin Biotech into Sinopharm's portfolio will increase the number of listed companies under the Sinopharm umbrella to eight, enhancing its presence in the healthcare market [11][12]. - The strategic focus of Palin Biotech remains on blood products, with ongoing efforts to expand production capacity and improve operational efficiency [14][15].