New Stock Issuance - New stock issued by Dingjia Precision at a price of 11.16 on July 22, 2025[1] - ST Kelly's tender offer period is from July 17 to August 15, 2025[1] - ST Zitian and other companies have also announced new stock issuances[1] Market Alerts - Significant abnormal fluctuations reported for several stocks including Guangshengtang and Huayin Power[1] - Multiple companies have disclosed announcements regarding stock performance and market activities[1] - The report includes links to detailed announcements for various stocks, indicating ongoing market monitoring[1]

证券代码：002940 证券简称：昂利康 公告编号：2025-054 浙江昂利康制药股份有限公司 股票交易异常波动公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记载、 误导性陈述或重大遗漏。 一、股票交易异常波动的情况介绍 二、公司关注并核实的相关情况 针对公司股票交易异常波动情况，公司董事会对有关事项进行了核查，有关 情况说明如下： 1、公司前期披露的信息不存在需要更正或补充披露的事项； 2、公司未发现近期公共传媒报道了可能或已经对公司股票交易价格产生较 大影响的未公开重大信息； 3、经核查，公司目前经营情况正常，主营业务未发生变化，内外部经营环 境未发生重大变化； 4、经核查，公司及控股股东、实际控制人不存在关于本公司的应披露而未 披露的重大事项，也不存在处于筹划阶段的重大事项； 5、经核查，公司控股股东和实际控制人在股票交易异常波动期间不存在买 卖公司股票的行为； 6、公司关注到近期市场对创新药业务关注度较高。公司目前在研的创新药 项目仅有一个，系 ALK-N001 项目，该项目于 2025 年 4 月获得药物临床试验批 1 准通知书，截至本公告披露日，该项目尚处于 I 期临床 ...

Core Viewpoint - The company is focusing on its innovative drug business, particularly the ALK-N001 project, which is currently in Phase I clinical trials and received approval in April 2025 [1] Group 1: Innovative Drug Projects - The company has only one innovative drug project in development, ALK-N001, which is in Phase I clinical trials as of the announcement date [1] - There is growing investor interest in the ALK-N002 project, which is planned to be introduced in early 2025 and is included in the annual fundraising investment project adjustment plan [1] - Multiple candidate drugs for the ALK-N002 project are currently under screening and discussion, but specific pipeline details have not been confirmed due to commercial confidentiality [1]

Core Investment Logic - The impact of the national procurement of Lefuyin is gradually diminishing, and with the launch and promotion of new products, the company's performance is expected to return to a growth trajectory [1][2] - The company is firmly advancing its innovation transformation, introducing the ALK-N001 (DXd) which opens up new possibilities. ALK-N001 is a tumor-responsive prodrug designed based on the TMEA platform, which has shown significant efficacy and safety trends compared to existing first-line chemotherapy regimens in phase 3 trials of its first drug, Legu Bixin [1][3] Business Overview - Established in 2001, the company has over 20 years of experience in the pharmaceutical field, transitioning from generic to innovative drugs. It primarily engages in the R&D, production, and sales of chemical raw materials, chemical preparations, pharmaceutical excipients, and specialty intermediates [1] - The company has a significant advantage in cardiovascular preparations, oral cephalosporin raw materials, alpha-keto acid raw materials, inhalation anesthetics, anti-androgen intermediates, and plant-derived cholesterol products [1] Financial Performance and Forecast - The company expects a revenue of 1.54 billion in 2024, a year-on-year decrease of 5%. The decline in performance is mainly due to the impact of the Lefuyin product, particularly from the eighth batch of national procurement [2] - The company anticipates a rebound in performance driven by the approval and promotion of new products, including the "light-foot" compound alpha-keto acid tablets and the cooperative product Ediguanol soft capsules [2] - Profit forecasts for 2025-2027 are projected at 132 million, 170 million, and 216 million respectively, with year-on-year growth rates of 64%, 29%, and 27% [4] New Growth Areas - The company is expanding into new fields such as plant cholesterol and animal health, aiming to create new growth drivers. The acquisition of Keri Bio in 2023 is expected to provide stable cash flow, with a projected net profit margin of 40% in 2024 [2] - The company's animal health business focuses on pet medications, with a target to double the sales of isoflurane by 2025, and numerous ongoing projects in pet medications that could become new growth points [2] Drug Development and Innovation - ALK-N001 is a tumor-responsive prodrug designed to achieve targeted delivery in the tumor microenvironment, aiming for high efficacy and low toxicity. The TMEA-SMDC platform has been validated through positive phase 3 trial results of Legu Bixin [3] - The company has reached an agreement with Affinity for the authorization of ALK-N001/QHL-1618, obtaining all rights in Greater China. ALK-N001 is expected to be a strong candidate for tumor treatment due to its enhanced cytotoxicity [3]

Investment Rating - The report assigns a "Buy" rating for the company, indicating a positive outlook for its stock performance [4][9]. Core Views - The company's main business is expected to stabilize and recover, with innovative anti-cancer drugs showing improved efficacy and reduced toxicity, suggesting that the platform may have been validated [4][11]. - The impact of the national procurement on the core product, Leflunomide, is gradually diminishing, and with new products being launched, the company's performance is anticipated to return to a growth trajectory [6][11]. Summary by Sections Company Overview - The company, established in 2001, specializes in the research, production, and sales of chemical raw materials, chemical preparations, pharmaceutical excipients, and specialty intermediates. It was listed on the Shenzhen Stock Exchange in 2018 [16]. - The company has a strong position in cardiovascular preparations, oral cephalosporin raw materials, alpha-keto acid raw materials, inhalation anesthetics, and androgen hormone intermediates [16]. Financial Performance - The company reported a revenue of 1.54 billion yuan in 2024, a decrease of 5% year-on-year. The decline is primarily attributed to the impact of Leflunomide's inclusion in national procurement [6][24]. - The company expects a rebound in revenue, projecting 1.81 billion yuan in 2025, with a year-on-year growth rate of 17.7% [8]. Product Development and Innovation - The introduction of ALK-N001, an innovative anti-cancer drug, is based on the TMEA platform, which has shown promising clinical results. The first drug from this platform, Legobit, has completed Phase III trials, demonstrating superior efficacy and safety compared to existing chemotherapy options [7][11]. - The company is actively expanding into new fields such as plant sterols and animal health, which are expected to become new growth drivers [6][11]. Profit Forecast and Valuation - The forecasted net profits for 2025, 2026, and 2027 are 132 million yuan, 170 million yuan, and 216 million yuan, respectively, with growth rates of 64%, 29%, and 27% [8][9]. - The current stock price corresponds to a price-to-earnings ratio (P/E) of 69, 54, and 42 for the years 2025, 2026, and 2027, respectively [9].

Group 1 - The A-share innovative drug concept stocks are experiencing a rebound, with notable increases in stock prices [1] - Leyi Group reached the daily limit increase, while Yipinhong surged by 14%, Hite Bio increased by over 13%, and Haipu Rui rose by over 5% [1] - Other companies such as Fuyuan Pharmaceutical, Anglikang, and Shutaishen also saw their stock prices rise [1]

Market Performance - A-shares steadily advanced this week, with the ChiNext Index reaching a new high for the year and the Shenzhen Component Index hitting a four-month high, approaching its highest point of the year [1] - Weekly trading volume increased to 7.73 trillion yuan, marking the largest weekly trading volume in three months [1] Fund Inflows - Leverage funds actively entered the market, with most industries under the Shenwan first-level industry classification seeing net buying, particularly the computer industry with over 4.4 billion yuan and the electronics industry with over 3 billion yuan [2] - The electronic, biopharmaceutical, and automotive sectors each received over 20 billion yuan in net inflows, while the non-bank financial sector saw a net outflow of over 8.3 billion yuan [2] Rare Earth Demand - The rare earth sector performed strongly, with the rare earth permanent magnet index reaching a three-and-a-half-year high [3] - Demand for rare earths is expected to grow rapidly due to advancements in humanoid robots and electric vehicles, with estimates suggesting a demand of at least 70,000 tons of neodymium-iron-boron by 2025 [3] Energy Metals - The energy metals sector, including lithium and cobalt, reached a two-year high, with lithium carbonate futures breaking 70,000 yuan/ton, marking a 20% increase from recent lows [4] - Short-term lithium salt supply may decline due to reduced exports from Chile and domestic production halts, leading to a potential price stabilization [4] Biopharmaceutical Sector - The biopharmaceutical sector saw significant gains, with the innovative drug index hitting record highs multiple times this week [6] - Notable stocks in the sector, such as Lianhuan Pharmaceutical and Aosaikang, experienced consecutive trading halts, with some stocks showing year-to-date gains exceeding 200% [6][7] Earnings Forecasts - Several pharmaceutical companies have recently forecasted substantial profit increases for the first half of 2025, with estimates suggesting net profit growth exceeding 19 times for some firms [7]

Group 1: Stock Performance - Zhejiang Zhenyuan and Asia-Pacific Pharmaceutical both achieved a 2-day limit-up with increases of 10.01% and 9.98% respectively, driven by innovation in pharmaceuticals [2] - Chengdu XianDao saw a first board listing with a significant rise of 20.02%, attributed to innovative drug developments [2] - TaiJing Technology and YanHua Intelligent both recorded first board listings with increases of 9.97% and 9.94%, linked to Huawei's influence in robotics [5] Group 2: AI and Robotics - Nvidia's CEO suggested that Huawei's AI chips could potentially replace Nvidia's offerings, indicating a competitive shift in the AI chip market [4] - The domestic robotics industry is gaining traction with significant orders being awarded, highlighting its importance in national competition [7] Group 3: Market Trends - The light communication sector is expected to see sustained growth due to high demand in both domestic and international markets, with performance likely to continue improving [13] - The low-altitude economy is gaining attention, with a notable $1 billion procurement agreement signed for eVTOL aircraft, indicating growth potential in this sector [17] Group 4: Consumer and Retail - The Chinese government is implementing measures to boost consumer spending, which is expected to positively impact the retail sector [21] - Companies like Guoguang Chain and Hanshang Group have seen first board listings with increases of 9.98% and 9.97%, reflecting the positive sentiment in the retail market [23] Group 5: Solar and Food & Beverage - The price of polysilicon has increased by 12.4% week-on-week, indicating a rising trend in the solar industry [24] - The food and beverage sector is also benefiting from government initiatives aimed at enhancing consumer demand, with companies like Huangshi Group seeing a 10.10% increase [26]

Market Overview - A-shares experienced a slight upward trend with the Shanghai Composite Index rising by 0.07% to 3506.37, the Shenzhen Component Index increasing by 0.57% to 10782.12, and the ChiNext Index up by 0.58% to 2243.15 [1][2] - Hong Kong stocks also saw gains, with the Hang Seng Index up by 0.40% to 24617.01 and the Hang Seng Tech Index rising by 0.54% to 5447.66 [2][3] Sector Performance - The pharmaceutical sector in Hong Kong showed strong performance, with notable stocks like 康方生物 (Kangfang Biologics) rising over 10% and 百济神州 (BeiGene) increasing by over 5% [5][6] - A-share innovative drug concept stocks maintained strength, with 维康药业 (Weikang Pharmaceutical) hitting the daily limit up and 成都先导 (Chengdu Leading) rising over 10% [8][10] - The retail sector saw significant movements, with 国光连锁 (Guoguang Chain) and 国芳集团 (Guofang Group) both hitting the daily limit up [13] Commodity Market - In the commodity market, polysilicon prices increased by over 2%, while the shipping index for European routes dropped by over 4% [1][20] - The average transaction price for polysilicon n-type raw materials rose by 12.4% week-on-week, indicating a strong demand in the solar energy sector [15] Policy and Regulatory Updates - The National Medical Insurance, Maternity Insurance, and Work Injury Insurance drug catalog adjustments for 2025 have been officially initiated, with new innovative drugs being added to commercial health insurance [6][7] - The State Council proposed actions to boost consumption, including optimizing policies for replacing consumer goods and addressing unreasonable restrictions on consumer spending [13]

Group 1 - The A-share innovative drug sector continues to show strong performance, with Weikang Pharmaceutical hitting a 20% daily limit increase [1] - Seer Medical also reached its limit, while companies such as Nanjing New Pharmaceutical, Lianhuan Pharmaceutical, Anglikang, and Boji Medical experienced upward trends [1]