一、日常关联交易基本情况 （一）日常关联交易概述 1、重庆智飞生物制品股份有限公司（以下简称"公司"）于 2025 年 4 月 18 日召开第六届董事会第五次会议，审议通过了《关于 2025 年度日常关联交易预 计的议案》，关联董事蒋仁生先生、蒋凌峰先生已回避表决，出席会议的非关联 董事一致同意该议案。根据《深圳证券交易所创业板股票上市规则》及《公司章 程》《关联交易决策制度》的相关规定，本议案在董事会审议权限范围内，无需 提交公司股东大会审议。 证券代码：300122 证券简称：智飞生物 公告编号：2025-21 重庆智飞生物制品股份有限公司 关于 2025 年度日常关联交易预计的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 2、根据公司日常经营及业务发展的需要，公司及子公司预计 2025 年度将与 关联方发生日常关联交易不超过 2,046 万元。公司 2024 年度日常关联交易实际 发生额为 298.00 万元。 | | | | | 合同签订 | 截 至 2025 | | | | | --- | --- | --- | --- | --- | -- ...

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology industry, expecting the industry index to outperform the market index by over 10% in the next six months [2][29]. Core Insights - The SW pharmaceutical and biotechnology industry underperformed the CSI 300 index, declining by 5.20% from March 28 to April 10, 2025, which is approximately 0.18 percentage points lower than the index [14][29]. - Most sub-sectors within the industry recorded negative returns during the same period, with blood products and offline pharmacy sectors showing gains of 7.36% and 1.41%, respectively, while medical R&D outsourcing and in vitro diagnostics faced declines of 21.38% and 10.62% [15][29]. - Approximately 17% of stocks in the industry recorded positive returns, while around 83% experienced negative returns during the reporting period [16][19]. - The overall price-to-earnings (PE) ratio for the SW pharmaceutical and biotechnology industry is approximately 38.81 times, which is 3.38 times relative to the CSI 300, indicating a decline in industry valuation and positioning at a relatively low level compared to recent years [20][29]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry underperformed the CSI 300 index, with a decline of 5.20% from March 28 to April 10, 2025 [14]. - Most sub-sectors recorded negative returns, with blood products and offline pharmacies leading in gains [15]. - About 17% of stocks in the industry had positive returns, while 83% had negative returns [16]. 2. Industry News - The national Chinese medicine procurement alliance began centralized procurement and information maintenance for selected drugs starting April 9, 2025, involving 20 product groups and 95 products, with 174 drugs selected [26]. 3. Important Announcements from Listed Companies - Zai Lab received approval for clinical trials of its drug ZG005 for use in combination with chemotherapy for digestive tumors [27]. - Opcon Vision received a medical device registration certificate for its orthokeratology contact lenses [28]. 4. Industry Weekly Perspective - The report suggests focusing on investment opportunities in medical devices and innovative drugs, particularly those with import substitution potential [29]. - Recommended stocks include Mindray Medical, Yuyuan Pharmaceutical, and others across various segments such as medical aesthetics and innovative drugs [30].

Core Viewpoint - The company, Zhifei Biological, has accelerated its self-research and development, with significant advancements in its vaccine pipeline, including the four-valent meningococcal conjugate vaccine, therapeutic BCG vaccine, and bivalent shigella conjugate vaccine, which have entered critical research stages [1][2][3]. Group 1: Four-Valent Meningococcal Conjugate Vaccine - Zhifei Biological's subsidiary, Beijing Zhifei Green Bamboo Biological Pharmaceutical Co., Ltd., has received the III phase clinical trial summary report for its four-valent meningococcal conjugate vaccine, which aims to prevent meningococcal meningitis caused by groups A, C, Y, and W135 [1][2]. - The clinical trial results indicate that the vaccine demonstrates good immunogenicity and safety, meeting the predefined clinical trial objectives and showing non-inferiority to the control vaccine [1][2]. - If approved, this vaccine will complement existing products in Zhifei's meningitis vaccine portfolio, enhancing the company's market position and competitiveness [2]. Group 2: Bivalent Shigella Conjugate Vaccine - The bivalent shigella conjugate vaccine is designed to prevent acute intestinal infections caused by Shigella flexneri and Shigella sonnei, which pose significant health risks, especially to children under five [3][4]. - The World Health Organization reports that bacterial dysentery affects approximately 165 million people globally each year, with a significant portion of cases occurring in developing countries [3]. - Zhifei has received approval from the Bangladesh Drug Administration to conduct III phase clinical trials for this vaccine, which will further support its registration application [4]. Group 3: Therapeutic BCG Vaccine - The therapeutic BCG vaccine developed by Zhifei Longkema Biological Pharmaceutical Co., Ltd. has entered III phase clinical trials, targeting non-muscle invasive bladder cancer [5]. - This vaccine is intended to reduce tumor recurrence and prevent progression after transurethral resection of bladder tumors, addressing a significant medical need given the high recurrence rates of bladder cancer [5]. - The clinical trial design includes a multi-center, randomized, and blinded approach to evaluate the vaccine's effectiveness and safety in preventing recurrence in patients aged 18 and older [5]. Group 4: R&D Investment and Pipeline - Zhifei Biological has significantly increased its R&D investment, from over 2 billion yuan in 2022 to 2.389 billion yuan in 2023, focusing on talent acquisition, technological innovation, and industrial layout [6]. - The company currently has 33 self-research projects, with 17 in clinical trials and registration application stages, indicating a robust pipeline of innovative vaccines [6]. - Recent approvals for the four-valent influenza vaccine and advancements in other vaccine candidates position Zhifei at the forefront of the industry [6].

Core Viewpoint - The company, Zhifei Biological, has made significant advancements in vaccine development, including a quadrivalent meningococcal vaccine, a therapeutic BCG vaccine for bladder cancer, and a bivalent shigella vaccine, indicating a strategic focus on infectious disease prevention and cancer treatment [1][5]. Group 1: Quadrivalent Meningococcal Vaccine - The quadrivalent meningococcal polysaccharide conjugate vaccine has completed its Phase III clinical trial, demonstrating good immunogenicity and safety, meeting the predefined clinical trial goals [2][5]. - If approved, this vaccine will complement existing meningococcal vaccines, enhancing the company's market position in the meningitis vaccine sector [2][5]. Group 2: Therapeutic BCG Vaccine - The therapeutic BCG vaccine has entered Phase III clinical trials aimed at preventing recurrence in non-muscle invasive bladder cancer patients, with the first subject treated in Hunan Province [3][5]. - This product could become the company's first oncology therapeutic biological product, addressing the high recurrence rates of bladder cancer [3][5]. Group 3: Bivalent Shigella Vaccine - The bivalent shigella vaccine is set to initiate Phase III trials in Bangladesh, targeting bacterial dysentery caused by Shigella flexneri and Shigella sonnei, with the potential to fill a significant market gap as no similar vaccines are currently approved globally [4][5]. - The trial will assess the vaccine's efficacy and safety in infants aged 6 months to 5 years, contributing to the global fight against dysentery, particularly in developing countries [4][5].

证券代码：300122 证券简称：智飞生物 公告编号：2025-13 重庆智飞生物制品股份有限公司 关于双价痢疾结合疫苗将于孟加拉国启动Ⅲ期临床试验的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）近日获悉，由全资子公 司北京智飞绿竹生物制药有限公司（以下简称"智飞绿竹"）研发的福氏宋内氏痢 疾双价结合疫苗（以下简称"双价痢疾结合疫苗"）根据孟加拉国药品管理总局签 发的Ⅲ期临床试验批件，已经完成于孟加拉国开展Ⅲ期临床试验的准备工作，即 将启动受试者入组。现将相关情况公告如下： 四、风险提示 1、药品研制是非常复杂严谨的科学活动，具有投入大，周期长，风险高的 特点，公司将根据当地法规及批件要求，有序开展和推进临床试验相关工作。 一、研发项目简介 双价痢疾结合疫苗用于预防福氏志贺菌、宋内氏志贺菌引起的急性肠道传染 病，即细菌性痢疾。细菌性痢疾是由志贺菌属引起的一种肠道传染病，又称志贺 菌病，以腹痛、腹泻、里急后重、脓血便等为主要临床症状，各年龄群均可发病， 常见于婴幼儿和老年人，多发于夏秋季节。该疾病被列为我国 ...

证券代码：300122 证券简称：智飞生物 公告编号：2025-12 重庆智飞生物制品股份有限公司 关于四价流脑结合疫苗获得Ⅲ期临床试验总结报告 的提示性公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 二、同类产品的市场情况 截至本公告披露日，经查询国家药品监督管理局网站，国内有 1 款四价流 脑结合疫苗上市。 1 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资子 公司北京智飞绿竹生物制药有限公司（以下简称"智飞绿竹"）研发的 ACYW135 群脑膜炎球菌多糖结合疫苗（以下简称"四价流脑结合疫苗"）获得了Ⅲ期临床试 验总结报告。根据《深圳证券交易所上市公司自律监管指引第 4 号——创业板行 业信息披露》规定，现将相关情况公告如下： 一、基本情况 疫苗名称：四价流脑结合疫苗 适应症：预防由 A、C、Y、W135 群脑膜炎球菌引起的流行性脑脊髓膜炎 临床试验批件号：2014L01922 临床试验分期：Ⅲ期临床试验 研究方法：随机、盲法、同类疫苗对照的临床试验 流行性脑脊髓膜炎是由脑膜炎奈瑟菌引起的急性化脓性脑膜炎，具有起病 急、进展快、传 ...

证券代码：300122 证券简称：智飞生物 公告编号：2025-14 重庆智飞生物制品股份有限公司 关于治疗用卡介苗进入Ⅲ期临床试验的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资子 公司安徽智飞龙科马生物制药有限公司（以下简称"智飞龙科马"）自主研发的治 疗用卡介苗进入Ⅲ期临床试验。现将相关情况公告如下： 三、Ⅲ期临床试验相关情况 1 治疗用卡介苗的Ⅲ期临床试验在湖南省完成首例受试者给药。该临床试验采 用多中心、随机、盲法对照设计，以评价该产品用于预防 18 周岁及以上人群非 肌层浸润性膀胱癌术后复发的有效性和安全性。 四、风险提示 1、药品研制是非常复杂严谨的科学活动，具有投入大，周期长，风险高的 特点，产品的研发和行政审批主要有以下几个阶段：临床前研究；申请临床试验； 开展临床试验；申请生产文号；上市销售。 2、公司治疗用卡介苗进入Ⅲ期临床试验阶段不会对公司近期业绩产生重大 影响。若未来该产品研发顺利，将进一步丰富公司产品布局，强化公司的市场竞 争地位，满足更广泛的民众健康需求。 ...

证券代码：300122 证券简称：智飞生物 公告编号：2025-11 重庆智飞生物制品股份有限公司 关于三价流感病毒裂解疫苗（ZFA02 佐剂） 获得临床试验批准通知书的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资子 公司安徽智飞龙科马生物制药有限公司（以下简称"智飞龙科马"）研发的三价流 感病毒裂解疫苗（ZFA02 佐剂）（以下简称"佐剂三价流感疫苗"）获得国家药品 监督管理局药物临床试验批准通知书（通知书编号：2025LP00953），同意开展 预防疫苗相关型别流感病毒引起的流行性感冒的临床试验。公司将根据临床试验 批准通知书的要求，尽快开展相关临床试验工作。 一、研发项目简介 流感是由流行性感冒病毒引起的可造成大规模流行的急性呼吸道传染病。流 感的传染性强，可引发肺炎、支气管炎、心肌炎等并发症，也可加重老年人、体 弱者等高危人群的基础疾病。接种流感疫苗是预防流感疾病及流感大爆发最经济、 有效的措施。本次临床试验申请获得批准的佐剂三价流感疫苗，含公司自主研制 的 ZFA02 佐剂， ...