证券代码：300676 证券简称：华大基因 公告编号：2025-033 深圳华大基因股份有限公司 2024 年年度股东会决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 重要提示： 1、本次股东会召开期间不存在增加、否决或变更议案情形； 2、本次股东会未涉及变更前次股东会决议的情形。 一、会议召开情况 1、会议召开的日期、时间： （1）现场会议召开时间：2025年5月20日（星期二）14:30 （2）网络投票时间： ① 通过深圳证券交易所交易系统进行网络投票的具体时间为：2025年5月20 日9:15—9:25，9:30—11:30和13:00—15:00； ② 通过深圳证券交易所互联网投票系统进行网络投票的具体时间为：2025 年5月20日9:15至2025年5月20日15:00期间的任意时间。 2、会议召开地点：广东省深圳市盐田区梅沙街道云华路9号华大时空中心 C 区国际会议中心419会议室 3、会议召开方式：本次股东会采取现场表决与网络投票相结合的方式 4、会议召集人：深圳华大基因股份有限公司（以下简称公司）董事会 5、会议主持人：公司董事长汪建 ...

国浩律师（深圳）事务所 关于 深圳华大基因股份有限公司 二〇二四年年度股东会 之 法律意见书 广东省深圳市福田区深南大道 6008 号特区报业大厦 42、41、31DE、2403、2405，邮编：518034 42、41、31DE、2403、2405, Tequbaoye Building 6008 Shennan Avenue Shenzhen 518034, China 电话/Tel: +86 755 83515666 传真/Fax: +86 755 83515333 网址/Website: http://www.grandall.com.cn 二〇二五年五月 1 深圳华大基因股份有限公司 2024 年年度股东会法律意见书 国浩律师（深圳）事务所 关于深圳华大基因股份有限公司 二〇二四年年度股东会之法律意见书 编号： GLG/SZ/A2626/FY/2025-497 号 致：深圳华大基因股份有限公司 国浩律师（深圳）事务所（以下简称本所）接受深圳华大基因股份有限公司 （以下简称公司、贵公司）委托，指派本所律师出席公司 2024 年年度股东会（以 下简称本次股东会）。本所律师根据《中华人民共和国证券法》（以 ...

Investment Rating - The report maintains a positive outlook on the innovative drug sector within the healthcare industry [1]. Core Insights - The pharmaceutical sector outperformed the CSI 300 index slightly, with the Shenwan Pharmaceutical and Biological Index rising by 1.27% from May 12 to May 16, 2025, and by 2.48% year-to-date, ranking 11th among 31 Shenwan primary industry indices [1][12]. - The current valuation of the pharmaceutical sector stands at 26.80 times (TTM overall method, excluding negative values), with a premium of 141.06% compared to the CSI 300 index [15]. - The innovative drug segment is experiencing a pullback due to U.S. President Trump's announcement regarding drug price reductions, but the report suggests that the actual implementation of such policies will be challenging and will not significantly impact Chinese innovative drug companies' international expansion [3][20]. Summary by Sections 1. Market Review - The pharmaceutical sector's performance from May 12 to May 16, 2025, showed a 1.27% increase, outperforming the CSI 300 index by 0.15 percentage points [10]. - Year-to-date, the sector has increased by 2.48%, surpassing the CSI 300 index by 3.64 percentage points [12]. 2. Key Events - On May 12, 2025, President Trump announced plans to sign an executive order aimed at reducing prescription drug prices in the U.S., potentially lowering prices by 30% to 80% [19]. 3. Industry Perspective - The innovative drug sector is expected to continue as a key investment theme for 2025, with a focus on international expansion and emerging markets, particularly in companies like Kexing Pharmaceutical [4][21]. - The report highlights that the ongoing collection and procurement policies in various pharmaceutical fields are accelerating, with potential growth in segments like insulin and orthopedics [4][21].

Core Insights - The presence of tertiary lymphoid organs (PTLOs) in carotid atherosclerotic plaques is closely related to whether patients exhibit symptoms such as stroke, serving as an independent risk factor for symptomatic carotid stenosis [1][2] - The research provides new perspectives on the immune mechanisms of atherosclerosis and identifies potential therapeutic targets for precise interventions [1][3] Group 1: Research Findings - The study utilized single-cell RNA sequencing and spatial omics technology (Stereo-seq) to construct a high-resolution single-cell spatial map of human carotid atherosclerotic plaques [2] - PTLOs were identified in human arterial plaques, characterized by significant spatial aggregation of lymphocytes, lack of typical germinal center structures, and active B cell immune responses [2] - The presence of effector B cells in plaques is linked to the formation of "ectopic germinal center reactions," indicating clonal selection and the potential generation of specific antibodies against plaque antigens [2] Group 2: Clinical Implications - The findings suggest a molecular basis for the interaction between B cells in plaques and those in surrounding vascular adipose tissue, supporting the existence of a "vascular adipose tissue-plaque immune axis" [2] - The study highlights the potential for future clinical diagnostics and interventions in atherosclerosis, particularly through the role of IgG antibodies secreted by effector B cells in activating macrophage functions [2][3]

Market Performance - The market rebounded last week, with the China Securities Xinhua National Brand Index rising by 0.94% to 1666.03 points [1] - The Shanghai Composite Index increased by 0.76%, the Shenzhen Component Index by 0.52%, the ChiNext Index by 1.38%, and the CSI 300 Index by 1.12% [1] Strong Stock Performances - Notable strong performers in the brand index included BGI Genomics, which rose by 17.27%, and Yiling Pharmaceutical, which increased by 9.81% [1] - Other significant gainers included Stone Technology and Marubi Biological, which rose by 7.18% and 6.79%, respectively [1] Year-to-Date Stock Gains - Since the beginning of 2025, Marubi Biological has surged by 60.82%, leading the gains, followed by Shanghai Jahwa with a 46.72% increase and BGI Genomics with a 34.45% rise [2] - Other stocks with notable increases include Anji Technology, Xintai, and Weir Shares, each rising over 20% [2] Market Outlook - Institutions expect the market to refocus on domestic economic fundamentals, with a positive policy response anticipated [2][3] - The current market is viewed as being in a high cost-performance range, with significant policy support expected to stabilize the economy and market [2] Economic Data Focus - Attention is drawn to upcoming economic data, particularly export performance and the sustainability of the export supply chain recovery [3] - The prevailing market conditions are supported by policy measures and liquidity easing, which are expected to bolster the stability of the domestic economy and capital markets [3]

Core Viewpoint - The high-end medical device industry in Shenzhen is a significant indicator of national manufacturing capability and technological development, with a projected revenue of 200 billion yuan by 2025, highlighting its importance in the global medical device market [1]. Group 1: Industry Overview - Shenzhen's medical device output reached 99 billion yuan in 2023, accounting for approximately 10% of the national total, with exports also around 10% [1]. - The city is home to leading companies like Mindray Medical and BGI, which are recognized among the top 100 global medical device firms [1]. Group 2: Technological Advancements - The brain-computer interface technology developed by Shenzhen Ruihan Medical has shown significant promise in rehabilitation, with patients experiencing better recovery outcomes compared to traditional methods [2][3]. - Ruihan Medical's brain-computer interface rehabilitation robot system is the first commercialized product of its kind globally, with over 100 patents and a focus on practical application [3]. Group 3: Collaborative Innovation - The National High-Performance Medical Device Innovation Center in Shenzhen is addressing core technological challenges in the medical device sector through collaborative projects with key enterprises [6][7]. - The center has successfully developed a 5.0T whole-body MRI system, marking a significant breakthrough in high-field MRI technology [6]. Group 4: Market Dynamics - The medical device industry in Shenzhen is characterized by a "chain development" model, where breakthroughs in technology stimulate growth across the entire supply chain [8]. - Companies like Mindray Medical and Libang Instruments have successfully disrupted international monopolies in their respective fields, leading to increased domestic production capabilities [9][10]. Group 5: Spatial and Policy Support - Shenzhen's medical device industry faces challenges such as limited industrial space, prompting local governments to create favorable conditions for business growth [11][12]. - The city has introduced comprehensive support measures for the medical and pharmaceutical sectors, aiming to solidify its position as a leading hub for medical device innovation [13].

证券代码：300676 证券简称：华大基因 公告编号：2025-032 深圳华大基因股份有限公司 关于召开 2024 年年度股东会的提示性公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 根据《中华人民共和国公司法》和《深圳华大基因股份有限公司章程》（以 下简称《公司章程》）的有关规定，经深圳华大基因股份有限公司（以下简称公 司）第四届董事会第五次会议审议通过，公司董事会决定于2025年5月20日（星 期二）召开公司2024年年度股东会。《关于召开2024年年度股东会的通知》（公 告编号：2025-029）已于2025年4月26日在巨潮资讯网（http://www.cninfo.com.cn， 下同）进行了公告。本次会议将采取现场表决与网络投票相结合的方式召开，根 据相关规定，现就本次会议有关事项提示如下： 一、召开会议的基本情况 1、股东会届次：深圳华大基因股份有限公司2024年年度股东会 2、股东会召集人：公司董事会 3、会议召开的合法性及合规性：经公司第四届董事会第五次会议审议通过， 决定召开2024年年度股东会，召集程序符合有关法律、行政法规、部门 ...

Investment Rating - The report maintains an investment rating of "Outperform the Market" for the medical device industry [2]. Core Insights - The report emphasizes that AI in healthcare is restructuring diagnostic and treatment processes, creating investment opportunities driven by efficiency and market growth. The global healthcare sector faces challenges such as aging populations and uneven distribution of medical resources, which AI can address by optimizing the healthcare value chain and promoting equitable access to medical resources [5][6]. Summary by Sections 1. AI Healthcare Development Environment - The domestic AI healthcare development environment is mature, supported by data resources and services that enhance algorithm accuracy and generalization [11]. - AI technology is breaking the uneven distribution of medical resources, addressing the growing demand for healthcare services due to an aging population [18][19]. 2. AI Medical Imaging - AI medical imaging is the most mature application of AI in healthcare, with a complete ecosystem covering various imaging modalities such as CT, MRI, and X-ray. The market for AI medical imaging in China is projected to reach 6.17 billion yuan by 2025 [5][39]. - Companies like Mindray and United Imaging are leveraging hardware advantages to build "device + AI" ecosystems, while pure AI companies focus on lesion recognition and cross-disease generalization capabilities [5][39]. 3. AI In Vitro Diagnostics - The AI in vitro diagnostics market is rapidly growing, with applications in hematology, microbiology, and pathology. Companies like BGI and Anbiping are innovating with AI-driven solutions to enhance diagnostic efficiency [5][6]. 4. AI Wearable Devices - AI wearable devices are transforming health management by providing real-time monitoring and data analysis, becoming essential for chronic disease management. The market for smart wearable devices in China is expected to exceed 15 billion yuan in 2023 and reach 33 billion yuan by 2026, with a compound annual growth rate of 18.1% [6]. 5. Investment Recommendations - The report suggests that the industry is poised for multidimensional development, transitioning from scale expansion to higher-level growth. It highlights long-term investment opportunities in leading companies like Mindray, United Imaging, Yuyue Medical, and Kefu Medical, which are early adopters of AI healthcare solutions [6].

Group 1 - The core viewpoint of the news highlights the recent performance and financial metrics of BGI Genomics, including a significant stock price increase and a decline in revenue and profit [1] - As of March 31, 2025, BGI Genomics has 61,929 shareholders, an increase of 301 from the previous count, with an average holding value of 352,800 yuan and an average shareholding of 27,600 shares [1] - The company specializes in providing research services and precision medical testing solutions through multi-omics big data technologies, with key products including prenatal nutrition testing and human amino acid and vitamin testing [1] Group 2 - The latest financial report for Q1 2025 shows BGI Genomics achieved a revenue of 672 million yuan, a year-on-year decrease of 18.18%, and a net loss of approximately 52.7 million yuan, a decline of 524.87%, with a gross profit margin of 43.55% [1] - The company's current price-to-earnings (P/E) ratio is -24.86, with a price-to-book (P/B) ratio of 2.64 and a total market capitalization of 24.059 billion yuan [2] - BGI Genomics has received multiple awards for its corporate social responsibility and strategic positioning in the medical device sector, enhancing its brand recognition and influence [1]

近期，华大基因总经理赵立见及公司管理团队共同接待了高盛及海外机构投资者调研。在此期间，公司 总经理赵立见先是整体介绍了华大基因的核心业务与技术创新研发的相关情况。华大基因作为全球基因 行业的前沿企业，依托20余年的人才积累、科研积淀与产业布局，已成功构建了覆盖全球百余个国家及 本国所有省市自治区的营销服务网络，并成为行业内极少数能够实现本行业全产业链、全应用领域覆盖 的科技企业。不仅如此，华大基因依托先进的技术、齐全的配置及业内颇具规模的多组学产出平台，成 为了全球知名的科技服务供应商与精准医疗服务的运营商。 不仅如此，在智能化领域，华大基因还推出了GBI ALL、SIRO一站式解决方案，以此促进公司的智能 化转型和全球布局。在2025年，华大基因还将基于"ALL计划"的核心战略目标，将业务模式全面转型为 智能型服务，实现前端样本处理的自动化、智能化，并依托短读长和长读长测序技术平台，持续完善数 据库建设，为未来业务转型奠定坚实的基础。 目前，华大基因的产品布局明晰且全面，可为不同健康领域提供精准、高效的基因检测与健康管理解决 方案。在生育健康领域，华大基因构建了涵盖婚前、孕前、产前、新生儿及儿童成长阶段完整 ...