Investment Rating - The report maintains a "Buy" rating for China Biologic Products Holdings, with a target price of 3.02 HKD [1]. Core Views - The company reported a revenue of 26.2 billion HKD for 2023, a year-on-year increase of 0.7% (excluding discontinued operations), while the net profit attributable to shareholders was 2.33 billion HKD, down 8.3% year-on-year [1]. - The innovative drug segment achieved a revenue of 9.89 billion HKD, growing 13.3% year-on-year, and accounted for 37.8% of total revenue, an increase of 4.3 percentage points from the previous year [1]. - The company is focusing on innovation and has been optimizing its asset and business structure since 2023, including divesting non-core businesses [1]. Summary by Sections Financial Performance - Revenue for 2023 was 26.2 billion HKD, with a net profit of 2.33 billion HKD, reflecting a decline due to underperformance from associates [1]. - Adjusted non-HKFRS net profit was 2.59 billion HKD, a 1.5% increase year-on-year [1]. Innovative Drug Segment - The core innovative drug, Anlotinib, is expanding its commercialization potential with multiple combination therapies entering clinical trials [1]. - The company has introduced nine potential products since 2021, with significant progress in clinical trials for key drugs expected to contribute to revenue growth [1]. Generic Drug Segment - The generic drug segment remains promising, with several products entering the centralized procurement range, and new biosimilars launched in 2023 expected to drive growth [1]. Organizational Restructuring - The company has sold off its non-core pharmaceutical distribution businesses to focus on innovative drug development and enhance its global presence [1]. Earnings Forecast - Projected revenues for 2024-2026 are 29.84 billion HKD, 33.69 billion HKD, and 37.94 billion HKD, respectively, with adjusted non-HKFRS net profits expected to be 2.98 billion HKD, 3.38 billion HKD, and 3.88 billion HKD [1].

交银国际研究 公司更新 医药 收盘价 目标价 潜在涨幅 2024年4月1日 港元3.02 港元4.80↑ +59.0% 中国生物制药 (1177 HK) 2023 业绩韧性强，研发成果加速兑现有望驱动增速复苏，上调目标价  2023内地业务利润较快增长，降本增效成果显著：2023收入增长0.7%至 个股评级 262亿元（人民币，下同），增速符合我们的预期；创新产品（包括生物 买入 类似药）收入增长13.3%至99亿元，占比从2022年的33%进一步提升至 38%。分治疗领域看，肿瘤领域全年收入下滑4.2%，但2H23在行业整治 中依旧录得 2%的增长；其余核心板块均保持稳定或录得正增长：肝病- 1年股价表现 0.4%、呼吸+1.4%、外科+9.0%、心脑血管+2.5%。全年持续经营业务的经调 1177 HK 恒生指数 整净利润增长1.5%，剔除F-star等海外业务的影响后，内地业务经调整净 10% 5% 利润增长13.3%。经营利润率持续微升0.2ppts至20.8%，得益于销售及管 0% -5% 理费用的有效管控（费用率-2.8ppts至42.2%），营销人员数量减少4%的 -10% -15% 同时、人 ...

研究报告Research Report 29 Mar 2024 中国生物制药 Sino Biopharmaceutical (1177 HK) 创新产品稳健增长，国内企业经营效率持续提升 Steady Growth of Innovative Product, Operating efficiency of Domestic Enterprise Continue to Optimize [观Ta点bl聚e_焦yem Inevie1s] tment Focus [Tab维le_持Inf优o] 于大市Maintain OUTPERFORM (Please see APPENDIX 1 for English summary) 事件 评级 优于大市OUTPERFORM 现价 HK$3.02 中国生物制药2023年持续经营业务收入262.0亿元（+0.7%），其 目标价 HK$5.17 中创新产品收入 98.9 亿元（+13.3%）。按治疗领域划分，肿瘤领 HTI ESG 1.3-2.0-3.5 域 88.0 亿元（-4.2%），肝病领域 38.2 亿元（-0.4%），呼吸领域 E-S-G: 0-5, (Pleas ...

智通财经APP讯，中国生物制药(01177)发布截至2023年12月31日止年度业绩，该集团期内取得持续经营业务收入261.99亿元(人民币，下同)，同比增加0.67%;股东应占溢利23.32亿元，同比减少8.32%;每股基本盈利12.59分;拟派发末期股息每股3港仙。 公告称，一直以来，集团十分重视研发，以结合自主创新、联合开发及创仿开发的研发理念，不断提升研发水平和速度，并视其为可持续发展的基础，加大研发的资金投入。截至2023年12月31日止年度，研发总开支约470427万元，占集团收入约18.0%，当中大部份已计入损益表中。于报告期内，创新药及生物药的研发投入占比超过77%，投入金额同比增加约10%;抗肿瘤领域研发投入占比约71%，投入金额同比增加超过1%。 截止报告期末，集团共有43个肿瘤领域的创新候选药物处在临床及以上开发阶段，包括5个产品处在上市申请阶段，4个产品处在临床III期，13个产品处在临床II期，以及21个产品处在临床I期。另外，集团还有17个肿瘤领域的生物类似药或仿制药候选药物处在临床及以上开发阶段，包括7个产品处在上市申请阶段，2个产品处在关键临床，以及8个产品处在生物相等性(BE ...

Financial Performance - Revenue for the year ended December 31, 2023, was RMB 26.20 billion, a slight increase of 0.7% compared to RMB 26.03 billion in 2022[2] - The profit attributable to equity holders of the parent decreased by 8.3% to RMB 2.33 billion from RMB 2.54 billion in the previous year[2] - Adjusted net profit attributable to the parent under non-HKFRS increased by 1.5% to RMB 2.59 billion from RMB 2.55 billion[2] - The company recorded revenue of approximately RMB 2,619,941,000, representing a year-on-year growth of about 0.7%[23] - Profit attributable to equity holders decreased to approximately RMB 233,194,000, a decline of about 8.3% compared to the previous year[23] - The net profit attributable to the company's shareholders for the year was RMB 5,097,398 thousand, up from RMB 5,002,618 thousand in 2022, reflecting an increase of approximately 1.89%[52] - The company reported a total comprehensive income for the year of RMB 5,187,385 thousand, compared to RMB 4,289,080 thousand in 2022, representing an increase of approximately 20.93%[53] Research and Development - Research and development expenses as a percentage of revenue rose to 16.8%, up by 0.8 percentage points from 16.0%[2] - Research and development (R&D) expenses totaled approximately RMB 4,704.27 million, accounting for about 18.0% of the group's revenue, with a year-on-year increase of approximately 10% in innovative and biological drug R&D investment[36] - The group submitted 841 patent applications and received 264 patent grants during the reporting period, totaling 4,311 effective patents and patent applications as of the end of the reporting period[36] - The company continues to focus on R&D in four major therapeutic areas: oncology, liver disease, respiratory, and surgical/pain management[138] Product Development and Pipeline - Innovative product revenue reached RMB 9.89 billion, representing a significant growth of 13.3% from RMB 8.73 billion[2] - The proportion of innovative product revenue to total revenue increased to 37.8% from 33.5%[2] - The company has 145 products under development, including 60 oncology drugs, 9 liver disease drugs, 31 respiratory drugs, and 15 surgical/pain relief drugs, with 67 classified as innovative products[35] - The company has a strong product pipeline in oncology, liver disease, respiratory, and surgical/pain management sectors[4] - The company has 43 innovative drug candidates in oncology at clinical stages, with 7 innovative drugs and 9 biosimilars expected to be approved between 2024 and 2026[11] - The company has 6 innovative drug candidates in the liver disease field, with 2 biosimilars expected to be approved between 2024 and 2026[14] - The company has 8 innovative drug candidates in the respiratory field at clinical stages, with 1 product in the listing application stage and 4 in Phase II clinical trials, expecting 1 innovative drug and 11 biosimilars or generics to be approved in the next three years (2024-2026)[16] Market and Economic Context - In 2023, China's GDP reached RMB 126 trillion, growing by 5.2% year-on-year[8] - The pharmaceutical manufacturing industry's revenue in Q1 2023 was RMB 674.09 billion, a decrease of 3.3% year-on-year, with total profits down by 19.9% to RMB 89.22 billion[8] - In 2023, 126 new drugs were added to the national medical insurance catalog, bringing the total to 3,088[9] - The average price reduction for the eighth and ninth batches of centralized procurement was 56% and 58%, respectively[9] Dividends and Shareholder Returns - The company proposed a final dividend of HKD 0.03 per share, totaling an annual dividend of HKD 0.05 per share[2] - The board proposed a final dividend of HKD 0.03 per share for the year ended December 31, 2023, down from HKD 0.06 in 2022[88] Financial Position and Assets - The company had cash and bank balances of approximately RMB 945,188,000 and total financial reserves of approximately RMB 2,112,999,000 as of December 31, 2023[23] - The total assets of the group were approximately RMB 63,604.82 million, with total liabilities of approximately RMB 25,434.87 million, resulting in a debt-to-asset ratio of about 40.0%[42] - The group had short-term loans of approximately RMB 11,135.94 million and long-term loans of approximately RMB 1,057.94 million as of December 31, 2023, compared to RMB 6,217.15 million and RMB 3,933.86 million, respectively, on December 31, 2022[40] Corporate Governance and ESG - The company achieved a total of 651 ESG indicators managed through its digital platform, covering all key member enterprises' ESG performance management[45] - The company has not experienced any major quality safety incidents or recalls during the year, ensuring effective operation of its quality safety management system[46] - The company has been recognized with an MSCI ESG rating upgrade to A and ranked in the top 9% of the global pharmaceutical industry by S&P CSA for the second consecutive year[46] - The company has implemented a responsible supply chain management system, achieving a 100% dissemination rate of key supplier behavior guidelines and over 90% signing rate[45] Strategic Focus and Future Plans - The company is focused on innovation and aims to become a leading global pharmaceutical enterprise[5] - The company plans to launch over ten innovative products in the next three years, with more than thirty additional innovative products expected to be launched by 2030[47] - The company aims to accelerate growth in 2024 through enhanced R&D efficiency and quality in its key therapeutic areas[48] - The company is actively pursuing a dual-path internationalization strategy to bring global pharmaceutical innovations to China and expand into new markets[151]

Financial Performance - For the six months ended June 30, 2023, the company's revenue was RMB 15.28 billion, a slight increase of 0.5% compared to RMB 15.19 billion in the same period of 2022[8]. - The net profit attributable to shareholders for the same period was RMB 1.26 billion, representing a decrease of 34.5% from RMB 1.92 billion year-on-year[11]. - Adjusted net profit under non-HKFRS for the six months was RMB 1.48 billion, up 1.2% from RMB 1.46 billion in the previous year[10]. - In Q2 2023, the company reported revenue of RMB 8.63 billion, a significant increase of 30.0% from RMB 6.64 billion in Q2 2022[9]. - The adjusted net profit for Q2 2023 was RMB 960 million, reflecting a growth of 20.7% compared to RMB 800 million in Q2 2022[9]. - The decline in net profit attributable to shareholders was primarily due to the underperformance of an associated company compared to the previous year[9]. - The financial results indicate a stable revenue stream with a focus on innovative drug development and market expansion strategies[8]. - The basic earnings per share based on the adjusted net profit attributable to the parent company rose by 1.8% to RMB 7.96[12]. - The profit attributable to equity holders of the parent company for the first half of 2023 was RMB 1,258,784,000, compared to RMB 1,921,037,000 in the same period of 2022, reflecting a decline of approximately 34.4%[81]. Innovative Drug Development - Innovative drug revenue reached RMB 3.86 billion, an increase of 10.9% year-on-year, accounting for 25.3% of total revenue[8]. - The company is transitioning from a generics-based model to a fully innovative approach, with the revenue contribution from innovative drugs increasing year by year[14]. - The company has a strong pipeline of products in oncology, liver disease, respiratory, and pain management, with several key drugs already in the market[16]. - The company launched two innovative products during the reporting period and received approval for two biosimilars, focusing on oncology, liver disease, respiratory, and surgical/pain treatment areas[21]. - The company expects to have 7 innovative drugs and 9 biosimilars or generics approved for market in the oncology field over the next three years (2023-2025)[23]. - The group has 127 products in development, including 60 oncology drugs, 10 liver disease drugs, 21 respiratory drugs, and 17 surgical/pain relief drugs, with 69 of these being Class I innovative products[37]. - The group anticipates that 1 innovative drug and 8 biosimilars or generic drugs in the respiratory system field will be approved for market launch in the next three years (2023-2025)[26]. - The group expects to launch 1 innovative drug and 10 biosimilars or generic drugs in the surgical/pain relief field in the next three years (2023-2025)[29]. Research and Development - The company continues to focus on core business performance, adjusting for non-cash items and contributions from associated companies[10]. - Total R&D expenditure for the six months ended June 30, 2023, was approximately RMB 2,604.95 million, accounting for about 17.1% of total group revenue[39]. - The company reported an increase in research and development costs to RMB 2,357,257 thousand from RMB 2,048,604 thousand, reflecting a growth of 15.06%[54]. - The company has established research centers recognized for their contributions to drug development, particularly in liver disease and oncology[17]. Market Position and Recognition - The company has been recognized as a top pharmaceutical company, ranking in the "Top 50 Global Pharmaceutical Companies" by Pharmaceutical Executive for five consecutive years[14]. - The company has been included in multiple indices, such as the MSCI Global Standard Index and the Hang Seng Index, reflecting its strong market position[20]. - The group was recognized as one of the 88 selected companies in the "Sustainable Development Yearbook (China Edition) 2023" by S&P Global, highlighting its commitment to ESG management[50]. Financial Position and Cash Flow - The group maintains a strong cash position with total cash reserves of approximately RMB 1,960.9 million, including RMB 1,157.7 million in cash and bank balances[30]. - The group reported a net cash position of approximately RMB 424,812 million as of June 30, 2023, down from RMB 443,625 million at the end of 2022[45]. - The total cash and cash equivalents at the end of the period were RMB 3,293,964 thousand, down from RMB 6,065,442 thousand at the end of the same period last year[59]. - The company’s cash flow from financing activities showed a net outflow of RMB 4,042,087 thousand, compared to RMB 1,460,527 thousand in the previous year, indicating a substantial increase in cash outflow[59]. Corporate Governance and Shareholder Information - The company has complied with the corporate governance code as per the listing rules, except for the absence of two independent non-executive directors at the annual general meeting[122]. - The audit committee consists of four independent non-executive directors, ensuring compliance with relevant listing rules[125]. - The company’s directors and key executives hold significant shares, with Xie Qirun holding approximately 12.13% of the total issued share capital[107]. - The company aims to attract and retain top talent through the 2023 stock option plan, which is effective for 10 years[116]. Regulatory and Market Environment - The new regulations from the National Healthcare Security Administration are expected to alleviate price reduction pressures for innovative drugs, benefiting their development[21]. - The average price drop for the 39 drugs selected in the eighth batch of national centralized procurement was 56%, indicating a shift towards normalized and institutionalized procurement management[21].

Financial Performance - For the six months ended June 30, 2023, the company's revenue was RMB 15.28 billion, a slight increase of 0.5% compared to RMB 15.19 billion in the same period of 2022[2]. - The net profit for the same period was RMB 2.70 billion, representing a decrease of 15.2% from RMB 3.18 billion year-on-year[2]. - Profit attributable to equity holders of the parent company was RMB 1.26 billion, down 34.5% from RMB 1.92 billion in the previous year[2]. - Adjusted net profit not in accordance with Hong Kong Financial Reporting Standards was RMB 1.48 billion, an increase of 1.2% from RMB 1.46 billion in the same period last year[2][4]. - In Q2 2023, revenue was RMB 8.63 billion, a significant increase of 30.0% compared to RMB 6.64 billion in Q2 2022[2]. - The adjusted net profit for Q2 2023 was RMB 960 million, reflecting a growth of 20.7% from RMB 800 million in Q2 2022[2]. - The group recorded revenue of approximately RMB 1,527,704 million for the period, representing a year-on-year increase of about 0.5%[18]. - The group reported a profit attributable to equity holders of approximately RMB 125,878 million, a decrease of about 34.5% compared to the previous year[18]. - The net profit for the period was RMB 3,183,221 thousand, compared to RMB 3,545,258 thousand in the previous year, indicating a decrease of approximately 10.25%[54]. Revenue Breakdown - Innovative drug revenue reached RMB 3.86 billion, up 10.9% year-on-year, accounting for 25.3% of total revenue[2]. - Revenue from oncology drugs was approximately RMB 449,186 million, accounting for about 29.4% of total revenue, a decrease of approximately 9.4% year-on-year[19]. - Revenue from liver disease drugs was approximately RMB 228,931 million, accounting for about 15.0% of total revenue, an increase of approximately 14.0% year-on-year[19]. - Revenue from the modern Chinese medicine and Western medicine segment was RMB 14,963,976, contributing to total segment revenue of RMB 15,277,037[50]. Research and Development - The company continues to focus on innovation and aims to enhance its technology platform while expanding its international presence[7]. - The company launched two innovative products during the period and received approval for two biosimilars[11]. - The group has 127 products under development, including 60 oncology drugs, 10 liver disease drugs, 21 respiratory drugs, and 17 surgical/pain relief drugs, with 69 classified as innovative products[25]. - Research and development expenses for the six months ended June 30, 2023, amounted to approximately RMB 2,604.95 million, representing about 17.1% of the group's revenue[25]. - Research and development costs for the period were RMB 2,357,257 thousand, an increase from RMB 2,048,604 thousand in the previous year, indicating a focus on innovation[39]. Market and Regulatory Environment - The pharmaceutical manufacturing industry's revenue in China for the first half of 2023 was RMB 1,249.6 billion, a decrease of 2.9% year-on-year, while total profit fell by 17.1% to RMB 179.45 billion[11]. - The new rules issued by the National Medical Insurance Administration on July 21, 2023, clarified the management of drug inclusion in regular catalogs, benefiting the development of innovative drugs[11]. - The average price drop for the eighth batch of national drug centralized procurement was 56%, with 39 drugs successfully procured[11]. Corporate Governance and Recognition - The company has been recognized as one of the "Top 50 Pharmaceutical Companies" by Pharmaceutical Executive magazine for five consecutive years from 2019 to 2023[10]. - The company has been recognized as one of the 88 selected enterprises in the "Sustainable Development Yearbook (China Edition) 2023" by S&P Global, highlighting its commitment to ESG management[35]. - The group’s ESG index ranking was 57 out of 855 listed companies, receiving a rating of "leading level in ESG development" for its high-quality ESG management[35]. Capital and Financial Position - The group has cash and bank balances of approximately RMB 1,157,719 million, with total financial reserves amounting to approximately RMB 1,960,921 million[18]. - The total assets of the group were approximately RMB 65,640.89 million as of June 30, 2023, with total liabilities of approximately RMB 29,182.08 million, resulting in a debt ratio of approximately 44.5%[31]. - The group has implemented foreign exchange forward contracts to hedge part of its euro-denominated liabilities and will continue to monitor foreign exchange net risks[33]. - The group reported a net loss from its joint ventures and associates of approximately RMB 20,640 million after tax adjustments[22]. Shareholder Returns - The company declared an interim dividend of HKD 0.02 per share for the six months ended June 30, 2023[2]. - The interim dividend declared for the six months ended June 30, 2023, is HKD 0.02 per ordinary share, down from HKD 0.06 per share in 2022[66]. - The company repurchased a total of 12,650,000 shares at a total cost of approximately HKD 46,032,500 during the six months ended June 30, 2023[76]. Future Outlook - The company plans to launch nearly 10 innovative drugs in the next three years, with over 40 innovative drugs in the pipeline expected to be launched by 2030[36]. - The group aims to achieve a revenue target of HKD 100 billion by 2030, positioning itself as a world-class innovative pharmaceutical group[36].

Research and Development - The company reported a strong focus on research and development, with industry-leading investment in R&D and product innovation capabilities [8]. - Research and development expenses accounted for over 15% of total sales revenue, highlighting the company's commitment to innovation [28]. - The group reported a total R&D expenditure of approximately RMB 4,454.18 million, representing about 15.5% of the group's revenue, with over 74% of this investment allocated to innovative and biological drugs [64]. - The company has 40 innovative drug candidates in the oncology field at clinical application stages, with 8 expected to be approved for market in the next three years (2023-2025) [40]. - The company has 8 innovative drug candidates in the liver disease field, with 4 expected to be approved for market in the next three years (2023-2025) [41]. - The company has 10 innovative drug candidates in the respiratory system field at clinical application stage or above, including 1 in the market application stage and 5 in Phase II clinical trials [45]. - The company is conducting Phase II clinical trials for TDI01, a selective ROCK2 inhibitor, targeting conditions such as pneumoconiosis and COVID-19 [46]. - The company has submitted a market application for Enzastaurin, a new oral COVID-19 treatment, which shows significant improvement in symptoms associated with the Omicron variant [45]. - The company plans to launch several innovative drug products in the next three years, including TQB2450 and TQ-B3101, which are currently in the application stage [33]. Financial Performance - Revenue for 2022 reached RMB 28,780,412 thousand, an increase from RMB 26,861,356 thousand in 2021, representing a growth of approximately 7.1% [25]. - Gross profit for 2022 was RMB 22,984,902 thousand, compared to RMB 21,529,261 thousand in 2021, indicating a year-over-year increase of about 6.8% [25]. - The net profit for 2022 was RMB 5,002,618 thousand, a decrease from RMB 16,614,793 thousand in 2021, representing a decline of approximately 69.9% [25]. - The company reported a pre-tax profit of RMB 5,778,604 thousand for 2022, down from RMB 18,572,673 thousand in 2021, indicating a decline of approximately 68.9% [25]. - Profit attributable to equity holders decreased by approximately 82.6% to RMB 2,543.57 million, with earnings per share of RMB 0.1366, down about 82.4% [50]. - Adjusted net profit under non-HKFRS was approximately RMB 2,986.33 million, an increase of about 16.4% compared to the previous year [50]. - The company’s total liabilities increased to RMB 26,120,736 thousand in 2022 from RMB 22,814,314 thousand in 2021, marking an increase of about 14.0% [25]. - The total assets of the company increased to RMB 64,064,284 thousand in 2022, up from RMB 60,543,337 thousand in 2021, reflecting a growth of approximately 4.2% [25]. Market Position and Recognition - The company has been recognized as a leading innovative pharmaceutical group in China, with a comprehensive product portfolio covering oncology, liver disease, and respiratory diseases [8]. - The company was included in the MSCI Global Standard Index as a constituent stock of the China Index, effective May 31, 2013 [11]. - The company has been listed among the "Top 50 Global Pharmaceutical Companies" for four consecutive years from 2019 to 2022 [14]. - The company successfully bid for 9 products in the national procurement process, the highest number among listed pharmaceutical companies [38]. Corporate Governance and ESG Initiatives - The company has established an ESG vision focused on high-quality management to support the United Nations Sustainable Development Goals and the Healthy China strategy [73]. - The company received awards for being one of the "Best ESG Employers" in China in 2022, highlighting its commitment to ESG principles [73]. - The board of directors is focused on overall corporate strategy and financial performance, ensuring sustainable development aligned with the company's mission [76]. - The company has implemented a strategic planning process to identify and assess risks and opportunities, aiming to create long-term value for shareholders [78]. - The company has established an ESG committee under the board to oversee significant ESG-related matters and ensure the implementation of ESG strategies [71]. Employee and Management Structure - The group had approximately 26,272 employees as of December 31, 2022 [69]. - Employee costs, including director remuneration and equity-settled share-based payment expenses, totaled approximately RMB 4,750.93 million for the year, compared to RMB 4,568.98 million in the previous year, representing an increase of about 4.0% [69]. - The company emphasizes employee development through competitive compensation, performance assessments, and training opportunities [144]. - The leadership team has received multiple awards and recognitions for their contributions to the industry and society [170][172]. Strategic Initiatives and Future Outlook - The company aims to achieve a revenue target of HKD 100 billion by 2030, driven by the launch of over ten innovative drug products in the next three years and more than forty innovative drugs expected to be launched by 2030 [51]. - The company is actively pursuing market expansion and new strategies to enhance its competitive position in the pharmaceutical industry [35]. - The company is committed to developing new drugs and modern healthcare products for cardiovascular and respiratory diseases [164]. - The company is positioned for market expansion, leveraging the expertise of its board and management team [181].

Financial Performance - Revenue for the year ended December 31, 2022, was RMB 28.78 billion, an increase of 7.1% from RMB 26.86 billion in 2021[2] - Gross profit for the same period was RMB 22.98 billion, reflecting a growth of 6.8% compared to RMB 21.53 billion in the previous year[2] - Profit attributable to owners of the parent company significantly decreased by 82.6% to RMB 2.54 billion from RMB 14.61 billion in 2021[2] - Adjusted net profit attributable to owners of the parent company increased by 16.4% to RMB 2.99 billion from RMB 2.56 billion in the prior year[2] - The company recorded revenue of approximately RMB 2,878,041,000, representing a year-on-year growth of about 7.1%[17] - Net profit attributable to shareholders decreased by approximately 82.6% to RMB 254,357,000, with earnings per share dropping by about 82.4% to RMB 0.1366[17] - Adjusted net profit, after accounting for various financial adjustments, increased by approximately 16.4% to RMB 298,633,000[17] - The company's annual profit for the year ended December 31, 2022, was RMB 5,002,618, a significant decrease from RMB 16,614,793 in 2021, representing a decline of approximately 69.9%[42] - Total comprehensive income for the year, after tax, was RMB 4,289,080, down from RMB 16,815,754 in the previous year, indicating a decrease of about 74.5%[43] Revenue Breakdown - Revenue from new products reached RMB 12.51 billion, representing a 19.8% increase from RMB 10.45 billion in 2021, accounting for 43.5% of total revenue[2] - Revenue from anti-tumor drugs was RMB 9.19 billion, up 14.3% from RMB 8.04 billion, making up 31.9% of total revenue[2] - Revenue from innovative drugs increased by 20.0% to RMB 6.75 billion from RMB 5.63 billion, representing 23.5% of total revenue[2] - Surgical and analgesic drug revenue for the year ended December 31, 2022, was approximately RMB 4,881.77 million, accounting for 17% of total revenue, an increase of about 2.8% year-over-year[20] - Cardiovascular drug revenue for the year ended December 31, 2022, was approximately RMB 2,697.50 million, representing about 9.4% of total revenue, with a year-over-year growth of approximately 7.8%[20] - Other revenue for the year ended December 31, 2022, was approximately RMB 5,249.14 million, accounting for about 18.2% of total revenue, an increase of approximately 2.5% year-over-year[21] Research and Development - The company emphasizes R&D and innovation, maintaining industry-leading R&D investment and product innovation capabilities[4] - Research and development (R&D) expenses totaled approximately RMB 4,454.18 million, accounting for about 15.5% of the group's revenue, with a year-on-year increase of approximately 19% in innovative and biological drug R&D investment[27] - The group has 103 products under development, including 53 oncology drugs, 12 liver disease drugs, 26 respiratory drugs, and 12 surgical/pain relief drugs, with 58 being innovative products[27] - The company has 40 innovative drug candidates in the oncology field at various clinical stages, with 8 innovative drugs expected to be approved between 2023 and 2025[10] - The company has 8 innovative drug candidates in the liver disease field, with 4 biosimilars or generics expected to be approved between 2023 and 2025[12] - The company has 10 innovative drug candidates in the respiratory system field at clinical application stage or above, including 1 in the market application stage and 5 in Phase II clinical trials[14] Market and Industry Context - In 2022, China's GDP reached RMB 121 trillion, growing by 3% year-on-year[8] - The revenue of China's pharmaceutical manufacturing industry decreased by 1.6% year-on-year to RMB 291.114 billion in 2022[8] - The total profit of the pharmaceutical manufacturing industry fell by 31.8% year-on-year to RMB 42.887 billion in 2022[8] - The average price drop for 327 selected products in the seventh batch of national drug procurement was 48%[9] - China National Pharmaceutical Group won bids for 9 out of 11 products in the procurement, primarily for newly launched products[9] Corporate Governance and Shareholder Engagement - The company actively engages with investors through various channels, including investor briefings and participation in investment summits, to enhance corporate governance and transparency[28] - The company has implemented a share repurchase plan with a budget of up to HKD 1 billion, of which HKD 916.64 million has been utilized for share repurchases and incentive share purchases[34] - The audit committee consists of four independent non-executive directors, ensuring compliance with listing rules regarding financial management expertise[72] - The company has adhered to the Corporate Governance Code, with minor deviations noted regarding attendance at the annual general meeting[71] - The company is committed to maintaining adequate independent director representation as per listing regulations[72] Financial Position and Assets - The total assets of the group were approximately RMB 64,064.28 million, with total liabilities of approximately RMB 26,120.74 million, resulting in a debt-to-asset ratio of approximately 40.8%[32] - As of December 31, 2022, the group's cash and bank balances were approximately RMB 12,066.22 million, an increase from RMB 10,568.81 million as of December 31, 2021[29] - The company held non-current equity investments valued at approximately RMB 1,574.81 million as of December 31, 2022, down from RMB 1,988.24 million the previous year[25] - The total amount of wealth management products held by the company was approximately RMB 4,543.24 million, accounting for about 7.1% of total assets as of December 31, 2022[26] - The company's net assets stood at RMB 37,943,548 as of December 31, 2022, slightly up from RMB 37,729,023 in 2021, indicating a growth of about 0.6%[45] Future Outlook - The company plans to launch over ten innovative drug products in the next three years, with more than forty innovative drugs expected to be launched by 2030[39] - The company aims to achieve a revenue target of HKD 100 billion by 2030, positioning itself as a world-class innovative pharmaceutical group[39] - The company has completed carbon inventory work for key member enterprises as part of its carbon neutrality planning project, with a roadmap expected to be published by mid-2023[37] - The company continues to focus on four strategic areas: organizational integration, comprehensive innovation, internationalization, and digitalization to enhance operational efficiency[39]

Financial Performance - Revenue for the six months ended June 30, 2022, was RMB 15.19 billion, an increase of 5.9% from RMB 14.35 billion in 2021[9] - Gross profit for the same period was RMB 12.23 billion, reflecting a 5.5% increase from RMB 11.60 billion in the previous year[9] - Profit attributable to owners of the parent decreased by 77.3% to RMB 1.92 billion from RMB 8.48 billion in 2021[9] - Adjusted net profit attributable to owners of the parent was RMB 1.66 billion, up 4.5% from RMB 1.59 billion in the prior year[9] - Total comprehensive income for the period was RMB 2,575,491, significantly lower than RMB 9,905,092 in the prior year[51] - The company reported a net profit of RMB 3,183,221 for the six months ended June 30, 2022, compared to RMB 9,641,604 for the same period in 2021, indicating a significant decrease[63] - The profit from equity investments at fair value through profit or loss was RMB 154,199,000 for the first half of 2022, compared to a loss of RMB 19,618,000 in the same period of 2021, indicating a significant turnaround[72] - The profit attributable to equity holders of the parent company for the six months ended June 30, 2022, was RMB 1,921,037,000, a decrease of 77.3% compared to RMB 8,480,340,000 for the same period in 2021[78] Revenue Breakdown - Revenue from new products reached RMB 6.61 billion, representing a 24.6% increase and accounting for 43.5% of total revenue[9] - Revenue from anti-tumor drugs was RMB 4.96 billion, a 16.7% increase, making up 32.6% of total revenue[9] - Revenue from innovative drugs was RMB 3.49 billion, up 14.2%, contributing 22.9% to total revenue[9] - Sales revenue from new products increased from approximately 36.9% to 43.5% of total revenue[25] - Revenue from surgical/pain relief drugs was approximately RMB 252,050 million, accounting for about 16.6% of total revenue, with a growth of about 7.1% year-on-year[26] - Revenue from liver disease drugs was approximately RMB 200,891 million, accounting for about 13.2% of total revenue, with a growth of about 11.1% year-on-year[27] - Revenue from cardiovascular drugs was approximately RMB 155,220 million, accounting for about 10.2% of total revenue, with a growth of about 13.8% year-on-year[29] Research and Development - The company emphasizes R&D and innovation, maintaining industry-leading investment in R&D and product innovation capabilities[12] - The group has a total of 418 products under research and development, including 230 oncology drugs and 29 liver disease drugs, as of June 30, 2022[35] - Research and development expenses for the six months ended June 30, 2022, totaled approximately RMB 2,191.59 million, representing 14.4% of the group's revenue, compared to 13.1% in the previous year[35] - Research and development costs for the period were RMB 2,048,604, compared to RMB 1,781,597 in the same period last year, indicating a focus on innovation[50] - The company is focusing on high-innovation and high-market-potential products in its pipeline, reassessing its R&D investments in light of the potential impacts of national procurement policies on generic drugs[47] Market and Economic Context - In the first half of 2022, China's GDP reached RMB 56.3 trillion, with a year-on-year growth of 2.5%[18] - The pharmaceutical manufacturing industry's revenue growth in Q1 2022 was lower than GDP growth, primarily due to the high base from the previous year and ongoing pandemic impacts[18] - In Q2 2022, the severe pandemic affected medical service volumes and pharmaceutical consumption, leading to a decline in healthcare expenditure and consumer income levels[18] Corporate Governance and ESG - The company has committed to a comprehensive ESG governance strategy, focusing on disease treatment, pharmaceutical accessibility, environmental friendliness, and win-win relationships[44] - The company has initiated the construction of an ESG digital platform, expected to be fully operational by Q4 2022, to improve ESG management through data visualization and performance tracking[45] - The company has not experienced any significant ESG-related risk incidents in the first half of 2022, indicating effective risk management practices[45] - The company held six monthly ESG management committee meetings in the first half of 2022, ensuring over 75% attendance from committee members[45] Shareholder Information - As of June 30, 2022, the company had a total issued share capital of 18,800,000,000 shares[100] - Ms. Xie Qirun holds 2,279,254,761 shares, representing approximately 12.11% of the total issued share capital[101] - Mr. Xie Chengrun holds 4,050,000,000 shares, accounting for 21.53% of the total issued share capital[101] - The company has a stock option plan approved on May 28, 2013, allowing for the issuance of shares not exceeding 10% of the total issued share capital at the time of adoption[107] - The company’s stock option grants to major shareholders require prior approval from independent non-executive directors[107] Cash Flow and Liquidity - The net cash flow from operating activities for the six months ended June 30, 2022, was RMB 3,948,941, compared to RMB 2,335,554 for the same period in 2021, representing a significant increase[57] - Cash and bank balances decreased to RMB 7,768,292 from RMB 10,568,812 at the end of 2021, reflecting liquidity challenges[52] - The company experienced a net decrease in cash and cash equivalents of RMB (3,501,245) for the first half of 2022, compared to RMB (2,482,102) in the same period of 2021[57] Investment and Capital Expenditure - The company issued €750 million zero-coupon convertible bonds due in 2025, with net proceeds allocated for R&D, production facilities, sales, and general corporate purposes[111] - The group had capital commitments of RMB 1,717,675,000 as of June 30, 2022, compared to RMB 910,967,000 as of December 31, 2021, reflecting an increase of 88.8%[84] - Capital expenditure for the six months ended June 30, 2022, was RMB 789,555, compared to RMB 566,721 in the same period of 2021, showing an increase of approximately 39.3%[63]