证券代码：300676 证券简称：华大基因 公告编号：2026-001 深圳华大基因股份有限公司 关于控股股东部分股份解除质押及再质押的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 深圳华大基因股份有限公司（以下简称公司或上市公司）近日收到公司控股股 东深圳华大基因科技有限公司（以下简称华大控股）的通知，获悉华大控股将其持 有的部分公司股份办理了解除质押及再质押。现将具体情况公告如下： （二）本次股份质押的基本情况 一、控股股东及其一致行动人部分股份解除质押及再质押的基本情况 | 股东名称 | 是否为控股 股东或第一 | 本次质押数 | 占其所持 | 占公司 总股本 | 是否为限 售股（如 | 是否为 补充质 | 质押起 | 质押到期 | 质权人 | 质押用 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 大股东及其 | 量（股） | 股份比例 | | 是，注明限 | 押 | 始日 | 日 | | 途 | | | 一致行动人 | | | 比例 | 售类型 ...

其一为"外部环境所逼"，这让企业坚定了从核心工具到技术平台完全自主研发的决心，"只有掌握自主 技术，才能在复杂环境中立足"。 其二为"行业发展所需"，人类对生老病死的认知仍有巨大提升空间，通过基因组学技术降低出生缺陷、 防控肿瘤发生发展、防范重大传感染疾病，是行业必须用前沿科技解决的关键问题。正是这份坚持，让 华大基因从参与人类基因组计划，成长为在基因组学领域部分领先的企业。 人民网北京12月31日电 (记者杨曦)"坚持高比例研发与实现完全自主自强，是企业战略定力的核心体 现。"12月30日，华大基因总裁赵立见在"2025人民财经论坛"上表示，面对基因科技前期投入大、周期 长的特点，企业应在核心工具与技术平台上坚持实现自主突破，并通过"技术自主、成本可控、渠道可 及"的发展路径，让前沿科技惠及更多人群。 针对"如何平衡前沿科技高投入与科技自立自强紧迫性"的提问，赵立见坦言，华大基因过去十多年坚持 高研发投入，核心源于两大因素： 当被人民网智媒大模型问及"前沿技术如何惠及更多人群"时，赵立见提出"基因科技人人可及"的实现路 径，核心在于三个层面的落地：首先是确保技术自主，为普惠奠定基础；其次是实现成本可控，通过 ...

Core Viewpoint - GeneTech (Shaoxing) Co., Ltd. has submitted an IPO application to the Hong Kong Stock Exchange, aiming to raise funds for enhancing R&D capabilities and expanding its product portfolio [1][2] Company Overview - Founded in 2015, GeneTech specializes in precision medicine, integrating AI capabilities into the biomarker value chain [3] - The company offers three main solutions: precision diagnostics, drug development empowerment, and clinical research and transformation [3] - GeneTech operates China's only integrated platform covering the entire chain of biomarker discovery, validation, product development, and commercialization [3] Financial Performance - Revenue from 2022 to 2024 was 1.815 billion RMB, 473 million RMB, and 557 million RMB, respectively, with profits of 372 million RMB, 54.1 million RMB, and a loss of 424 million RMB [5] - In the first half of 2025, revenue was 285 million RMB, a year-on-year increase of 12.69%, while the loss was 414 million RMB, indicating an expanded loss compared to the previous year [5] - The decline in revenue from 2022 to 2023 was primarily due to the cessation of COVID-19 nucleic acid testing services following the end of the pandemic [5] Revenue Structure - Precision diagnostics solutions account for over 70% of GeneTech's revenue, with 77.7% of total revenue in the first half of 2025 coming from this segment [6][7] - The gross margin for precision diagnostics solutions reached 75.6% in the first half of 2025 [6] Supplier Dependency - GeneTech faces a high dependency on major suppliers, with procurement from the top five suppliers accounting for 41.5%, 71.5%, 67.4%, and 68.1% of total procurement in 2022, 2023, 2024, and the first half of 2025, respectively [9] - As of June 30, 2025, the company had approximately 96 million RMB in cash and cash equivalents, while its bank loans due within one year were about 140 million RMB, indicating potential liquidity pressure [9] Investment and Future Plans - The company has received multiple rounds of financing from investors including BGI Genomics and Aier Eye Hospital [11] - The funds raised from the IPO will be used for enhancing R&D capabilities, expanding product offerings, marketing, and upgrading manufacturing capabilities [11]

Core Viewpoint - The in vitro diagnostic (IVD) sector is experiencing significant growth, with a notable increase in stock performance among key companies in the industry, driven by strong downstream demand and market expansion [1] Group 1: Market Performance - As of September 22, the IVD sector saw an overall increase of 3.13%, ranking high on the stock performance list [1] - Notable stock performances include: - Bohui Innovation reached a limit-up - Lide Man surged by 11.76% - Shuoshi Biology and Daan Gene increased by 9.17% and 9.01% respectively - Other companies like Dongfang Biology, Shengxiang Biology, Mingde Biology, BGI, Libang Instruments, and Wantai Biology also saw gains exceeding 6% [1] Group 2: Industry Growth - The IVD industry is primarily utilized in hospital laboratories, independent clinical laboratories (ICL), health check centers, epidemic prevention stations, and blood stations [1] - The downstream demand is robust, with IVD growth nearing 20% [1] - In 2018, the revenue from public hospitals for IVD products reached 315.7 billion yuan, with a year-on-year growth rate of 12.48% [1] - Key clients such as ICL and health check centers are also experiencing growth rates around 20% or higher [1] Group 3: Market Size and Comparison - The Chinese IVD industry size reached 71.3 billion yuan in 2018, reflecting a year-on-year growth of 25.6%, significantly outpacing the global IVD market growth of 6.0% [1] - The strong downstream demand is driving rapid growth in the upstream market size [1] - The IVD sector is nurturing large enterprises, and the favorable conditions in specific segments make leading stocks with performance support worth monitoring [1]

Summary of Conference Call Records Industry Overview - The pharmaceutical sector is experiencing structural heat, with certain stocks entering a value range, indicating potential for rebound. The focus for 2026 includes three main narratives: innovation going global, turnaround from difficulties, and impulse-driven growth, particularly in BD 2.0, small nucleic acids, and supply chains [1][2] Key Insights and Arguments - The CRO (Contract Research Organization) industry has seen short-term risks largely mitigated, with limited impact from the U.S. NBA 2026 Act. The CRO supply chain is expected to experience a resonance of internal and external demand starting in 2024, leading to a strong fundamental outlook by 2026 [1][4] - In the clinical CRO space, companies like Tigermed are showing significant order growth, with EPS expected to experience nonlinear growth, enhancing stock price elasticity. The peptide CDMO (Contract Development and Manufacturing Organization) sector is also expected to grow at least 25% by 2026, with companies like WuXi AppTec and Notch being noteworthy [1][4][5] - CDMO companies are driven by large product orders, with ADC (Antibody-Drug Conjugates) and small nucleic acids identified as key future growth areas. ADC commercialization is entering a boom phase, benefiting companies like WuXi Biologics, Haoyuan, and Kelaiying [1][6] Additional Important Content - The Ant Group's healthcare model, Antifufu, aims to become a leading health service consultation platform, targeting 500 million registered users and over 100 million monthly active users by the end of 2026. The healthcare team has been elevated to a business group, aiming for revenue exceeding 100 billion [2][7] - Antifufu's technology is based on the "Bailing" general model, integrating Deepseek and Tongyi Qianwen technologies, utilizing proprietary medical data from various sources, including 700 million medical insurance users and 40,000 doctors from acquired platforms [2][8] - User retention strategies for Antifufu include health goal setting and integration with wearable devices, aiming for increased interaction frequency [2][9] - The commercialization strategy includes paid consultations, medication purchases, and health membership services, with B2B collaborations with insurance companies for disease-specific insurance products [2][10] - Collaboration with Alibaba Health leverages a vast user base and medical data, enhancing competitive advantages in the healthcare sector [2][11] - The AI-powered "Famous Doctor Avatar" service is currently in a testing phase, with plans for monetization contingent on achieving high diagnostic accuracy [2][12]

从资金流向上来看，当日医疗服务板块主力资金净流出8.24亿元，游资资金净流入4129.99万元，散户资 金净流入7.83亿元。医疗服务板块个股资金流向见下表： 证券之星消息，12月26日医疗服务板块较上一交易日下跌0.21%，皓元医药领跌。当日上证指数报收于 3963.68，上涨0.1%。深证成指报收于13603.89，上涨0.54%。医疗服务板块个股涨跌见下表： | 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | | --- | --- | --- | --- | --- | --- | --- | | 600721 | 自花医药 | 12.24 | 5.88% | 48.95万 | | 5.94亿 | | 301096 | 百诚医药 | 55.93 | 3.79% | 5.12万 | | 2.84亿 | | 000504 | *ST生物 | 9.20 | 3.25% | 2.70万 | | 2461.38万 | | 301201 | 诚达药业 | 41.95 | 0.84% | 6.37万 | | 2.72亿 | | 603259 | 药明康德 | 92.70 | 0. ...

Core Viewpoint - The article discusses the proposed list of key laboratories and technology innovation centers in Shanxi Province for the year 2025, highlighting the focus on various research areas including traditional medicine, veterinary medicine, and cancer treatment [2][11]. Summary by Sections Key Laboratories - The proposed list includes 69 key laboratories, such as the Research and Development of Effective Substances of Famous Jin Medicine and the Modernization of Veterinary Medicine [2][3]. - Notable institutions involved include Shanxi University, Shanxi Agricultural University, and various pharmaceutical companies [3][4]. Technology Innovation Centers - The list features 26 technology innovation centers, including the Shanxi Province Antitumor Drug Complex Preparation Technology Innovation Center and the Shanxi Province Biomolecular Imaging and Tumor Precision Diagnosis Technology Innovation Center [2][9]. - These centers aim to advance research in areas like drug development and precision medicine, with collaborations from hospitals and universities [9][10]. Public Notice - The proposed projects are open for public comment for five working days, allowing individuals and organizations to submit objections or feedback [11].

Core Insights - The article highlights the rapid development and innovation within the Shijiazhuang International Biopharmaceutical Park, showcasing the establishment of over 300 companies and a thriving ecosystem of large, medium, and small enterprises [3][6] - The park is focused on accelerating project construction and enhancing the quality of biopharmaceutical projects through effective collaboration between government and enterprises [4][8] Group 1: Project Development - The Green Leaf Jiaao Pharmaceutical Company has recently completed three batches of engineering products and plans to produce 3 million units annually after full production begins [3][4] - In 2023, the high-tech zone has introduced 59 biopharmaceutical projects, indicating a strong growth trajectory for the industry [6] Group 2: Innovation Ecosystem - The biopharmaceutical park features a complete industrial chain that includes research, incubation, industrialization, and sales services, facilitating efficient product development [8] - Public service platforms, such as the National Drug Administration's special drug inspection center, enhance the speed and convenience of testing and inspection for companies [8] Group 3: Collaborative Innovation - The park has established a shared laboratory that allows companies to access high-end equipment, significantly reducing costs and accelerating research and development timelines [9] - The shared laboratory model has proven beneficial for companies like Nuoao Biotechnology, which has expedited its HPV nucleic acid immunotherapy drug development by several months [9] Group 4: Overall Impact - The Shijiazhuang International Biopharmaceutical Park is positioned as a key driver of high-quality development in the biopharmaceutical industry, with ongoing projects and breakthroughs contributing to a robust industrial ecosystem [10]

Core Viewpoint - The company, Geneplus Technology, is seeking to go public on the Hong Kong Stock Exchange, focusing on AI-driven multi-omics technology to innovate precision diagnostics and drug development [1][4]. Company Overview - Geneplus has developed one of the earliest large-scale multi-omics baseline databases in the industry, integrating AI capabilities throughout the biomarker value chain [1][4]. - The company offers a full-chain capability from biomarker discovery to commercialization, covering precision diagnostics, drug development empowerment, and clinical research solutions [1][4]. Financial Performance - The company has experienced a shift from profitability to losses, with revenues of 18.15 billion RMB in 2022, dropping to 4.73 billion RMB in 2023, and slightly increasing to 5.57 billion RMB in 2024. Net profits transitioned from 3.72 billion RMB in 2022 to a loss of 4.24 billion RMB in 2024, with further losses of 4.14 billion RMB in the first half of 2025 [2][9][13]. - In the first half of 2025, precision diagnostics solutions accounted for 77.7% of revenue, while clinical research and drug development solutions contributed 17.7% and 4.6%, respectively [2][9]. Market Position and Strategy - The company has established partnerships with over 1,000 hospitals, including 30 of China's top 100 hospitals, and collaborated with more than 200 pharmaceutical companies and 500 clinical research institutions [2][9]. - The ongoing strategic investment aims to build long-term competitive advantages, despite the challenges of returning to profitability [3][10]. Industry Context - The biotechnology sector is characterized by long R&D cycles, high investment, and significant risks, with stage losses being common, especially during critical phases of technology upgrades and product transitions [3][10]. - The Hong Kong market is seen as more accommodating for unprofitable biotech companies compared to the A-share market, making it a suitable platform for Geneplus to seek funding [4][11]. Future Outlook - The integration of AI and multi-omics technology is expected to expand applications in tumor diagnostics, treatment, and drug development, with increasing market demand supported by favorable government policies [6][12]. - The company aims to enhance its core competitiveness in precision medicine and expand its global service network, leveraging its extensive multi-omics database and customer collaboration [6][12].

Core Viewpoint - BGI Genomics has indicated that investors should refer to official announcements or the company's website and official WeChat account for information regarding business collaborations [2] Group 1 - BGI Genomics responded to investor inquiries on December 24, emphasizing the importance of official channels for updates on business partnerships [2]