该行指出，昭衍新药拥有优质稀缺实验猴资源，一方面，猴场每年出栏一定数量实验猴供公司使用贡献 利润基本盘；另一方面，实验猴供给愈发紧张背景下，掌握优质实验猴资源可能有更强话语权，或带来 拿单率提升，甚至享受服务费溢价。 消息面上，据媒体报道，目前3—5岁左右的食蟹猴价格已涨至14万元一只，且年内已出现供不应求的局 面。长江证券发布研报称，当前，实验猴供给端不断下降，需求端企稳回升以及新技术如小核酸、 CAR-T 等大多也需要使用实验猴带来的结构化占比提升，实验猴供需缺口或正不断拉大，猴价也开始 呈现上升趋势。 智通财经APP获悉，昭衍新药(06127)再涨超4%，截至发稿，涨3.36%，报24港元，成交额1.08亿港元。 ...

2025年，是中国创新药在技术、市场、国际化领域破釜沉舟的一年，药企"走出去"迈出了关键一 步。对外授权交易（BD）爆发是最佳证明，全年对外授权总金额突破1000亿美元，首付款达81亿美 元，超九成跨国药企已经与中国药企达成合作，模式已不再局限于单纯技术转让，而是向"授权+联合 开发+商业化参与"多层次合作迈进。总体看，中国正加速从医药大国向医药强国转型。 "十四五"收官，我国生物医药市场规模稳居全球第二，在研创新药约占全球的30%，标志着我国医 药产业实现了从跟跑到并跑的关键跨越。"十四五"期间，我国共批准上市创新药220个、创新医疗器械 282个，分别达到"十三五"期间的6.2倍、3.1倍。批准415个儿童药品、155个罕见病药品上市，批准上市 中药创新药28个，新批准注册和备案公示化妆品新原料344件，医药产业创新发展活力不断增强。 国际化：从跟跑到领跑 医药行业国际化势头在2025年彻底爆发，一方面表现在BD交易激增，另一方面是"A+H"布局火 热。 数据显示，2025年中国创新药对外授权出海总金额已突破1000亿美元，较2024年同期飙升约75%， 从"卖产品"到"卖技术"，从"被动授权"到"主动布 ...

Summary of Conference Call Records Industry Overview - The pharmaceutical sector is experiencing structural heat, with certain stocks entering a value range, indicating potential for rebound. The focus for 2026 includes three main narratives: innovation going global, turnaround from difficulties, and impulse-driven growth, particularly in BD 2.0, small nucleic acids, and supply chains [1][2] Key Insights and Arguments - The CRO (Contract Research Organization) industry has seen short-term risks largely mitigated, with limited impact from the U.S. NBA 2026 Act. The CRO supply chain is expected to experience a resonance of internal and external demand starting in 2024, leading to a strong fundamental outlook by 2026 [1][4] - In the clinical CRO space, companies like Tigermed are showing significant order growth, with EPS expected to experience nonlinear growth, enhancing stock price elasticity. The peptide CDMO (Contract Development and Manufacturing Organization) sector is also expected to grow at least 25% by 2026, with companies like WuXi AppTec and Notch being noteworthy [1][4][5] - CDMO companies are driven by large product orders, with ADC (Antibody-Drug Conjugates) and small nucleic acids identified as key future growth areas. ADC commercialization is entering a boom phase, benefiting companies like WuXi Biologics, Haoyuan, and Kelaiying [1][6] Additional Important Content - The Ant Group's healthcare model, Antifufu, aims to become a leading health service consultation platform, targeting 500 million registered users and over 100 million monthly active users by the end of 2026. The healthcare team has been elevated to a business group, aiming for revenue exceeding 100 billion [2][7] - Antifufu's technology is based on the "Bailing" general model, integrating Deepseek and Tongyi Qianwen technologies, utilizing proprietary medical data from various sources, including 700 million medical insurance users and 40,000 doctors from acquired platforms [2][8] - User retention strategies for Antifufu include health goal setting and integration with wearable devices, aiming for increased interaction frequency [2][9] - The commercialization strategy includes paid consultations, medication purchases, and health membership services, with B2B collaborations with insurance companies for disease-specific insurance products [2][10] - Collaboration with Alibaba Health leverages a vast user base and medical data, enhancing competitive advantages in the healthcare sector [2][11] - The AI-powered "Famous Doctor Avatar" service is currently in a testing phase, with plans for monetization contingent on achieving high diagnostic accuracy [2][12]

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology industry [1] Core Insights - The number of innovative drugs listed in China continues to grow, with domestic products accounting for approximately half of the total market share. The R&D capabilities for innovative drugs in China are also increasing, attracting global attention. Notably, the number and value of domestic innovative drug business development (BD) transactions have reached new highs, with ADC, bispecific antibodies, small nucleic acids, and CAR-T being the four key R&D directions to watch in 2026 [15][21][22] - The Chinese innovative drug market has seen a significant increase in the number of new drug applications (NDA), with domestic products making up a growing proportion. From 2017 to 2024, the number of innovative drugs listed in China rose from 41 to 92, with domestic products accounting for 50% of the total by 2024 [17][21] - The report highlights that the license-out transaction volume and total amount for Chinese companies reached $92.03 billion in the first three quarters of 2025, a 77% increase compared to the total for 2024. The upfront payment for license-out transactions has also surpassed the total financing amount in the primary market for the same period [22][25] Summary by Sections Industry Trends - The A-share pharmaceutical index has shown a year-to-date increase of 14.29%, while the Hang Seng Healthcare Index has surged by 62.29% [3][8] - The report notes that the pharmaceutical sector has experienced fluctuations, with raw materials and medical devices showing positive growth [8] R&D Progress and Company Dynamics - The report provides an overview of the R&D progress for innovative and modified drugs, including approvals and clinical applications [5] - It lists key companies to watch in various sub-sectors, including innovative drugs, research services, and medical devices, with specific recommendations for companies like Innovent Biologics, Hengrui Medicine, and WuXi AppTec [11][12] Market Insights and Regulatory Observations - The report tracks the price-to-earnings ratio of the pharmaceutical index, noting that it is currently lower than historical averages [5] - It emphasizes the importance of the regulatory environment and market dynamics in shaping the future of the pharmaceutical industry [5]

华福证券指出，结构上创新主线表现突出，CXO和创新药涨幅靠前，而血制品、医药零售、疫苗和IVD 指数跌幅居前。中长期看好三大方向：1）创新药领域，重点关注有商业化能力且管线丰富的BioPharma 和Pharma，以及前沿技术如基因治疗、小核酸等；2）医疗器械方面，医疗设备经过2025年清库存后叠 加新品上市，看好内镜、机器人等板块性机会，同时神经介入、外周介入等创新耗材也是国家重点支持 方向；3）内需消费相关医药公司，受益于中央经济工作会议提出的内需主导政策。此外，随着美联储 降息落地及新版《生物安全法案》通过众议院投票，政策不确定性消除，外需型CXO的海外订单需求 有望持续回暖，板块估值压制或将解除。 疫苗ETF（159643）跟踪的是疫苗生科指数（980015），该指数从市场中选取涉及疫苗研发、生产及销 售等业务的上市公司证券作为指数样本，以反映生物科学特别是疫苗领域相关上市公司证券的整体表 现。该指数聚焦于生物制品、医疗研发等相关领域，具有较高的成长性和创新性特征，适合关注生物医 药行业的投资者配置。 （文章来源：每日经济新闻） ...

Investment Rating - The report does not explicitly provide an investment rating for the biopharmaceutical sector [5]. Core Insights - The biopharmaceutical sector is experiencing significant activity with multiple companies focusing on innovative drug development, particularly in the area of siRNA targeting INHBE, which shows promise for fat reduction without muscle loss [3][24]. - The report highlights the recent performance of new drug stocks, with notable gains from companies such as Saint Nor Pharmaceutical (+30.88%) and Dongyao Pharmaceutical (+16.37%), while companies like Kexin Pharmaceutical (-14.19%) and Rongchang Biotechnology (-10.09%) faced declines [1][15]. - There is an expectation of multiple catalysts in the sector, including academic conferences and data releases, which could drive further interest and investment [2]. Weekly New Drug Market Review - From December 8 to December 14, 2025, the new drug sector saw significant stock movements, with the top five gainers and losers listed [1][15]. - The report notes that there were no new drug approvals during this week, but 11 new drug applications were accepted [4][31]. Weekly New Drug Industry Analysis - Wave Life Sciences has reported promising initial data for its siRNA drug WVE-007, which targets INHBE and demonstrates potential for reducing visceral fat while preserving muscle mass [3][24]. - The report indicates that several companies, both globally and domestically, are actively developing siRNA drugs targeting INHBE, with five drugs already in clinical development [27][28]. Weekly New Drug Approval & Acceptance Status - No new drug or new indication approvals were reported this week, but 11 new drug applications were accepted [4][31]. - A total of 55 new drug clinical applications were approved, and 47 new drug clinical applications were accepted during the week [9][34]. Key Events in Domestic Market - Significant events include the approval of new drugs by companies such as Zhengda Tianqing and Nuo Cheng Jian Hua, which received approval for their respective new drugs [10][11]. Key Events in Overseas Market - Noteworthy overseas events include Eli Lilly's announcement of positive results from its TRIUMPH-4 Phase 3 trial and the FDA's approval of a gene therapy by Fondazione Telethon [11].

Investment Rating - The report rates the pharmaceutical and biotechnology industry as "Outperforming the Market" [1][8]. Core Insights - The report highlights a significant increase in the success rate of negotiations for high-value innovative drugs, with the 2025 National Medical Insurance Directory adding 114 new drugs, including 50 innovative drugs, and achieving a negotiation success rate of 88%, up from 76% in 2024 [3]. - The introduction of a commercial insurance drug directory marks a new phase in healthcare, aiming to create a multi-layered insurance system that complements basic medical insurance, with 19 innovative drugs included in the first version [3]. - The report emphasizes the potential for Chinese innovative drugs to expand internationally, with a focus on ADCs, bispecific antibodies, small nucleic acids, and weight-loss drugs as key investment opportunities [3]. Summary by Sections Industry Performance - The SW Pharmaceutical and Biotechnology Index decreased by 0.74% in the week of December 1-7, underperforming the Shanghai and Shenzhen 300 Index, which increased by 1.28% [2]. - Within the pharmaceutical sector, the drug distribution (+6.48%) and offline pharmacy (+1.85%) segments performed relatively well, while raw materials (-2.54%), vaccines (-1.62%), and CXO (-1.29%) segments showed weaker performance [2]. National Medical Insurance Directory - The 2025 version of the National Medical Insurance Directory will officially implement on January 1, 2026, with a total of 3,253 drugs included, enhancing coverage for critical areas such as oncology, chronic diseases, mental health, rare diseases, and pediatric medications [3]. - Notably, 105 of the newly added drugs are exclusive products, including 98 Western medicines and 7 traditional Chinese medicines [3]. Commercial Insurance Drug Directory - The first version of the commercial insurance innovative drug directory includes 19 drugs, focusing on high clinical value and significant patient benefits, which are beyond the scope of basic medical insurance [5]. - This directory includes treatments for rare diseases, cancer therapies, and Alzheimer's disease, establishing a foundation for the development of a multi-tiered medical insurance system [3][5]. Investment Recommendations - The report suggests a positive outlook for the international expansion of Chinese innovative drugs and recommends monitoring ADCs, bispecific antibodies, small nucleic acids, and weight-loss drugs for investment opportunities [3]. - Key companies to watch include Yiming Biotechnology-B, WuXi AppTec, Maiwei Biotechnology-U, Kelun-Biotech, and Kangfang Biotech [3].

Group 1 - The core viewpoint of the article highlights a breakthrough in the small nucleic acid field with Arrowhead Pharmaceuticals' first small nucleic acid product, Plozasiran, receiving FDA approval, marking a new phase of commercialization in this sector [1] - The intersection of AI and biomedicine is accelerating innovation, with AI-native biotech companies valued at nearly twice that of their peers, and venture capital investment in AI drug development reaching $2.7 billion [1] - Over the next 5-10 years, global biomedicine is expected to see innovations driven by advancements in AI technology, explosive biological data, and interdisciplinary research, particularly in cardiovascular, metabolic chronic diseases, and CNS disorders [1] Group 2 - A significant wave of drug patent expirations is anticipated in 2026, covering oncology, metabolic, and CNS fields, with annual sales of approximately $230 billion facing generic competition, prompting pharmaceutical companies to respond through mergers and accelerated R&D to address the "patent cliff" [1] - Cell and gene therapies, AI drug development, and the small nucleic acid field are expected to become new hotspots in the coming year [1] - The ChiNext Medical ETF (159377) tracks the Innovation Medicine Index (399275), which saw a daily fluctuation of 20%, focusing on leading companies in biopharmaceuticals, chemical pharmaceuticals, and medical devices, emphasizing high R&D investment, innovation capability, and significant growth potential [1]

医疗ETF（159828）跟踪的是中证医疗指数（399989），该指数从沪深市场中选取医药卫生和药品零售 行业的上市公司证券作为指数样本，主要覆盖医疗器械、医疗服务及医疗研发外包等领域，以反映医疗 主题相关上市公司证券的整体表现。该指数成分股偏向中小市值，具有较高的成长性与波动性特征。 （文章来源：每日经济新闻） 国金证券表示，REDEMPLO获批，CNS领域突破，Arrowhead如箭在弦。小核酸领域领军公司 Arrowhead制药上周市值上涨16.6亿美元。2025年11月18日，公司的第一款小核酸产品Plozasiran获FDA 批准上市，这标志着公司步入商业化兑现的历史新阶段。同时，公司在研产品正在向更大患者市场的慢 病与中枢神经系统领域推进。 医疗ETF（159828）连续5日迎净流入，小核酸进军慢病，如箭在弦。 ...

Dale是一位晚期癌症患者，去年在上海接受了CAR-T药物治疗，并已实现完全缓解。CAR-T是最近十年发展 出来的新型治疗方式，相关开发企业集中于美国和中国。中国药物售价约120万，但也只有美国售价的三分之 一，医疗服务价格同样更低。这吸引了不少类似Dale的全球患者。 中国创新药与全球患者以不同的方式相遇。 "我带着大家庭去巴厘岛庆祝了我的重生。"新西兰人Dale De Penning最近在上海的一场分享会上说。 中国创新药与全球患者以不同的方式相遇：海外患者来中国寻药，同时，越来越多中国创新药出海了。中国 创新药获得了患者的初步认可，但在全球立足、立稳，一些重要关节还需要打通。 癌症患者来了中国 在来中国治疗之前，Dale曾接受过治疗。 Dale被确诊为弥漫性大 B 细胞淋巴瘤，之前在奥克兰医院接受过化疗、放疗等传统治疗方式，但无法让肿瘤 缩小到可做干细胞移植的标准。之后他多方搜索，决定来到上海，在上海曜影医院接受CAR-T药物治疗。 CAR-T细胞疗法，是一种个体化定制的细胞治疗，能通过对患者自身的免疫细胞——T细胞采集后进行体外基 因改造，从而加强其特异性识别和杀伤肿瘤的能力。它的制备条件苛刻。全球已 ...