Group 1 - The stock of Israeli clinical biopharmaceutical company UroGen Pharma (ADR) has resumed trading, experiencing a 63% increase [1] - UroGen Pharma focuses on developing novel therapies aimed at changing the standard of care for urological pathology [1] Group 2 - The stock price reached a high of $12.50 and a low of $6.92, with a previous close of $7.30 [3] - The trading volume was 1.97 million shares, with a turnover rate of 4.27% [3] - The stock's market capitalization is approximately $535 million, with a 52-week high of $20.70 and a low of $3.42 [3]

Core Viewpoint - The 2024 Annual General Meeting of Chongqing Zhixiang Jintai Biopharmaceutical Co., Ltd. outlines the procedures and agenda for the meeting, including various proposals for shareholder approval, reflecting the company's operational status and future plans [1][2][3]. Meeting Procedures - Shareholders or their representatives must arrive 30 minutes before the meeting and present identification for attendance verification [2]. - Only authorized personnel, including shareholders, directors, supervisors, and invited guests, are allowed to enter the meeting venue [1][2]. - Shareholders have the right to speak, inquire, and vote during the meeting, with specific rules governing the order and duration of speeches [2][3]. Voting and Proposals - The meeting will utilize both on-site and online voting methods, with specific timeframes for each [4][6]. - Key proposals include the 2024 Board of Directors' work report, the 2024 Supervisory Board's work report, and the 2024 annual financial report, all of which have been approved by the board and supervisory committee [5][8][9]. Financial Performance - The company reported a total asset decrease of 12.49% year-on-year, with total liabilities increasing by 25.83% [21][25]. - The net profit for the year was -79.73 million yuan, a slight improvement from the previous year's loss [21]. - Operating revenue reached 30.10 million yuan, a significant increase of 2384.11% compared to the previous year, primarily due to the launch of the product "Sailiqi Monoclonal Antibody Injection" [21][24]. Expense Analysis - Sales expenses surged by 1030.29% to 117.89 million yuan, attributed to the expansion of the sales team and marketing efforts for the new product [22][23]. - Management expenses decreased by 17.60%, while R&D expenses slightly reduced by 1.71% [22][23]. - Financial expenses showed a significant decrease of 313.63%, mainly due to increased interest income from temporarily idle funds [24]. Future Plans - The company plans to apply for a new comprehensive credit limit of up to 2.5 billion yuan to support its operational goals [12][13]. - Proposals for the 2025 director and supervisor remuneration plans have been outlined, reflecting the company's commitment to aligning compensation with performance [10][12].

Core Viewpoint - The company has received acceptance for its H-share full circulation filing by the China Securities Regulatory Commission, which is expected to enhance liquidity, governance, and market competitiveness, driving business growth and shareholder value [1] Group 1: Company Developments - The company's stock price increased by 2.17% to HKD 49.40 on June 10, following the announcement of the H-share full circulation application [1] - The company has six products approved in China and four internationally, reaching over 50 countries and benefiting more than 800,000 patients globally [2] - The company has been included in the MSCI Global Small Cap Index, which is likely to attract more international capital [2] Group 2: Research and Clinical Trials - The company showcased its research results at the American Society of Clinical Oncology (ASCO) annual meeting, including the innovative anti-HER2 monoclonal antibody HLX22 and the anti-PD-1 monoclonal antibody H药 汉斯状® [1] - The company presented Phase I clinical trial data for HLX43 (PD-L1 ADC) for treating advanced/metastatic solid tumor patients, addressing issues of non-response or resistance to PD-1/L1 immunotherapy [1]

Core Viewpoint - The company, Maiwei Biotech, is under investigation by the China Securities Regulatory Commission (CSRC) for suspected short-term trading involving its chairman and general manager, Liu Datao, but this investigation is stated to not significantly impact the company's daily operations [1] Group 1: Company Overview - Maiwei Biotech is an innovative biopharmaceutical company with a full industry chain layout, focusing on products such as antibodies, ADC drugs, recombinant proteins, and small molecule chemical drugs [3] - The company has not yet achieved profitability and has accumulated losses exceeding 3 billion yuan over the past three years [5] Group 2: Financial Performance - From 2022 to 2024, the company's net profits were reported as -955 million yuan, -1.053 billion yuan, and -1.044 billion yuan respectively, indicating consistent losses [5] - In 2024, the company achieved approximately 200 million yuan in revenue, representing a year-on-year growth of 56.28%, while still reporting a net loss of 1.044 billion yuan [5] Group 3: Funding and Market Position - Maiwei Biotech was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board in January 2022, raising a net amount of 3.303 billion yuan [7] - The company is currently advancing its IPO process in Hong Kong, having submitted an application to the Hong Kong Stock Exchange for H-share listing on January 6, 2025 [7] - As of May 9, the company's stock price closed at 19.99 yuan per share, with a total market capitalization of 7.988 billion yuan [7]

Core Viewpoint - CICC maintains the profit forecast for Rongchang Biologics (09995) at a loss of 9.15 billion yuan for 2025 and a loss of 3.33 billion yuan for 2026, while raising the target price by 40.6% to 45 HKD, indicating a potential upside of 21.8% from the current stock price due to positive data from the gMG trial of Taitasip [1] Group 1 - The company's Q1 2025 performance met expectations, with revenue of 526 million yuan, a year-on-year increase of 59.17%, and a net profit loss of 254 million yuan, which is a nearly 1 billion yuan reduction in loss compared to the previous year [2] - Product revenue showed strong year-on-year growth, with operating cash flow improving significantly; the company reported a net cash outflow of 188 million yuan in Q1 2025, an improvement of 238 million yuan year-on-year, mainly due to increased sales collections [3] Group 2 - Taitasip's Phase III clinical trial data for treating generalized myasthenia gravis (gMG) showed excellent results, with 98.1% of patients improving their MG-ADL score by at least 3 points after 24 weeks, compared to 12% in the placebo group; the overall score decreased by 5.74 points [4] - The safety profile of Taitasip was comparable to the placebo group, with a lower incidence of infection-related adverse events (45.6% vs. 59.6%); the drug's market application for gMG is expected to be approved in the second quarter of this year [4]

核心培养基业务收入快速增长。2024年公司产品业务实现收入2.4亿元(+42%)，其中CHO培养基实现收 入2亿元(+49%)；海外业务实现收入9446万元，同比+144%。2024 年销售毛利率为53%，同比-5.8pp， 预计主要系CDMO 业务的固定成本摊销。费用率方面，销售费用率8.5%(+1.8pp)， 管理费用率27.1% (+3.2pp)，研发费用率11.5%(-6.2pp)。2024 年公司计提资产减值损失954万元，计提信用减值损失692 万 元。此外，由于公司高新技术企业资格取消致使税率提升，2024 年所得税费用增加656 万元。 盈利预测与投资建议。预计公司2025-2027 年收入分别为4亿元、5.3 亿元、7亿元，公司储备药企项目 丰富，未来抗体商业化生产订单将驱动业绩增长，建议关注。 事件：公司发布 2024年报，2024年实现收入3亿元(+22.3%)，归母净利润2105万元(-61%)，扣非净利润 658.6 万元(-81%)。 风险提示：产品出海不及预期风险、创新药行业投融资不及预期风险、市场竞争风险。 培养基业务持续放量，产品管线数量突破性增长。2024 年使用公司培养基 ...

Core Viewpoint - Rongchang Biopharma disclosed its research reception announcement, indicating strong financial performance and significant progress in core pipeline development for 2024, with a focus on various therapeutic areas [1][2]. Financial Overview - The company reported a revenue of 1.717 billion yuan for 2024, representing a year-on-year growth of 58.5% [7]. - The sales expense ratio for 2024 was 55.3%, a decrease of 16.3 percentage points compared to the previous year [7]. - Research and development expenses increased to 1.54 billion yuan, up 17.9% year-on-year [7]. - The overall gross margin for 2024 was 80.4%, an increase of 3.0 percentage points from the previous year [7]. - As of the end of 2024, the company had approximately 1 billion yuan in cash and cash equivalents, with sufficient loan credit lines available [7]. Core Pipeline Development Progress 1. **RC18 in China** - Myasthenia Gravis (MG): BLA application has been accepted, with data presented at the AAN conference showing significant clinical efficacy [4]. - Primary Sjögren's Syndrome (pSS): Phase III enrollment is complete, with normal progress in medication and follow-up [4]. - IgA Nephropathy (IgAN): Phase III enrollment is complete, with normal progress in medication and follow-up [4]. 2. **RC18 Overseas** - Systemic Lupus Erythematosus (SLE): Phase III international multicenter clinical research is ready [5]. - Myasthenia Gravis (MG): Continuous enrollment in Phase III [5]. 3. **RC48 in China** - Urothelial Carcinoma (UC): Phase III for first-line combination therapy is complete, with normal progress in medication and follow-up [6]. - Gastric Cancer (GC): Phase III for first-line combination therapy has started, with patient enrollment underway [6]. 4. **Other Pipeline Developments** - RC88: Phase II clinical trial for advanced malignant solid tumors has completed enrollment [10]. - RC148: Observed good efficacy and safety in single-agent clinical exploration, with ongoing Phase II trials for advanced lung cancer [11]. - RC278: ADC drug using next-generation conjugation technology for various solid tumors [12]. - RC28: Phase III clinical trials for diabetic macular edema (DME) and wet age-related macular degeneration (wAMD) have completed enrollment [13].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 Shanghai Henlius Biotech, Inc. 上海復宏漢霖生物技術股份有限公司 本公告由上海復宏漢霖生物技術股份有限公司（「本公司」）自願作出，以告知 本公司股東及潛在投資者本公司最新業務更新。 茲提述本公司於2020年10月15日及2023年2月22日刊發的公告，內容有關本 公司將漢貝泰® （貝伐珠單抗注射液）於全球範圍眼科治療用途和/或療法的獨 家權利許可給Essex Bio-Investment Limited及珠海億勝生物製藥有限公司（合 稱「Essex」），並約定與Essex共同開發相關產品。本公司和Essex將分別承擔 20%及80%與相關產品開發活動有關的成本及開支。 本公司董事會（「董事會」）欣然宣佈，近日，重組抗VEGF人源化單克隆抗 體注射液HLX04-O（「HLX04-O」）在一項於濕性年齡相關性黃斑變性(wet age-related macular degener ...