流动性方面，港股创新药精选ETF盘中换手14.35%，成交5985.34万元，市场交投活跃。拉长时间看，截至10月10日，港股创新药精选ETF近1月日均成交 1.33亿元。 据报道，2025年欧洲肿瘤内科学会（ESMO）将于10月17日至21日在德国柏林召开，常规摘要已于10月13日发布，最新突破性数据将在会议期间陆续公布。 多家国产创新药企如康方生物、科伦博泰、恒瑞医药、荣昌生物、君实生物等均有研究入围，市场期待双抗、ADC等新技术平台的临床数据读出，有望进 一步提升中国创新药在全球的影响力。 消息面上，荣昌生物的泰它西普拟纳入我国药监局优先审评，针对具有进展风险的IgA肾病成人患者，显著降低蛋白尿水平。此外，信达生物IBI363启动III 期临床，适应症为鳞状非小细胞肺癌。BD进展方面，10月12日晚，百利天恒公告称，全资子公司SystImmune与百时美施贵宝（BMS）就iza-bren（BL- B01D1、EGFR×HER3双抗ADC）项目达成的全球战略合作协议已触发第一笔2.5亿美元的近期或有付款条件，SystImmune将于近期收到款项。 华鑫证券指出，创新药出海是长期趋势，外部环境变化影响有限。 ...

截至2025年9月29日 13:04，恒生医疗保健指数强势上涨1.22%，成分股映恩生物-B上涨7.03%，晶泰控 股上涨6.33%，阿里健康上涨4.51%，巨子生物，微创机器人-B等个股跟涨。恒生医疗ETF(513060)上涨 0.14%，最新价报0.71元。拉长时间看，截至2025年9月26日，恒生医疗ETF近1月累计上涨4.55%，涨幅 排名可比基金1/3。 流动性方面，恒生医疗ETF盘中换手10.9%，成交7.84亿元，市场交投活跃。拉长时间看，截至9月26 日，恒生医疗ETF近1月日均成交22.95亿元，排名可比基金第一。 截至2025年9月29日 13:04，恒生港股通创新药精选指数上涨0.95%，成分股映恩生物-B上涨7.03%，荣 昌生物上涨5.78%，三生制药上涨3.44%，康诺亚-B上涨3.13%，先声药业上涨2.80%。港股创新药精选 ETF(520690)下跌0.20%，最新报价1元。拉长时间看，截至2025年9月26日，港股创新药精选ETF近1月 累计上涨2.99%，涨幅排名可比基金1/2。 流动性方面，港股创新药精选ETF盘中换手16.1%，成交6826.52万元，市场交投活跃。拉 ...

A(IgA)肾病成人患者，显著降低蛋白尿水平。此前8月27日，荣昌生物宣布泰它西普治疗lgA肾病的国内 III期研究达成A阶段的主要终点。研究结果显示，与安慰剂组相比，泰它西普组患者在治疗39周时24小 时尿蛋白肌酐比值(UPCR)降低了55%。 据了解，泰它西普是目前唯一可同时抑制B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)的药物， 而这两种细胞因子在IgA肾病患者中的水平显著高于正常人群，是疾病发生的关键驱动因素。通过抑制 这两种因子，泰它西普可减少B细胞增殖、降低浆细胞数量及异常免疫球蛋白生成，从源头阻断免疫复 合物沉积，减轻肾脏免疫炎症反应。 智通财经APP获悉， 荣昌生物 (09995)涨超7%，截至发稿，涨7.25%，报109.4港元，成交额3.57亿港 元。 消息面上，9月28日，CDE官网显示，荣昌生物泰它西普拟纳入优先审评品种，用于治疗具有进展风险 的原发性免疫球蛋白 ...

来源：智通财经网 荣昌生物(09995)涨超7%，截至发稿，涨7.25%，报109.4港元，成交额3.57亿港元。 消息面上，9月28日，CDE官网显示，荣昌生物泰它西普拟纳入优先审评品种，用于治疗具有进展风险 的原发性免疫球蛋白 A(IgA)肾病成人患者，显著降低蛋白尿水平。此前8月27日，荣昌生物宣布泰它西 普治疗lgA肾病的国内III期研究达成A阶段的主要终点。研究结果显示，与安慰剂组相比，泰它西普组 患者在治疗39周时24小时尿蛋白肌酐比值(UPCR)降低了55%。 据了解，泰它西普是目前唯一可同时抑制B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)的药物， 而这两种细胞因子在IgA肾病患者中的水平显著高于正常人群，是疾病发生的关键驱动因素。通过抑制 这两种因子，泰它西普可减少B细胞增殖、降低浆细胞数量及异常免疫球蛋白生成，从源头阻断免疫复 合物沉积，减轻肾脏免疫炎症反应。 ...

消息面上，9月28日，CDE官网显示，荣昌生物泰它西普拟纳入优先审评品种，用于治疗具有进展风险 的原发性免疫球蛋白 A(IgA)肾病成人患者，显著降低蛋白尿水平。此前8月27日，荣昌生物宣布泰它西 普治疗lgA肾病的国内III期研究达成A阶段的主要终点。研究结果显示，与安慰剂组相比，泰它西普组 患者在治疗39周时24小时尿蛋白肌酐比值(UPCR)降低了55%。 智通财经APP获悉，荣昌生物(09995)涨超7%，截至发稿，涨7.25%，报109.4港元，成交额3.57亿港元。 据了解，泰它西普是目前唯一可同时抑制B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)的药物， 而这两种细胞因子在IgA肾病患者中的水平显著高于正常人群，是疾病发生的关键驱动因素。通过抑制 这两种因子，泰它西普可减少B细胞增殖、降低浆细胞数量及异常免疫球蛋白生成，从源头阻断免疫复 合物沉积，减轻肾脏免疫炎症反应。 ...

据了解，泰它西普是目前唯一可同时抑制B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)的药物， 而这两种细胞因子在IgA肾病患者中的水平显著高于正常人群，是疾病发生的关键驱动因素。通过抑制 这两种因子，泰它西普可减少B细胞增殖、降低浆细胞数量及异常免疫球蛋白生成，从源头阻断免疫复 合物沉积，减轻肾脏免疫炎症反应。 荣昌生物(09995)涨超7%，截至发稿，涨7.25%，报109.4港元，成交额3.57亿港元。 消息面上，9月28日，CDE官网显示，荣昌生物泰它西普拟纳入优先审评品种，用于治疗具有进展风险 的原发性免疫球蛋白 A(IgA)肾病成人患者，显著降低蛋白尿水平。此前8月27日，荣昌生物宣布泰它西 普治疗lgA肾病的国内III期研究达成A阶段的主要终点。研究结果显示，与安慰剂组相比，泰它西普组 患者在治疗39周时24小时尿蛋白肌酐比值(UPCR)降低了55%。 ...

Group 1 - Rongchang Biopharma's "Taitasip" is proposed for priority review by CDE for treating adult patients with primary IgA nephropathy, showing significant reduction in proteinuria levels [1] - "Taitasip" has already been approved for three indications in China, including myasthenia gravis, rheumatoid arthritis, and systemic lupus erythematosus, with a recent application for Sjögren's syndrome also accepted [1] Group 2 - Baiyunshan and Guangzhou Pharmaceutical Phase II Fund signed a strategic investment agreement to acquire over 144 million shares of Nanjing Pharmaceutical, making it the second-largest shareholder with an 11.04% stake [2] - This strategic investment aims to enhance market competitiveness through resource integration and synergy, potentially impacting Nanjing Pharmaceutical's governance structure and market performance [2] Group 3 - Pian Zai Huang's Chief Financial Officer Yang Haipeng resigned due to work adjustments, with Deputy General Manager He Wei temporarily taking over the CFO duties [3] - The long-term brand value and market position of Pian Zai Huang remain strong, and if the management transition is smooth, the impact on the company's long-term development may be limited [3] Group 4 - Former Chief Technology Officer of Kailai Ying, Hu Xinhui, has joined Hengrui Medicine as Vice President and Chief Technology Officer, indicating a strategic move to strengthen R&D capabilities [4] - Hu Xinhui's appointment is expected to bring new opportunities for Hengrui Medicine's R&D system upgrades, technological breakthroughs, and international development [4] Group 5 - The former Chairman of Guangzhou Pharmaceutical Group, Li Chuyuan, has been reported for violations of discipline and law, leading to his expulsion from the party and public office [5] - This incident highlights governance and internal oversight issues within Guangzhou Pharmaceutical Group, which may affect investor trust and subsequently impact its stock performance and market reputation [5]

Core Viewpoint - The surge in A-share and Hong Kong stock prices of innovative drug companies is driven by potential business development (BD) expectations, particularly for those seen as acquisition targets by multinational pharmaceutical companies [2][3] Group 1: Business Development Trends - Pfizer's recent $7.3 billion acquisition of Metsera signals a significant return to the weight-loss drug market, impacting domestic stock prices of related companies [2] - Global pharmaceutical transactions have increased from 358 in 2015 to 743 in 2024, with a compound annual growth rate of 8%, while China's transactions surged from 55 to 213, with total values rising from $3.1 billion to $57.1 billion [3] - Major Chinese companies like 3SBio, CSPC, and Hengrui have secured BD deals exceeding $5 billion this year, with Hengrui's $12.5 billion agreement with GSK setting a record for Chinese innovative drug exports [3] Group 2: Market Sentiment and Investor Behavior - Investors are becoming more discerning, focusing on the specifics of BD deals, such as upfront payment ratios and the long-term capabilities of partners, rather than merely the announcement of negotiations [4] - There is a growing concern that many top buyers have already completed their acquisitions, leading to potential valuation declines and tougher negotiations for remaining assets [4][5] - Past instances show that underwhelming BD deals can lead to significant stock price declines, as seen with Rongchang Bio and Hengrui [5] Group 3: Future Opportunities and Market Dynamics - Despite concerns about a potential slowdown in BD activity, industry leaders assert that opportunities continue to emerge, particularly as multinational companies adjust their R&D strategies every 5 to 10 years [7] - The demand for innovative assets remains strong, with a shift towards ADCs and bispecific antibodies, indicating a recognition of Chinese companies' R&D capabilities [8][9] - The trend of multinational companies seeking earlier-stage projects reflects a strategic shift towards building comprehensive product portfolios, as seen in Pfizer's acquisition of Metsera, which enhances its offerings in the GLP-1 space [9]

近日，辉瑞宣布，拟斥资73亿美元收购减肥药物开发商Metsera。这一大手笔收购被普遍视为辉瑞重返 减肥药赛道的重要信号，但也引发了国内资本市场的连锁反应。A股市场上，多家减肥药概念股的股价 因此承压。 当辉瑞选择了Metsera而非中国企业时，外界不免追问：资本市场如今热炒的BD预期，能否真正兑现？ BD预期推动创新药行情 今年以来，国内不少A股、港股创新药企凭借潜在BD（商务拓展）预期被投资者追捧，股价节节攀 升。特别是一些被视作与跨国药企合作或被收购潜在标的的企业，其股价涨幅位居板块前列。 事实上，在此前辉瑞与三生制药的合作中，康方生物也曾受到过波及，成为BD预期落空的一大受害 者。在辉瑞最终选择三生制药之前，曾有投资者对辉瑞与康方生物海外合作方Summit更深入的合作甚 至收购抱有期待。资本市场上，三生制药与康方生物股价的此消彼长也印证了这一点。5月20日开盘， 港股康方生物的股价就震荡走低，盘中一度跌超5%，最终收报82.4港元/股，下跌1.38%。 据医药魔方披露的数据，全球医药交易数量从2015年的358笔增至2024年的743笔，年复合增长率为 8%，总交易金额从569亿美元跃升至1874亿美 ...

Group 1: Hong Kong Stocks - SUTENG JUCHUANG (02498) rose over 6% due to increased demand in the robotics market, highlighting the company's scale effect [1] - China Duty Free Group (01880) increased nearly 4% as the decline in Hainan's offshore duty-free sales narrowed, supported by new consumer service policies [1] - Weimob Group (02013) gained over 4% after announcing a $200 million investment from international long-term institutions to accelerate AI technology applications [1] - Shoucheng Holdings (00697) surged over 9% following an announcement of additional investment in Weifeng Zhifei by its subsidiary [1] - Horizon Robotics-W (09660) rose over 7% after signing a strategic cooperation agreement with Hello to accelerate the deployment of robotaxis [1] - Rongchang Bio (09995) increased over 2% as its clinical research was selected for a major conference [1] - Tongcheng Travel (00780) rose over 1% due to high tourism demand during the Golden Week, with institutions optimistic about the OTA sector [1] - Sanhua Intelligent Control (02050) surged over 10% as Tesla's new operational targets catalyzed growth in the company's new business [1] Group 2: U.S. Stocks - NIO (NIO.US) rose 6.13% as Deutsche Bank reported approximately 100,000 cancellable orders for the ES8 [3] - Li Auto (LI.US) increased 2.22% with the announcement of the launch date for the Li Xiang i6, its second pure electric SUV [3] - Trip.com (TCOM.US) rose 0.27% as policies to expand service consumption were discussed, with early booking peaks for the National Day holiday [3] - New Oriental (EDU.US) increased 2.90% following the release of policies to encourage vocational training and improve evaluation mechanisms [3] - Nokia (NOK.US) rose 1.95% after announcing the establishment of a new AI department [3] - Workday (WDAY.US) surged 7.25% after Elliott Management disclosed a $2 billion stake and expressed support for the current leadership [4] - Adobe (ADBE.US) rose 2.65% as Goldman Sachs reiterated a "buy" rating [4] - Novo Nordisk (NVO.US) increased 1.75% after positive results from a late-stage trial of a new weight-loss drug [4] - Bank of America (BAC.US) rose 1.46% as the CEO indicated no immediate plans to leave [4] - Uber (UBER.US) fell 4.99% as Lyft announced a partnership with Waymo for autonomous taxi services [4] - Kingsoft Cloud (KC.US) rose 5.35%, and GDS Holdings (GDS.US) increased 7.56%, both receiving "buy" ratings from Bank of America [5]