Group 1 - Huayi Family plans to invest up to 300 million CNY to acquire 5%-8.09% of Haihe Pharmaceutical's shares, marking a significant move after years of inactivity in external investments [1] - Haihe Pharmaceutical has successfully commercialized three products, including Gumeitini tablets, which received conditional approval in March 2023 and was included in the national medical insurance directory [2] - The company has a strong pipeline with five products in clinical research, including a PI3Kα inhibitor, indicating potential for growth in unmet clinical needs [3] Group 2 - The domestic innovative drug industry is accelerating, with small molecule drugs maintaining an irreplaceable position in clinical treatment due to their convenience and cost-effectiveness [4] - Huayi Family's investment in Haihe Pharmaceutical is a strategic move to optimize its business structure amid challenges in the real estate sector, aiming for predictable returns as Haihe Pharmaceutical is expected to enter a rapid growth phase by 2027 [4] - This investment reflects Huayi Family's recognition of Haihe Pharmaceutical's R&D capabilities and commercial prospects, serving as a crucial step for future business transformation [4]

百时美施贵宝的科学家们设计氘可来昔替尼来选择性地靶向TYK2，从而抑制IL-23、IL-12和 I型干扰素 (IFN)的信号传导，而这些细胞因子都是参与多种免疫介导疾病发病机制的关键细胞因子。氘可来昔替 尼通过与TYK2的调节结构域结合实现高度选择性，促成对TYK2及其下游功能的变构抑制。在生理浓 度范围内，氘可来昔替尼可选择性地抑制 TYK2。在治疗剂量下，氘可来昔替尼不会抑制JAK1、JAK2 或JAK3。氘可来昔替尼已在全球多个国家和地区获批，用于治疗成年中重度斑块状银屑病患者。 智通财经APP获悉，6月12日，百时美施贵宝(BMY.US)公布了POETYK PsA-1(IM011-054)这一关键3期 试验的积极结果。该试验旨在评估氘可来昔替尼在治疗既往未接受过生物制剂类改善病情抗风湿药物 (bDMARD)的活动性银屑病关节炎成人患者中的疗效和安全性。试验达到了主要终点，即治疗16周时， 氘可来昔替尼治疗组患者的ACR20(疾病体征和症状至少改善20%)应答比例显著高于安慰剂组(分别为： 54.2% vs. 34.1%)。 16周治疗期间，氘可来昔替尼的安全性特征与其此前的临床试验项目中观察到的结果一 ...