Core Viewpoint - Cancer cachexia significantly alters the metabolism of patients, leading to involuntary weight loss and increased mortality, with no FDA-approved treatments available to fully reverse the condition [2][3][6]. Group 1: Cancer Cachexia Overview - 50%-80% of cancer patients experience cancer cachexia, resulting in functional decline, decreased quality of life, increased chemotherapy toxicity, and higher mortality rates [3]. - Cancer cachexia accounts for at least 20% of cancer-related deaths, highlighting the urgency for effective treatments [3]. Group 2: Research Findings - A study published in Cell identified the liver as a previously overlooked driver of cancer cachexia, revealing that the disruption of the biological clock gene REV-ERBα in the liver promotes the release of hepatokines that enhance catabolism [4][5]. - Reactivating REV-ERBα expression or inhibiting specific hepatokines (LBP, ITIH3, IGFBP1) significantly improved weight loss in mouse models of cancer cachexia [5][11]. Group 3: Mechanisms of Action - The study demonstrated that the liver undergoes metabolic reprogramming in cancer cachexia, with the biological clock gene REV-ERBα becoming inactive, leading to increased release of catabolic hepatokines [10][11]. - In cancer cachexia patients, levels of LBP, ITIH3, and IGFBP1 were significantly elevated compared to weight-stable cancer patients, indicating their role in promoting tissue wasting [12][15]. Group 4: Implications for Treatment - The findings suggest that the liver actively contributes to the progression of cancer cachexia rather than being a passive responder, providing new biomarkers and therapeutic targets for better diagnosis and treatment interventions [16].

"在一定范围内，水稻接收的光照时间越短，抽穗越快，水稻越早熟。"论文的共同通讯作者、南京 农业大学教授周时荣介绍，水稻的抽穗受光信号与内源生物钟系统的复杂调控。然而，关于光信号整合 至水稻生物钟网络的机制仍迷雾重重。 研究团队克隆了一个在长日照条件下特异性调控水稻抽穗的基因ELD1。该基因功能完全缺失会导 致水稻胚胎死亡，但当特定氨基酸发生突变时，不仅能够显著促进水稻抽穗，而且不会出现明显的农艺 性状缺陷。 原标题：我科学家发现调控水稻抽穗期关键基因 科技日报讯 （记者金凤）挖掘水稻新的抽穗期基因并解析其作用机制，对培育高产、优质、广适 的水稻品种具有重要意义。记者7月21日获悉，中国工程院院士万建民团队通过克隆一个在长日照条件 下特异性调控水稻抽穗的基因，发现该基因可以调控水稻生物钟核心基因OsCCA1的mRNA剪接，影响 水稻抽穗期。相关研究成果日前发表在国际学术期刊《自然·通讯》上。 周时荣介绍，上述研究不仅揭示了光信号调控水稻抽穗期的全新机制，还在分子育种上取得了突 破。研究团队利用碱基编辑技术，对ELD1关键氨基酸进行定点突变，为宁粳7号、宁粳4号等优良品种 培育出早抽穗新种质开辟了新路径。 "本研 ...

然而，有一个衰老信号几乎无法伪装——睡眠。即使外表保养得再好，50岁人的睡眠状态也骗不了 人。当睡觉出现这3个变化，说明可能是真的老了！赶紧对照一下。 当睡觉出现这3个变化 如今光看外表越来越难猜准一个人的年龄。医疗和医美技术的进步，让许多人保养得格外年轻，四 五十岁也能拥有三四十岁的样貌。 说明可能是真的老了！ 入睡时间显著提前：真熬不动夜了 你有没有发现曾经特别能熬夜的自己，突然有一天熬不动夜了？曾经的"夜猫子"，如今也早早地就 困意难当。没错，上了年纪的人往往一到晚上早早入睡。这就是上了年纪后，生物钟的悄然偏移。 有研究发现，大部分老年人他们经常在晚上8~9点就开始困了，睡到清晨4~5点就自然醒了。这 种"睡眠时间提前"的原因，其实与人体内掌管昼夜节律的"生物钟"密切相关。例如，老年人的褪黑激素 分泌高峰比年轻人早1~2小时，核心体温最低点也前移。这就导致老年人会比年轻人的"睡觉困点"提 前。 所以，这也就是为什么老年人很难再像年轻时一样熬夜晚睡。而入睡提前意味着整体睡眠节律的前 移，可能导致清晨过早醒来，成为衰老的清晰信号。 碎片化睡眠的增多：睡眠断断续续 上了年纪后，安睡一整夜仿佛成了奢侈品。夜里频 ...

以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展。 现代社会的快节奏生活正在悄然重塑人类的睡眠模式，熬夜与紊乱的作息逐渐成为健康隐患。最新科学研究证实，睡眠问题不仅导致日 间疲惫，更会直接干扰血糖代谢稳态。来自JAMA Ne twor k Ope n的突破性研究《成人睡眠时长、入睡时间与连续血糖监测的变化轨 迹》首次采用动态监测方法，揭示睡眠时长缩短与入睡时间推迟会显著加剧血糖波动，这种影响甚至超过单纯熬夜的危害。该研究为理 解睡眠紊乱与代谢疾病之间的关联提供了全新证据。 这项开创性研究采用连续血糖监测技术，对受试者睡眠模式与血糖水平进行长期追踪。结果显示，持续睡眠不足6小时的人群，其血糖 波动幅度比睡眠充足者高出40%。更令人警惕的是，相比固定时间熬夜，不规律的就寝时间会导致更严重的血糖调节异常。研究团队指 出，人体生物钟与糖代谢存在精密协同，当入睡时间每日差异超过90分钟时，胰岛素敏感性会出现明显下降。这些发现完美解释了为何 轮班工作者和跨时区旅行者更容易出现代谢紊乱。 深入分析数据发现，睡眠对血糖的影响呈现双重 ...

Core Insights - The research team led by academician Wan Jianmin has identified a new gene, ELD1, that specifically regulates the heading date of rice under long-day conditions, which is crucial for breeding high-yield, high-quality, and widely adaptable rice varieties [1][2] - The study reveals that the ELD1 gene can significantly promote heading without causing obvious agronomic defects, indicating its potential for molecular breeding applications [2] Group 1: Gene Discovery and Mechanism - The ELD1 gene regulates the mRNA splicing of the core biological clock gene OsCCA1, affecting the heading date of rice [1] - The research indicates that shorter light exposure leads to faster heading and earlier maturity in rice [1] - ELD1 interacts with OsNKAP protein and multiple core mRNA splicing factors, influencing the splicing of thousands of genes across the genome [1] Group 2: Implications for Breeding - The study provides a new mechanism for understanding how light signals regulate the heading date of rice, which is significant for molecular breeding [2] - The team utilized base editing technology to create targeted mutations in key amino acids of ELD1, resulting in new early-heading germplasm for high-quality rice varieties such as Ningjing 7 and Ningjing 4 [2] - This research offers important genetic resources and theoretical support for addressing the late maturity issues in hybrid rice breeding [2]

光明网讯6月20日，记者从南京农业大学获悉，该校万建民院士团队在水稻抽穗期的调控上取得重要进 展，相关成果于6月19日在《自然·通讯》（Nature Communications）上在线发表。 a-b：ELD1在长日照条件下抑制水稻抽穗；c：ELD1与剪接体核心组分互作；d-e：ELD1调控OsCCA1可 变剪接；f：ELD1与OsCCA1，Hd1遗传关系验证；g：ELD1调控水稻抽穗期的模式图 研究发现，ELD1可与OsNKAP（哺乳动物NF-κB activating protein同源物）及多个核心mRNA剪接因子 互作。全长转录组测序分析发现，ELD1在全基因组范围内调控上千个基因的可变剪接，特别是在生物 钟核心基因 OsCCA1 上介导多个位点的剪接事件。分子与遗传分析表明，ELD1主要通过 OsCCA1-Hd1 通路影响水稻抽穗期。 来源：光明网 水稻抽穗期是决定品种地区和季节适应性的关键性状，影响水稻的产量和品质。不同地区、不同季节的 光照和温度不同，水稻的"作息时间"也得跟着调整。所以，找到调控抽穗期的基因，就好比掌握了水稻 生长的"遥控器"，对培育高产、优质、适应性强的水稻品种至关重要。 水 ...

清晨的闹钟声响起，你是否会瞬间冒火，心情差到极点，感觉自己像个随时要炸的火药桶？相信不少人 都有过被起床气支配的经历。起床气是发生在睡眠之后的一种负面情绪，医学上称为"睡眠惯性"或"睡 眠惰性"，它可能会影响我们的情绪、行为和人际关系。 那么，起床气究竟从何而来？又该如何将其驱散，以愉悦的心情开启新的一天呢？ 揭秘起床气 缓解起床气 妙招来助力 养成良好的睡眠习惯 规律睡眠能调整生物钟，提升睡眠质量，让我们早上醒来神清气爽，还能减少压力和焦虑，降低起床气 发生的概率。因此，我们要保持规律的睡眠时间，尽量在固定时间上床睡觉和起床，让身体和大脑适应 固定的睡眠-觉醒周期，从而提高睡眠质量。打造舒适的睡眠环境也很重要。要保持卧室安静，光线和 温度适宜。避免在睡前使用电子设备，因为电子设备发出的蓝光会抑制褪黑素的分泌，干扰我们的睡 眠。另外，要减少摄入含咖啡因的饮料，以免刺激神经系统，影响睡眠时间和睡眠质量。 要让身体缓慢"开机" 多因素引发 第一，睡眠惯性是导致起床气的重要因素。人刚起床时，脑干等脑区的觉醒中枢苏醒，而大脑皮质和负 责情绪调控的脑区还没"上岗"。这时，外周神经系统逐渐敏感，体温、血压上升，心跳加快， ...

植物通过光敏色素等一系列"传感器"感知光照、温度变化等信号，随后进行细胞内生物钟校准。植物细 胞内有一个核心振荡器，是由一系列相互调控的基因和蛋白质共同构成的复杂网络。核心振荡器能对植 物的生理活动进行调节，例如，通过控制叶片气孔开闭，优化光合作用和水分利用等。精细的调控机制 不仅能帮助植物适应昼夜节律，还使其能灵活应对环境变化，增强生存竞争力。 植物的昼夜节律现象，揭示了生物钟在植物生理活动中的重要作用，背后蕴藏着的自然规律和生命智 慧，令人惊叹。 （作者为中国科学院植物研究所高级工程师，本报记者施芳采访整理） 选题线索来信邮箱：rmrbstb@peopledaily.cn 植物的"睡眠"行为，是由植物内部生物钟调控的生理过程，隐藏着植物适应环境的独特智慧 夜晚，含羞草的叶片会自然下垂闭合，到白天再展开；合欢树的羽状叶入夜后会"折叠"；一些睡莲的花 朵白天开放、晚上闭合……那么，植物晚上也会"睡觉"吗？ 在植物界，无论是野生种群还是人工栽培植物，这种节律性的"睡眠"行为相当普遍。植物的"睡眠"行 为，实际上是由植物内部生物钟调控的生理过程。这种"睡眠"行为的背后，隐藏着植物适应环境的独特 智慧。 首先，植物 ...

Core Insights - The research led by Professor Wang Yaohui's team from Anhui Agricultural University and researcher Zhan Shuai from the Chinese Academy of Sciences has identified a biological clock gene named Cycle that plays a crucial role in regulating insect diapause, revealing the molecular mechanisms behind this phenomenon [1][2]. Group 1: Research Findings - Insects have evolved a survival strategy known as diapause, allowing them to pause their life cycle in response to harsh environmental conditions such as food shortages and extreme temperatures [1]. - The study focused on the silkworm and corn borer, utilizing genomic data analysis and genome editing to uncover the genetic regulation of diapause [1]. - The Cycle gene can produce three different variants (A, B, and C subtypes) through alternative splicing, with A and B subtypes regulating circadian rhythms, while the C subtype is responsible for triggering diapause in response to low temperatures or short daylight signals [1]. Group 2: Implications - This research represents a significant breakthrough in understanding seasonal adaptation in insects, providing new theories on how life interacts with the environment [2]. - The findings have important implications for understanding pest population dynamics, ensuring food security, and promoting ecosystem stability [2].

Core Insights - The research team from the Chinese Academy of Sciences has discovered that insects can cleverly utilize circadian rhythm genes to regulate their seasonal rhythms, enabling adaptation to different habitats and climates [1][2]. Group 1: Research Findings - The study focuses on the Lepidoptera order of insects, which includes moths and butterflies, and identifies the biological clock gene Cycle as a key molecular "switch" controlling diapause in silkworms [1]. - The Cycle gene in silkworms and Lepidoptera insects encodes three subtypes, with some responsible for circadian regulation and others for diapause control, achieving dual regulation of circadian and seasonal rhythms [1][2]. - Tropical silkworms have lost the subtype that regulates diapause due to genetic mutations, resulting in an inability to undergo diapause [1]. Group 2: Implications - The research provides a theoretical basis for understanding the seasonal occurrence patterns of pest insects, particularly in the context of global climate change, which may affect population dynamics [2].