以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 ▍糖尿病逆转的科学依据与关键机制 长期以来，医学界普遍认为胰岛β细胞一旦受损便无法再生，高血糖环境会加速其凋亡，最终导致糖尿病不可逆转。然而，最新研究颠 覆了这一传统认知，揭示了糖尿病可逆的关键机制。 研究发现，胰岛β细胞并非完全不可再生，而是存在一定的"储备细胞"，部分功能受损的细胞只是暂时处于"休眠"状态，而非彻底死 亡。这意味着，即使糖尿病病程长达10年，患者体内仍可能保留约50%的胰岛β细胞，而 只要30%的细胞维持正常功能，血糖水平即可 稳定在合理范围内 。 更关键的是，持续的高血糖环境会引发"糖毒性"，进一步抑制胰岛β细胞功能。但若能通过科学干预，使血糖长期稳定在正常范围，这 种毒性作用可被逆转，休眠的β细胞有望重新被激活，甚至部分功能得以恢复。因此，糖尿病并非终身不可治愈，关键在于抓住逆转的 黄金窗口期，通过精准控糖、代谢调节和生活方式干预，实现病情的有效缓解。这一发现为糖尿病患者带来了新的希望，也强调了早期 干预和长期管理的重 ...

Core Viewpoint - The article emphasizes the potential of strawberries as a dietary intervention for managing prediabetes and improving metabolic health, supported by clinical research findings that demonstrate significant benefits in blood sugar control and cardiovascular health indicators [4][11][17]. Group 1: Clinical Research Findings - A recent clinical study published in *The Journal of Nutrition* indicates that consuming 2.5 servings of strawberries daily for 12 weeks significantly improves blood glucose metabolism and various cardiovascular metabolic indicators in adults with prediabetes [4][11]. - The study involved a randomized controlled trial design, confirming a causal relationship between strawberry intake and metabolic improvements, rather than mere correlation [4][9]. - Key metabolic improvements observed include an average reduction of 8.9 mg/dl in fasting blood glucose, a 0.2% decrease in glycated hemoglobin, and a 6.9 μIU/ml reduction in serum insulin levels [11]. Group 2: Mechanisms of Action - Strawberries contain various bioactive compounds, such as anthocyanins and ellagic acid, which may enhance insulin sensitivity and reduce chronic inflammation, critical factors in the development of type 2 diabetes [4][13]. - The health benefits of strawberries are attributed to their high polyphenol content, which exhibits antioxidant properties, reduces oxidative stress, and modulates inflammatory pathways [14][15]. - Strawberries also improve lipid metabolism by downregulating key enzymes involved in fat synthesis, leading to favorable changes in cholesterol levels [15]. Group 3: Practical Implications - From a public health perspective, strawberries could provide a palatable and sustainable dietary option for high-risk populations to prevent diabetes [5][17]. - Recommendations suggest a daily intake of approximately 250-300 grams of fresh strawberries for individuals with prediabetes, emphasizing the importance of incorporating them into a balanced diet [16]. - The article highlights the need for further research with larger sample sizes and longer observation periods to establish optimal intake levels and long-term effects of strawberries on metabolic health [5][16].