Core Viewpoint - The article emphasizes the significant rise in global diabetes prevalence, projecting over 1.3 billion cases by 2050, with annual healthcare costs reaching $1.5 trillion. It highlights the critical link between obesity and diabetes, advocating for weight management as a key strategy for disease reversal [5][6][8]. Summary by Sections Global Diabetes Trends - The number of diabetes patients is expected to exceed 1.3 billion by 2050, with healthcare expenditures soaring to $1.5 trillion annually. Type 2 diabetes is recognized as a leading chronic epidemic of the century [5]. Weight Management and Diabetes Reversal - Scientific weight loss can effectively halt disease progression, with over 50% of patients reversing their condition after losing more than 10 kg. The 2025 American Diabetes Management Guidelines prioritize weight management as a first-line treatment for Type 2 diabetes [6][7]. New Clinical Guidelines - The American College of Lifestyle Medicine released the first global clinical guidelines for Type 2 diabetes and prediabetes, emphasizing lifestyle interventions as core strategies. Six key pillars are identified: scientific nutrition, regular exercise, stress management, quality sleep, healthy social connections, and avoidance of harmful substances [7][11]. Evidence of Reversal - Recent consensus redefines diabetes treatment, indicating that patients can achieve remission after stopping medication for over three months while maintaining stable blood sugar levels. This challenges the notion of lifelong medication dependency [8][9]. Impact of Weight Loss on Reversal Rates - Studies show that weight loss significantly increases the likelihood of diabetes reversal: an 86% reversal rate for those losing over 15 kg, 57% for 10-15 kg, and 34% for 5-10 kg [9][10]. Recommended Weight Loss Goals - Experts recommend a 10% weight loss target for diabetes remission, achievable through a daily caloric deficit of 500-1000 kcal. Various dietary patterns, including Mediterranean and low-carb diets, can support this goal [10]. Six Core Intervention Strategies 1. **Scientific Nutrition**: Focus on low glycemic index foods, balanced macronutrient intake, and sufficient dietary fiber [12]. 2. **Exercise Prescription**: At least 150 minutes of moderate-intensity aerobic exercise weekly, combined with resistance training [13]. 3. **Psychological Adjustment**: Address chronic stress through cognitive behavioral therapy and relaxation techniques [14]. 4. **Sleep Optimization**: Aim for 7-8 hours of quality sleep to enhance insulin sensitivity [15]. 5. **Social Support**: Strong social networks improve treatment adherence and metabolic outcomes [16]. 6. **Avoiding Harmful Substances**: Smoking cessation and alcohol moderation are essential for metabolic health [18]. Long-term Benefits - Implementing these strategies can lead to over 60% remission rates within a year, with some patients achieving up to 86% reversal rates. This shift from medication-based management to lifestyle interventions represents a significant advancement in diabetes care [18].

Core Insights - ADM showcased its innovative health solutions at the 15th China International Health Products Exhibition, emphasizing its commitment to future health and scientific empowerment [1][3] - The company introduced two new probiotic combinations, Balance and Restore, to enhance its scientific nutrition product lineup [1][7] Industry Trends - There is a growing consumer demand for functional nutrition, particularly in areas such as weight management, emotional balance, immune support, and gut health [3] - The HNC event serves as a significant platform for industry collaboration and exploration of future nutritional science [3] Product Offerings - ADM presented a range of clinically supported nutritional solutions targeting key health areas for Chinese consumers, including metabolic health, gut health, emotional health, and skin health [4][5] - Specific solutions include probiotics and postbiotics aimed at managing visceral fat, blood sugar levels, and enhancing gut health across various age groups [4][5] Innovation and Technology - The company highlighted its innovative delivery technology, Flashmelt, which offers a superior taste experience and convenience for probiotic consumption [8] - ADM has established a comprehensive turnkey service platform in China, facilitating the entire process from target definition to commercialization [10] Local Development and Global Integration - Celebrating its 30th anniversary in China, ADM has built a robust local strategy encompassing research, innovation, and manufacturing [12] - The company has successfully integrated global innovations into the Chinese market, exemplified by the approval of the DE111 probiotic strain for food use in China [12] Strategic Vision - ADM aims to provide more than just raw materials by leveraging scientific validation and local R&D to enhance product value and reduce development cycles [13]

Core Viewpoint - China has the highest number of overweight and obese individuals globally, with over half of the adult population affected, leading to significant health concerns and potential market opportunities for weight loss solutions [1][2]. Group 1: Obesity Statistics - As of 2021, 16.4% of adults in China are classified as obese, while 34.3% are overweight, totaling approximately 532 million individuals, with nearly 100 million being obese [1]. - A 2020 study predicts that by 2030, the number of overweight adults in China will reach 540 million, and the obese population will increase to 150 million, representing growth of 2.8 times and 7.5 times, respectively, since 2000 [1]. Group 2: Medication Usage and Compliance - Semaglutide, a GLP-1 receptor agonist, has transformed the weight loss market, but many users discontinue its use after a period [2]. - Research indicates that 44% of patients remain on semaglutide after three months, 33% after six months, and only 19% after one year. In contrast, 63%, 56%, and 40% of semaglutide users continue after three months, six months, and one year, respectively [4]. Group 3: Effects of Discontinuation - A clinical trial showed that participants lost an average of 10.6% of their body weight during 20 weeks of semaglutide treatment, but those who switched to a placebo regained an average of 6.9% of their weight, while those who continued with semaglutide lost an additional 7.9% [5]. - An observational study found that 18% of patients regained their lost weight after one year off semaglutide, with 26% regaining more than 25% of their lost weight, while 56% maintained or continued to lose weight [5]. Group 4: Reasons for Discontinuation - Common side effects of GLP-1RA drugs include nausea, diarrhea, and vomiting, which may lead to discontinuation. Even at low doses, 17% of patients reported nausea, with higher rates of gastrointestinal issues at increased doses [6]. - Supply issues have also contributed to discontinuation, as semaglutide has been in short supply since 2022 [7]. - Other reasons for stopping include reaching a weight loss plateau or achieving target weight [9][10]. Group 5: Recommendations for Discontinuation - Gradual dose reduction is recommended to minimize rebound hunger and maintain weight loss. Patients should monitor their appetite and weight closely after discontinuation [11][14]. - Maintaining a healthy lifestyle post-medication is crucial to prevent weight regain, as obesity is a chronic condition requiring ongoing management [22]. Group 6: Lifestyle Management - The latest Chinese weight loss guidelines emphasize lifestyle interventions, including dietary management, exercise, and behavioral changes, as essential for long-term weight management [15]. - Dietary management aims to reduce caloric intake while improving metabolic health, with various dietary patterns showing short-term weight loss effects [16][18]. - Exercise plays a significant role in maintaining weight loss and improving quality of life, despite only achieving modest weight reductions on its own [19]. - Behavioral management is critical for successful weight loss, with structured programs showing significant weight reduction in the initial months [20][21].