Core Viewpoint - Chongqing Zhixiang Jintai Biopharmaceutical Co., Ltd. has received approval from the National Medical Products Administration for the clinical trial of its product, Sileweimi Monoclonal Antibody Injection, aimed at passive immunity for children and adolescents aged 2 to 18 suspected of rabies virus exposure [1][2]. Group 1: Drug Information - The drug Sileweimi Monoclonal Antibody Injection is a recombinant fully human bispecific antibody targeting the rabies virus (Rabies Virus, RABV) [2]. - It is classified as a Class 1 therapeutic biological product, with its action target being the glycoprotein (G protein) of RABV [2]. - The drug employs scFv+Fab structure and KIH technology to address heavy chain mismatch issues, and scFv fusion technology to resolve light chain mismatch issues [2]. - It is the world's first bispecific antibody for passive immunity against rabies, designed to ensure effectiveness against different strains or genotypes of the virus [2]. Group 2: Clinical Trial Approval - The clinical trial application for Sileweimi Monoclonal Antibody Injection has been approved for the indication of passive immunity in children and adolescents aged 2 to 18 suspected of rabies virus exposure [1][2]. - The approval is in accordance with the relevant requirements for drug registration under the Drug Administration Law of the People's Republic of China [1]. Group 3: Market Context - As of the announcement date, Sileweimi Monoclonal Antibody Injection is under review for new drug marketing application for adult passive immunity against suspected rabies virus exposure [2]. - Currently, only two rabies virus antibody drugs have been approved for marketing in China [2].

Group 1 - The company expects a net loss attributable to shareholders of the parent company for the first half of 2025 to be between -110 million and -140 million yuan, representing a reduction in loss of 96.84 million to 126.84 million yuan compared to the same period last year [2] - The expected net loss attributable to shareholders after deducting non-recurring gains and losses is projected to be between -160 million and -190 million yuan, indicating a reduction in loss of 80.33 million to 110.33 million yuan [2] - The previous year's net loss attributable to shareholders was -236.85 million yuan, with a net loss after deducting non-recurring gains and losses of -270.33 million yuan [4] Group 2 - The company anticipates a decrease in losses due to increased market expansion, with sales of Adalimumab injection (Geleli) expected to rise, contributing an additional revenue of 20 million to 50 million yuan compared to the previous year [6] - Research and development expenses are expected to decrease by 40 million to 70 million yuan compared to the previous year, primarily because several R&D projects have completed Phase III clinical trials, with BAT2206, BAT2306, and BAT2506 currently in the application stage for market approval [6] - BAT2206 has already received FDA approval for market launch in the United States, which has contributed to the reduction in R&D expenses [6]

每经讯，2025年7月29日，北交所上市公司三元基因（837344，收盘价：34.84元）登上龙虎榜，交易方式是连续竞价，披露原因 是当日收盘价涨幅达到20.76%，成交数量1438.74万股，成交金额4.83亿元。买一席位为国金证券股份有限公司深圳分公司，买 入1112.04万元；卖一席位为国泰海通证券股份有限公司深圳海岸城海德三道营业部，卖出1367.66万元。 | | 2025-07-29三元基因(837344) 龙虎榜 | | | | --- | --- | --- | --- | | 序号 | 交易营业部名称 | 买入金额(元) | 卖出金额(元) | | ポリ | 国金证券股份有限公司深圳分公司 | 11120395.2 | 5765598.34 | | 买2 | 机构专用 | 9274827.26 | 4197721.83 | | 考3 | 国联民生证券股份有限公司国联民生证券北京分公司 | 8837973.24 | 0 | | 买4 | 国信证券股份有限公司深圳红岭中路证券营业部 | 8127951.58 | 6179868.15 | | ન્નેર | 东方财富证券股份有限公司拉萨团结路第二 ...

Core Viewpoint - Astaxanthin, a highly effective antioxidant pigment, is gaining attention for its applications in food, cosmetics, and pharmaceuticals, with a recent study demonstrating a high-yield production system using Schizochytrium for both astaxanthin and DHA [1][3]. Group 1: Research Findings - The study reported an increase in astaxanthin content from 7.56 μg/g to 55.17 μg/g through electroporation-induced color screening [2]. - Further enhancement of astaxanthin content to 374.85 μg/g was achieved by overexpressing five key genes involved in the astaxanthin synthesis pathway [2]. - The final engineered strain produced astaxanthin at a yield of 29.53 mg/L (1.913 mg/g DCW) while maintaining DHA production at 3.83 g/L, constituting 45% of total lipid content [2]. Group 2: Implications for Industry - The reported astaxanthin yield represents the highest level achieved in Schizochytrium to date, laying a foundation for the commercial scalability of astaxanthin biosynthesis [3]. - The advancements in metabolic engineering and mutagenesis techniques highlight the potential for increased production efficiency in the biotechnology sector [1][3]. Group 3: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, focusing on AI and bio-manufacturing, green chemistry, new materials, future food, and agriculture [6][8]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on AI-enabled innovations in bio-manufacturing [6][7].

Core Viewpoint - The Hang Seng Index fell by 0.15% to close at 25,524.45 points on July 29, with a net inflow of HKD 12.72 billion through the southbound trading channel [1] Group 1: Market Activity - The total trading volume for the southbound trading on July 29 was HKD 155.49 billion, with a net buy of HKD 12.72 billion [1] - The Shanghai Stock Exchange's southbound trading accounted for HKD 98.34 billion in trading volume, with a net buy of HKD 5.88 billion, while the Shenzhen Stock Exchange had a trading volume of HKD 57.15 billion and a net buy of HKD 6.84 billion [1] Group 2: Active Stocks - The most actively traded stock on the Shanghai Stock Exchange was Xiaomi Group-W, with a trading volume of HKD 5.36 billion, followed by Guotai Junan International and Tencent Holdings, with trading volumes of HKD 4.15 billion and HKD 3.00 billion, respectively [2] - In terms of net buying, Tencent Holdings led with a net buy of HKD 1.06 billion, despite its stock price closing down by 0.09% [1][2] - The stock with the highest net sell was Pop Mart, with a net sell of HKD 272 million, while its stock price increased by 5.91% [1][2] Group 3: Detailed Stock Data - The top ten actively traded stocks on the Shenzhen Stock Exchange included Xiaomi Group-W with a trading volume of HKD 3.00 billion and a net buy of HKD 670 million, despite a closing drop of 2.64% [2] - Meituan-W had the highest net sell amount of HKD 509 million, with a closing price decrease of 0.62% [2] - Other notable stocks included Alibaba-W and Southbound Hang Seng Technology, with trading volumes of HKD 2.24 billion and HKD 1.67 billion, respectively [2]

| 成交量 | 成交金 | 成交价 | 相对当日收盘 | | | | --- | --- | --- | --- | --- | --- | | （万 | 额（万 | 格 | 折溢价（%） | 买方营业部 | 卖方营业部 | | 股） | 元） | （元） | | | | | 26.00 | 795.60 | 30.60 | -20.25 | 国海证券股份有限公司机构 | 国投证券股份有限公司深 | | | | | | 席位 | 圳宝安海秀路证券营业部 | | 25.00 | 765.00 | 30.60 | -20.25 | 机构专用 | 国投证券股份有限公司深 | | | | | | | 圳宝安海秀路证券营业部 | | 24.50 | 749.70 | 30.60 | -20.25 | 机构专用 | 国投证券股份有限公司深 | | | | | | | 圳宝安海秀路证券营业部 | | 15.50 | 474.30 | 30.60 | -20.25 | 机构专用 | 国投证券股份有限公司深 | | | | | | | 圳宝安海秀路证券营业部 | | 15.00 | 459.00 | 30.60 | -20.2 ...

Summary of Key Points Core Viewpoint - Yifang Bio conducted five block trades on July 29, totaling 1 million shares and a transaction amount of 40.69 million yuan, with a trading price of 40.69 yuan, reflecting a discount of 13.43% compared to the closing price of the day [2]. Trading Activity - The total transaction amount for the five block trades was 40.69 million yuan, with a net buying amount of 40.69 million yuan from institutional special seats [2]. - Over the past three months, Yifang Bio has recorded 39 block trades, with a cumulative transaction amount of 223 million yuan [2]. Stock Performance - The closing price of Yifang Bio on the day was 47.00 yuan, marking an increase of 5.10%, with a turnover rate of 2.79% and a total transaction amount of 547 million yuan [2]. - The net inflow of main funds for the day was 46.59 million yuan, and over the past five days, the stock has increased by 5.36% with a total net inflow of 6.02 million yuan [2]. Margin Trading Data - The latest margin financing balance for Yifang Bio is 12.9 million yuan, which has decreased by 2.43 million yuan over the past five days, representing a decline of 15.91% [2].

2024年1至12月份，成大生物的营业收入构成为：生物制药占比100.0%。 （文章来源：每日经济新闻） 成大生物（SH 688739，收盘价：28.57元）7月29日晚间发布公告称，辽宁成大生物股份有限公司崔建 伟先生因工作职责调整原因，不再担任公司董事会秘书职务，仍继续担任公司董事、副总经理及财务总 监职务。为确保公司董事会的日常运作及公司信息披露等工作的有序开展，经公司董事长提名、董事会 提名委员会审查，同意聘任李业基先生为公司董事会秘书。 ...

Group 1 - The company, Zhixiang Jintai (688443.SH), has received approval from the National Medical Products Administration for the clinical trial of its product, Sileweimi Monoclonal Antibody Injection [1] - The clinical trial is aimed at evaluating the passive immunity indication for children and adolescents aged 2 to 18 years who are suspected of rabies virus exposure [1]

Core Viewpoint - Shanghai Pharmaceuticals announced that its subsidiary, Shanghai Pharmaceuticals Group Biotherapy Technology Co., Ltd., has received approval from the National Medical Products Administration for clinical trials of its self-developed drug "B019" for the treatment of refractory systemic lupus erythematosus [1] Group 1 - B019 injection is a chimeric antigen receptor T-cell injection targeting CD19 and CD22, aimed at treating refractory systemic lupus erythematosus [1] - The project has accumulated research and development expenses of approximately 149,000 RMB for this new indication [1]