（原标题：科创板股破发幅度榜 最高破发75.93%） | 代码 | 简称 | 上市日期 | 发行价（元） | 最新收盘价（元） | 较发行价 | | --- | --- | --- | --- | --- | --- | | | | | | | 折溢价（%） | | 688184 | ST帕瓦 | 2022.09.19 | 51.88 | 10.30 | -75.93 | | 688739 | 成大生物 | 2021.10.28 | 110.00 | 27.33 | -72.26 | | 688275 | 万润新能 | 2022.09.29 | 299.88 | 59.17 | -70.07 | | 688033 | 天宜新材 | 2019.07.22 | 20.37 | 6.94 | -65.40 | | 688185 | 康希诺 | 2020.08.13 | 209.71 | 74.55 | -64.27 | | 688211 | 中科微至 | 2021.10.26 | 90.20 | 31.95 | -63.92 | | 688137 | 近岸蛋白 | 2022.09.29 | 106.19 | 41. ...

【环球网财经综合报道】10月22日，上市公司成大生物（688739.SH）发布公告称，与中国科学院微生 物研究所签署《战略合作协议》。双方聚焦新发突发传染病领域，重点围绕虫媒传染病预防，联合申报 国家级、省部级科研项目，协同发力应对传染病防控。 同时，成大生物也在全力推进疫苗出海战略。今年上半年，公司加强与埃及、泰国和孟加拉等进口国经 销商的合作力度与产品海外注册准入工作，成功获得印尼市场准入，积极拓展巴西等市场容量较大的国 家和地区，全力开拓国际市场。2025年上半年，公司实现境外收入1.23亿元，同比增长26.96%。 值得关注的是，今年7月，成大生物刚与中国科学院自动化所孵化的AI大模型中科紫东太初（北京）科 技有限公司签订合作协议。双方决定联合共建"AI+疫苗研发联合实验室"，通过 AI 技术的逐步应用， 推动公司科研范式升级，为公司在多品类疫苗研发领域的持续创新注入强劲动力。 公司相关人士在接受环球网记者采访时强调："公司将继续专注人用疫苗主业，同时将发展视野外延至 创新药、创新疗法等领域，密切关注生物医药技术创新动态，通过实施积极的产业投资拓展策略，全力 以赴筛选具备投资价值和发展潜力的新项目和新 ...

| 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | --- | --- | --- | --- | --- | --- | | 688293 | 奧浦迈 | 55.19 | -4.40% | 2.11万 | 1.18亿 | | 300357 | 我武生物 | 31.63 | -3.18% | 10.07万 | 3.23亿 | | 688336 | 三生国健 | 59.60 | -2.39% | 7.34万 | 4.41亿 | | 000534 | 万泽股份 | 15.89 | -2.09% | 1 5.99万 | 9597.12万 | | 688331 | 荣昌生物 | 95.10 | -2.06% | 8.00万 | 7.91亿 | | 603590 | 康辰药业 | 49.56 | -1.84% | 2.32万 | 1.17亿 | | 600211 | 西藏药业 | 46.94 | -1.66% | 4.30万 | 2.03亿 | | 688278 | 特宝生物 | 77.31 | -1.58% | 1.75万 | 1.36亿 | | 002773 | 康弘药业 | + ...

丨2025年10月22日星期三丨 NO.1 浩欧博：公司近期与罗氏诊断签署框架协议 10月21日，浩欧博公告，公司近期与罗氏诊断产品（上海）有限公司签署框架协议，合作内容为罗氏诊 断采购浩欧博化学发光自身抗体检测产品并在中国进行商业推广。该协议为框架协议，不涉及具体金 额，是双方相互合作项目的基础和指导性文件。具体的交易细节需要双方在后期签署的正式合同或协议 中另行约定，预计不会对浩欧博本年度的业绩及经营成果产生重大影响。 点评：与罗氏诊断合作有利于增强浩欧博在本土市场的品牌认可度、拓展市场份额，但由于是框架协议 不涉及具体金额，该利好消息对股价的提振作用可能有限。 NO.2 成大生物：与中国科学院微生物所达成战略合作，协同发力应对传染病防控 10月21日，成大生物公告，公司与中国科学院微生物研究所（以下简称"微生物所"）近日签署《战略合 作协议》，双方聚焦新发突发传染病领域，重点围绕虫媒传染病预防，联合申报国家级、省部级科研项 目，协同发力应对传染病防控。该协议属于意向性合作范畴，对公司2025年度及未来业绩不构成直接影 响。 10月21日，国药股份发布公告称，2025年前三季度营收约393.81亿元，同比 ...

Core Viewpoint - The announcement details a strategic cooperation agreement between Liaoning Chengda Biological Co., Ltd. and the Institute of Microbiology, Chinese Academy of Sciences, focusing on the prevention of vector-borne infectious diseases and collaborative research projects [2][15]. Group 1: Agreement Overview - The strategic cooperation agreement is an intention-based collaboration aimed at addressing emerging infectious diseases, particularly vector-borne diseases [2][10]. - The agreement was signed on October 21, 2025, in Shenyang, Liaoning Province [5]. - The agreement does not require board or shareholder approval, as it is an intention-based agreement [7][8]. Group 2: Parties Involved - The Institute of Microbiology is a research institution with a registered capital of 63.23 million yuan, located in Beijing [4]. - There is no related party relationship between the Institute of Microbiology and Chengda Biological [4]. Group 3: Cooperation Details - The cooperation will focus on joint research projects, strategic consulting for disease prevention, and deep integration of industry and academia [10][11]. - A joint laboratory will be established to support the development of a key laboratory for synthetic immunology and vaccine manufacturing [11]. - Both parties will share knowledge and conduct training to enhance technological capabilities in the field of infectious disease prevention [11]. Group 4: Impact on Company - The collaboration is expected to integrate top resources from the Institute of Microbiology with the company's vaccine development platform, accelerating the research and development of vaccines and biopharmaceuticals [15]. - The partnership aligns with the company's long-term strategy to focus on vaccines and expand into the biopharmaceutical sector, laying a solid foundation for building a biopharmaceutical industry cluster [15]. - The agreement is not expected to have a direct impact on the company's performance in 2025, with specific effects dependent on future project developments [2][15].

Core Insights - Company signed a strategic cooperation agreement with the Institute of Microbiology, Chinese Academy of Sciences, focusing on emerging infectious diseases and vector-borne disease prevention [2][3] - The collaboration aims to leverage both parties' resources and expertise to enhance research and development in vaccine and biopharmaceuticals [3] Group 1: Strategic Collaboration - The agreement emphasizes joint applications for national and provincial research projects to secure government support and resources [2] - Both parties will establish a long-term partnership to share resources and amplify their efforts in infectious disease prevention [2][3] Group 2: Research and Development Focus - The collaboration will enhance the company's vaccine development platform by integrating top-tier resources from the Institute of Microbiology [3] - The partnership aims to accelerate the R&D process for vaccines and biopharmaceuticals targeting emerging infectious diseases [3] Group 3: Intellectual Property and Confidentiality - Each party retains ownership of their respective intellectual property, with jointly developed results being co-owned as per specific agreements [3] - Both parties will maintain confidentiality regarding project details and proprietary technologies throughout the collaboration [3] Group 4: Long-term Strategy - The strategic cooperation aligns with the company's long-term strategy to focus on vaccines while expanding into the biopharmaceutical sector [3] - The agreement is considered an intention for collaboration and is not expected to have a direct impact on the company's performance until specific projects are advanced [3]

Core Viewpoint - Chengda Bio (688739) has signed a strategic cooperation agreement with the Institute of Microbiology, Chinese Academy of Sciences, focusing on the prevention of emerging infectious diseases, particularly vector-borne diseases, and aims to jointly apply for national and provincial research projects [1][2]. Group 1: Strategic Cooperation - The agreement emphasizes collaboration in the field of emerging infectious disease prevention, leveraging both parties' resources and expertise to enhance research and development efforts [1]. - Chengda Bio and the Institute of Microbiology will establish a long-term partnership to share resources and amplify their respective strengths in vaccine and biopharmaceutical development [1][2]. Group 2: Research and Development Focus - The collaboration will focus on joint research projects targeting vector-borne disease prevention, with plans to apply for government support and resources to foster innovation [1]. - The strategic partnership aims to accelerate the development of vaccines and biopharmaceuticals for emerging infectious diseases, enriching Chengda Bio's innovation pipeline [2]. Group 3: Intellectual Property and Confidentiality - Each party retains ownership of their respective intellectual property, with jointly developed project outcomes being co-owned as per specific agreements [2]. - Both parties will maintain confidentiality regarding project details and proprietary technologies throughout the collaboration [2].

证券日报网讯 10月21日晚间，成大生物发布公告称，公司与中国科学院微生物研究所于近日签署《战 略合作协议》，双方聚焦新发突发传染病领域，重点围绕虫媒传染病预防，联合申报国家级、省部级科 研项目，协同发力应对传染病防控。 （文章来源：证券日报） ...

Core Viewpoint - The strategic cooperation agreement between Chengda Biological and the Institute of Microbiology focuses on addressing emerging infectious diseases, particularly vector-borne diseases, through joint research and project applications for national and provincial funding [1][2][4]. Company Overview - Chengda Biological is a biopharmaceutical company specializing in the research, production, and sales of human vaccines, with a leading market position in rabies and Japanese encephalitis vaccines in China [1]. - The company has established production bases in Shenyang and Benxi, and has a dedicated R&D team of over 200 personnel, with independent research capabilities and a comprehensive management system [1]. Research Collaboration - The collaboration aims to leverage the strengths of both parties, combining the Institute's research capabilities with Chengda's development and production resources to enhance vaccine and biopharmaceutical research [2][4]. - The focus will be on joint applications for national and provincial research projects to secure government support and resources, fostering innovation and high-quality industrial development [2][3]. Strategic Goals - The partnership is expected to accelerate the development of vaccines and biopharmaceuticals for emerging infectious diseases, enriching Chengda's innovation pipeline and strengthening its core competitiveness in the field of infectious disease prevention [4]. - The agreement is characterized as an intention-based collaboration, with no immediate impact on the company's financial performance for 2025, as the effects will depend on the progress of specific projects [4].

Group 1 - Pinggao Electric reported a 6.98% increase in revenue to 8.436 billion yuan and a 14.62% increase in net profit to 982 million yuan for the first three quarters of 2025 [1] - Wanchen Group achieved a 77.37% increase in revenue to 36.562 billion yuan and a staggering 917.04% increase in net profit to 855 million yuan for the first three quarters of 2025 [2] - Xintian's revenue decreased by 10.42% to 481 million yuan, with a net profit decline of 35.19% to 91.9 million yuan for the first three quarters of 2025 [3] Group 2 - Chuangye Heima reported a revenue drop of 35.68% to 102 million yuan and a net loss of 24.93 million yuan for the first three quarters of 2025 [4] - Huaxin New Materials saw a 16.11% increase in revenue to 265 million yuan and an 18.56% increase in net profit to 40.81 million yuan for the first three quarters of 2025 [5] - Meihua Medical's revenue increased by 3.28% to 1.194 billion yuan, but net profit fell by 19.25% to 208 million yuan for the first three quarters of 2025 [6] Group 3 - Silica Technology reported a 24.30% increase in revenue to 2.651 billion yuan and a 44.63% increase in net profit to 229 million yuan for the first three quarters of 2025 [7] - Anada experienced a revenue decline of 6.03% to 1.31 billion yuan and a net loss of 46.37 million yuan for the first three quarters of 2025 [8] - StarNet Ruijie achieved a 19.20% increase in revenue to 14.168 billion yuan and a 31.06% increase in net profit to 344 million yuan for the first three quarters of 2025 [9] Group 4 - New Link Electronics reported a revenue decrease of 0.37% to 550 million yuan but a significant net profit increase of 421.43% to 535 million yuan for the first three quarters of 2025 [10] - Tianyin Electromechanical's revenue fell by 22.75% to 581 million yuan, with a net profit decline of 56.10% to 24.27 million yuan for the first three quarters of 2025 [11] - Hengtong Co. reported a revenue decrease of 39.29% to 1.05 billion yuan, but a net profit increase of 78.33% to 176 million yuan for the first three quarters of 2025 [12] Group 5 - Xigao Institute achieved a 15.05% revenue increase to 651 million yuan and a 21.28% net profit increase to 198 million yuan for the first three quarters of 2025 [13] - Good Housewife reported a revenue decrease of 0.91% to 1.059 billion yuan and a net profit decline of 24.79% to 143 million yuan for the first three quarters of 2025 [14] - China Pharmaceutical's subsidiary received approval for Vitamin B6 injection, indicating a positive development in its product pipeline [20] Group 6 - Xi Zhong Technology received approval for the issuance of convertible bonds, indicating potential for future capital raising [22] - Chengda Bio signed a strategic cooperation agreement with the Chinese Academy of Microbiology, focusing on infectious disease prevention [25] - Fuyuan Pharmaceutical received a drug registration certificate for Dydrogesterone tablets, enhancing its product offerings [26] Group 7 - Zhehai Deman received 8.1202 million yuan in land acquisition compensation, indicating a successful resolution of land-related issues [27] - Zhongjin Irradiation announced the resignation of its deputy general manager, indicating potential changes in management [29] - Hendi Pharmaceutical received a drug registration certificate for Febuxostat tablets, expanding its product portfolio [30] Group 8 - David Medical's subsidiary received a medical device registration certificate for a surgical stapler, enhancing its product offerings [32] - Liaoning Energy announced plans for a share reduction by a major shareholder, indicating potential changes in ownership structure [34] - Fengyuan Co. signed a framework agreement for the supply of lithium iron phosphate, indicating growth in its supply chain [35] Group 9 - Shengda Resources announced the resumption of construction at a mining site, indicating recovery from previous operational disruptions [37] - Shiyuan Co. reported a revenue increase of 5.45% to 18.087 billion yuan, but a net profit decline of 6.81% to 867 million yuan for the first three quarters of 2025 [39] - Feilida reported a revenue decrease of 6.81% to 4.659 billion yuan, but a net profit increase of 49.1% to 33.19 million yuan for the first three quarters of 2025 [40] Group 10 - Changyuan Donggu reported a revenue increase of 29.75% to 1.648 billion yuan and a net profit increase of 76.71% to 274 million yuan for the first three quarters of 2025 [41] - Liyuanheng reported a net profit of 47.49 million yuan for the first three quarters of 2025, indicating stable performance [42] - Fangyuan Co. reported a net loss of 121 million yuan for the first three quarters of 2025, indicating challenges in its operations [43] Group 11 - China Mobile reported a revenue increase of 0.4% to 794.7 billion yuan and a net profit increase of 4% to 115.4 billion yuan for the first three quarters of 2025 [44] - Huangshanghuang reported a revenue decrease of 5.08% to 1.379 billion yuan but a net profit increase of 28.59% to 101 million yuan for the first three quarters of 2025 [46] - Youcai Resources announced plans to invest approximately 150 million yuan in a new materials production base project [47] Group 12 - Huawei Technology announced plans to invest up to 20 million euros in two German subsidiaries [49] - China Shipbuilding projected a net profit increase of 144.42% to 170.85% for the first three quarters of 2025, indicating strong performance [51] - Aeston's subsidiary plans to transfer a 48% stake in a company for 245 million yuan, indicating strategic divestment [52] Group 13 - Jinxinno plans to raise up to 292 million yuan through a private placement, indicating potential for expansion [53] - China Power Construction reported a 5.04% increase in new contract amounts to 904.527 billion yuan for the first three quarters of 2025 [54] - Helitai reported a net profit increase of 101.45% to 17.81 million yuan for the first three quarters of 2025 [55] Group 14 - Xuefeng Technology reported a revenue decrease of 8.28% to 4.183 billion yuan and a net profit decline of 34.6% to 394 million yuan for the first three quarters of 2025 [57] - Juzhi Technology reported a revenue increase of 21.40% to 615 million yuan and a net profit increase of 33.78% to 82.47 million yuan for the first three quarters of 2025 [59] - Jinxi Axle reported a revenue decrease of 0.11% to 872 million yuan but a net profit increase of 268.03% to 22.11 million yuan for the first three quarters of 2025 [60] Group 15 - Longsheng Technology reported a revenue increase of 10.13% to 1.810 billion yuan and a net profit increase of 36.89% to 210 million yuan for the first three quarters of 2025 [62] - Shannon Chip Creation announced plans for a share reduction by a major shareholder, indicating potential changes in ownership structure [63]