Group 1 - The cryptocurrency market is experiencing a significant downturn, with Bitcoin dropping below $103,000 and Ethereum falling below $3,410, leading to over 150,000 liquidations totaling $506 million in the past 24 hours [1] - The recent sell-off is attributed to short-term holders facing pressure as Bitcoin prices remain below the average cost of $110,000, prompting increased selling activity [1] - Analysts indicate that this sell-off is one of the most intense since 2025, suggesting forced liquidations or panic selling due to leveraged positions [1] Group 2 - Some analysts believe that the rapid decline in Bitcoin's price in November is driven by profit-taking, macroeconomic uncertainty, and institutional rebalancing rather than a fundamental collapse [2] - Despite bearish technical indicators and ETF outflows, structural bull market support remains from ETF inflows, infrastructure investments, and clearer regulatory policies [2] - Blockchain data analysis platform Glassnode suggests that Bitcoin's upside potential is limited, indicating a critical turning point with cautious but improving market conditions [2]

Market Operations on Veterans Day - The US stock market, including the New York Stock Exchange (NYSE) and Nasdaq, will remain open on Veterans Day, November 11, operating from 9:30 am to 4 pm Eastern time [2][4] - The bond market will be closed on Veterans Day, following a schedule set by the Securities Industry and Financial Markets Association (SIFMA), which includes a pause in Treasury trading and other bond activities [3][4] Upcoming Market Closures - The next market closure will occur for Thanksgiving on November 27, with trading resuming on November 28, but with early closures at 1 pm for stocks and 2 pm for bonds [9] - Markets will also close early on December 24, with stocks closing at 1 pm and bonds at 2 pm, before shutting completely for Christmas Day on December 25 [10] Crypto Market Operations - The crypto market will continue to operate 24/7, including on Veterans Day, without any interruptions [11]

Core Insights - The cryptocurrency market is currently experiencing significant volatility, with Bitcoin's price struggling around $100,000, contrary to earlier predictions of reaching $200,000 by the end of 2025 [1][2] - The total crypto market has lost approximately $800 billion in value, representing a decline of about 19% [1] - Analysts have revised their price forecasts downward, with Galaxy Digital now predicting Bitcoin may only reach $120,000 before 2026, down from an earlier estimate of $185,000 [4] Market Sentiment - Market sentiment has shifted negatively, with traders feeling the impact of recent market events, including a significant crash on October 10 that resulted in $20 billion in liquidations and a $128 million hack on November 3 [4] - The psychological threshold of $100,000 is being closely monitored, as it is both technically significant and a major psychological barrier for traders [2] - Long-term investors are reportedly locking in profits based on a perceived four-year cycle, contributing to the downward pressure on prices [5] Consumer Confidence - Broader consumer sentiment in the U.S. has also declined, reaching near-record lows due to rising inflation, unemployment, and ongoing economic challenges, including trade wars and a prolonged government shutdown [6]

Core Insights - Bitcoin has recently fallen below the $100,000 mark for the first time in six months, leading to a shift in market sentiment among traders and predictors [1][4] - The price of Bitcoin has decreased nearly 20% from its all-time high of over $126,000, now trading at approximately $101,261 [2][4] - Predictions for Bitcoin reaching a new all-time high before the end of the year have turned bearish, with the odds of it not achieving this milestone rising to 66% [3] Market Dynamics - Analysts at Galaxy have revised their year-end price target for Bitcoin from $185,000 to $120,000, indicating a shift towards more gradual growth [4] - The recent market uncertainty and record-breaking crypto liquidations have contributed to the bearish sentiment among investors [2][4] - Technical analysis suggests that while bearish exhaustion may be waning, it is not sufficient for a strong breakout in Bitcoin's price [5] Investment Opportunities - Investors looking to hedge their bets on Bitcoin can earn around 33% based on current odds if Bitcoin does not reach a new all-time high this year [5] - Potential catalysts for Bitcoin's price recovery could include an end to the government shutdown or increased certainty regarding a December rate cut [5] Other Market Movements - Zcash holders have experienced less volatility compared to other cryptocurrencies, with a market inquiry regarding its price performance upcoming [6]

Core Insights - Ethereum (ETH) experienced a significant price drop of over 12% in early November, reaching a low of around $3,000, which is its lowest point in nearly four months [1][2] - Major holders, referred to as "whales," have aggressively bought the dip, accumulating approximately $1.37 billion worth of ETH over three days, indicating strong confidence among large investors [1][3] - The average buying price during this accumulation was $3,462, with notable purchases from entities like an "Aave whale" and Bitmine Immersion Technologies [3][4] Accumulation by Major Holders - Eight major entities collectively purchased 394,682 ETH valued at around $1.37 billion during the recent downturn [3] - The largest buyer, an "Aave whale," acquired 257,543 ETH for approximately $896 million [3] - Bitmine Immersion Technologies, the second-largest buyer, purchased 40,719 ETH for about $139.6 million, continuing its strategy of accumulating ETH during market dips [4][5] Market Behavior and Trends - Ethereum exchange reserves have dropped to their lowest level since 2016, suggesting that investors are moving their holdings into long-term storage, which may reduce selling pressure and support potential price increases [6] - On-chain analytics from Santiment indicate that Ethereum is signaling a strong buying opportunity based on the Market Value to Realized Value (MVRV) metric, with traders currently facing average losses of 12.8% [7]

Group 1 - The crypto market is experiencing a significant downturn, with Bitcoin nearing levels not seen since June, indicating a potential full retracement of gains made in Q3 and early Q4 [1][2] - Over the last 24 hours, more than $550 million in Bitcoin has been liquidated, contributing to a total of nearly $1.8 billion lost across all crypto markets [1] - Bitcoin is trading below the critical $100,000 level, which is seen as a pivotal price point for maintaining market confidence [2] Group 2 - Ethereum is facing a sharper decline than Bitcoin, approaching the $3,000 mark, which is its lowest level since July [3] - Traders are increasingly positioning for further declines, with December 26 expiry options showing rising volumes for puts below the $2,000 level, indicating bearish sentiment [3] - The market is under pressure from large sell orders, creating a reflexive situation that could exacerbate the downward trend unless positive news emerges [4]

Market Overview - The cryptocurrency market experienced significant turbulence, with total market capitalization declining by 4% over the past 24 hours, resulting in over $1.3 billion in liquidations, primarily from long positions [1][2][3] - The downturn in October was exacerbated by tariff-driven crashes, and November has started with continued poor performance, showing little sign of recovery [2] Liquidation Details - A total of 336,622 traders were liquidated in the past 24 hours, with $1.37 billion worth of leveraged positions wiped out [3][4] - Long positions accounted for $1.22 billion of the liquidations, with Bitcoin leading the losses at $406.94 million and Ethereum following with $356.34 million [4][5] Notable Trades - One trader, identified as an "Anti-CZ Whale," capitalized on the market decline by shorting various cryptocurrencies, achieving unrealized gains exceeding $36 million [6] - This trader has a reported total profit of nearly $100 million on the Hyperliquid platform, maintaining a 100% win rate across two wallets [7]

Core Insights - The ongoing U.S. government shutdown has entered its fifth week, causing significant economic impacts, with estimated losses ranging from $7 billion to $14 billion [1] - The shutdown has led to the suspension of key economic data releases, creating uncertainty in the macroeconomic environment and affecting risk assets, particularly the cryptocurrency market [1][3] - XBIT, a decentralized trading platform, has maintained stable operations during market volatility, highlighting the importance of reliable trading platforms in turbulent times [1][3][4] Economic Impact - The shutdown has resulted in 800,000 federal employees being furloughed, which has weakened consumer spending [1] - The Congressional Budget Office warns that if the shutdown continues into mid-November, it could significantly drag down U.S. GDP growth in Q4 [9] Cryptocurrency Market Reaction - The uncertainty from the shutdown has led to increased volatility in the cryptocurrency market, with Bitcoin experiencing a 1.97% drop on October 31 [3] - Over $1 billion in cryptocurrency contracts were liquidated within 24 hours, with Bitcoin accounting for over 60% of this figure, affecting more than 240,000 investors [3][7] XBIT Platform Performance - XBIT's decentralized exchange has demonstrated resilience during extreme market conditions, processing up to 1.8 million transactions in a single day while keeping Bitcoin trading slippage below 0.3%, significantly lower than the industry average of 1.2% [4][5] - The platform's risk warning system actively monitors market fluctuations and alerts users when Bitcoin's price drops over 10%, helping to mitigate the risk of liquidation [5] Market Trends and Investor Behavior - The recent events have highlighted the high sensitivity of the cryptocurrency market to macroeconomic conditions and the risks associated with high-leverage trading [7] - Data indicates that over 75% of liquidated users did not utilize the risk management tools provided by their platforms, suggesting a need for better investor education on risk management [7]

Core Insights - dYdX, a leading decentralized cryptocurrency trading platform, is set to enter the U.S. market by the end of the year, marking a significant shift for the derivatives-focused exchange that was previously unavailable to American users [1][4] Company Overview - dYdX specializes in perpetual contracts, allowing traders to speculate on asset prices without owning them, and has surpassed $1.5 trillion in total trading volume since its inception [3] - The platform aims to enhance its offerings by introducing spot trading for Solana and other linked cryptocurrencies in the U.S. by year-end [4] Market Context - The move by dYdX follows a favorable shift in the regulatory landscape for cryptocurrencies in the U.S., influenced by President Donald Trump's support for the sector, which has led to the dismissal of lawsuits against crypto platforms and the development of specialized rules for digital assets [5] - Upon entering the U.S. market, dYdX plans to reduce its trading fees by up to 50%, setting them between 50 and 65 basis points [5] Regulatory Environment - While perpetual contracts will not be available in the U.S. initially, dYdX is optimistic that U.S. regulators will eventually provide guidance to allow decentralized platforms to offer these products [6] - Recent statements from the U.S. Securities and Exchange Commission and the Commodity Futures Trading Commission suggest a potential future for crypto perpetual contracts on regulated platforms in the U.S. [6]

Table of Contents As filed with the Securities and Exchange Commission on October 29, 2025. Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Applied DNA Sciences, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) 50 Health Sciences Drive Stony Brook, New York 11 ...