王大成先生热爱祖国，对党忠诚，严于律己，治学严谨，拥有高瞻远瞩的战略眼光。他将毕生精力献给 了祖国的科学研究事业，桃李满天下，为我国结构生物学的开创与发展作出了杰出贡献。在中国生物物 理学会工作期间，他积极推动学会建设和学科发展，关心青年人才成长，并长期担任《生物化学与生物 物理进展》主编，为推动我国学术期刊的发展与学科交流发挥了重要作用。 王大成先生的逝世，是我国生命科学研究领域的重大损失。他的学术思想、组织贡献和育人精神，将长 久地影响和激励后来者。根据王大成先生家属意愿，丧事从简，不举行遗体告别仪式。 来源：中国生物物理学会 中国科学院生物物理研究所消息，王大成先生治丧工作委员会9月19日发布讣告：中国共产党党员，中 国科学院院士、分子生物物理学家、中国科学院生物物理研究所原副所长、中国生物物理学会原副理事 长王大成先生因病医治无效，于2025年9月19日10时02分在北京逝世，享年85岁。 ...

来源：中国生物物理学会 王大成先生热爱祖国，对党忠诚，严于律己，治学严谨，拥有高瞻远瞩的战略眼光。他将毕生 精力献给了祖国的科学研究事业，桃李满天下，为我国结构生物学的开创与发展作出了杰出贡 献。在中国生物物理学会工作期间，他积极推动学会建设和学科发展，关心青年人才成长，并 长期担任《生物化学与生物物理进展》主编，为推动我国学术期刊的发展与学科交流发挥了重 要作用。 王大成先生的逝世，是我国生命科学研究领域的重大损失。他的学术思想、组织贡献和育人精 神，将长久地影响和激励后来者。根据王大成先生家属意愿，丧事从简，不举行遗体告别仪 式。 中国科学院生物物理研究所消息，王大成先生治丧工作委员会9月19日发布讣告：中国共产党 党员，中国科学院院士、分子生物物理学家、中国科学院生物物理研究所原副所长、中国生物 物理学会原副理事长王大成先生因病医治无效，于2025年9月19日10时02分在北京逝世，享 年85岁。 ...

如今，许多曾被视为纯理论的数学方向找到了实际应用场景。例如，微分几何被应用于计算机图形 学，数论被应用于密码学。"我看到了数学在人工智能等新兴领域变得日益重要。"孙理察在现场连线中 说。 "生命科学或医学奖"授予康奈尔大学分子生物学与遗传学系名誉教授斯科特·埃默尔和犹他大学生 物化学系特聘教授兼系主任韦斯·桑德奎斯特，以表彰他们在受体膜蛋白转运与降解细胞机制研究中的 突破性发现，该机制与病毒出芽、感染进程及艾滋病药物干预密切相关。该奖项遴选委员会主席兰迪· 谢克曼介绍，两位科学家成功破解了细胞膜蛋白在细胞内被捕获和降解这一长期悬而未决的难题，揭示 了艾滋病病毒如何利用这一过程在感染的细胞中制作获取包膜，并最终转化为具有全球健康影响力的实 际应用，堪称科学造福人类的典范。 记者 黄海华 沈思怡 昨天，2025世界顶尖科学家协会奖在临港揭晓。 "智能科学或数学奖"授予斯坦福大学名誉讲席教授孙理察，以表彰其在几何分析与微分几何领域的 开创性工作。该奖项遴选委员会主席迈克尔·I·乔丹介绍，孙理察解决了看似不可攻克的问题，创造了重 新定义几何分析框架的数学工具，并以其教学洞见与开创性方法激励了几代几何学家。 现场连线中 ...

Core Viewpoint - The article highlights the announcement of the 2025 "Scientific Exploration Award," recognizing 50 young scientists across various fields, with a focus on their significant research contributions in life sciences and medical sciences [2][47]. Life Sciences - Five young scientists were awarded in the life sciences category, including Mao Yafei, Xu Tongda, Xue Yuanchao, Yan Zhen, and Zhu Shujia [3][4]. - Mao Yafei's research published in Nature discusses the complete genome assembly of a macaque, revealing genetic differences with humans and providing a genetic basis for biomedical models [7]. - Xu Tongda's study in Nature uncovers a new mechanism of auxin signaling in plants, which is crucial for understanding plant growth and development [10]. - Xue Yuanchao's research in Nature identifies the principles of enhancer-promoter selectivity, linking non-coding variations to gene expression regulation [14]. - Yan Zhen's work in Cell explores the mechanisms of chloroplast protein import, potentially enhancing crop yields and carbon fixation [18]. - Zhu Shujia's research in Cell reveals the structure of NMDA receptors, providing insights for developing new drugs for neurological disorders [20]. Medical Sciences - Five young scientists were recognized in the medical sciences category, including Li Wei, Lin Xianfeng, Shu Yilai, Xu Heping, and Zhou Qing [4][5]. - Li Wei's research in Cell presents a novel gene therapy for autosomal recessive deafness, demonstrating safety and efficacy in clinical trials [23]. - Lin Xianfeng's study in Nature introduces a plant-derived photosynthetic system that enhances cellular metabolism, showing promise for treating degenerative diseases [27]. - Shu Yilai's research in The Lancet reports on a gene therapy trial for hearing loss, indicating significant improvements in patients [31]. - Xu Heping's work in Science reveals the role of neuromedin U in regulating intestinal immunity, providing new insights into immune system interactions [35]. - Zhou Qing's research in Nature identifies a molecular mechanism behind a dominant autoinflammatory disease, guiding clinical treatment strategies [38]. Frontier Interdisciplinary - Six scientists were awarded in the frontier interdisciplinary category, including Zhang Jiayi and Zhao Fangqing [5]. - Zhang Jiayi's research in Science develops a retinal nanoprosthesis that restores vision in blind models, showcasing advancements in visual prosthetics [41]. - Zhao Fangqing's study in Cell introduces a new framework for high-resolution spatial proteomics, enhancing tissue analysis capabilities [44].

Group 1 - The Tianzhou-9 cargo spacecraft successfully delivered 23 scientific experiment materials to the Chinese space station, with ongoing experiments showing positive progress, particularly in space life sciences [1][11] - Recent experiments in microgravity have revealed that brain cells move faster in space, while muscle repair processes slow down, and the treatment effects of lipid metabolism disease drugs are significantly improved, potentially opening new avenues for Alzheimer's disease treatment and drug development [2][10] Group 2 - Three space life science experiments were conducted to explore the effects of microgravity on brain organoid structure and function, the migration behavior of skeletal muscle precursor cells, and the transport mechanisms of nucleic acid lipid nanoparticles within cells, enhancing understanding of physiological and pathological processes [4][17] - Observations indicate that neurons in organ-on-a-chip experiments move faster in space, suggesting that the unique environment may promote cell movement and maturation, offering new treatment strategies for neurodegenerative diseases [6][15] Group 3 - The experiments also found that skeletal muscle precursor cell migration slows down in microgravity, delaying muscle regeneration, which could hinder muscle repair [8] - The study of nucleic acid lipid carriers in microgravity showed increased cellular uptake efficiency of nucleic acid drugs and a rapid decrease in disease-related protein expression, indicating potential advantages for space applications [8][10] Group 4 - The samples from the completed experiments are currently stored in a low-temperature storage cabinet and are expected to return to Earth with a crewed spacecraft for further research [11][15] - The Chinese space station has conducted a total of 58 scientific and application projects this year, achieving significant advancements, including a record-setting experiment that heated tungsten alloy to over 3100 degrees Celsius [18][24] Group 5 - The tungsten alloy experiment, conducted by a research team from Northwestern Polytechnical University, utilized microgravity conditions to achieve a uniform state of the alloy, which is beneficial for enhancing material properties [20][22] - The successful heating of tungsten alloy to such high temperatures not only validates the performance of China's self-designed space materials science experiment cabinet but also provides valuable data for the development of new tungsten alloys and their applications in extreme environments [24][26]

Core Points - The Life Sciences Open Alliance was established on August 12, involving 15 universities and research institutions from mainland China and Hong Kong-Macau, aiming to promote innovation in life sciences and address global challenges [1][2] - The alliance seeks to integrate technology and industry innovation, enhance talent cultivation, and facilitate international collaboration among high-level universities and research institutions [1][2] Group 1 - The alliance includes major universities from mainland China such as Peking University, Tsinghua University, and Fudan University, along with universities from Hong Kong and Macau [1] - The initiative aims to create a global innovation network and a high ground for talent cultivation in life sciences [1][2] - The alliance will establish high-level journals in life sciences and utilize new technologies like blockchain for academic preprint platforms [2] Group 2 - The alliance will focus on building an international open ecosystem for research data, addressing issues related to data compliance and usability [2] - The Guangdong-Hong Kong-Macau Greater Bay Area will be leveraged for technology transfer and industrial incubation mechanisms [2] - A global open and cooperative initiative in life sciences was announced, encouraging collaboration and resource sharing to enhance human health and well-being [2][3]

Financial Data and Key Metrics Changes - Q1 revenues were $737 million, up 6% from Q1 last year [5] - Order bookings were $693 million, down 15% compared to Q1 last year [16] - Adjusted earnings from operations in Q1 were CAD 78.6 million, representing 10.7% of revenues [18] - Gross margin for Q1 was 29.8%, consistent with Q1 last year [18] - Cash flows from operating activities were CAD 156 million [22] - Net debt to adjusted EBITDA ratio was 3.6 times on a pro forma basis at Q1 [22] Business Line Data and Key Metrics Changes - In Life Sciences, order backlog at quarter end was $1.2 billion, with strong contributions from auto injectors and blood glucose monitoring wearables [6] - Food and Beverage backlog was $229 million, an increase of 6% compared to Q1 last year [8] - Energy sector saw growth primarily in nuclear refurbishment activities, particularly around CANDU reactors [42] - Consumer Products and Transportation sectors remained stable, with transportation experiencing lower EV end market demand [10] Market Data and Key Metrics Changes - The order backlog ended the quarter at approximately $2.1 billion, reflecting a healthy funnel across diversified offerings [5] - Orders in the first half of the calendar year were up over 10% year over year, excluding transportation [39] Company Strategy and Development Direction - The company is focused on returning leverage to its target range of 2 to 3 times and realizing further synergies from recent acquisitions [12][23] - The strategy includes growing repeatable revenue through services, consumables, and digital offerings [6] - The company remains committed to creating long-term value for shareholders and customers through strong execution and continued growth in targeted markets [25] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth outlook for the year, supported by a strong backlog and a trailing twelve-month book-to-bill ratio of 1.17 [33] - The company is closely monitoring the business environment due to cross-border tariffs but has not seen a material impact to date [20] - Management noted that while some customers in the lab research space are taking a more measured approach to capital spending, the overall outlook for Life Sciences remains positive [7] Other Important Information - ATS was included in Time Magazine's inaugural list of Canada's Best Companies 2025, ranking number one in the engineering, manufacturing, and medical technology category [14] - The company is actively engaged in M&A opportunities that align with long-term growth ambitions [11] Q&A Session Summary Question: Can you discuss the demand environment further? - Management noted that the trailing twelve-month book-to-bill ratio is 1.17, indicating alignment with growth targets and a healthy funnel of customer conversations [33][34] Question: What is driving the uptick in the energy business? - The growth in the energy sector is primarily driven by nuclear refurbishment activities, particularly around CANDU reactors, with a strong demand environment [42] Question: Can you provide an update on the integration process and cross-selling opportunities? - Integration across recent acquisitions is progressing well, with strong uptake in ABM deployments and cost synergies being realized [54] Question: How is the company addressing the impact of U.S. government funding changes on Life Sciences? - The impact is low, representing less than a single-digit percentage of the business, and has not materially affected overall Life Sciences performance [55] Question: What is the outlook for margin progression? - Management expects margin expansion for the year, driven by gross margin improvements and operational efficiencies, though variability is anticipated [88] Question: What is the status of the M&A pipeline during the leadership transition? - The company continues to pursue both organic and acquisition-related growth, with M&A activity ongoing despite the leadership transition [62]

Core Viewpoint - The collaborative research led by Chinese institutions and international scientists has achieved significant advancements in brain mapping at single-cell resolution, marking a leap from rodent to primate studies, with ten important results published in a special issue of the journal "Cell" [1] Group 1 - The series of results covers key species including reptiles, birds, rodents, non-human primates, and humans, expanding the international brain atlas in terms of cross-species comparison and spatiotemporal dynamics [1] - Unlike previous breakthroughs that focused on isolated points, this series of findings is expected to facilitate a transition from structural to functional research, providing new perspectives and critical tools for understanding the brain [1]

Core Viewpoint - Strengthening fundamental research is an urgent requirement for achieving high-level technological self-reliance and is essential for building a world-class scientific power [1][4] Group 1: Research Achievements - Huang Zhiwei's team discovered the structure of the HIV virus virulence factor, which had not been resolved for over 30 years, providing a foundation for developing anti-HIV drugs [2][4] - The research on the working mechanism of DNA molecular scissors Cpf1 was revealed in 2016, allowing for more efficient and precise gene editing [3] - In April 2024, a new family of RNA-guided DNA endonucleases was discovered, contributing to advancements in enzyme engineering for gene editing [3] Group 2: Research Environment and Philosophy - The establishment of the Life Sciences Center in 2016 provided a research environment that encourages free exploration, allowing previously overlooked researchers to develop their ideas [3][4] - Huang Zhiwei emphasizes the importance of hands-on involvement in experiments and detailed record-keeping to ensure reproducibility and high-quality research outcomes [2][4] - The center has nurtured many emerging researchers, some of whom have become independent scientific leaders [4] Group 3: Future Aspirations - Huang Zhiwei maintains a beginner's mindset, aiming to tackle significant scientific questions and explore the mysteries of life, contributing to the advancement of fundamental research in life sciences on a global scale [4]

Core Viewpoint - The article emphasizes the importance of plasmid extraction in the life sciences industry, highlighting the need to understand the challenges faced by professionals in this area [1]. Group 1: Survey Details - A survey is being conducted to gather insights from life science professionals regarding their experiences with plasmid extraction [2]. - The survey is open from June 20 to July 6, with various prizes available for participants, including 50 Xiaomi backpacks, 50 stylish umbrellas, 10 Xiaomi Bluetooth speakers, and 3 Apple AirPods Max valued at 3,999 yuan each [2]. Group 2: Participation and Rewards - Participants can join the survey by scanning a QR code or clicking on a link provided at the end of the article, which takes approximately 30 seconds to complete [4]. - After the survey closes, the organizers will verify the responses and select winners for the prizes [5]. - The list of winners will be announced in an article published on July 18 on the "Instrument Information Network" public account [6].