值得一提的是，此次高折价配售（较前一日收盘价折让11.52%）不仅创下年内港股生物医药板块最大折价融资纪 录，更暴露出公司现金流的严峻形势，折射出市场对创新药企"融资—研发—再融资"循环模式的担忧。 对此，中国企业资本联盟副理事长柏文喜对《华夏时报》记者表示，"君实生物此次折价配售，主要是因为公司面 临较大的资金压力，公司需要通过配售来快速筹集资金以维持研发和运营。此次以11.52%的年内最大折价配售， 可以看作是公司在资金压力下的无奈之举。" 资本困局：十载亏百亿元，四年融七十亿元 这已经是君实生物最近四年间的第三次大规模融资。 华夏时报（www.chinatimes.net.cn）记者 于娜 见习记者 赵文娟 北京报道 近日，君实生物（688180.SH，01877.HK）以每股25.35港元配售4100万股H股，预计募资净额约10.26亿港元。今 年以来，得益于多项BD交易达成，以及基本面的改善，创新药整体表现突出。截至6月18日收盘，君实生物的H 股年涨幅超100%；其A股亦同步冲高，年涨幅超25%。 从资金消耗与偿债能力指标看，君实生物的财务压力呈持续攀升态势。2021—2024年间，公司资产负债率 ...

格隆汇6月18日丨君实生物(688180.SH)在互动平台表示，公司的创新研发领域已经从单抗药物类型扩展 至包括小分子药物、多肽类药物、抗体药物偶联物（ADCs）、双特异性或多特异性抗体药物、双特异 性抗体偶联药物、融合蛋白、核酸类药物等更多类型的药物研发以及癌症、自身免疫性疾病的下一代创 新疗法探索。公司在研产品管线覆盖五大治疗领域，包括恶性肿瘤、自身免疫系统疾病、慢性代谢类疾 病、神经系统类疾病以及感染类疾病。截至目前，公司已有4款商业化药品（拓益®、君迈康®、民得 维®以及君适达®），近30项在研药物处于临床试验阶段，超过20项在研药物处在临床前开发阶段。公 司核心产品特瑞普利单抗（拓益®）的12项适应症已于中国内地获批，其中10项适应症已纳入国家医保 目录。目前公司正在加快推进抗BTLA单抗tifcemalimab（代号：TAB004/JS004）、抗IL-17A单抗（代 号：JS005）、PD-1单抗皮下注射制剂（代号：JS001sc）、PD-1/VEGF双特异性抗体（代号：JS207） 等后期阶段管线的研发和上市申请等工作，并持续探索包括抗Claudin18.2 ADC（代号：JS107）、 PI ...

Core Viewpoint - The company is preparing for the 2024 Annual General Meeting (AGM) to ensure the rights of shareholders and maintain order and efficiency during the meeting [1][2][3] Group 1: Meeting Procedures - Only eligible shareholders, directors, supervisors, senior management, and other attendees can participate in the AGM, and the company reserves the right to refuse entry to those who do not meet the criteria [2] - The meeting will follow the agenda as notified, and no agenda items can be postponed or omitted from voting [2] - Attendees must maintain order and respect the rights of other shareholders during the meeting, with the company authorized to take measures against disruptions [2][3] Group 2: Shareholder Rights - Shareholders have the right to speak, inquire, and vote during the AGM, with a maximum speaking time of five minutes per shareholder [3] - The meeting will be witnessed by a lawyer from a law firm to provide legal opinions on the proceedings [3] Group 3: Financial Performance - The company reported a significant increase in sales revenue, with a 29.7% rise to 194,832 million yuan compared to 150,255 million yuan in the previous year [28][32] - The company managed to reduce its operating loss significantly, with a decrease in net loss attributed to improved sales efficiency and cost control measures [34] - The total assets of the company at the end of 2024 were 1,078,196 million yuan, a decrease from 1,134,287 million yuan in 2023 [28][30] Group 4: Governance and Board Activities - The company completed the election of the fourth board of directors on June 21, 2024, with 14 members, including 5 independent non-executive directors [9][11] - The board held 13 meetings during the reporting period, approving all agenda items without any rejections [10] - The board established four specialized committees to enhance governance efficiency and decision-making [10][12] Group 5: Future Plans - The company plans to apply for financing and credit limits totaling up to 8 billion yuan to support its operational and project development needs [39] - The board aims to strengthen its governance structure and enhance compliance management in 2025 [13]