Core Insights - Tibet Pharmaceutical has evolved from its establishment in 1999 to a modern pharmaceutical company integrating R&D, production, and sales, contributing significantly to the modernization of ethnic medicine and rural revitalization [1][2] - The company reported a revenue of 16.51 billion yuan and a net profit of 5.43 billion yuan for the first half of 2025, with a total revenue of 28.07 billion yuan and a net profit of 10.51 billion yuan in 2024, marking a year-on-year growth of 31.26% [1][2] - Tibet Pharmaceutical is recognized as a pioneer in the modernization of Tibetan medicine, with a focus on cardiovascular treatments and a global marketing network spanning over 40 countries [2] Company Development - Since its inception, Tibet Pharmaceutical has established a comprehensive management platform covering R&D, production, and marketing, with nine subsidiaries and a focus on modern Tibetan medicine, biopharmaceuticals, and innovative chemical drugs [2] - The company has achieved several industry firsts, including the development of "New Active Substance," the first gene-engineered drug for acute heart failure in China, and the inclusion of its unique Tibetan medicine "Nodikon Capsule" in national essential drug and medical insurance directories [2] Social Responsibility - Tibet Pharmaceutical has contributed significantly to local development, with a total tax contribution of 28.99 billion yuan since its listing, of which 26.08 billion yuan was paid in Tibet, accounting for 89.96% of the total [2] - The company actively supports rural revitalization through initiatives that combine industry, livelihood, and culture, including the artificial cultivation of Tibetan medicinal materials to enhance local farmers' income while protecting the fragile ecosystem [3] - Employment support initiatives include partnerships with educational institutions and training programs for Tibetan students, fostering local talent and promoting community development [3]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部分內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 *僅供識別 1 自願性及業務進展公告 創新藥心肌肌球蛋白抑制劑CMS-D003獲藥物臨床試驗批准通知書 China Medical System Holdings Limited（「本公司」，連同其附屬公司統稱為「本集團」） 欣然宣佈，本集團自主研發的創新藥CMS-D003膠囊（「CMS-D003」）於二零二五年 三月十一日獲得中國國家藥品監督管理局（「NMPA」）簽發的藥物臨床試驗批准通知 書，於三月十二日收到藥物臨床試驗批准通知書。NMPA同意本集團在中國健康以及症 狀性梗阻性肥厚型心肌病（oHCM）成人受試者中開展評價CMS-D003安全性、耐受性 及藥代動力學和藥效學特徵的臨床試驗。 CMS-D003 CMS-D003是一種小分子心肌肌球蛋白抑制劑，是靶向治療肥厚型心肌病的藥物。通過 靶向抑制心肌肌球蛋白三磷酸腺苷（ATP）酶，抑制肌球蛋白-肌動蛋白相互作用，減少 肌絲滑動，抑制心肌的過度收縮，改善心 ...