Core Viewpoint - Kangzhe Pharmaceutical has successfully completed a secondary listing on the Singapore Exchange, marking its expansion into international capital markets after its initial public offering on the Hong Kong Stock Exchange in September 2010 [1] Group 1: Company Background - Kangzhe Pharmaceutical was established in 1995, initially focusing on contract sales organization (CSO) and marketing foreign and domestic pharmaceuticals [3] - The company transitioned from pure agency operations to self-operated products after acquiring full control of Ganfu Le in 2013 [3] - Kangzhe's business currently spans four major areas: cardiovascular, digestive, dermatology/aesthetic medicine, and ophthalmology [3] Group 2: Recent Developments - In April 2024, Kangzhe Pharmaceutical spun off its dermatology business, Demai Pharmaceutical, for independent listing [1][4] - The decision to list in Singapore is part of the company's strategy to enhance its presence in Southeast Asia and create more opportunities for international business development and potential financing needs [4] Group 3: Financial Performance - Kangzhe Pharmaceutical has experienced a decline in revenue for two consecutive years, with revenues of 6.8 billion, 8.5 billion, 9.24 billion, 7.76 billion, and 7.4 billion from 2020 to 2024 [6] - Net profits during the same period were 2.5 billion, 3 billion, 3.2 billion, 2.4 billion, and 1.6 billion, with a significant 32% year-on-year decline in 2024 [6] - The company's cash flow from operations dropped nearly 50% to 1.269 billion in 2024, indicating deteriorating operational quality [7] Group 4: Market Challenges - The decline in performance is attributed to the impact of centralized procurement, with major products like Dailixin, Yousif, and Bo Yiding losing market share, resulting in a nearly 30% revenue drop to 2.691 billion [7] - The company is facing increased competition in the dermatology sector, and Demai Pharmaceutical has reported cumulative losses of 165 million from 2022 to 2024 [8] - Despite the challenges, Kangzhe is accelerating the commercialization of its innovative drug, Lurcobatin Cream, expected to launch in the second half of 2025, targeting a market with over 22 million patients in China [8]

来源：环球网 新兴市场：全球医药产业新增长极 根据 IQVIA 预测，2028年亚太、印度、非洲 & 中东、拉丁美洲四大新兴市场经济体医药市场规模合计 有望达 3360-3840 亿美元，体量与西欧整体医药市场规模 2028 年预计的 4100 亿美元接近。新加坡具备 面向东南亚、中东及更广阔新兴市场的区位与制度优势，正逐步成为全球资本与创新力量汇聚的高地。 而随着东南亚多国传统依赖第三方物流（3PL）的分销体系正在逐步被融合更强商业化能力与授权合作 策略的新模式所取代，构建具有竞争力的产品组合，配备具备深厚本地市场经验的强大销售团队，或建 立本地化生产制造能力，被一致认为是在东南亚等新兴市场实现可持续的商业化成功至关重要的战略优 势。 康哲之道：打造中新双枢纽，全链发展的创新药企 康哲药业在中国市场积累了丰富的差异化品种资源和成熟的商业化能力，康哲药业主席兼行政总裁、总 裁 林刚先生发表主旨演讲并表示：如今，集团正加快将战略视野拓展至全亚太市场，以中国市场为根 基、以新加坡为亚太枢纽，通过"研-产-销-投"全链条布局驱动创新，推动向"产业资源全球化配置"的升 维，为全球患者提供高品质医药产品和服务。 本次活 ...

康哲药业创始人、主席兼行政总裁、总裁林刚表示："今天是康哲药业发展史上又一重要里程碑。我们 通过新加坡上市进一步完善国际资本市场布局。同时，借助新加坡国际创新与跨国企业总部的优势，我 们将推动医药产业国际化战略步伐，加快药品研、产、销全生态链建设，并携手合作伙伴，共同推动新 兴市场医药产业发展，为全球患者带来福祉。" 新交所集团执行副总裁、全球业务发起和拓展部主管保得胜（Pol de Win）表示："我们非常高兴地迎来 康哲药业在新交所上市。作为医疗保健行业的领军企业，康哲药业的上市充分体现出亚洲地区对医疗创 新及医疗服务可及性的需求与日俱增。随着康哲药业寻求拓展东南亚地区的业务版图，公司在新交所的 上市将为其提供一个战略跳板，助力康哲药业连接国际投资者，并进一步增强新加坡资本汇聚与增长枢 纽的显著地位。" 新加坡交易所（下称"新交所"）证券市场很高兴地迎来康哲药业在主板进行二次上市，股票代码 为"8A8"。 康哲药业（CMS）是一家在中国有近30年深厚根基的专业制药企业。自2010年在香港交易所上市以 来，康哲药业已在心脑血管、中枢神经系统、消化系统、皮肤和眼科等关键治疗领域建立了具有差异化 的产品组合。 ...

Core Viewpoint - The innovative drug market is experiencing a surge in interest and investment, with significant inflows of capital and strong performance in related stocks [1][5]. Group 1: Market Performance - On July 15, the pharmaceutical ETF (562050) experienced a sharp increase during the opening auction, indicating heightened investor enthusiasm for innovative drugs [2][3]. - The ETF closed up 0.59% at 1.017 yuan per share, with a total trading volume of approximately 26.34 million yuan and a turnover rate of 22.94% [4]. - A-shares in innovative drugs have shown notable gains, with companies like ShenZhou Cell rising nearly 50% in the past month, and others like BoRui Medicine and Jilin AoDong increasing over 10% [5]. Group 2: Fund Performance and Strategy - The latest public fund reports reveal a significant shift towards innovative drugs, with the Changcheng Pharmaceutical Industry Selected Fund achieving over 90% returns, increasing its scale nearly 30 times in the second quarter [6][9]. - The fund manager of Yongying Medical Health Fund indicated a complete portfolio overhaul towards innovative drugs, with top holdings including ShuTaiShen and Rejing Biology, the latter seeing a staggering 443.59% increase this year [6][7]. - The Changcheng fund plans to continue focusing on innovative drugs in the third quarter, emphasizing clinical data, overseas licensing, and domestic sales growth [8]. Group 3: Policy and Market Trends - The innovative drug sector is benefiting from favorable policy developments, with the National Medical Insurance Bureau initiating adjustments to the drug catalog for 2025 [10]. - Data shows that the total amount for Chinese innovative drug licenses reached nearly 66 billion USD in the first half of 2025, surpassing the total for 2024, indicating a rapid rise in global competitiveness [11]. - The current market rally is primarily driven by clinical results and expectations for overseas licensing, with a focus on companies that have the potential for international expansion and those that have successfully transformed [11].

Group 1 - The core viewpoint of the article is that Kangzheng Pharmaceutical (00867.HK) has announced a secondary listing on the Singapore Exchange, which aims to enhance its business presence in Southeast Asia and tap into the mature investor market in Singapore [1] - The company emphasizes that Southeast Asia, with a population of nearly 700 million, is experiencing rising pharmaceutical demand due to economic growth, an expanding middle class, aging populations, and an increase in non-communicable diseases [1] - Kangzheng Pharmaceutical has established Singapore as its regional headquarters for Southeast Asia and the Middle East [1] Group 2 - Kangzheng Pharmaceutical was listed in Hong Kong on September 28, 2010, and focuses on specialized fields such as cardiovascular, central nervous system, digestive, and ophthalmology [1] - The company currently has five innovative drugs in the commercialization stage, including "Meitai Tong" for psoriasis and "Laifulan" for methylene blue enteric-coated sustained-release tablets, along with three drugs entering national procurement [1] - As of the latest trading session, Kangzheng Pharmaceutical's stock price was HK$12.94, with a total market capitalization of HK$31.567 billion [2]

Group 1: Company Actions and Financials - Lianlian Digital plans to issue 38.4 million new H-shares at a price of HKD 10.25 per share, representing a 10.09% discount from the last closing price, aiming to raise approximately HKD 393.6 million for global payment innovations and business expansion [1] - Kangji Pharmaceutical announced its intention to list on the Singapore Exchange, which is expected to enhance its international visibility and broaden financing channels [3] - China Shipbuilding Defense anticipates a net profit of HKD 460 million to HKD 540 million for the first half of 2025, reflecting a year-on-year increase of 213.25% to 267.73%, driven by improved production efficiency and revenue from ship products [4] Group 2: Industry Trends - The healthcare sector in Hong Kong has seen a significant increase in IPOs, with 11 companies raising a total of approximately HKD 18.119 billion, indicating strong market interest in the healthcare industry [2] - The overall performance of the Hong Kong stock market shows positive trends, with the Hang Seng Index rising by 0.26% [5]

Group 1 - The China Securities Regulatory Commission (CSRC) has issued supplementary material requirements for overseas listing applications for 22 companies, including SANY Heavy Industry and TUS Holdings [1][2][3] - SANY Heavy Industry is required to clarify the reasons for inconsistencies in the identification of its controlling shareholder and provide a conclusive opinion on the matter [1][3] - TUS Holdings must explain the real estate development activities of its subsidiaries and their future business plans, as well as the involvement of foreign capital in its operations [2][3] Group 2 - The supplementary requirements for Dipo Technology include an explanation of a share transfer at zero cost that led to a change in control, and whether there are any shareholding arrangements that need regulatory scrutiny [3][4] - Anxuyuan is required to clarify the compliance of its offshore structure and reverse mergers, including foreign exchange management and tax compliance [3][4] - The requirements for Zhihui Mining focus on the scope of its exploration activities and whether its projects fall under high energy consumption or high emissions categories [2][3] Group 3 - The CSRC has mandated that companies provide legal opinions on their compliance with regulations regarding offshore structures and foreign investments [5][6] - Companies must also clarify their business models, including any involvement in restricted foreign investment sectors, and provide details on their user data management practices [5][6][7] - Specific companies like World Road and Copper Master are required to explain their shareholder structures and any potential conflicts of interest [6][10] Group 4 - The supplementary materials for companies like Huaxi Da and Zhongwei New Materials require detailed explanations of their business operations and compliance with foreign investment regulations [24][25] - Companies must also address any discrepancies in their previous filings and how these may affect their current overseas listing applications [9][10] - The focus is on ensuring that all business activities align with the latest foreign investment policies and regulations [5][6][7]

Investment Rating - The report maintains a positive outlook on the cosmetics and medical beauty industry, indicating a "Buy" recommendation for several companies within the sector [2][14]. Core Insights - The cosmetics and medical beauty sector has shown weaker performance compared to the market, with the Shenwan Beauty Care Index rising by 1.5% from July 4 to July 11, 2025, which is below the market average [3][5]. - The introduction of new products in the regenerative medicine sector, particularly in the "童颜针" (youthful needle) category, is expected to enhance consumer interest and expand the market [2][8]. - The report highlights strong anticipated earnings growth for several key companies in the cosmetics sector for the second quarter of 2025, with notable increases in revenue and net profit for brands like 上美股份 (Shangmei), 丸美股份 (Marubi), and 珀莱雅 (Proya) [9][10][11]. Summary by Sections Industry Performance - The cosmetics and medical beauty sector has underperformed the market, with specific indices showing varied performance, such as the Shenwan Cosmetics Index increasing by 2.6% [3][5]. - The report notes that the demand for cosmetics is recovering, with a 4.1% year-on-year increase in retail sales for the first five months of 2025 [19][20]. Company Performance - 上美股份 (Shangmei) is expected to see a revenue increase of 16% and a net profit increase of 25% in the first half of 2025 [10]. - 丸美股份 (Marubi) anticipates a 22% revenue growth and a 28% increase in net profit for the second quarter of 2025 [10]. - 珀莱雅 (Proya) is projected to achieve a 10% revenue growth and a 15% increase in net profit for the second quarter of 2025 [10]. - 毛戈平 (Mao Geping) expects a significant revenue increase of 38% and a net profit increase of 35% in the first half of 2025 [10]. - 若羽臣 (Ruoyuchen) forecasts a remarkable 70% revenue growth and a 75% increase in net profit for the second quarter of 2025 [10]. Market Trends - The report emphasizes the ongoing trend of domestic brands gaining market share, with national brands occupying five of the top ten positions in the skincare market [32]. - The regenerative medicine sector is expanding, with new products enhancing consumer engagement and market growth potential [2][8]. Investment Recommendations - The report recommends focusing on companies with strong brand matrices and high growth potential, such as 上美股份 (Shangmei), 珀莱雅 (Proya), and 丸美股份 (Marubi) [14]. - It suggests monitoring companies that leverage e-commerce and social media platforms effectively, such as 若羽臣 (Ruoyuchen) and 毛戈平 (Mao Geping) [14].

Summary of Key Points Core Viewpoint - As of July 3, a total of 120 stocks reached their 52-week highs, indicating a strong market performance with notable leaders in the list [1]. Group 1: Top Performers - The top three stocks with the highest increase rates are: - 富誉控股 (Fuyou Holdings) at 90.76%, closing at 0.435 with a peak of 0.475 [1] - 信义能源 (Xinyi Energy) at 65.00%, closing at 1.200 with a peak of 1.980 [1] - 中国三三传媒 (China San San Media) at 42.86%, closing at 1.710 with a peak of 1.900 [1] Group 2: Additional Notable Stocks - Other notable stocks include: - ITE HOLDINGS at 34.21% increase, closing at 0.047 with a peak of 0.051 [1] - 星凯控股 (Xingkai Holdings) at 30.00%, closing at 0.480 with a peak of 0.650 [1] - 北京北辰实业股份 (Beijing Beichen Industrial) at 26.47%, closing at 0.940 with a peak of 1.290 [1] Group 3: Overall Market Trends - The overall trend shows a significant number of stocks achieving new highs, reflecting positive investor sentiment and market conditions [1].

康哲药业 20250630 摘要 康哲药业正经历从原研药向创新药的战略转型，通过合作开发和自主研 发双轮驱动，已获批 5 款创新药共 6 个适应症，并积极进行国际化拓展， 包括在新加坡二次上市，但不涉及融资或股权稀释。 公司四大业务板块中，心脑血管和消化业务受 VBP 影响后已趋于稳定， 眼科业务盈利能力强劲，皮肤健康业务德美医药即将分拆上市，国际化 业务以东南亚为核心，未来将贡献新的增长点。 受国家带量采购影响，公司核心品种收入有所下滑，2024 年三个核心 品种收入 26 亿元，但集采影响已基本出清，随着创新药陆续获批，预 计业绩将进入高速增长阶段。 公司重点产品组合包括存量国采品种（如波依定、黛力新和优思弗， 2024 年合计贡献 26 亿元）、独家存量和品牌药以及创新药，确保在不 同领域具备竞争优势和持续增长潜力，预计独家存量和品牌药维持 10% 左右增速。 2024 年商业化的美泰彤、依洛曲和维图可四个品种，预计 2025 年收 入至少翻倍增长。拟上市创新产品包括卢可替尼乳膏、德西度司他片和 童颜针，有望在今年获批。 Q&A 截至去年（2024 年），三个核心品种贡献收入 26 亿元，相较之前减少了 ...