H国卒中学 1 CHINESE STROKE ASSOCIATION s (2)中国卒中学会 世界空中E 与健康促进 朱榆红 tri 急性缺血性卒中防治任重道远 急性缺血性脑卒中俗称"脑梗死"。 随着中国生活方式改变和人口老龄化进程加快，中国脑卒中疾病负担日渐沉重，我国每年约有330万卒中新发病例，已成为中国成人致死、致残的首位病 因，更重要的是，发病患者的年轻化趋势更加显著，疾病负担显著高于英美日等发达国家。 国家卫生健康委员会在《健康中国行动——心脑血管疾病防治行动实施方案（2023-2030年）》中明确提出，要全面提升缺血性卒中再灌注治疗的数量和质 量，力争到2030年实现全国所有二级及以上医疗机构均能开展静脉溶栓治疗。 缺血性脑卒中的防治当前面临多重挑战。一是公众对卒中症状认识不足、急救意识非常薄弱，溶栓黄金时间窗内就诊率低，我国目前有67%-75%的急性缺血 性卒中患者因延迟就诊或发病时间不明而错过溶栓机会。二是再灌注治疗率低，一方面，静脉溶栓率低，新发患者静脉溶栓率仅为10%左右；另一方面，血 管内治疗率不足1%，与发达国家存在巨大差距。三是临床医生和患者对药物静脉溶栓治疗的安全性缺乏信心，对溶栓 ...

Core Viewpoint - In the third quarter of 2025, many pharmaceutical companies are seeking a balance between cost reduction and growth, with A-share pharmaceutical companies experiencing a 5.5% decline in overall revenue and a 14.3% drop in net profit excluding non-recurring items in the first half of the year. The performance of listed pharmaceutical companies in the third quarter serves as an important window to observe their resilience in development [1]. Group 1: Company Performance - China Resources Sanjiu (华润三九) reported a revenue of 21.986 billion yuan in the first three quarters, a year-on-year increase of 11.38%, primarily driven by the consolidation of Tianjin Tasly Pharmaceutical (天士力) [1]. - The net profit attributable to shareholders was 2.353 billion yuan, with a significant narrowing of the decline compared to the second quarter, indicating clear signs of improvement [1]. - The company is actively pursuing short-term recovery, merger synergies, and cost control, with a clearer rhythm in long-term layout implementation [1]. Group 2: Strategic Initiatives - China Resources Sanjiu is proactively positioning itself in channels and brands, which serves as a solid foundation for its current performance amidst industry adjustments [2]. - The company has not adjusted its annual growth target for respiratory products despite challenges, reflecting confidence derived from channel and brand certainty [2]. - The retail pharmacy market in China saw a decline of 1.3% in the first five months of the year, with one-third of stores experiencing sales declines exceeding 15%, indicating a shift to a competitive phase [2]. Group 3: Brand Development - The "999" series of products continues to perform well, with Ganmaoling ranking first in sales among traditional Chinese medicine products in pharmacies during the first half of the year [3]. - The product 999 Yiqi Qingfei Granules is preparing for negotiations related to national medical insurance, forming a closed loop of "prevention-treatment-recovery" with core products [3]. - The company expects its revenue to surpass the industry average growth rate in 2025, aiming for double-digit growth while maintaining stable profits [3]. Group 4: Mergers and Acquisitions - The value of China Resources Sanjiu's mergers and acquisitions is gradually moving beyond short-term financial impacts, avoiding the common industry issue of "heavy acquisition, light integration" [4]. - Following the completion of the "100-day integration" with Tianjin Tasly, business synergies have entered a practical implementation phase, focusing on stabilizing teams, operations, and business before advancing specific collaborations [4]. - The integration with Kunming Pharmaceutical Group (昆药集团) also reflects a long-term value creation strategy, expanding into retail and building new growth curves [4]. Group 5: Innovation and Future Outlook - China Resources Sanjiu is increasing its focus on innovation, particularly in the field of cell therapy, with a project in collaboration with Nanjing Aierpu Regenerative Medicine that is the first globally to receive clinical approval for heart failure treatment [5]. - The company has maintained a strong financial position, with a total dividend of 1.695 billion yuan in 2024 and nearly 750 million yuan in the first half of 2025, reflecting a commitment to shareholder returns [6]. - The company has distributed over 10 billion yuan in dividends since its listing, indicating a significant cash return to shareholders compared to the average level in the A-share market [6]. Group 6: Market Trends and Future Prospects - During the "14th Five-Year Plan" period, China Resources Sanjiu's dividends reached 6.4 billion yuan, showcasing confidence in long-term operations [7]. - The current performance fluctuations are seen as a temporary reflection of cyclical and integration costs, with signs of narrowing declines in the third quarter [7]. - As the industry approaches a recovery phase, the value logic behind this pharmaceutical leader is expected to gain increasing attention [7].

Summary of Tianjin Tasly Pharmaceutical Conference Call Company Overview - **Company**: Tianjin Tasly Pharmaceutical Co., Ltd. - **Industry**: Pharmaceutical Industry in China Key Points and Arguments Integration with China Resources Sanjiu - The integration with China Resources Sanjiu has progressed smoothly, achieving the 100-day integration goal and entering the first year of integration phase [2][6] - Focus areas include stabilizing business, teams, and customers while promoting synergy and empowerment [2][6] - The vision is to become a leading enterprise in the Chinese pharmaceutical market through innovation-driven strategies [6] Financial Performance - For the first three quarters of 2025, the company reported revenue of 6.31 billion yuan and a net profit of 984 million yuan [4] - Pharmaceutical industrial sales remained stable at 5.709 billion yuan, with cardiovascular and metabolic segments showing a slight growth of 1.16% [4] - The collaboration with China Resources Sanjiu has led to a 20% increase in terminal coverage in lower-tier cities [4][12] Product Development and Market Opportunities - Core products like Compound Danshen Dripping Pills are seeing steady sales growth, with expectations to reach 250 to 300 million yuan this year, nearly doubling year-on-year [4][16] - The newly approved indication for the drug Puyouke for cerebral infarction is expected to enter the national medical insurance negotiation directory next year, with significant growth anticipated by 2026-2027 [2][8] - The market potential for cerebral infarction treatment is substantial, with 4.5 to 5.5 million new cases annually and a low treatment rate of around 5% [8] R&D Strategies - The company emphasizes innovation in drug development, focusing on cardiovascular, neurological, and digestive fields [9][10] - Plans to enhance the pipeline of innovative traditional Chinese medicine (TCM) and strengthen existing projects [11] - The company is developing advanced therapeutic drugs, particularly in cell and gene therapy (CGT) and small nucleic acid products [11] Clinical Trials and New Products - The PD-L1/VGF dual antibody project has shown promising results in Phase I trials, with Phase II studies underway [13][14] - The FGF21 analog project has demonstrated good safety and efficacy in improving glucose and lipid metabolism [15] - New antidepressant GS1,101 has completed Phase II trials and is expected to become a significant innovative treatment option [17][18] Market Trends and Future Outlook - The company aims to leverage national policy opportunities to drive growth in county-level medical community drug directories [2][7] - Plans to expand retail channels and integrate online sales resources to build a healthy consumption ecosystem [8][12] - The company is actively pursuing inclusion in the national basic medical insurance directory for more proprietary products [20] Potential Products in Clinical Trials - Several innovative TCM products are in Phase III clinical trials, including those targeting common ailments like colds and acute gout [19] - The company is also exploring treatments for conditions like acute ischemic stroke and chronic heart failure through stem cell therapies [21] Additional Important Information - The company is implementing a 6S management system to enhance operational efficiency [6] - The integration with China Resources Sanjiu is expected to strengthen the company's market position and operational capabilities [12]

Core Viewpoint - Tianjin Tasly Pharmaceutical Group Co., Ltd. reported steady growth in its pharmaceutical industrial revenue and net profit for the first three quarters of 2025, with a focus on innovative drug development as a dual-engine strategy for future performance enhancement [1][2]. Group 1: Financial Performance - For the first three quarters, the company achieved pharmaceutical industrial revenue of 5.709 billion yuan, maintaining stability [1] - The net profit attributable to shareholders reached 984 million yuan, representing a year-on-year growth of 16.88% [1] - The cardiovascular/metabolic segment generated revenue of 3.186 billion yuan, showing a slight year-on-year increase of 1.16% [1] Group 2: Research and Development Progress - The company is committed to enhancing its innovative capabilities in traditional Chinese medicine and biopharmaceuticals, with significant advancements reported in the third quarter [1] - Multiple achievements in innovative drug development were announced, including the approval of a new indication for the major biopharmaceutical product, Puyouke, for acute ischemic stroke treatment [1] - The company has 31 innovative drugs in its pipeline, with nearly 20 products in the clinical mid-to-late stages in traditional Chinese medicine and several in the high-demand biopharmaceutical sector [1] Group 3: Strategic Focus Areas - The company is strategically focusing on high clinical value products in three major disease areas: cardiovascular/metabolic, neurological/psychiatric, and digestive diseases [2] - It has obtained clinical approvals for advanced treatment products, including three types of stem cell injection therapies, with one being the first of its kind approved for IND in the U.S. [2] - The PD-L1/VEGF dual antibody product is undergoing clinical trials for solid tumors and colorectal cancer, showing promising progress in patient enrollment [2]

Core Viewpoint - Tian Shi Li reported a steady performance in Q3 2025, with revenue of 6.311 billion and a net profit of 984 million, marking a year-on-year growth of 16.88%, defying the industry trend of decline [1] Group 1: Financial Performance - The company achieved a revenue of 6.311 billion in the first three quarters, maintaining stability [1] - The net profit attributable to shareholders reached 984 million, reflecting a year-on-year increase of 16.88% [1] - The pharmaceutical industrial revenue was 5.709 billion, showing steady performance [1] - The cardiovascular/metabolic segment generated 3.186 billion, with a slight year-on-year growth of 1.16% [1] Group 2: Product Development - The key product, Pu You Ke, received approval to expand its indication to treat acute ischemic stroke, which is expected to contribute to future performance [3] - The company’s three major basic drug products are performing well, with the compound Danshen dripping pill expanding its indications to diabetic retinopathy, further driving growth [2] - The company has a rich pipeline of 31 innovative drugs in development, including nearly 20 clinical mid-to-late stage products in traditional Chinese medicine and several in the high-attention biopharmaceutical field [3] Group 3: Market Potential - Analysts predict that Pu You Ke could become a billion-dollar product following its new indication approval, with sales potential expected to exceed 1 billion [3] - The company is focusing on three core disease areas and continuously optimizing its R&D pipeline, which is expected to bring incremental contributions [4]

Core Viewpoint - Tianjin Tasly Pharmaceutical achieved a robust performance in the third quarter, with a 16.88% year-on-year increase in net profit, contrasting with the overall decline in the pharmaceutical manufacturing industry [1][2]. Group 1: Financial Performance - The company reported pharmaceutical industrial revenue of 5.709 billion yuan for the first three quarters, maintaining stability [2]. - The net profit attributable to shareholders reached 984 million yuan, marking a 16.88% increase year-on-year [1][2]. - The cardiovascular/metabolic segment generated 3.186 billion yuan in revenue, showing a slight growth of 1.16% [2]. Group 2: Product Development and Approvals - The company’s key products, including Compound Danshen Dripping Pills, have expanded their indications, contributing to revenue growth [3]. - The approval of the new indication for the innovative drug, Puyouke, for acute ischemic stroke treatment is expected to significantly enhance future sales potential [4]. - Puyouke is anticipated to become a billion-yuan product due to its unique thrombolytic mechanism and low systemic bleeding risk [4]. Group 3: Research and Development - Tasly has a rich pipeline of 31 innovative drugs in development, focusing on both traditional Chinese medicine and biopharmaceuticals [5]. - The company is advancing nearly 20 clinical mid-to-late stage products in the innovative Chinese medicine sector and has several high-profile biopharmaceuticals in clinical trials [5]. - Following its integration into China Resources Sanjiu, Tasly aims to leverage innovation as a core strategy to become a leading player in the Chinese pharmaceutical market [5].

Core Insights - Despite the overall decline in the national pharmaceutical manufacturing industry, the company Tianjin Tasly Pharmaceutical is experiencing growth, with a focus on innovative traditional Chinese medicine and biopharmaceuticals as dual engines for research and development [1][2] - The company has made significant progress in its innovative drug pipeline, with 31 innovative drugs currently under research, including new indications for its flagship drug and several other products entering clinical trials [2][3] Industry Performance - As of August, the national pharmaceutical manufacturing industry's cumulative revenue was 15,833.10 billion yuan, a year-on-year decrease of 2.0%, while the total profit dropped by 3.9% to 2,129.50 billion yuan [1] Company Developments - In the third quarter, the company announced multiple achievements in its innovative drug research, including the approval of a new indication for its major biopharmaceutical product for acute ischemic stroke and the launch of a traditional Chinese medicine product [2] - The company is strategically focusing on three major disease areas: cardiovascular and metabolic diseases, neurological/psychiatric disorders, and digestive diseases, while avoiding excessive competition in saturated markets [3] - The company has received clinical approvals for three advanced treatment products, including the world's first mesenchymal stem cell injection approved for IND in the U.S. [3] - The company is advancing its PD-L1/VEGF dual antibody product through clinical trials, which aims to enhance anti-tumor activity by blocking multiple pathways [3]

Core Insights - Tianjin Tasly Pharmaceutical achieved a pharmaceutical industrial revenue of 5.709 billion yuan in the first three quarters, maintaining steady growth, with a net profit attributable to shareholders of 984 million yuan, representing a year-on-year increase of 16.88%, reversing the industry's downward trend [1][2] Group 1: Business Performance - Despite a decline in the national pharmaceutical manufacturing industry, where revenue fell by 2.0% and total profit decreased by 3.9%, Tianjin Tasly's pharmaceutical industrial revenue remained stable [2] - The cardiovascular/metabolic segment generated 3.186 billion yuan in revenue, showing a slight year-on-year growth of 1.16% [2] Group 2: Product Development - The company's key products, including Compound Danshen Dripping Pills, Yangxue Qingnao (granules and pills), and Qishen Yiqi Dripping Pills, are performing well, with the former expanding its indications to diabetic retinopathy, contributing to growth [3] - The innovative drug Puyouke received approval for a new indication for acute ischemic stroke (AIS) treatment, with potential sales exceeding 1 billion yuan due to its unique thrombolytic mechanism and low systemic bleeding risk [4] Group 3: R&D Pipeline - Tianjin Tasly has a robust pipeline with 31 innovative drugs under development, including nearly 20 traditional Chinese medicine products in late-stage clinical trials and several biopharmaceuticals targeting high-interest areas [5] - The company aims to enhance its R&D capabilities as part of the "one body, two wings" strategy of China Resources Sanjiu, focusing on becoming a leading innovative pharmaceutical enterprise in China [5]

Group 1: Market Overview - Institutional research focus is concentrated on robotics, AI, and semiconductors, indicating a shift in investor interest towards these sectors [4][5][6] - The total number of institutional research engagements has increased, particularly in the machinery, pharmaceutical, and basic chemical sectors [6][7] Group 2: Company Insights - Tianjin Tianshili (600535.SH) has received approval for a new indication for its drug, Puyouke, enhancing its market potential in the treatment of acute ischemic stroke [25][26][27] - New Henghui is a leading player in the integrated circuit packaging industry, with a focus on eSIM applications, which are expected to drive future growth [11] - Yitang Co., Ltd. is recognized as a global leader in wafer processing equipment, continuously expanding its technological capabilities [12] - Suzhou Tianmai is a leading enterprise in the thermal management industry, with innovative products that meet the needs of major electronics brands [13] Group 3: Industry Trends - The European electric vehicle market is experiencing significant growth, with sales reaching 176,000 units in August 2025, a year-on-year increase of 41.2% [20][21] - The demand for liquid cooling solutions is expected to rise due to advancements in AI and GPU technologies, particularly with NVIDIA's new GPU, RubinCPX [17][18]

Core Viewpoint - The approval of the innovative drug "普佑克" (recombinant human urokinase) for treating acute ischemic stroke (AIS) marks a significant breakthrough in China's thrombolytic therapy for stroke, reflecting the country's push for innovation in biomedicine [1][2]. Company Summary - Tian Shi Li Pharmaceutical Group has received approval from the National Medical Products Administration for its innovative drug "普佑克," which is now indicated for AIS treatment, following its previous approval for acute ST-segment elevation myocardial infarction [1]. - The drug has demonstrated a lower risk of bleeding compared to competitors, as evidenced by clinical trials published in reputable medical journals [1]. - The company has 31 innovative drug projects in development, including advancements in cell and gene therapy and bispecific antibodies, with three products recently receiving clinical approval [2]. Industry Summary - The biopharmaceutical industry in China is experiencing unprecedented growth, with a 59% year-on-year increase in the number of innovative drugs approved in the first half of 2025, totaling 43 approvals, of which 93% are domestic innovations [3]. - The integration of Tian Shi Li into China Resources Sanjiu is expected to enhance its capabilities in key therapeutic areas, optimizing its research and development pipeline [3]. - The Chinese government has implemented supportive policies for the development of innovative drugs, creating a favorable environment for the biopharmaceutical sector [3].