澳门科技大学副校长姜志宏 实验室筑基破局 如今，姜志宏身兼澳门科技大学分管科研副校长、中药机制与质量全国重点实验室主任。他说："我们 始终以'国家所需、澳门所长'为原则，承担中药现代化的开路先锋角色，目前聚焦6大研究方向——中 药tRNA来源小核酸新药研发、中药暗物质质量控制技术、tRNA表观遗传抗肺纤维化新药、航天育种人 参评价、离子通道创新药，以及新药与保健产品转化研究。" 十余年间，姜志宏带领团队交出了亮眼答卷：发表SCI论文1600多篇，获授权专利68项，更有多项成果 打破"科研与产业脱节"的壁垒。"我们最看重成果转化，要让研究真正服务民生。"姜志宏举例，与广药 集团合作研发的白云山复方板蓝根颗粒，成了澳门药监局挂牌后首个口服创新型同名同方新药；三项小 核酸专利转让，创下澳门高校科研成果转化金额最高纪录，还拿下澳门首个生物医学领域技术发明一等 奖；从红树林植物中提取的甾体化合物，作为抗黑色素瘤新药，2021年已获国家药监局I、II期临床批 文。 深澳携手谋创新 深圳商报记者 刘娥 文/图 "深澳在生物医药领域的合作，不是'选择题'，而是'必答题'——两地优势互补，才能在分子药物创新赛 道上跑出加速度。 ...

Core Viewpoint - The article highlights the modernization of traditional Chinese medicine (TCM) through digitalization and innovative technologies, particularly focusing on the practices of Shandong Buchang Pharmaceutical Co., Ltd. Group 1: Digitalization and Traceability - Buchang Pharmaceutical has established a digital traceability system covering 350 nodes for Chinese medicinal materials, allowing for full lifecycle tracking from seedling to product delivery [4][6] - The system has accumulated traceable information for over 200,000 acres of standardized medicinal material management, addressing the industry's "difficult traceability" issue [6] Group 2: Quality Control and Raw Material Sourcing - The company emphasizes the importance of selecting the right cultivation areas to ensure the quality of medicinal materials, with specific bases in the Yimeng Mountains and Xinjiang [3] - The effective components in the medicinal materials from these regions exceed pharmacopoeia standards by over 40% due to favorable growing conditions [3] Group 3: Technological Innovations in Production - Buchang Pharmaceutical has implemented several technological breakthroughs in the production process, including precise material delivery, stable granulation, and intelligent drying technologies, resulting in a 40% reduction in energy consumption and a doubling of production efficiency [7] - The company has transitioned from traditional experience-based methods to a scientific verification approach in drug development, establishing a comprehensive quality control research system [9] Group 4: Integration of Traditional and Modern Practices - The modernization of TCM at Buchang Pharmaceutical does not discard traditional methods but enhances them with technology, converting experiential knowledge into digital parameters for precise control [10] - The DCS system allows for temperature control within ±0.1℃, replicating traditional extraction methods while improving yield and consistency by over 10% compared to manual operations [10]

Group 1 - The visit of the French media group to China National Pharmaceutical Group (China Resources Sanjiu) highlighted the integration of traditional Chinese medicine (TCM) with modern technology, showcasing the modernization of the TCM industry [1][3] - The use of digitalization and artificial intelligence in the production of TCM was emphasized, transforming the complexity of TCM usage and enhancing its accessibility [5][8] - The French media representatives expressed a strong belief in the efficacy of TCM and suggested that collaboration with China could help address the current drug shortages in France, indicating a potential for deeper Sino-French cooperation in the pharmaceutical sector [8] Group 2 - The visit underscored the growing global interest in natural medicines and traditional healing practices, positioning TCM for international development opportunities [8] - The integration of modern technology into TCM practices is seen as a way to standardize and enhance the global reach of Chinese herbal medicine [5][8] - The French media group leader highlighted the need for joint research and development in pharmaceuticals between France and China, reflecting a strategic approach to healthcare challenges [8]

Core Insights - The core message emphasizes the need for a systemic approach to chronic disease management, moving away from fragmented treatments to comprehensive care solutions for patients with cardiovascular diseases and diabetes [1][2] Group 1: Disease Statistics and Impact - As of 2023, there are 578 million diabetes patients globally, with 233 million in China, indicating that 1 in 6 Chinese individuals is affected, and 34.6% of these patients are at risk of diabetic retinopathy [1] - The number of cardiovascular disease patients in China has reached 330 million, with 2 out of 5 deaths attributed to myocardial infarction, stroke, and heart failure [1] Group 2: Challenges in Current Treatment Approaches - Clinical data shows that 59.8% of diabetes patients also suffer from coronary heart disease or diabetic retinopathy, requiring an average of 4.3 medications daily, leading to a medical expenditure 2.7 times higher than that of the general population [2] - The median secondary prevention period for coronary heart disease patients in China is only 5.2 months, which is less than half of the duration recommended by international guidelines [2] Group 3: Innovative Solutions by the Company - The company introduces a comprehensive management solution for chronic disease patients, focusing on both medication and diagnostic tools, such as the compound Danshen dripping pill, which has dual mechanisms for treating diabetic retinopathy [3][6] - The "Heart Protection" project aims to address the increasing incidence of cardiovascular diseases in China, which is growing at 5% annually, and aims to implement the "Healthy China 2030" strategy into actionable solutions [3][4] Group 4: Community and Grassroots Initiatives - The company collaborates with the China Medical Education Association to launch the "Heart Power - Rewalk the Long March" initiative, which includes free clinics and training for grassroots healthcare providers, enhancing awareness and early screening for diabetes [5] - The initiative has reached 16 cities across China, emphasizing the importance of community engagement in chronic disease management [5] Group 5: Product Innovation and Market Position - The company’s compound Danshen dripping pill has been recognized as a leading brand in heart disease treatment and has expanded its indications to include diabetic retinopathy, showcasing its commitment to innovation [6][7] - The company maintains a robust pipeline of 83 products under development, including those targeting women's and rare diseases, ensuring a diverse range of treatment options [11] Group 6: Corporate Social Responsibility and ESG Practices - The company integrates its healthcare solutions with social responsibility initiatives, participating in various public welfare activities and maintaining a commitment to sustainable development [10][12] - The "Heart Power" initiative has received multiple awards for its contributions to social responsibility, highlighting the company's dedication to community health [10]

Core Viewpoint - Yiling Pharmaceutical demonstrates strong resilience in a complex pharmaceutical industry environment, achieving significant growth in net profit and cash flow despite a slight decline in revenue [1][3][4]. Financial Performance - In the first half of 2025, the company reported revenue of 4.04 billion yuan, with a net profit of 669 million yuan, reflecting a year-on-year increase of 26.03% [3][4]. - Operating cash flow improved significantly by 214.97% year-on-year, indicating enhanced management efficiency in accounts receivable [4][5]. - The gross margin reached 59.48%, up by 6.11 percentage points, while the net profit margin increased by 5.03 percentage points to 16.47% [4]. R&D Investment - The company invested 399 million yuan in R&D in the first half of 2025, accounting for 9.87% of revenue, maintaining a leading position in the traditional Chinese medicine industry [3][4][5]. - Cumulatively, over the past six years, the total R&D investment exceeded 5 billion yuan, showcasing a strong commitment to innovation [4][5]. Product Development - Yiling Pharmaceutical has achieved a notable milestone with the approval of five new traditional Chinese medicine products over the past five years, averaging one new drug per year [6]. - The newly approved Qifang Nasal Tablet targets a significant patient population with allergic rhinitis, reflecting the company's focus on unmet clinical needs [7]. Internationalization Strategy - The company is advancing its internationalization strategy through its subsidiary Yiling Wanzhou, focusing on markets in Canada and Europe, with a gradual market entry approach [9][11]. - As of the report date, the company has registered innovative patented traditional Chinese medicines in over 50 countries, enhancing its global footprint [9][11]. Academic Influence - Yiling Pharmaceutical has published several evidence-based research findings in top international journals, which have garnered global attention and recognition [9][10]. - The company emphasizes the importance of academic innovation as a support for its internationalization strategy, establishing a comprehensive academic promotion system [10].

Core Viewpoint - Jilin Aodong Pharmaceutical Group Co., Ltd. reported a significant increase in net profit despite a decline in revenue, demonstrating strong operational capabilities and strategic execution [1][4]. Financial Performance - In the first half of 2025, the company achieved operating revenue of 1.126 billion yuan, a year-on-year decrease of 20.21% - The net profit attributable to shareholders reached 1.282 billion yuan, a year-on-year increase of 138.44% [1]. Business Structure - The traditional Chinese medicine segment remains the core business, generating sales revenue of 686 million yuan, accounting for 60.90% of total revenue - The chemical drugs, chain pharmacy wholesale and retail, and health industry segments contributed sales revenues of 143 million yuan, 187 million yuan, and 83 million yuan, representing 12.73%, 16.59%, and 7.39% of total revenue, respectively [1]. Strategic Initiatives - The company is actively reforming its marketing system in the traditional Chinese medicine segment, having completed the marketing restructuring of 22 products and adjusted pricing policies for over 50 products - The company has made significant progress in its Chinese medicine formula granule business, obtaining 525 registration certificates for market access [2]. - A plan to issue convertible bonds to raise 134 million yuan for capital increase in its subsidiary, aimed at constructing a project for Chinese medicine formula granules with an annual production capacity of 2,000 tons [2]. Market Trends - The recovery of the consumer market is expected to accelerate the sales of consumer-oriented traditional Chinese medicine - Long-term growth is supported by an aging population and increasing health awareness among residents, providing a solid foundation for the industry [3]. Operational Efficiency - The company has optimized operational efficiency and adjusted regional layouts by closing some chain pharmacy stores, while enhancing brand management and deepening industry chain collaboration - The chain pharmacy business added 73,000 new members during the reporting period [3]. Asset Management - As of June 30, 2025, the company reported total assets of 34.151 billion yuan, a 3.48% increase from the beginning of the year, and net assets of 29.960 billion yuan, a 3.21% increase - The asset-liability ratio stands at 11.54%, indicating a low level within the industry [4].

Core Insights - Yiling Pharmaceutical has achieved significant innovation milestones in 2025, including the acceptance of its first classic prescription product, Banxia Baizhu Tianma Granules, and the approval for clinical trials of the chemical drug G201-Na Capsule [1] - The company has successfully launched Qifang Bitong Tablets in both domestic and Macau markets, indicating a potential expansion in sales [1] Group 1: Innovation and Product Development - Yiling Pharmaceutical is a leading representative in the modernization of traditional Chinese medicine, operating in three main business segments: traditional Chinese medicine, chemical medicine, and health products [2] - The company has launched 17 patented traditional Chinese medicines, covering eight major clinical disease systems, with 11 products included in the national medical insurance catalog [2] - From 2020 to 2024, Yiling Pharmaceutical has developed five new drugs, averaging one new drug per year, which is notable compared to the national average of fewer than 10 new traditional Chinese medicines approved annually [2] Group 2: Research and Development Pipeline - The company has a robust pipeline of research projects, with two traditional Chinese medicines approved for production, six in clinical trial phases, and over a hundred hospital preparations as reserves for new drug development [5] - A detailed list of ongoing research projects includes various traditional Chinese medicines targeting conditions such as allergic rhinitis, chronic cholecystitis, and pediatric colds, with several in different stages of clinical trials [3][4] Group 3: Strategic Expansion and Internationalization - Yiling Pharmaceutical is focusing on high-quality development by increasing innovation investments and accelerating high-end and international industrial layouts, aiming to create a globally influential industrial cluster [6] - The company's core products are now available in over 50 countries and regions, reflecting its solid internationalization efforts [6] - Yiling has developed a unique theory system on "Luo Disease," which has gained international recognition, and has published the first English textbook on this subject, further promoting traditional Chinese medicine globally [6]

Core Viewpoint - The traditional Chinese medicine company Baiyunshan is facing significant challenges, with its net profit continuing to decline for the second consecutive year due to insufficient demand, intensified industry competition, and regulatory pressures [1][2]. Financial Performance - In the first half of the year, Baiyunshan reported an operating income of approximately 418.35 billion yuan, a year-on-year increase of 1.93%, while the net profit attributable to shareholders was about 25.16 billion yuan, a decrease of 1.31% [2]. - The company’s net profit for the first half of 2024 is projected to be around 25.5 billion yuan, reflecting a year-on-year decline of 9.31% [2]. - Quarterly performance shows a significant drop in Q1, with operating income of about 224.7 billion yuan, down 2.06%, and a net profit of approximately 18.21 billion yuan, down 6.99%. However, Q2 showed signs of recovery with operating income of about 193.6 billion yuan, up 6.99%, and a net profit of 6.95 billion yuan, up 17.48% [3]. Business Segment Analysis - Baiyunshan's business is divided into four main segments: Traditional Chinese Medicine (TCM), Health Products, Commercial, and Medical [5]. - The TCM segment, which is the core business, saw a revenue decline of 15.23%, with the main revenue from TCM products dropping by 20.12% to approximately 32.46 billion yuan [5][6]. - The Health Products and Commercial segments reported revenue growth of 7.42% and 4.25%, respectively, with revenues of 70.23 billion yuan and 290 billion yuan [5]. R&D and Marketing Expenditure - Baiyunshan's R&D expenses decreased by 27.06% to 2.85 billion yuan in the first half of the year, continuing a downward trend over the past three years [8]. - In contrast, sales expenses were 30.28 billion yuan, down 2.92%, but still significantly higher than R&D expenses, indicating a long-standing focus on marketing over R&D [8]. Management Changes - Baiyunshan has experienced management instability, with the former chairman resigning in July 2024 amid allegations of serious violations, and a new chairman, Li Xiaojun, taking over in January 2024 [9].

Core Viewpoint - The traditional Chinese medicine company Baiyunshan is facing a challenging period with continuous declines in net profit due to insufficient demand, intensified industry competition, and regulatory pressures [1][3]. Financial Performance - In the first half of the year, Baiyunshan reported a revenue of approximately 418.35 billion yuan, a year-on-year increase of 1.93%, while the net profit attributable to shareholders was about 25.16 billion yuan, down 1.31% year-on-year [3]. - The company’s net profit for the first half of 2024 was approximately 25.5 billion yuan, reflecting a year-on-year decline of 9.31% [3]. - The pharmaceutical industry is experiencing a slowdown, with a reported revenue of 1.23 trillion yuan in the first half of 2025, down 1.2% year-on-year [3]. Business Segment Analysis - Baiyunshan's business segments show significant divergence in performance. The traditional Chinese medicine segment (Danan Yao) saw a revenue decline of 15.23%, while the health and commercial segments reported revenue growth of 7.42% and 4.25%, respectively [8][9]. - Specifically, the revenue from traditional Chinese medicine products fell by 20.12%, while chemical drugs also experienced a decline of 5.85% [9]. R&D and Marketing Expenditure - Baiyunshan's R&D expenses for the first half of the year were 2.85 billion yuan, a decrease of 27.06% year-on-year, indicating a trend of reduced investment in R&D [10]. - In contrast, the sales expenses were significantly higher at 30.28 billion yuan, reflecting a decrease of only 2.92% [10]. - The company has been criticized for prioritizing marketing over R&D, which may hinder its ability to innovate and adapt to market changes [11]. Management Changes - Baiyunshan recently appointed a new chairman, Li Xiaojun, who faces the challenge of navigating the company through multiple pressures while balancing short-term performance with long-term innovation [11].

Core Viewpoint - The announcement by the National Medical Products Administration regarding the optimization of clinical trial review and approval for innovative drugs is a significant positive development for the industry, particularly as it reduces the review time from 60 to 30 working days for innovative drug applications, including traditional Chinese medicine (TCM) [1] Group 1: Industry Overview - The recognition of TCM as an essential part of innovative drugs contrasts with the capital market's perception, which has not seen significant growth in TCM companies despite a surge in innovative drug stocks this year [1] - The modernization of TCM is gaining traction, supported by national policies, emphasizing the integration of traditional advantages with modern scientific techniques [3][4] Group 2: Company Profile - Yiling Pharmaceutical - Yiling Pharmaceutical is a leading innovative drug company with a focus on TCM, biopharmaceuticals, and health products, with TCM being the primary revenue and profit contributor [1] - As of the end of 2024, Yiling Pharmaceutical holds 17 patented TCM products covering eight major clinical disease systems, leading in the cardiovascular and respiratory disease treatment sectors [1] Group 3: Financial Performance - In 2024, Yiling Pharmaceutical's revenue from cardiovascular drugs exceeded 3.8 billion, while respiratory drugs accounted for less than 800 million, together representing over 70% of total revenue [9] - The company has experienced a decline in revenue over the past two years, primarily due to a significant drop in demand for its product Lianhua Qingwen post-pandemic [11] Group 4: Research and Development - Yiling Pharmaceutical has consistently ranked among the top in R&D investment within the A-share TCM sector, with annual R&D expenditures of approximately 895 million, 935 million, and 908 million over the past three years, representing 7.15%, 9.06%, and 13.94% of revenue respectively [5] - The company has achieved notable academic breakthroughs, including a landmark study published in a top medical journal demonstrating the efficacy of its product Tongxinluo in reducing cardiovascular events [6] Group 5: Growth Potential - Yiling Pharmaceutical's core competitive advantage lies in its founder's innovative theory on vascular diseases, which has attracted international research interest [12] - The company has five new drugs approved in the past five years, with four included in the medical insurance directory, indicating a strong pipeline for future growth [12] - The current market valuation of Yiling Pharmaceutical is estimated to be around 300 billion, with potential for significant appreciation as the market begins to recognize the value of innovative TCM [16]