Core Viewpoint - The report outlines the ongoing supervision and compliance of Suzhou Zejing Biopharmaceutical Co., Ltd. by China International Capital Corporation, emphasizing the company's adherence to regulations and the status of its financial performance in the first half of 2025. Summary by Sections Continuous Supervision Work - The supervising institution has established a comprehensive and effective supervision system and has signed a continuous supervision agreement with the company, clarifying the rights and obligations of both parties during the supervision period [1]. - During the supervision period from January to June 2025, the company did not report any violations or illegal activities [1][2]. - The supervising institution conducted regular communications, site visits, and due diligence to monitor the company's compliance with laws and regulations [1]. Financial Performance - For the first half of 2025, the company reported a revenue of CNY 375.65 million, a 56.07% increase compared to CNY 240.70 million in the same period of 2024 [1]. - The total profit for the same period was a loss of CNY 77.41 million, slightly improved from a loss of CNY 79.49 million in the previous year [1]. - The net loss attributable to shareholders was CNY 72.80 million, compared to a loss of CNY 66.54 million in the previous year [1]. - The cash flow from operating activities showed a significant decline, with a net outflow of CNY 17.02 million, down from an inflow of CNY 112.55 million in the same period last year [1]. Research and Development - The company has a strong focus on R&D, with R&D expenses accounting for 52.31% of its revenue in the first half of 2025, a decrease from 75.26% in the previous year [1]. - The company is actively developing a pipeline of innovative drugs targeting oncology and autoimmune diseases, with several products in various stages of clinical trials [20][21][24]. Competitive Advantages - The company possesses a differentiated product pipeline with several drugs already approved or nearing commercialization, including treatments for advanced liver cancer and thyroid cancer [20][21]. - The company is also exploring new targets and technologies to enhance its product offerings and maintain a competitive edge in the biopharmaceutical industry [22][26]. Risks and Challenges - The company faces significant risks, including the potential for unprofitability, reliance on external financing for R&D, and challenges in clinical trial recruitment and regulatory approvals [3][4][14]. - The competitive landscape in the pharmaceutical industry is intense, with the company needing to adapt to rapid technological changes and regulatory shifts [15][16]. Future Outlook - The company aims to enhance its international presence and collaboration capabilities, leveraging its innovative drug development platforms and established clinical networks [25][26]. - As more products approach commercialization, the company anticipates sustained revenue growth, which will support further R&D investments and strategic initiatives [24][25].

Investment Rating - The investment rating for the company is "Buy" [6] Core Views - The company reported a revenue of 376 million yuan in the first half of 2025, representing a year-on-year increase of 56.07%. However, it recorded a net loss attributable to shareholders of 72.8 million yuan, with a slight increase in losses compared to the previous year [1][6] - The commercialized products, including Donafenib and recombinant human thrombin, are showing steady growth. Donafenib has been introduced in over 1,200 hospitals, while recombinant human thrombin has been included in the national medical insurance directory for 2024, with significant sales growth [1][2] - The company has multiple promising pipelines, including ZG006 and ZG005, which are showing good efficacy and safety in clinical trials for various cancers [2] Summary by Sections Financial Performance - In the first half of 2025, the company achieved a revenue of 376 million yuan, with a year-on-year growth of 56.07%. The net profit attributable to shareholders was -72.8 million yuan, and the net profit after deducting non-recurring items was -103 million yuan, indicating a slight increase in losses compared to the previous year [1][6] - Revenue projections for 2025 to 2027 are estimated at 825 million yuan, 1.36 billion yuan, and 1.94 billion yuan, respectively, with growth rates of 54.8%, 65.2%, and 42.6% [2][4] Product Pipeline - The company is actively promoting its products, with Donafenib and recombinant human thrombin showing robust market penetration. Donafenib has been introduced in over 1,200 hospitals, while recombinant human thrombin has been adopted by over 590 hospitals [1][2] - The company has received approval for the marketing of Jikaxitinib for bone marrow fibrosis and is progressing with its NDA application for severe alopecia areata [1] - ZG006 has shown significant anti-tumor activity in clinical trials for small cell lung cancer, and ZG005 is being developed for multiple solid tumors [2]

Core Viewpoint - Zai Jian Pharmaceutical (688266.SH) reported a revenue of 376 million yuan for the first half of 2025, marking a year-on-year increase of 56.07%, but the net loss expanded from 66.54 million yuan to 72.80 million yuan, indicating ongoing financial challenges despite product approvals [1][3]. Group 1: Financial Performance - The company achieved a revenue of 376 million yuan in H1 2025, a 56.07% increase year-on-year [1]. - The net profit loss increased from 66.54 million yuan in the same period last year to 72.80 million yuan [1]. - The non-GAAP net profit loss rose from 72.37 million yuan to 102 million yuan [1]. - Cumulative losses since the company's listing in 2020 amount to approximately 1.72 billion yuan [3]. Group 2: Product Development and Market Strategy - Zai Jian Pharmaceutical has three products approved for sale, including Donafenib tablets, which are gradually increasing market share [1]. - The company is actively promoting Donafenib, having entered over 1,200 hospitals and 1,000 pharmacies by the end of the reporting period [1]. - The recombinant thrombin product has entered 590 hospitals and has seen significant sales growth after being included in the national medical insurance catalog [1]. - The company is focusing on the commercialization of Jikaxitini tablets, which were approved for treating primary myelofibrosis and are also being developed for other indications [2]. Group 3: Sales and Marketing Expenses - Sales expenses surged by 75.76% to 211 million yuan, accounting for 56% of total revenue [3]. - The increase in marketing expenses is attributed to new exclusive promotion fees for thrombin and expanded marketing efforts for Donafenib and Jikaxitini [3].

Core Viewpoint - The company has not yet achieved profitability and faces significant cumulative losses due to ongoing research and development expenses, despite having several products approved for commercial sale [1][2]. Group 1: Company Overview - The company, Suzhou Zelgen Biopharmaceutical Co., Ltd., has several products included in the medical insurance directory, including Tofacitinib tablets for advanced liver cancer and other conditions [1]. - The company has received approval for the marketing of recombinant human thrombin and Tofacitinib tablets, but these products are still in the market access phase [1][2]. Group 2: Financial Situation - As of June 30, 2025, the company has accumulated losses and may continue to incur losses in the future, which will depend on the success of its drug commercialization and the number of ongoing research projects [2]. - The company has significant reliance on external financing for its working capital, which may pressure its financial situation if expenses exceed available financing [2]. Group 3: Fundraising and Use of Funds - The company raised a total of RMB 2,025.6 million from its initial public offering in 2020, with a net amount of RMB 1,908.22 million after deducting related expenses [8][31]. - In 2021, the company raised RMB 1,199.99 million through a private placement, with a net amount of RMB 1,181.93 million after expenses [9][32]. - As of June 30, 2025, the company has used RMB 1,677.81 million of the initial public offering funds and RMB 406.25 million of the private placement funds [10][15]. Group 4: Risk Factors - The company faces risks related to its ongoing research and development projects, which require substantial investment and may not yield successful outcomes [2][3]. - The company has not declared any cash dividends due to its inability to generate profits, which may negatively impact shareholder returns [2].

Financial Performance - The company reported total operating revenue of approximately 375.65 million, a significant increase from 240.70 million in the same period last year, reflecting a year-on-year growth [3] - The total profit for the period was -77.41 million, slightly improved from -79.49 million year-on-year [3] - The net profit attributable to shareholders was -72.80 million, compared to -66.54 million in the previous year [3] - The net profit after deducting non-recurring gains and losses was -102.64 million, worsening from -72.37 million year-on-year [3] - The net cash flow from operating activities was -17.02 million, a decrease from a positive cash flow of 112.55 million in the same period last year [3] Non-Recurring Gains and Losses - The total non-recurring gains and losses amounted to 29.84 million, with government subsidies contributing 22.82 million and other non-recurring items accounting for 10.24 million, while the tax impact was -3.30 million [1] Shareholder Structure - The top ten shareholders at the end of the first half of 2025 included new entrants such as Huatai Fuhua Innovation Medical Theme Mixed Securities Investment Fund and Ningbo Jingchen Investment Partnership, replacing previous shareholders [52] - The shareholding ratio of China Europe Medical Health Mixed Securities Investment Fund increased, while other funds saw a decrease in their holdings [52] Financial Ratios - As of the end of the first half of 2025, the company's current ratio was 1.9 and the quick ratio was 1.78, indicating a stable liquidity position [48] - The company’s price-to-earnings ratio (TTM) was approximately -200.42, with a price-to-book ratio of about 24.54 and a price-to-sales ratio of approximately 43.24 [3] Asset and Liability Changes - As of mid-2025, cash and cash equivalents decreased by 1.68%, while accounts receivable increased by 22.12% [41] - Long-term borrowings increased by 183.42%, while other payables decreased by 57.26% [44]

Core Viewpoint - Suzhou Zelgen Biopharmaceutical Co., Ltd. has received approval from the National Medical Products Administration for clinical trials of injectable ZG005, ZGGS18, and JAK inhibitor Jika Xini tablets in combination for advanced solid tumors [2][3]. Group 1: Drug Information - Injectable ZG005 is a recombinant humanized anti-PD-1/TIGIT bispecific antibody, classified as a Class 1 innovative tumor immunotherapy product, with potential applications for various solid tumors. It is one of the first drugs globally to enter clinical research targeting the same mechanism [3][4]. - Injectable ZGGS18 is a recombinant humanized bispecific antibody fusion protein targeting VEGF and TGF-β, also classified as a Class 1 therapeutic biological product, expected to be an innovative treatment for solid tumors [4][5]. - JAK inhibitor Jika Xini tablets, developed by the company, are a new Class 1 drug with independent intellectual property rights. They have received NDA approval for treating high-risk myelofibrosis and are undergoing clinical trials for other indications [5][6]. Group 2: Clinical Trial Approval Impact - The approval for the clinical trial of the combination therapy is not expected to have a significant impact on the company's recent performance due to the lengthy and uncertain nature of drug development and approval processes [2][7]. - The company will actively promote the research projects in accordance with national regulations and fulfill information disclosure obligations regarding subsequent project developments [7][8].

Company Announcements - Dameng Data's board member and senior vice president is under investigation by the Hubei Provincial Supervisory Committee, but the company's operations remain normal [1] - Jishi Media reported a net loss of 232 million yuan in the first half of 2025, despite a revenue increase of 8.7% to 999.7 million yuan [2] - Wantai Biological's nine-valent HPV vaccine has received its first batch release certificate, marking its market entry and potential revenue growth [2] - Feilu Co., Ltd. is undergoing a change in control, leading to a suspension of its stock trading starting August 22 [2] Financial Performance - Sany Heavy Industry reported a 46% increase in net profit to 5.216 billion yuan in the first half of 2025, with a revenue of 44.534 billion yuan, up 14.96% [3] - EVE Energy's net profit decreased by 24.9% to 1.605 billion yuan, despite a revenue increase of 30.06% to 28.169 billion yuan [5] - GoerTek achieved a net profit increase of 15.65% to 1.42 billion yuan, with a revenue of 37.55 billion yuan, down 7.02% [6] Approvals and Projects - Changchun High-tech's subsidiary received acceptance for a clinical trial application for GenSci143, a dual-specificity antibody drug targeting B7-H3 and PSMA [7] - Zejing Pharmaceutical received approval for clinical trials of ZG005 and ZGGS18 in combination with a specific cancer drug [7] Financing and Capital Increase - Zhenghe Industrial plans to raise no more than 818 million yuan through a private placement for various projects and working capital [8] Shareholding Changes - Zhongyin Securities announced that Jiangxi Copper plans to reduce its stake by up to 3%, equating to 83.34 million shares [9] - Mengke Pharmaceutical's shareholders plan to transfer 22.946 million shares, representing 3.5% of the total share capital [15] Investments and Strategic Partnerships - Diou Home plans to establish a wholly-owned subsidiary with an investment of 500 million yuan to expand into the generative AI field [11] - Gree Green signed a strategic cooperation agreement with Weilan Lithium to develop ultra-high energy density battery materials and solid-state battery innovations [12]

Suspension - Feilu Co., Ltd. is planning a change in company control, leading to the suspension of its stock [1] Capital Increase and Mergers - Yunnan Copper Industry has submitted an application to acquire 40% of Liangshan Mining, which has been accepted by the Shenzhen Stock Exchange [2] - Zhenghe Industrial plans to raise no more than 818 million yuan through a private placement for agricultural machinery component expansion, garden tool chain saw system project, micro chain system software and hardware integration R&D, and to supplement working capital [2] - iFlytek intends to raise no more than 4 billion yuan through a private placement for the Spark Education large model and typical products, and to supplement working capital; a shareholder, Yanzhi Technology, plans to subscribe for no less than 250 million yuan and no more than 350 million yuan [2] External Investment and Daily Operations - Wantai Biological Pharmacy's nine-valent human papillomavirus vaccine has received its first batch release certificate [3] - Hanyu Pharmaceutical's acetic acid atoziban injection has obtained marketing approval in Vietnam [4] - Zai Jian Pharmaceutical has received clinical trial approval for injectable ZG005, injectable ZGGS18, and the combination with hydrochloride gikaixin tablets [5] - Changchun High-tech's subsidiary has had its clinical trial application for injectable GenSci143 accepted [6] - Jinbo Co., Ltd. has received a notification from a leading OEM, selecting the company as a designated supplier for developing and supplying carbon-ceramic brake disc products [6] - Greeenmei has signed a strategic cooperation agreement with Weilan Lithium Core to create a high-energy battery materials and solid-state battery innovation consortium [7] - Anyuan Coal Industry plans to change its stock name to "Jiang Tung Equipment" [8] Performance Changes - Qianfang Technology reported a net profit of 170 million yuan in the first half of the year, a year-on-year increase of 1287.12% [9] - Sainuo Medical's net profit in the first half of the year increased by 296.54% year-on-year [10] - Jin Qilin reported a net profit of 108 million yuan in the first half of the year, a year-on-year increase of 226.14% [11] - Qianzhao Optoelectronics reported a net profit of 69.23 million yuan in the first half of the year, a year-on-year increase of 88.04% [12] - Miaokelando reported a net profit of 133 million yuan in the first half of the year, a year-on-year increase of 86.27% [12] - Hudian Co., Ltd. reported a net profit of 1.683 billion yuan in the first half of the year, a year-on-year increase of 48% [12] - GoerTek reported a net profit of 1.417 billion yuan in the first half of the year, a year-on-year increase of 15.65% [12] - Yunnan Ge Industry reported a net profit of 22.15 million yuan in the first half of the year, returning to profitability [12]

Core Viewpoint - Zai Jian Pharmaceutical has received approval from the National Medical Products Administration for clinical trials of its innovative cancer immunotherapy products, ZG005 and ZGGS18, in combination with JAK and ACVR1 dual inhibitor, JAK inhibitor [1] Group 1 - ZG005 is a recombinant humanized anti-PD-1/TIGIT bispecific antibody classified as a Class 1 innovative tumor immunotherapy biological product, expected to treat various solid tumors [1] - ZG005 is one of the first drugs globally to enter clinical research targeting the same mechanism, with no similar mechanism drugs approved for market worldwide [1] - ZGGS18 is a recombinant humanized bispecific antibody fusion protein targeting VEGF/TGF-β, classified as a Class 1 therapeutic biological product, anticipated to be an innovative treatment for solid tumors [1] Group 2 - JAK inhibitor, also known as JAK and ACVR1 dual inhibitor, is a new Class 1 drug independently developed by the company, which holds the intellectual property rights for this product [1]

Core Viewpoint - Zai Jing Pharmaceutical has received approval from the National Medical Products Administration for clinical trials of ZG005 and ZGGS18 in combination with Jikaxitinib for advanced solid tumors [2] Group 1: Company Developments - Zai Jing Pharmaceutical announced the approval of clinical trials for ZG005 and ZGGS18, indicating progress in its oncology pipeline [2] - The company's revenue composition for the year 2024 is projected to be 99.73% from pharmaceutical manufacturing and 0.27% from other businesses, highlighting its focus on the pharmaceutical sector [2]