撰文丨王聪 编辑丨王多鱼 排版丨水成文 类器官 （ Organoid ） 是从干细胞衍生出的三维 （3D） 结构，能够重现相应组织的关键结构和功能特 征。与传统的二维 （2D） 细胞系相比，人类类器官能提供更贴近人体生理的实验模型。它们能够捕捉人 体组织的复杂性和异质性，从而有助于研究疾病机制、药物疗效和毒性。当由患者来源的生成时，类器官 还能用于评估个体对治疗药物的响应。 近日，"类器官之父" Hans Clevers 教授、 王代松 博士等在 Nature 旗下综述期刊 Nature Reviews Drug Discovery 上发表了题为 ： Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges 的研究论文。 在这篇综述中，作者们探讨了 类器官在药物发现中的应用 ，概述了当前的生成和维持类器官的方法，考察 了它们在疾病建模、药物筛选和安全性评估方面的应用，并考虑了监管方面以及在药物发现中更广泛采用 所面临的挑战。 在药物研发领域，体外模型发挥着关键作用，为研究细胞对药物的反应提 ...

摘要 ： 第六届中国干细胞与再生医学大会发布多项国际标准，推动产业规范化与国际合作。 特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我 们的推送。 " 会议成果既是我国生物技术标准化领域的重大突破，更是干细胞与类器官产业规范化与高质 量发展的重要里程碑。"中国科学院动物研究所研究员赵同标 11月3 0日，第六届中国干细胞与再生医学协同创新平台大会在北京隆重召开。大会以"规范・ 融合・创新"为主题，旨在搭建高水平交流与合作平台，汇聚各方力量共商干细胞与再生医学 领域标准化建设、资源整合与协同创新大计，为行业高质量发展注入强劲动力。 平 台 理 事 长 卞 修 武 院 士 作 年 度 工 作 报 告 ； 平 台 秘 书 长 胡 宝 洋 研 究 员 主 持 开 幕 式 。 来 自 科 研 院 所、高校、医院、企业及监管机构的各界代表齐聚一堂，围绕干细胞监管体系、资源与质量标 准、前沿技术应用及临床转化等核心议题展开深入探讨。 科技平台相关负责同志在致辞中指出，平台对提升我国高水平科技自立自强、引领新质生产力 发展具有重大意义。科技平台相关负责同志肯定平台在资 ...

本届大会由中国干细胞与再生医学协同创新平台主办，北京干细胞与再生医学研究院、中国科学院 动物研究所承办，国家干细胞资源库等14家成员单位协办。 "会议成果既是我国生物技术标准化领域的重大突破，更是干细胞与类器官产业规范化与高质量发 展的重要里程碑。"中国科学院动物研究所研究员赵同标说，标准体系的建设将推动我国生物技术产业 深度参与国际合作，为全球科技创新生态建设做出积极贡献。 国际标准是全球通用的技术语言，也是促进技术国际合作与交流的核心要素。与会专家认为，标准 的出台将搭建科研与临床的转化桥梁，提高新药研发效率，为产业降低成本并减少风险。 记者从日前举行的第六届中国干细胞与再生医学协同创新平台大会上获悉，我国科研人员牵头组建 了国际标准化组织生物技术委员会类器官工作组。大会还为我国专家主导、多国参与的2项国际标准以 及中国细胞生物学学会制定的5项团体标准举行了发布仪式。 据了解，类器官是基于干细胞体外培养形成的、具有类似体内器官结构和功能的微型组织模型，能 精准模拟人体器官的生理状态与疾病进程，在生物医学领域价值重大。其可用于疾病精准诊断、个性化 药物筛选等，还能助力再生医学研究，为人类疾病治疗与健康保障开 ...

国际标准是全球通用的技术语言，也是促进技术国际合作与交流的核心要素。与会专家认为，标准的出 台将搭建科研与临床的转化桥梁，提高新药研发效率，为产业降低成本并减少风险。 本届大会由中国干细胞与再生医学协同创新平台主办，北京干细胞与再生医学研究院、中国科学院动物 研究所承办，国家干细胞资源库等14家成员单位协办。（记者彭韵佳） 据了解，类器官是基于干细胞体外培养形成的、具有类似体内器官结构和功能的微型组织模型，能精准 模拟人体器官的生理状态与疾病进程，在生物医学领域价值重大。其可用于疾病精准诊断、个性化药物 筛选等，还能助力再生医学研究，为人类疾病治疗与健康保障开辟新路径。 "会议成果既是我国生物技术标准化领域的重大突破，更是干细胞与类器官产业规范化与高质量发展的 重要里程碑。"中国科学院动物研究所研究员赵同标说，标准体系的建设将推动我国生物技术产业深度 参与国际合作，为全球科技创新生态建设做出积极贡献。 记者从日前举行的第六届中国干细胞与再生医学协同创新平台大会上获悉，我国科研人员牵头组建了国 际标准化组织生物技术委员会类器官工作组。大会还为我国专家主导、多国参与的2项国际标准以及中 国细胞生物学学会制定的5项 ...

Core Viewpoint - The CDC has issued a directive to end all research projects involving the use of monkeys by the end of this year, marking a significant shift in animal research policy in the U.S. [3][4] Group 1: CDC Directive and Its Implications - The directive affects approximately 200 monkeys used primarily for infectious disease research, including HIV prevention and antiviral treatments [3]. - This is the first time a U.S. government agency has terminated non-human primate research since the NIH initiated a retirement plan for chimpanzees a decade ago [3]. - The future of these monkeys is uncertain, with possibilities including relocation to primate sanctuaries or euthanasia [3]. Group 2: New Methodologies in Research - Advocates for "new methodologies" such as organoids believe this marks the beginning of a "post-animal era" in research [3]. - The CDC's directive is seen as a potential model for transitioning to advanced alternative technologies, although achieving complete replacement of animal models is complex [4]. - The NIH still oversees nearly 7,000 non-human primates, indicating that the CDC's directive does not apply to all research institutions [4]. Group 3: Challenges of Replacement Technologies - Experts caution that while organoids and other new methodologies show promise, they cannot fully replicate the complexity of human diseases [4]. - The current state of recognized alternatives to animal testing remains limited, with few validated methods available [4]. - The debate continues on the extent to which organoids can replace animal models in biomedical research [4]. Group 4: Global Perspective and Future Directions - The focus should be on which countries can effectively implement alternative methodologies in translational medicine and drug evaluation [5]. - The CDC's decision highlights a growing contradiction in biomedical research: the need for new therapies while still relying on animal models for certain critical research areas [5]. - Addressing the balance between ethical considerations and scientific needs is essential for the advancement of both science and ethics [5].

Core Viewpoint - The CDC has issued a directive to end all research projects involving the use of monkeys by the end of this year, marking a significant shift in animal research policy in the U.S. [2] Group 1: Research and Policy Changes - Approximately 200 monkeys used for infectious disease research, including HIV and hepatitis, will be affected by the CDC's directive [2] - This is the first time a U.S. government agency has terminated non-human primate research projects since the NIH initiated a retirement plan for chimpanzees a decade ago [2] - The directive may lead to some monkeys being transferred to primate sanctuaries, while others may face euthanasia [2] Group 2: Alternative Research Methods - The announcement has sparked discussions among advocates of "new methodologies," suggesting a transition to a "post-animal era" in research [2] - The NIH still oversees nearly 7,000 non-human primates, indicating that the CDC's directive does not apply to all animal research in the U.S. [3] - Experts highlight that while the CDC's decision may be framed as a move towards advanced alternative technologies, fully replacing animal models is complex and not straightforward [3] Group 3: Global Perspective and Future Implications - The focus should be on which countries can develop solid results in alternative methodologies to gain a competitive edge in translational medicine and drug evaluation [4] - The termination of the monkey research program highlights a growing contradiction in biomedical research: the need for new therapies while determining when animal models are essential [4] - Responsible answers to the questions of when to use animals versus alternative methods are crucial for advancing both science and ethics [4]

Core Viewpoint - The article discusses the advancements in organoid technology, particularly the development of a single-chain antibody (scTS2/16) that enhances organoid growth in defined matrices, paving the way for standardized and clinically applicable organoid cultures [3][19]. Group 1: Organoid Technology Overview - Organoids are miniaturized, self-organizing tissue models that can be cultured in vitro, providing powerful tools for drug development, precision medicine, and regenerative medicine [2]. - The reliance on Matrigel, a mouse-derived matrix, poses significant limitations due to its unclear chemical composition and batch-to-batch variability, hindering the translational application of organoids [2][6]. Group 2: Research Breakthrough - A study published by Hans Clevers in Nature Biotechnology introduced scTS2/16, a single-chain derivative of an integrin-activating antibody that significantly enhances organoid growth in both Matrigel and collagen hydrogels [3]. - The research indicates that scTS2/16 can increase the yield of gastrointestinal organoids by up to 5 times in traditional matrices and 6-7 times in defined collagen hydrogels [14]. Group 3: Mechanism of Action - The mechanism behind scTS2/16's effectiveness lies in its ability to maintain integrin β1 in an active state, enhancing the interaction between cells and the extracellular matrix [16][17]. - The study confirmed that scTS2/16 specifically enhances the interaction between integrins and collagen, facilitating better organoid growth [17]. Group 4: Clinical Application Potential - The research highlights the potential for scTS2/16 to be used in clinical applications due to its controllable quality and compatibility with existing clinical-grade collagen products [19]. - The versatility of scTS2/16 allows for its use in both 3D hydrogel cultures and 2D platforms, making it suitable for high-throughput drug screening [19].

Group 1 - QYResearch is recognized for its authoritative industry analysis and customized reports, widely cited by numerous well-known domestic and international companies, securities firms, and media [1] - The ASIC design service market in China is projected to generate sales revenue of $1.503 billion in 2023, with expectations to reach $3.416 billion by 2030 [2] - The global servo system market is estimated to be $15.611 billion in 2023, with a compound annual growth rate (CAGR) of 4.73%, reaching $20.604 billion by 2029 [5] Group 2 - The global vehicle dashboard market is dominated by a leading domestic company, ranked first in China and eighth globally, according to QYResearch [7] - The global humidifier market is expected to grow at a CAGR of over 10% in the next five years, with integrated and smart products taking a leading position [10] - The market for osmotic laxatives in China is projected to exceed 7.313 billion yuan by 2029, capturing 33.65% of the total constipation medication market [12] Group 3 - The global high-speed connector market is anticipated to reach $21.6 billion by 2030, providing significant expansion opportunities for suppliers [15] - The directional drilling tools market is expected to exceed $9.42 billion in 2024 and surpass $26.88 billion by 2037, with a CAGR of over 8.4% [17] - The global optical switch market is projected to reach $2.02 billion by 2031, with a CAGR of 16.3% [20] Group 4 - The global semiconductor robot market is currently dominated by foreign manufacturers, holding over 90% of the market share in China [22] - The global automatic wafer testing probe market is estimated to be around $1.156 billion in 2024, characterized by high market concentration [24] - The global emergency kit market is expected to reach $1.061 billion by 2031, with a CAGR of approximately 7.3% [27] Group 5 - The global home wireless router market is projected to grow at a CAGR of 5.8% from 2025 to 2031 [29] - The global medical device market is expected to reach $635.8 billion by 2024 [32] - The global SD-WAN market is estimated to reach $51.8 billion by 2031, with a CAGR of 32.6% [35] Group 6 - The global organ-on-a-chip market is expected to grow at a CAGR of 31.2% from 2024 to 2030 [69] - The global automotive drive motor core market is projected to reach $4.678 billion by 2030, with a CAGR of 11.85% [62] - The global eSIM card market is entering a rapid expansion phase, particularly in the IoT and consumer electronics sectors [65]

Core Insights - The rapid advancements in biomedical engineering are reshaping the future of human health, with innovations such as 3D bioprinting of organs and tissues becoming increasingly feasible [3][20] - Significant breakthroughs include the successful cultivation of a living heart organoid and the discovery of a molecular switch for organ regeneration in mammals [1][4] Group 1: Innovations in Biomedical Engineering - The first living heart organoid over 1 cm in diameter was successfully cultivated in Shanghai, offering new hope for organ transplantation [1][4] - Researchers have developed a method to 3D print active organoids using bioprinting technology, which can replicate the structure and function of real organs [4][20] - The production of bioprinting materials involves creating billions of living cells, which are cultivated in specialized environments to ensure rapid and large-scale expansion [6][8] Group 2: Applications of Bioprinting - Bioprinting technology is being utilized for drug testing, allowing for the creation of mini-tumor models that can simulate patient responses to various treatments [16][18] - The development of in-situ printing techniques enables the direct repair of damaged tissues within the body, such as printing new skin or heart patches [18][20] Group 3: Cross-Disciplinary Collaborations - Collaborative efforts among multiple research institutions have led to the creation of a novel visual prosthetic that allows blind animals to perceive infrared light, showcasing the potential of interdisciplinary research in biomedical engineering [21][27] - The integration of nanomaterials and advanced engineering techniques has resulted in significant improvements in the functionality and efficiency of bioelectronic devices [25][27] Group 4: Strategic Development in Life Sciences - The Chinese government is prioritizing life sciences in its strategic development plans, with initiatives aimed at accelerating the commercialization of cutting-edge technologies in cell and gene therapy [28] - Cities like Shanghai and Shenzhen are actively fostering innovation ecosystems around organoids and biomanufacturing, with ambitious targets for the growth of the biopharmaceutical industry [28]

OTC2025： 产学研医共促类器官技术突破 类器官技术正在快速发展，并逐步进入临床试验阶段。虽然仍面临挑战，但随着生物工程、人工智能和细 胞培养技术的进步，类器官有望成为精准医疗和再生医学的核心工具，为人类健康带来革命性突破。值此 之际， OTC2025 类器官前沿应用与 3D 培养论坛 重磅来袭：围绕 类器官与疾病建模、 3D 细胞培养、 AI+ 器官芯片推进新药研发、类器官培养及质量控制 等角度展开深度探讨。 论坛名称 ： OTC2025 类器官前沿应用与 3D 培养论坛 02 为何举办OTC2025 1 利用 AI 分析类器官大规模数据 ，加速个性化药物筛选疾病建模； 2 开发 自动化培养系统 ，提高类器官生产效率，降低成本； 3 结合 3D 生物打印和微流控技术，增加类器官的细胞类型和结构复杂度，以更好地模拟人体微环境； 4 研究如何引入血管系统和免疫细胞，增强类器官的功能性； 5 研发临床级培养基和支架材料，减少批次间差异； 6 建立类器官生物库，为临床应用提供稳定的细胞来源。 举办地点 ：上海 论坛规模 ： 50 余授课嘉宾， 800 余参会嘉宾 主办单位 ：上海傲顺医药、上海佰傲泰医药科技、药 ...