Core Viewpoint - The company is focusing on both endogenous growth and external expansion to achieve sustainable development, leveraging its core product and exploring innovative drug frontiers through strategic investments [1][5]. Internal Growth - The company has established a comprehensive industrial layout covering Tibet, Sichuan, Shanghai, and overseas markets over the past two decades [6]. - Its product range includes biopharmaceuticals, Tibetan medicine, traditional Chinese medicine, and chemical drugs, with key products addressing cardiovascular, liver, and respiratory issues [6]. - The core product, Xinhuasuan, is a self-developed national biological product for treating acute heart failure, which has maintained stable sales revenue [6]. - The company plans to invest several million yuan in evidence-based medical exploratory research for Xinhuasuan to expand its application scenarios and enhance academic promotion [6]. - Xinhuasuan has reached nearly 7,000 medical institutions, with plans to strengthen partnerships with commercial companies to further expand its coverage [6][7]. External Expansion - The company is investing in the cutting-edge field of gene editing, having invested $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake [8][9]. - Accuredit focuses on developing in vivo gene editing technologies and products, aiming to provide innovative treatment solutions with cost advantages [9]. - The company also invested $30 million in Jiangsu Chentai Pharmaceutical Technology Co., acquiring a 13.04% stake, with Chentai's Zorifertinib being a significant product for advanced non-small cell lung cancer [10]. Future Strategy - The company aims to enhance its innovation platform to support cutting-edge innovation and increase its product pipeline, focusing on both internal and external growth strategies [11]. - Future efforts will include increasing R&D investment and project introduction, driven by new media marketing and innovative drug development to improve profitability and sustainable growth [11].

◎记者 孙小程 西藏药业一度让不少同行艳羡——大单品新活素经久不衰，支撑其业绩常年保持稳定。 但硬币的另一面，显然是单一产品依赖度过高的风险，这是始终悬在西藏药业头顶的现实考题。 西藏药业生产线 西藏药业厂区 居安常思危，如何摆脱"单腿走路"的局面？ 近日，上海证券报记者走进西藏药业，探寻其在新时期的转型密码。西藏药业董事长陈达彬将其总结 为：内源性增长与外延式扩张并重。对内拓展新活素的市场覆盖率，深挖藏药资源护城河；对外通过投 资基因编辑企业，持续探索创新药前沿领域。"内外"兼修，让谋求可持续发展的西藏药业迈向更广阔的 增长空间。 守正于"内" 夯实发展根基 从雪域高原出发，西藏药业在二十余年的时间里，逐步构建起覆盖西藏、四川、上海及海外市场的产业 版图。 目前，西藏药业产品涵盖生物制药、藏药、中药和化学药领域，主要产品涉及心脑血管、肝胆、扭挫伤 及风湿、类风湿、感冒等，代表品种有新活素、依姆多、诺迪康、十味蒂达胶囊、雪山金罗汉止痛涂膜 剂、小儿双清颗粒等。 其中，新活素是西藏药业拥有自主研发的国家生物制品一类新药，是治疗急性心衰的基因工程药物。新 活素能快速改善心衰患者的心衰症状和体征，提高患者的生存质量 ...

Core Viewpoint - Tibet Pharmaceutical (600211.SH) reported a steady performance in Q3 2025, with revenue of 2.089 billion yuan and net profit of 722 million yuan, while actively seeking new growth points through investments in innovative drug development [1][2]. Group 1: Financial Performance - In the first three quarters of 2025, Tibet Pharmaceutical achieved operating revenue of 2.089 billion yuan and a net profit attributable to shareholders of 722 million yuan, indicating stable overall performance [1]. - The company reported a non-recurring net profit of 668 million yuan, reflecting its solid financial foundation [1]. Group 2: Strategic Investments - The company made a significant investment of 60 million USD in Suzhou Ruizheng Gene Co., Ltd., marking a key highlight in its management strategy for entering the innovative drug sector [1]. - In August 2025, Tibet Pharmaceutical announced a 60 million USD equity investment in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which aligns with its strategic focus on innovative drug development [1][2]. Group 3: Innovative Drug Pipeline - Ruizheng Gene is developing therapies targeting metabolic diseases, particularly in the liver disease area, addressing significant unmet clinical needs [2]. - The company is the first in China to enter exploratory clinical research for an LNP-based in vivo gene editing product and has received FDA clinical approval in the U.S. for its pipeline [2]. - The ART001 pipeline targets rare diseases, currently in Phase I/IIa clinical trials in China, and has received orphan drug designation from the FDA [2]. Group 4: Product Development and Market Strategy - The company reported sales of its product "New活素" reaching approximately 4.17 million units, generating revenue of 1.456 billion yuan, with a low market penetration rate despite a large annual incidence of heart failure patients in China [3]. - The company is actively promoting "New活素" sales and has initiated exploratory research to expand sales channels [3]. - Other products like "诺迪康" and "金罗汉" are performing well in the market, with expectations for gradual growth in market share [3]. Group 5: Additional Investments - In March 2025, the company completed a 300 million yuan equity investment in Jiangsu Chentai Pharmaceutical Technology Co., Ltd., acquiring a 13.04% stake [4]. - The drug "Zorifertinib" developed by Chentai is the first globally to conduct registration clinical trials for advanced non-small cell lung cancer with CNS metastasis, showing significant clinical value [4]. - The commercialization of Zorifertinib is underway, with preparations for negotiations regarding medical insurance, which could provide stable cash flow for the company [4].

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies and aiming for high-quality growth through increased R&D investment and strategic partnerships [1][2]. Group 1: Company Strategy and Growth - The company plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which is seen as a strategic move to enhance its innovation capabilities [1]. - Tibet Pharmaceutical has achieved significant growth over the past decade, with revenue increasing from 521 million to 2.807 billion yuan, representing a compound annual growth rate (CAGR) of 18.34%, and net profit rising from 92 million to 1.051 billion yuan, with a CAGR of 27.63% [2]. - The company aims to stabilize its core product "Xinhua Su" while exploring new growth opportunities through product rebranding and enhanced marketing strategies [3]. Group 2: Market Challenges and Opportunities - In 2024, the company experienced a revenue decline of 10.45%, raising concerns about its ability to maintain high growth rates, despite a 9.45% increase in net profit [3]. - The company is addressing its reliance on single products and insufficient R&D investment by pursuing mergers and acquisitions, particularly in the gene editing sector [3][4]. Group 3: Acquisition and Innovation - The acquisition of Accuredit Therapeutics is part of Tibet Pharmaceutical's strategy to enter the gene editing market, which is expected to drive innovation and growth [4][5]. - Accuredit Therapeutics focuses on developing gene editing drugs and has a strong team with experience in biopharmaceuticals, which aligns with Tibet Pharmaceutical's goals [5]. - The CEO of Accuredit, Wang Yongzhong, has a robust background in the biopharmaceutical industry, which could enhance the company's international expansion efforts [5]. Group 4: Safety and Regulatory Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with clinical data required to validate its safety over 2 to 5 years [6]. - The company is working on improving safety through reversible gene editing techniques and off-target detection methods [6].

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies, particularly in the field of innovative drugs and gene editing technology [1][3]. Group 1: Investment and Strategic Direction - Tibet Pharmaceutical plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which has been approved by the company's shareholders [1]. - The company aims to enhance its growth through both internal and external strategies, emphasizing R&D investment and project acquisition to drive sustainable development [1][2]. Group 2: Financial Performance - Over the past decade, Tibet Pharmaceutical's revenue increased from 521 million to 2.807 billion, with a compound annual growth rate (CAGR) of 18.34%, while net profit rose from 92 million to 1.051 billion, with a CAGR of 27.63% [2]. - However, in 2024, the company experienced a revenue decline of 10.45%, raising concerns about its growth sustainability, despite a 9.45% increase in net profit [2]. Group 3: Growth Strategy - To achieve sustained growth, the company must establish a second growth curve focusing on internal growth through product enhancement and external growth via R&D and acquisitions [3]. - The acquisition of Accuredit Therapeutics is seen as a critical step in the company's innovation journey, aligning with its transformation strategy [3][4]. Group 4: Gene Editing Focus - Accuredit Therapeutics, established in 2021, specializes in developing non-viral vector-based gene editing drugs and has a comprehensive technology platform [4]. - The company is currently conducting clinical trials for its lead product, ART001, which has received IND approval in both China and the U.S. [4][5]. Group 5: Safety and Market Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with a typical waiting period of 2 to 5 years for clinical data to confirm safety [5]. - The company is enhancing safety through reversible gene technology and off-target detection methods [5].

Core Viewpoint - Tibet Pharmaceutical (600211.SH) reported a slight increase in revenue and net profit for the first half of 2025, emphasizing its commitment to investor returns through stable dividend policies [1][2]. Financial Performance - The company achieved operating revenue of 1.651 billion yuan, a year-on-year increase of 2.23% [1] - The net profit attributable to shareholders, after deducting non-recurring items, was 543 million yuan, reflecting a growth of 3.69% [1] - A cash dividend of 8.81 yuan per 10 shares (including tax) is proposed, totaling approximately 284 million yuan, which represents 50.05% of the net profit for the period [1] Product Performance - The main product, Xinhuasu, generated sales of approximately 1.456 billion yuan, accounting for about 88.36% of the main business revenue, with a slight increase in sales volume to around 4.17 million units [1] - Other products contributed approximately 192 million yuan in sales, marking a significant year-on-year growth of 18.83% [2] - The company’s product line focuses on cardiovascular diseases, with Xinhuasu, Yimuduo, and Nuodikan as key offerings [2] R&D and Market Position - Tibet Pharmaceutical benefits from unique ecological Tibetan medicinal resources, with Nuodikan being a notable product derived from Rhodiola rosea [2] - The company is actively advancing research on traditional Tibetan medicine and cultivating Tibetan medicinal herbs to support product diversification and sustainable development [2] - In March 2025, the company invested 300 million yuan in Jiangsu Chentai Pharmaceutical Technology Co., acquiring a 13.04% stake, and became the exclusive distributor for Zorifertinib in mainland China [3]