Core Viewpoint - The company is focusing on both endogenous growth and external expansion to achieve sustainable development, leveraging its core product and exploring innovative drug frontiers through strategic investments [1][5]. Internal Growth - The company has established a comprehensive industrial layout covering Tibet, Sichuan, Shanghai, and overseas markets over the past two decades [6]. - Its product range includes biopharmaceuticals, Tibetan medicine, traditional Chinese medicine, and chemical drugs, with key products addressing cardiovascular, liver, and respiratory issues [6]. - The core product, Xinhuasuan, is a self-developed national biological product for treating acute heart failure, which has maintained stable sales revenue [6]. - The company plans to invest several million yuan in evidence-based medical exploratory research for Xinhuasuan to expand its application scenarios and enhance academic promotion [6]. - Xinhuasuan has reached nearly 7,000 medical institutions, with plans to strengthen partnerships with commercial companies to further expand its coverage [6][7]. External Expansion - The company is investing in the cutting-edge field of gene editing, having invested $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake [8][9]. - Accuredit focuses on developing in vivo gene editing technologies and products, aiming to provide innovative treatment solutions with cost advantages [9]. - The company also invested $30 million in Jiangsu Chentai Pharmaceutical Technology Co., acquiring a 13.04% stake, with Chentai's Zorifertinib being a significant product for advanced non-small cell lung cancer [10]. Future Strategy - The company aims to enhance its innovation platform to support cutting-edge innovation and increase its product pipeline, focusing on both internal and external growth strategies [11]. - Future efforts will include increasing R&D investment and project introduction, driven by new media marketing and innovative drug development to improve profitability and sustainable growth [11].

◎记者 孙小程 西藏药业一度让不少同行艳羡——大单品新活素经久不衰，支撑其业绩常年保持稳定。 但硬币的另一面，显然是单一产品依赖度过高的风险，这是始终悬在西藏药业头顶的现实考题。 西藏药业生产线 西藏药业厂区 居安常思危，如何摆脱"单腿走路"的局面？ 近日，上海证券报记者走进西藏药业，探寻其在新时期的转型密码。西藏药业董事长陈达彬将其总结 为：内源性增长与外延式扩张并重。对内拓展新活素的市场覆盖率，深挖藏药资源护城河；对外通过投 资基因编辑企业，持续探索创新药前沿领域。"内外"兼修，让谋求可持续发展的西藏药业迈向更广阔的 增长空间。 守正于"内" 夯实发展根基 从雪域高原出发，西藏药业在二十余年的时间里，逐步构建起覆盖西藏、四川、上海及海外市场的产业 版图。 目前，西藏药业产品涵盖生物制药、藏药、中药和化学药领域，主要产品涉及心脑血管、肝胆、扭挫伤 及风湿、类风湿、感冒等，代表品种有新活素、依姆多、诺迪康、十味蒂达胶囊、雪山金罗汉止痛涂膜 剂、小儿双清颗粒等。 其中，新活素是西藏药业拥有自主研发的国家生物制品一类新药，是治疗急性心衰的基因工程药物。新 活素能快速改善心衰患者的心衰症状和体征，提高患者的生存质量 ...

Core Viewpoint - Tibet Pharmaceutical (600211.SH) reported a steady performance in Q3 2025, with revenue of 2.089 billion yuan and net profit of 722 million yuan, while actively seeking new growth points through investments in innovative drug development [1][2]. Group 1: Financial Performance - In the first three quarters of 2025, Tibet Pharmaceutical achieved operating revenue of 2.089 billion yuan and a net profit attributable to shareholders of 722 million yuan, indicating stable overall performance [1]. - The company reported a non-recurring net profit of 668 million yuan, reflecting its solid financial foundation [1]. Group 2: Strategic Investments - The company made a significant investment of 60 million USD in Suzhou Ruizheng Gene Co., Ltd., marking a key highlight in its management strategy for entering the innovative drug sector [1]. - In August 2025, Tibet Pharmaceutical announced a 60 million USD equity investment in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which aligns with its strategic focus on innovative drug development [1][2]. Group 3: Innovative Drug Pipeline - Ruizheng Gene is developing therapies targeting metabolic diseases, particularly in the liver disease area, addressing significant unmet clinical needs [2]. - The company is the first in China to enter exploratory clinical research for an LNP-based in vivo gene editing product and has received FDA clinical approval in the U.S. for its pipeline [2]. - The ART001 pipeline targets rare diseases, currently in Phase I/IIa clinical trials in China, and has received orphan drug designation from the FDA [2]. Group 4: Product Development and Market Strategy - The company reported sales of its product "New活素" reaching approximately 4.17 million units, generating revenue of 1.456 billion yuan, with a low market penetration rate despite a large annual incidence of heart failure patients in China [3]. - The company is actively promoting "New活素" sales and has initiated exploratory research to expand sales channels [3]. - Other products like "诺迪康" and "金罗汉" are performing well in the market, with expectations for gradual growth in market share [3]. Group 5: Additional Investments - In March 2025, the company completed a 300 million yuan equity investment in Jiangsu Chentai Pharmaceutical Technology Co., Ltd., acquiring a 13.04% stake [4]. - The drug "Zorifertinib" developed by Chentai is the first globally to conduct registration clinical trials for advanced non-small cell lung cancer with CNS metastasis, showing significant clinical value [4]. - The commercialization of Zorifertinib is underway, with preparations for negotiations regarding medical insurance, which could provide stable cash flow for the company [4].

Core Viewpoint - The company is addressing concerns regarding the patent expiration of its flagship product, Xinhuosu, which is set to expire in 2031, and the potential impact of generic drugs entering the market [2] Group 1: Patent and Market Protection - The invention patent for Xinhuosu covers the formulation and preparation method, with a protection period from 2011 to 2031 [2] - The five-year new drug monitoring protection period has already expired, allowing other companies to develop and market related products [2] Group 2: Competitive Landscape - Suzhou Landing Biological has received approval for its recombinant human brain natriuretic peptide injection, indicating increased competition in the market [2] Group 3: Strategic Response - The company plans to enhance collaboration with commercial partners to expand the number of medical institutions covered by Xinhuosu, which currently includes nearly 7,000 institutions [2] - An investment of several million yuan is planned for exploratory research in evidence-based medicine for Xinhuosu, alongside ongoing academic promotion and production assurance efforts [2]

Core Viewpoint - Tibet Pharmaceutical (600211) reported a closing price of 48.89 yuan on October 10, 2025, with a 2.47% increase, indicating positive market sentiment and trading activity [1]. Trading Information Summary - On October 10, the net inflow of main funds was 39.73 million yuan, accounting for 7.52% of the total transaction amount [1]. - Retail investors experienced a net outflow of 41.00 million yuan, representing 7.76% of the total transaction amount [1]. Company Announcement Summary - Tibet Nodi Kang Pharmaceutical Co., Ltd. held a semi-annual performance briefing on October 10, 2025, attended by key executives to address investor inquiries [1]. - The company plans to invest several million yuan in new active substance evidence-based medical research, enhance academic promotion, and expand commercial cooperation [1]. - The existing production capacity of the new active substance is expected to meet demand, with a slight increase in annual sales compared to last year [1]. - The launch of a new production line is anticipated to improve efficiency and reduce costs [1]. - Zolizitin has initiated commercialization, with preparations for medical insurance negotiations underway, although its impact on company revenue is expected to be minimal this year [1]. - Sales of Zolizitin will adopt an agency model, with the major shareholder Kangzhe Pharmaceutical not participating in promotion [1]. - The investment in Rui Zheng Gene aligns with the company's innovative transformation strategy, aimed at enhancing R&D capabilities and expanding the product line [1]. - The overseas registration of the new active substance is under research evaluation, with international expansion to be pursued at an appropriate time [1]. - Medical insurance negotiation prices are expected to remain stable, with no significant fluctuations in sales volume [1].

Core Viewpoint - Tibet Pharmaceutical (600211) has shown a price increase of 4.69% this week, closing at 48.89 yuan, with a total market capitalization of 15.758 billion yuan, ranking 20th in the biopharmaceutical sector and 1216th in the A-share market [1] Company Announcements Summary - The company held a semi-annual performance briefing on October 10, 2025, attended by key executives to address investor inquiries [3] - The company plans to invest several million yuan in new evidence-based medical research for its product, New Active Substance, to enhance academic promotion and commercial collaboration, aiming to expand hospital coverage and ensure production supply [3][4] - The current production capacity of New Active Substance is sufficient to meet demand, with an expected slight increase in annual sales compared to last year [4] - The commercialization of Zolbetuximab has been initiated, and preparations for medical insurance negotiations are underway, with minimal expected impact on company revenue this year [3] - The sales model for Zolbetuximab will be through agents, and the major shareholder, Kangzhe Pharmaceutical, will not participate in its promotion [3] - The investment in Ruizheng Gene aligns with the company's strategic shift towards innovation, aimed at enhancing R&D capabilities and expanding the product line [3] - The overseas registration of New Active Substance is under research and evaluation, with international expansion to be pursued at an appropriate time [3] - The expected price for medical insurance negotiations is anticipated to remain stable, with no significant fluctuations in sales volume [3]

Core Viewpoint - The company held a half-year performance briefing on October 10, 2025, to address investor inquiries and discuss future strategies and product developments [1][2]. Group 1: Performance and Market Strategy - The company plans to invest several million yuan in evidence-based medical exploratory research to enhance the market penetration of its product, New活素 [2]. - New活素 has already reached nearly 7,000 medical institutions, and the company aims to strengthen partnerships with commercial companies to expand its coverage [2]. - The company is committed to ensuring the production of New活素 to meet market demand [2]. Group 2: Product Development and Sales - The product Zoliflodin, developed by晨泰, is the first drug targeting CNS metastasis in advanced non-small cell lung cancer and has shown significant results in clinical trials [3]. - Zoliflodin was commercialized in the first half of the year, but its revenue is not expected to significantly impact the company this year as it is still preparing for medical insurance negotiations [3]. Group 3: Investment and Innovation - The investment in锐正基因 aligns with the company's strategic transformation, aiming to leverage cutting-edge technology to enhance R&D capabilities and expand the product pipeline [4]. - The company plans to increase R&D investment and project acquisition to achieve both endogenous and exogenous growth, focusing on new media marketing and innovative drug development [4]. Group 4: International Expansion and Challenges - The company is evaluating regulatory requirements for New活素's registration in international markets and is preparing relevant materials for expansion [5]. - The strategic transformation poses challenges, including product selection and R&D progress, which the company plans to address by increasing R&D investment and enhancing team capabilities [5]. Group 5: Production Capacity and Sales Forecast - New活素's production capacity is currently sufficient to meet market demand, with an expected slight increase in sales compared to the previous year [6]. - The newly launched production lines for New活素 are anticipated to double output, ensuring future sales are not hindered by capacity constraints [6].

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies and aiming for high-quality growth through increased R&D investment and strategic partnerships [1][2]. Group 1: Company Strategy and Growth - The company plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which is seen as a strategic move to enhance its innovation capabilities [1]. - Tibet Pharmaceutical has achieved significant growth over the past decade, with revenue increasing from 521 million to 2.807 billion yuan, representing a compound annual growth rate (CAGR) of 18.34%, and net profit rising from 92 million to 1.051 billion yuan, with a CAGR of 27.63% [2]. - The company aims to stabilize its core product "Xinhua Su" while exploring new growth opportunities through product rebranding and enhanced marketing strategies [3]. Group 2: Market Challenges and Opportunities - In 2024, the company experienced a revenue decline of 10.45%, raising concerns about its ability to maintain high growth rates, despite a 9.45% increase in net profit [3]. - The company is addressing its reliance on single products and insufficient R&D investment by pursuing mergers and acquisitions, particularly in the gene editing sector [3][4]. Group 3: Acquisition and Innovation - The acquisition of Accuredit Therapeutics is part of Tibet Pharmaceutical's strategy to enter the gene editing market, which is expected to drive innovation and growth [4][5]. - Accuredit Therapeutics focuses on developing gene editing drugs and has a strong team with experience in biopharmaceuticals, which aligns with Tibet Pharmaceutical's goals [5]. - The CEO of Accuredit, Wang Yongzhong, has a robust background in the biopharmaceutical industry, which could enhance the company's international expansion efforts [5]. Group 4: Safety and Regulatory Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with clinical data required to validate its safety over 2 to 5 years [6]. - The company is working on improving safety through reversible gene editing techniques and off-target detection methods [6].

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies, particularly in the field of innovative drugs and gene editing technology [1][3]. Group 1: Investment and Strategic Direction - Tibet Pharmaceutical plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which has been approved by the company's shareholders [1]. - The company aims to enhance its growth through both internal and external strategies, emphasizing R&D investment and project acquisition to drive sustainable development [1][2]. Group 2: Financial Performance - Over the past decade, Tibet Pharmaceutical's revenue increased from 521 million to 2.807 billion, with a compound annual growth rate (CAGR) of 18.34%, while net profit rose from 92 million to 1.051 billion, with a CAGR of 27.63% [2]. - However, in 2024, the company experienced a revenue decline of 10.45%, raising concerns about its growth sustainability, despite a 9.45% increase in net profit [2]. Group 3: Growth Strategy - To achieve sustained growth, the company must establish a second growth curve focusing on internal growth through product enhancement and external growth via R&D and acquisitions [3]. - The acquisition of Accuredit Therapeutics is seen as a critical step in the company's innovation journey, aligning with its transformation strategy [3][4]. Group 4: Gene Editing Focus - Accuredit Therapeutics, established in 2021, specializes in developing non-viral vector-based gene editing drugs and has a comprehensive technology platform [4]. - The company is currently conducting clinical trials for its lead product, ART001, which has received IND approval in both China and the U.S. [4][5]. Group 5: Safety and Market Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with a typical waiting period of 2 to 5 years for clinical data to confirm safety [5]. - The company is enhancing safety through reversible gene technology and off-target detection methods [5].

Core Viewpoint - Tibet Pharmaceutical plans to invest $60 million in Accuredit Therapeutics Limited to acquire a 40.82% stake, aiming to enhance sustainable development and overcome R&D bottlenecks [1] Group 1: Investment Details - The investment will be made through a wholly-owned subsidiary, with the major shareholder's affiliate also investing $15 million for a 10.20% stake, resulting in a combined holding of over 51% [1] - The investment aligns with the company's strategy to focus on core business while expanding its product pipeline through both in-house and collaborative R&D efforts [1] Group 2: Target Company Overview - Accuredit Therapeutics specializes in developing in vivo gene editing technologies and products based on LNP and other non-viral vectors, aiming to provide innovative treatment solutions with cost advantages [1] - The core asset of Accuredit is its domestic holding company, Ruizheng Gene (Suzhou) Co., Ltd., which has established an end-to-end gene editing technology platform [2] Group 3: Product Pipeline - Key products in development include ART001, which targets transthyretin amyloidosis (ATTR) and has received orphan drug designation from the FDA, currently undergoing I/IIa clinical trials in China [2][3] - Another promising product, ART002, focuses on PCSK9 and shows potential to significantly reduce LDL-C levels in patients with familial hypercholesterolemia, addressing limitations of existing PCSK9 inhibitors [3] Group 4: Market Potential - The PCSK9 inhibitors market is projected to reach $4.2 billion in global sales by 2024, indicating a strong commercial outlook for ART002 [3] - Besides ART001 and ART002, Ruizheng Gene's pipeline also targets metabolic diseases, particularly in the liver, suggesting a broad potential market [4] Group 5: Company Performance - Tibet Pharmaceutical reported revenue and profit growth in the first half of 2025, driven by stable contributions from its existing products and an 18.83% increase in other product revenues [4] - The company has previously engaged in acquisitions and collaborations to expand its product line, including a $30 million investment in Chentai Pharmaceutical for a 13.04% stake [4]