Core Viewpoint - Aimee Vaccine has achieved a significant breakthrough in the pneumonia vaccine sector with the approval of its 20-valent pneumonia conjugate vaccine for clinical trials, enhancing its competitive position in the domestic high-end market [1][3][6]. Group 1: Product Development and Market Position - The newly approved 20-valent pneumonia conjugate vaccine builds on the existing 13-valent vaccine, adding 7 new serotypes to cover a total of 20 serotypes of pneumococcus, targeting individuals aged 2 months and older [3][7]. - The pneumonia conjugate vaccine is considered a "crown" product in the vaccine industry, with Pfizer's Prevnar series projected to generate global sales of $6.411 billion in 2024, highlighting the high commercial value of this market [4][5]. - Currently, Pfizer is the only company with a 20-valent pneumonia conjugate vaccine available internationally, leaving a gap in the domestic market that Aimee Vaccine aims to fill [6]. Group 2: Market Demand and Growth Potential - The market demand for pneumonia vaccines is underscored by the significant penetration rate gap; for instance, the penetration rate of the 13-valent vaccine in China is approximately 25%, compared to over 80% in the U.S., indicating substantial growth potential in the Chinese market [8]. - Aimee Vaccine has established a product matrix in the pneumonia sector, including the 13-valent and 24-valent vaccines, which positions the company to benefit from a clear growth model supported by market space, technological iterations, and opportunities for international expansion [7][8]. Group 3: Financial Outlook and Innovation - The company is at a critical turning point, with a clear path to profitability as multiple core products enter late-stage clinical trials or production phases, following significant R&D investments [10][11]. - Aimee Vaccine's R&D expenses are expected to decrease by 39% by 2025, coinciding with the completion of major clinical trials, and the company is projected to achieve profitability by 2026 [10]. - The recent approval of the 20-valent pneumonia conjugate vaccine reflects the company's ongoing innovation capabilities, with several innovative vaccines nearing market launch, providing solid performance support and cash flow [10][11].

艾美疫苗(06660)发布公告，集团研发的迭代工艺高效价人二倍体狂犬疫苗，目前III期临床现场工作已 顺利完成。这标志着该疫苗正式进入新的阶段，为未来商业化上市奠定坚实的基础。 狂犬病是世界上致死率最高的疾病，一旦发病，致死率接近100%。目前，在临床上缺乏治疗狂犬病的 有效方法，因此暴露后的预防至关重要，主要预防措施是接种人用狂犬病疫苗。与传统的Vero细胞狂犬 疫苗相比，人二倍体狂犬疫苗使用了人二倍体细胞代替了Vero细胞，该细胞与人同源，具有天然的安全 性优势。目前市场上的人二倍体狂犬疫苗与Vero细胞狂犬疫苗相比，价格高出3到5倍，具有更高的产品 附加值。 与传统的初代人二倍体狂犬疫苗相比，集团研发的迭代工艺高效价人二倍体狂犬疫苗，率先突破了传统 工艺中病毒滴度低、产量低的技术瓶颈，在纯化工艺上进行了优化创新，在产品质量和安全性方面均得 到显着提高。这不仅是公司研发实力的体现，也是全球狂犬疫苗高效价工艺领域的重大突破。 中国是全球最大的狂犬疫苗市场，根据灼识咨询统计，在产品更新迭代、狂犬疫苗普及度提高的推动 下，预计于2030年达148亿元。与传统的狂犬疫苗接种针次相比，集团研发的该款产品在接种方式上 ...

狂犬病是世界上致死率最高的疾病，一旦发病，致死率接近100%。目前，在临床上缺乏治疗狂犬病的 有效方法，因此暴露后的预防至关重要，主要预防措施是接种人用狂犬病疫苗。与传统的Vero细胞狂犬 疫苗相比，人二倍体狂犬疫苗使用了人二倍体细胞代替了Vero细胞，该细胞与人同源，具有天然的安全 性优势。目前市场上的人二倍体狂犬疫苗与Vero细胞狂犬疫苗相比，价格高出3到5倍，具有更高的产品 附加值。 与传统的初代人二倍体狂犬疫苗相比，集团研发的迭代工艺高效价人二倍体狂犬疫苗，率先突破了传统 工艺中病毒滴度低、产量低的技术瓶颈，在纯化工艺上进行了优化创新，在产品质量和安全性方面均得 到显着提高。这不仅是公司研发实力的体现，也是全球狂犬疫苗高效价工艺领域的重大突破。 中国是全球最大的狂犬疫苗市场，根据灼识咨询统计，在产品更新迭代、狂犬疫苗普及度提高的推动 下，预计于2030年达148亿元。与传统的狂犬疫苗接种针次相比，集团研发的该款产品在接种方式上既 可采用"五针法"接种，也可采用"简易四针法"以及"2-1-1四针法"接种，更加灵活方便。根据国家疾控局 和国家卫健委制定的《狂犬病暴露预防处置工作规范(2023年版)》，要求 ...

该产品是一款迭代升级的人二倍体狂犬疫苗，具有超高效价的明显特点，也是全球狂犬疫苗技术领域的 一次重大迭代升级。动物试验表明，集团人二倍体狂犬疫苗免疫后可产生高保护水平的抗体，在同一剂 量条件下，集团人二倍体狂犬疫苗效价，显著高于已上市的人二倍体狂犬疫苗。 人二倍体狂犬疫苗被WHO推荐为狂犬疫苗的金标准产品，已在多个发达国家广泛应用。集团作为全球 第二大狂犬疫苗供货商，致力于引领全球狂犬疫苗的深度技术迭代升级，为市场提供质量更好，安全性 更高的系列狂犬疫苗产品，进一步巩固公司在全球狂犬疫苗领域的领先地位，推动集团可持续发展。未 来该产品的获批将进一步丰富公司的产品结构，与现有狂犬疫苗系列形成协同，增强核心竞争力。作为 全球化布局的一部分，可贡献额外收益，强化公司的市场地位，为公司持续稳健发展增加新动力。 格隆汇1月15日丨艾美疫苗(06660.HK)发布公告，集团研发的迭代工艺高效价人二倍体狂犬疫苗，目前 III期临床现场工作已顺利完成。这标志着该疫苗正式进入新的阶段，为未来商业化上市奠定坚实的基 础。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的 任 何 損 失 承 擔 任 何 責 任。 AIM Vaccine Co., Ltd. 艾美疫苗股份有限公司 本 公 告 由 艾 美 疫 苗 股 份 有 限 公 司（「本公司」，連 同 其 附 屬 公 司 統 稱「本 集 團」）自 願 作 出，以 告 知 本 公 司 股 東 及 潛 在 投 資 者 本 集 團 的 最 新 業 務 發 展。 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：06660） 自願性公告 本 集 團 研 發 的 迭 代 工 藝 高 效 價 人 二 倍 體 狂 犬 疫 苗，目 前III期臨床現場工 作 已 順 利 完 成。這 標 誌 著 該 疫 苗 正 式 進 入 新 的 階 段，為 未 來 商 業 化 上 市 奠 定 堅 實 的 基 礎。 該 產 品 是 一 款 迭 代 升 級 的 人 二 倍 體 狂 犬 ...

Core Viewpoint - The biotechnology sector in Hong Kong is experiencing a surge, with companies like Ai Mei Vaccine gaining significant attention due to their stable performance and innovative technologies [1] Group 1: Company Performance - Ai Mei Vaccine reported steady revenue growth for the first half of 2025, with key innovative products nearing market launch, leading to expectations of improved performance and valuation [1][2] - The company has four major innovative products entering the market, including the 13-valent pneumococcal conjugate vaccine, which has a significant market potential in China, projected to exceed RMB 20 billion by 2030 [2][3] Group 2: Product Development - Ai Mei Vaccine is advancing in the rabies vaccine sector with multiple products, including a serum-free rabies vaccine and an mRNA rabies vaccine, positioning itself as a leader in a market expected to reach RMB 20 billion by 2030 [3] - The company holds 20 vaccine candidates in development across 12 disease areas, with 23 clinical approvals and 24 clinical trials ongoing, including seven innovative vaccines [3] Group 3: Market Potential and Valuation - The 13-valent pneumococcal conjugate vaccine is anticipated to capture a significant market share, with a penetration rate in China estimated at 25.9%, compared to over 80% in the U.S., indicating substantial growth opportunities [2] - DBS Bank's report suggests that Ai Mei Vaccine's current stock price is at the lower end of its peers' valuation range, with a projected fair target price of HKD 8.3 per share by 2026, indicating a potential upside of nearly 600% [4]

Group 1 - The Hong Kong innovative drug sector has significantly outperformed the market since 2025, with 49 pharmaceutical companies seeing stock price increases exceeding 100% [1] - The recent listing of Zhonghui Biotech has catalyzed a bullish trend in multiple biopharmaceutical stocks, including vaccine companies [1] - Chinese innovative drug companies are actively developing original innovative drugs, which are expected to create sustainable overseas opportunities [1] Group 2 - Aimee Vaccine (06660) reported stable revenue in its semi-annual report for the first half of 2025, with reduced R&D expenses and optimized operating costs [1] - The company has 20 vaccine products in development across 12 disease areas, with a pipeline covering the top ten global vaccine products [1] - Aimee has received clinical approval for two mRNA vaccines in both China and the U.S., validating its innovative capabilities and global market strategy [2] Group 3 - Aimee Vaccine is leading in the mRNA technology field, with its platform validated through extensive clinical trials, ensuring safety and efficacy [2] - The company has several key vaccine products nearing market launch, indicating an upcoming performance improvement [2] - The 13-valent pneumococcal conjugate vaccine is one of the broadest vaccines available, with a significant global market gap of 180 million doses [3] Group 4 - The innovative drug sector in Hong Kong is experiencing a new wave of development opportunities, with Aimee Vaccine positioned for rapid performance improvement due to its innovative vaccine R&D capabilities [4] - The company's stock price has strong upward momentum driven by industry growth and its improving fundamentals [4]

Core Viewpoint - The company, Ai Mei Vaccine, is poised for significant growth with the upcoming commercialization of key vaccine products and a reduction in R&D expenses, leading to a strong financial outlook for 2025 and beyond [1][2] Group 1: Financial Performance - Ai Mei Vaccine reported stable revenue for the first half of 2025, supported by the impending launch of four major vaccine products [1] - The company is expected to achieve profitability by 2026, with sales projected to grow at a compound annual growth rate (CAGR) of 45% from 2025 to 2027 [2] Group 2: Product Development - Four major vaccine products are nearing commercialization: - The registration application for the updated rabies vaccine has been accepted - The 13-valent pneumonia conjugate vaccine has applied for registration and completed on-site verification - The 23-valent pneumonia polysaccharide vaccine has completed Phase III clinical serum testing and is entering the statistical unblinding phase - The updated high-efficiency diploid rabies vaccine is in Phase III clinical trials, with a registration application expected in 2026 [1] - The company has 20 vaccine products in development across 12 disease areas, with 23 clinical approvals and 24 ongoing clinical trials, including 7 innovative Class 1 vaccines [1] Group 3: Market Expansion - Ai Mei Vaccine has successfully entered the African market with its quadrivalent meningococcal polysaccharide vaccine and is registering in Central Asia - The rabies vaccine has made its debut in the Central American market - The hepatitis B vaccine is actively undergoing registration processes in Southeast Asia, while the hepatitis A vaccine is progressing in South Asia [1]