● 本报记者 宋维东 东北制药相关负责人日前在接受中国证券报记者采访时表示，近年来，公司聚焦创新驱动与主业深耕， 在研发突破与主业提质方面取得重要成果，构建起了"研发创新破局、主业盈利稳盘、资产运营增效"的 协同发展格局。特别是在医药行业创新转型加速的背景下，公司以"传统主业筑牢基本盘、创新药业务 开辟增长极"的差异化战略，既守住了盈利底线，又打开了成长空间。日前，东北制药控股子公司鼎成 肽源自主研发的DCTY0801注射液获国家药品监督管理局核准签发的《药物临床试验批准通知书》。未 来，随着创新药管线研发逐步推进、传统业务结构持续升级，公司将进一步释放高质量发展动能，在激 烈的市场竞争中不断突围。 近年来，东北制药核心业务保持稳健发展态势。今年第三季度，公司扣非归母净利润较上年同期增长 27.54%。"这得益于公司在传统优势领域持续深耕细作与产品竞争力不断提升。"该负责人说。 作为国内重要的药品生产与出口基地，东北制药在多个细分领域占据全球重要地位。其中，东北制药是 全球维生素C原料药主要供应商、左卡系列产品核心供应商、全球最大的磷霉素系列产品生产商及全球 氯霉素主要供应商，同时拥有国际最大的黄连素全合成生 ...

Core Insights - Northeast Pharmaceutical has demonstrated significant progress in R&D and core business performance despite a complex market environment characterized by raw material price fluctuations and differentiated end-user demand [1] R&D Investment - The company has significantly increased its R&D investment, with expenses reaching 104 million yuan, a substantial increase of 95% year-on-year [2] - The approval of DCTY0801 injection for clinical trials marks a key breakthrough in the development of innovative cancer drugs, specifically targeting EGFRvIII positive recurrent or progressive high-grade gliomas [2] - This approval not only fills a gap in the company's oncology treatment portfolio but also positions it advantageously in the glioma segment, indicating a critical transition from sustained investment to tangible outcomes in innovative drug development [2] Core Business Growth - Despite external market pressures, the company's core business has shown resilience, with a net profit attributable to shareholders of 42.79 million yuan, reflecting a year-on-year increase of 27.54% [3] - The company maintains a leading position in several niche markets, including being a major global supplier of vitamin C raw materials and the largest producer of phosphomycin [3] - The dual-market strategy of expanding both domestic and international markets has enhanced the company's risk resilience [3] Operational Structure Optimization - The company has focused on optimizing its asset and financial management, leading to improved operational quality and financial flexibility [4] - The balance of prepaid accounts decreased by 49% compared to the beginning of the year, indicating enhanced cash flow management [4] - The company has established a synergistic development framework that combines R&D innovation, stable core business profitability, and efficient asset operations, positioning it well for future growth in a rapidly evolving pharmaceutical industry [4]

Group 1 - The upcoming National Day and Mid-Autumn Festival holiday is expected to see increased travel, necessitating health and safety precautions for travelers [1] - The transition between seasons is a peak period for respiratory diseases, highlighting the importance of personal protective measures such as wearing masks and maintaining hand hygiene in crowded places [2] - Recommendations for managing common ailments like flu and cold include using medications containing acetaminophen for fever and pain relief, and specific cold medications for symptoms like sneezing and nasal congestion [2] Group 2 - Travelers prone to motion sickness should prepare motion sickness medication in advance, with specific guidelines for usage timing and caution regarding children's medication [3] - In case of injuries during travel, it is advised to carry antiseptic supplies and band-aids, and to seek medical attention for serious injuries while applying ice for swelling [4] - Attention to food safety is crucial during the holiday, with recommendations to avoid undercooked foods and to be cautious with food storage and consumption [6][7]

Core Viewpoint - Berberine shows potential as a long-term preventive agent for colorectal adenoma recurrence after polypectomy, with significant reductions in recurrence and neoplasm occurrence rates observed in clinical studies [4][6][8]. Group 1: Study Findings - A recent study indicated that berberine treatment resulted in a lower adenoma recurrence rate of 34.7% compared to 52.1% in the control group, and a lower tumor occurrence rate of 63.4% versus 71.0% after a follow-up period of at least 6 years [4][7]. - In a previous two-year randomized clinical trial, berberine significantly reduced the recurrence rate of colorectal adenomas to 36% compared to 47% in the placebo group, with no serious adverse events reported [6][9]. - The long-term protective effect of berberine was confirmed in a retrospective cohort study that followed up on participants from the initial trial, demonstrating sustained benefits post-treatment [7][8]. Group 2: Research Background - The study on berberine was conducted by a team from Shanghai Jiao Tong University School of Medicine and published in Cell Reports Medicine, extending the follow-up of a prior clinical trial [4][6]. - The initial trial involved 895 patients, with 781 participants recruited for the follow-up study, which assessed the long-term effects of berberine on adenoma recurrence [7][8].

Group 1: Investor Relations Activities - The company held a performance briefing for the 2024 annual report on April 29, 2025, via online communication [4] - Participants included the chairman, general manager, board secretary, financial officer, and sponsor representative [4] Group 2: Market Expansion and Product Certification - The company has obtained the EU export certification for its products, which requires compliance with the European Pharmacopoeia (CEP) and on-site inspections [5] - The company aims to enhance its competitiveness in the EU market by improving production quality and collaborating with EU clients [5] Group 3: Revenue Composition and Market Share - The company's revenue is primarily derived from pharmaceutical raw materials, food additives, cosmetics, and health products [6] - The European market accounts for approximately 40% of exports, while the US, Japan, Australia, and Canada account for about 60% [6] - The NHDC product has captured over 27% of the company's main business revenue in the domestic food additive market [6] Group 4: Growth Drivers and Strategic Focus - Future growth in the plant extract industry is driven by increasing consumer health awareness and advancements in extraction technology [8] - The company plans to deepen its focus on both domestic and international markets, particularly in food additives and pharmaceutical raw materials [9] Group 5: Financial Performance and Profit Margins - The company's revenue increased by 27.78% year-on-year in 2024, attributed to the successful implementation of its strategic plan [7] - The overall gross margin for products increased in 2024, but is expected to decline in 2025 due to rising costs and market competition [10] Group 6: Production and R&D Updates - The company is currently optimizing production processes and has completed 11 R&D projects in 2024 [15] - The new production lines are expected to be fully operational by mid-2025, which will enhance production capacity [14] Group 7: Market Trends and Future Outlook - The company anticipates a gradual recovery in gross margins as production lines stabilize and international trade conditions improve [12][13] - The market for Vitamin P products is expected to grow significantly due to rising health consciousness and expanding application areas [17]