益方生物 20260629 摘要 益方生物在当前市场环境下，其核心驱动因素和管线布局是怎样的？ 的个位数百分比和武田药物宣称的约 33%。在 PASI 90 指标上，益方生物的 TYK2 抑制剂也显示出大幅领先的趋势。从药代动力学（PK）数据来看，益方 生物的 TYK2 抑制剂在全天 24 小时内均能保持药物暴露量在 IC90 以上，而 BMS 的药物无法保持在 IC50 以上，武田的药物则无法保持在 IC90 以上。这 种持续的药物暴露可能得益于药物的重吸收效应。 益方生物的 TYK2 抑制剂未来在临床试验设计上，特别是与现有药物进行头对 头比较时，将如何选择终点指标？ 益方生物的核心驱动因素仍是 TYK2 抑制剂的进展，包括其银屑病适应症的临 床数据和潜在的商务拓展（BD）。公司管线丰富，涵盖已上市销售的贝福和 KRAS G12C 抑制剂，处于三期临床的口服 SERD，以及 TYK2 抑制剂银屑病 适应症即将进入三期临床。此外，TYK2 抑制剂在溃疡性结肠炎方面的临床试 验已启动，预计在 2025 年底至 2026 年逐步获得数据。公司在 2025 年 AACR 会议上还展示了两个临床前分子。 益方生物的 ...

Investment Rating - The report maintains a "Buy" rating for multiple companies in the pharmaceutical sector, including Junshi Biosciences, Hualan Biological Engineering, and others [4]. Core Viewpoints - The report highlights the investment opportunities in innovative drugs against the backdrop of global asset rebalancing, particularly focusing on KRAS G12C mutation in non-small cell lung cancer (NSCLC) [2][8]. - It emphasizes the potential for KRAS G12C inhibitors to advance to first-line treatment for NSCLC, with an estimated 30% of KRAS mutations in NSCLC being of the G12C subtype, leading to approximately 30,000 new cases annually in China [5][17]. Summary by Sections 1. Industry Viewpoints and Investment Recommendations - KRAS G12C inhibitors are progressing towards first-line treatment for NSCLC, with current standard therapies being PD1 ± chemotherapy [18]. - The report suggests focusing on innovative drugs, particularly in the context of increased liquidity and risk appetite in the market, with significant data releases expected from major conferences [6][32]. 2. Pharmaceutical Industry Market Performance - The pharmaceutical sector saw a 1.01% increase, slightly underperforming the CSI 300 index by 1.00 percentage points [39]. - Sub-sectors such as drug packaging and medical devices performed well, while innovative drugs lagged behind [39]. 3. Company Dynamics - Notable company activities include the approval of new drugs and clinical trial advancements, such as the successful Phase III trials for AstraZeneca's Breztri and Genmab's Epcoritamab [46]. - Companies like Junshi Biosciences and Innovent Biologics are highlighted for their leading positions in the KRAS G12C inhibitor market [22][23]. 4. Industry Dynamics - The report discusses the impact of patent expirations on raw material demand, projecting a significant increase in sales due to the expiration of patents for top-selling small molecule drugs [35]. - It also notes the improvement in demand for raw materials and the end of inventory destocking phases, suggesting a positive outlook for the raw material sector [35].