Core Viewpoint - 2025 marks a significant year for China's innovative pharmaceuticals, with the Hengsheng Hong Kong Stock Connect Innovative Drug Select Index experiencing a year-to-date increase of over 125%, indicating a record high in industry prosperity. Heng Rui Pharmaceutical achieved historical revenue of 31.6 billion yuan and a net profit of 7.7 billion yuan, with innovative drug sales accounting for 58% of total revenue, expected to grow over 30% year-on-year in 2026 [2][11]. Group 1: Company Performance - Heng Rui Pharmaceutical's revenue and net profit reached 31.6 billion yuan and 7.7 billion yuan respectively, both setting historical records [2]. - The proportion of innovative drug sales surged to 58%, with a projected year-on-year growth rate exceeding 30% for 2026 [2][11]. - The company successfully completed an A+H listing, raising a net amount of 11.374 billion HKD, marking the largest IPO in the Hong Kong pharmaceutical sector in the past five years [9]. Group 2: Research and Development - Heng Rui's R&D investment reached 8.724 billion yuan in 2025, accounting for 27.58% of its revenue, translating to nearly 24 million yuan spent on R&D daily [5]. - The company ranked second globally in the scale of self-developed pipelines, with a growth rate among the top three worldwide [5]. - In 2025, Heng Rui obtained approvals for 7 class 1 innovative drugs and 1 class 2 new drug, significantly increasing the number of approved innovative drugs to 24 class 1 and 5 class 2 [8]. Group 3: Market Dynamics and Growth Drivers - The adjustment of the national medical insurance catalog at the end of 2025 is expected to drive growth in 2026, with 20 products/indications entering the new catalog, including 10 products newly covered by insurance [12]. - A significant increase in clinical data readouts is anticipated in 2026, with approximately 25 new molecular entities (NME) expected to report phase III clinical data [12]. - The company has established strategic alliances, including a notable partnership with GSK, which involves the development of up to 12 innovative drugs, with potential total payments reaching approximately 12 billion USD [15]. Group 4: Global Expansion and Strategic Positioning - Heng Rui is building a global network with 15 R&D centers established across Asia, Europe, and Australia, and has initiated overseas clinical trials [20]. - Since 2023, the company has completed 12 overseas business expansion transactions, with a potential total transaction value exceeding 27 billion USD, partnering with top global pharmaceutical companies [22]. - The strategic value of Heng Rui has transcended the company itself, aligning with China's biopharmaceutical industry growth, with an expected 53 innovative products and indications to be approved between 2026 and 2028 [23][24].

Investment Rating - The report maintains a "Recommended" rating for the company [3]. Core Insights - The company achieved a record high in revenue and profit, with a total revenue of 316.29 billion yuan in 2025, representing a year-on-year growth of 13.02%. The net profit attributable to shareholders reached 77.11 billion yuan, up 21.69% year-on-year [6]. - The sales of innovative drugs significantly contributed to the revenue growth, with innovative drug sales reaching 163.42 billion yuan, a 26.09% increase year-on-year, accounting for 58.34% of total drug sales [6]. - The company is focusing on accelerating the internationalization of its innovative drugs, with licensing income becoming a new growth engine, generating 33.92 billion yuan in revenue during the reporting period [6]. - The report anticipates that the company's net profit attributable to shareholders will grow to 95.19 billion yuan in 2026, reflecting a 23% year-on-year increase, with projected EPS of 1.43 yuan [6][7]. Financial Performance Forecast - Revenue is projected to grow from 31,629 million yuan in 2025 to 38,145 million yuan in 2026, with a growth rate of 20.60% [2]. - The net profit is expected to increase from 7,711 million yuan in 2025 to 9,519 million yuan in 2026, with a growth rate of 23.45% [7]. - The gross margin is forecasted to remain stable, with a slight decrease from 86.21% in 2025 to 85.86% in 2026 [7]. Revenue Breakdown - Innovative drug sales are expected to exceed 30% growth in 2026, driven by strong performance in oncology products and new market entries [6]. - The company’s generic drug revenue has slightly declined due to ongoing impacts from national and local procurement policies, but new products have shown some growth [6]. Valuation Metrics - The report indicates that the current stock price corresponds to a PE ratio of 44 for 2026, 36 for 2027, and 30 for 2028 [6][7].

Investment Rating - The investment rating for the company is "Buy" and is maintained [7] Core Views - The company achieved a revenue of 31.63 billion RMB in 2025, representing a year-on-year growth of 13.0%, with a net profit attributable to shareholders of 7.71 billion RMB, up 21.7% year-on-year [1] - The company expects a significant acceleration in innovative drug revenue starting in 2026, projected to exceed 30% growth, driven by the inclusion of multiple innovative drugs in the national medical insurance [1][2] - The company has a strong pipeline with 8 innovative drugs and 6 new indications approved in 2025, and anticipates further approvals in the coming years [2] Financial Performance - In 2025, the company reported a decline in the overall revenue from generic drugs, which impacted the overall performance, but innovative drug revenue reached 16.34 billion RMB, growing 26.1% year-on-year [1] - The company’s net profit margin improved to 24.4% in 2025, an increase of 1.8 percentage points year-on-year, with expectations for continued improvement in 2026 as innovative drug revenue increases [3] - The company’s expenses as a percentage of sales, management, and R&D decreased in 2025, contributing to the improved net profit margin [3] Business Development (BD) Contributions - The company has completed 12 BD transactions from 2023 to 2025, totaling nearly 28 billion USD, which is expected to provide ongoing cash flow [4] - The company has over 30 products in clinical development that are among the top three globally for their targets, indicating potential for double-digit growth in BD revenue [4] Profit Forecast and Valuation - The forecast for net profit attributable to shareholders for 2026-2028 is 9.78 billion RMB, 12.62 billion RMB, and 16.64 billion RMB respectively, with corresponding EPS of 1.47 RMB, 1.90 RMB, and 2.51 RMB [5] - The company is valued at 591.8 billion RMB and 650.9 billion HKD, with target prices set at 89.16 RMB and 98.06 HKD [5]

Investment Rating - The investment rating for the company is "Buy" [7] Core Views - The company achieved a revenue of 31.63 billion RMB in 2025, representing a year-on-year growth of 13.0%, with a net profit attributable to shareholders of 7.71 billion RMB, up 21.7% year-on-year [1] - The company expects a significant acceleration in innovative drug revenue growth starting in 2026, projected to exceed 30% due to multiple innovative drugs being included in the national medical insurance [1][2] - The company has maintained a strong focus on cost efficiency, resulting in a decrease in expense ratios and a notable increase in net profit margins [3] Revenue and Profitability - In 2025, the company reported innovative drug revenue of 16.34 billion RMB, a 26.1% increase year-on-year, with the contribution from innovative drugs expected to rise significantly in the coming years [1][2] - The company anticipates net profit attributable to shareholders of 9.78 billion RMB in 2026, 12.62 billion RMB in 2027, and 16.64 billion RMB in 2028, reflecting a compound annual growth rate of over 30% [5][11] Cost Management - The company successfully reduced its sales, management, and R&D expense ratios in 2025, leading to an increase in net profit margin to 24.4%, up 1.8 percentage points year-on-year [3] Business Development (BD) Contributions - The company has completed 12 BD transactions from 2023 to 2025, totaling nearly 28 billion USD, which is expected to provide ongoing cash flow [4] - The company has over 30 products in clinical development that are among the top three globally for their respective targets, indicating strong future BD revenue potential [4] Valuation and Forecast - The company is valued at 591.8 billion RMB for A-shares and 650.9 billion HKD for H-shares, with target prices set at 89.16 RMB and 98.06 HKD respectively [5][12]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2026年3月25日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 江苏恒瑞医药股份有限公司 2025 年年度报告 公司代码：600276 ...

Core Viewpoint - The article discusses the challenges and potential catalysts for Hengrui Medicine, highlighting the need for stable revenue contributions from BD transactions and the growth of innovative drug sales to restore market confidence [5][52]. Group 1: Current Market Situation - Hengrui Medicine has not seen significant market performance recently, contrasting with peers like Rongchang Biopharmaceutical and Geely Pharmaceutical, which have experienced double-digit stock price increases [4]. - Despite a warming capital market, Hengrui has faced a rare "eleven consecutive declines" in stock price, leading to negative annual fluctuations [4][5]. Group 2: BD Transactions and Performance - BD transactions have become a crucial driver for Hengrui's performance since 2024, but concerns about the sustainability of this model have emerged due to delayed revenue recognition [9][17]. - In 2023, Hengrui received €160 million (approximately RMB 1.2 billion) from BD transactions, and in 2024, it expects to confirm $100 million (approximately RMB 700 million) from Kailera Therapeutics [9][10]. - The company completed five BD transactions before September 2025, securing $783 million and €15 million in upfront payments, along with potential milestone payments totaling $15.8 billion, indicating a significant increase in transaction frequency and scale [13]. Group 3: Innovation and Product Pipeline - Hengrui's innovative drug sales and licensing revenue reached RMB 95.61 billion in the first half of 2025, accounting for about 60% of total revenue, indicating a shift towards "innovation-driven" growth [24]. - The company has received approvals for 17 innovative drugs from 2021 to 2024, creating a diversified product matrix that reduces reliance on single blockbuster products [23]. - Hengrui's innovative drugs, such as Haiqubopai, have shown strong market potential, with sales expected to exceed RMB 1 billion in 2024 [23]. Group 4: Challenges Ahead - Hengrui faces challenges, including a reliance on a "fast-follow" research model, which raises concerns about competition from similar products in the market [30]. - The company lacks a globally recognized blockbuster product, with its most successful products primarily concentrated in the domestic market [32][33]. - Hengrui's internationalization efforts are still in the early stages, with no innovative products approved for sale in overseas markets yet [34]. Group 5: Future Catalysts - Key signals to watch for include the maturation of the BD business model, sustained growth in innovative drug revenue (targeting a compound annual growth rate of over 25%), and breakthroughs in the research pipeline [39][41][42]. - The upcoming FDA review of Hengrui's "dual-Ai" therapy for liver cancer is a critical milestone that could significantly impact the company's international strategy and market perception [49][50].

Investment Rating - The report maintains a "Recommended" rating for the pharmaceutical industry as of February 1, 2026 [1] Core Insights - The competitiveness of China's active pharmaceutical ingredient (API) exports is supported by technological advancements, with a focus on supply variables [2] - Significant transactions in the industry highlight the ongoing validation of clinical data for innovative drugs, with multiple major deals occurring in early 2026 [3] - Leading companies are increasingly investing in the small nucleic acid field, which is expected to accelerate the development of the supporting industrial chain [4] - A new pricing system for GLP-1 drugs is forming domestically, while the oral GLP-1 market is rapidly expanding in the U.S. [5] - The market value of oral autoimmune drugs is gaining attention, with promising results from key clinical trials [6] Summary by Sections Industry Overview - In 2025, China's pharmaceutical and healthcare product exports reached $111.34 billion, growing by 3.14%, with API exports accounting for $42.87 billion, representing 76.8% of total Western medicine exports [2] - The report notes a 10.6% decline in pharmaceutical exports to the U.S. due to tariff impacts, while the EU and emerging markets saw increases of 11.38% and 4.49%, respectively [2] Major Transactions and Innovations - In January 2026, a significant licensing agreement between CSPC Pharmaceutical and AstraZeneca was announced, involving a $1.2 billion upfront payment and potential milestone payments totaling up to $3.5 billion [3] - The report emphasizes the need for continuous clinical data validation for authorized products to secure future milestone payments [3] Small Nucleic Acid Developments - Leading companies like China Biologic Products are acquiring innovative firms in the small interfering RNA (siRNA) sector, indicating a strategic focus on this area [4] - The report highlights successful clinical trial results for small nucleic acid drugs, which are attracting more attention from major pharmaceutical companies [4] GLP-1 Market Dynamics - A new pricing structure for GLP-1 products is emerging in China, with the anticipated launch of generic versions expected to further influence market prices [5] - The report notes that oral GLP-1 drugs are gaining traction in the U.S., with significant prescription numbers reported shortly after launch [5] Oral Autoimmune Drug Developments - Takeda's new oral TYK2 inhibitor has shown positive results in key clinical trials for psoriasis, indicating a potential breakthrough in oral autoimmune treatments [6] - The report mentions ongoing developments in oral autoimmune drugs targeting various pathways, with several domestic companies advancing their clinical trials [6] Stock Recommendations - The report suggests focusing on companies that are likely to benefit from the API cycle reversal, such as Chuan Ning Biological and Guobang Pharmaceutical, and highlights the potential of small nucleic acid drugs and oral autoimmune treatments [8]

Investment Rating - The report maintains a neutral rating for the biopharmaceutical industry, specifically focusing on the ADC (Antibody-Drug Conjugate) sector [1]. Core Insights - The global ADC market is experiencing rapid growth, with the total market size reaching approximately $10.4 billion in 2023 and projected to grow to $66.2 billion by 2030, reflecting a compound annual growth rate (CAGR) of over 30% [11]. - Domestic Chinese companies are catching up in ADC drug development, with the number of research pipelines expected to surpass that of the United States by 2024, positioning China as the leader in ADC research pipelines [11][16]. - Several domestic companies are optimizing ADC drugs by leveraging existing technologies and platforms developed by international firms, leading to the development of more effective and stable ADC products [7][9]. - Key targets for ADC drugs include HER2, TROP2, EGFR, and HER3, with multiple domestic companies showing promising clinical data for their pipelines in these areas [7][9]. Summary by Sections Section 1: Introduction to ADC Drugs - ADCs are a class of targeted cancer therapies that combine monoclonal antibodies with cytotoxic drugs, allowing for precise delivery of treatment to cancer cells while minimizing damage to normal cells [19]. Section 2: Domestic and International ADC Platforms - The report highlights the advancements made by domestic companies in establishing ADC platforms, with firms like Hengrui Medicine and Kolon Biotech leading the way in developing innovative ADC technologies [70][62]. Section 3: Popular Targets and Key Pipelines for ADC Drugs - Notable companies such as Hengrui Medicine and Kolon Biotech have developed ADCs targeting HER2 and TROP2, showing strong clinical efficacy in treating breast and lung cancers [7][9]. Section 4: Business Development (BD) Situations for Domestic ADC Drugs - The report notes an increasing trend of domestic ADC drugs being sought after by international firms, with the number of BD transactions for ADCs accounting for 12%-13% of total drug transactions from 2022 to 2024 [9]. Section 5: Related Companies and Investment Opportunities - The report suggests focusing on companies with established ADC platforms and promising product pipelines, including Hengrui Medicine, Kolon Biotech, BaiLi Tianheng, and China National Pharmaceutical Group [9].

Group 1 - The company Heng Rui Medicine (600276.SH) is scheduled to release its 2025 annual report on March 26, 2026 [1][6] - For Q4 2025, the expected revenue is projected to be between 32.072 billion to 36.062 billion RMB, representing a year-on-year growth of 14.6% to 28.9% [2][6] - The expected net profit for Q4 2025 is forecasted to be between 7.882 billion to 10.096 billion RMB, with a year-on-year increase of 24.4% to 59.3% [2][6] Group 2 - In the first three quarters of 2025, Heng Rui Medicine achieved a revenue growth of 14.85% and a net profit growth of 24.50% [3][8] - The company has successfully controlled its expense ratio while improving both gross and net profit margins [8] - Significant achievements in external authorization collaborations include partnerships with GSK, Glenmark, and Braveheart_Bio, involving upfront payments totaling 583 million USD and potential milestone payments up to 14.116 billion USD [4][9] Group 3 - The company has made breakthroughs in its innovative drug pipeline, with multiple new drugs approved for clinical trials and market launch [4][9] - Notable products include China's first independently developed oral hypoglycemic combination drug [9] - The company’s third-quarter results showed revenue, net profit, and net profit excluding non-recurring items of 23.188 billion, 5.751 billion, and 5.589 billion RMB respectively, with year-on-year growth rates of 14.85%, 24.50%, and 21.08% [8][9]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" (maintained) [1] Core Insights - The 2025 National Medical Insurance Negotiation results were announced, with 114 new drugs added to the medical insurance directory, achieving an overall success rate of 88%, the highest in nearly seven years, with a maximum price reduction of 94 [4][19] - The newly added drugs include monoclonal antibodies, bispecific antibodies, ADCs, siRNA, and small molecules, indicating a strong focus on innovative therapies [19][32] - The commercial insurance directory has added 19 innovative drugs, which, while not reimbursed by medical insurance, receive support for innovative drug applications, enhancing patient access and benefiting the innovative drug industry [5][24] Summary by Sections 1. National Medical Insurance Negotiation Results - The 2025 medical insurance directory added 114 new drugs, with a success rate of 88% and a maximum price reduction of 94% [4][13] - The total number of drugs in the national medical insurance directory reached 3,253, including 1,857 Western medicines and 1,396 traditional Chinese medicines [16][17] - The directory reflects a significant increase in the inclusion of innovative drugs, with 50 of the new additions classified as category 1 innovative drugs [19][21] 2. Commercial Insurance Directory - The commercial insurance directory added 19 innovative drugs, highlighting their clinical value and innovation [24][28] - The directory includes treatments for diseases such as Alzheimer's, rare diseases in children, and other critical conditions, showcasing a focus on addressing unmet medical needs [24][28] - The support for innovative drugs in the commercial insurance directory aims to fill gaps in patient coverage and enhance the overall healthcare system [25][28] 3. Market Performance - In the second week of December, the pharmaceutical and biotechnology sector declined by 1.04%, underperforming the CSI 300 index by 0.96 percentage points [6][34] - The medical research outsourcing sector showed the highest increase, up by 3.69%, while offline pharmacy and medical circulation sectors experienced the largest declines [6][36] 4. Recommended Companies - The report continues to favor innovative drugs and their supply chain, recommending companies such as Sanofi, Innovent Biologics, and others for investment [7][32]