Bristol Myers Squibb: Built for Growth 44th Annual J.P. Morgan Healthcare Conference Christopher Boerner, Ph.D., Board Chair & CEO January 12th, 2026 Forward Looking Statements This presentation (as well as the oral statements made with respect to the information contained in this presentation) contains statements about Bristol-Myers Squibb Company's (the "Company") future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute f ...

© 2 0 2 6 O R U K A T H E R A P E U T I C S Disclaimers The information contained in this presentation has been prepared by Oruka Therapeutics, Inc. (the "Company") and contains information pertaining to the business and operations of the Company. The information contained in this presentation: (a) is provided as at the date hereof, is subject to change without notice, and is based on publicly available information, internally developed data as well as third party information from other sources; (b) does no ...

Core Insights - Bristol Myers Squibb (BMY) has reached a pricing agreement with the U.S. government to provide Eliquis at no cost to Medicaid starting January 1, 2026, and will donate over 7 tons of the active pharmaceutical ingredient to ensure supply-chain resilience [1][8]. Group 1: Eliquis Overview - Eliquis is a prescription medication used to reduce the risk of stroke and blood clots in adults with atrial fibrillation, and it is co-developed and co-commercialized with Pfizer [2]. - Eliquis is one of the most widely prescribed oral blood thinners, generating $11 billion in sales in the first nine months of 2025, reflecting an 8% year-over-year increase [2][3]. Group 2: Financial Implications - The financial impact of the pricing deal on Eliquis sales remains uncertain, as it is the top revenue generator for BMY [3]. - The agreement also includes offering other drugs at an 80% discount to cash-paying patients, which may affect overall revenue [3]. Group 3: Competitive Landscape - BMY faces competition from Johnson & Johnson's Xarelto, which is also a Factor Xa inhibitor, but JNJ is currently dealing with patent challenges in the U.S. [5]. - Opdivo, another significant revenue generator for BMY, competes in the immuno-oncology space, which is dominated by Merck's Keytruda [5][6]. Group 4: Company Performance and Valuation - BMY's shares have decreased by 5.3% over the past year, contrasting with the industry's growth of 15.5% [7]. - BMY is trading at a price/earnings ratio of 9.07x forward earnings, which is higher than its historical mean of 8.40x but lower than the large-cap pharma industry's average of 17.27x [10]. Group 5: Earnings Estimates - The Zacks Consensus Estimate for 2025 earnings per share has increased, while the estimate for 2026 has decreased [12].

Group 1: Drug Approvals and Clinical Trials - AstraZeneca and Daiichi Sankyo's drug combination Enhertu and Perjeta received FDA approval as a first-line treatment for HER2-positive metastatic breast cancer, marking the first new first-line therapy in over a decade, showing a 44% reduction in disease progression or death risk compared to traditional THP therapy [1] - Takeda's oral TYK2 inhibitor zasocitinib demonstrated strong performance in two Phase III trials for moderate to severe plaque psoriasis, with over 75% improvement in key metrics after 16 weeks, and plans to submit for FDA approval in 2026 [2] Group 2: Clinical Trial Setbacks - Daiichi Sankyo's ADC drug ifinatamab deruxtecan has paused patient recruitment in its global Phase III trial due to unexpected interstitial lung disease deaths, which affects its accelerated approval plans based on Phase II data [1] Group 3: Mergers and Acquisitions - Fosun Pharma plans to acquire a 53% stake in Green Valley Pharmaceutical for approximately $200 million to revive the controversial Alzheimer's drug GV-971, which did not receive regulatory renewal in China [4] - Harbour BioMed entered into a collaboration agreement with Bristol-Myers Squibb worth up to $1.1 billion, including an initial payment of $90 million, for a multispecific antibody [5] - Sanofi signed two biotechnology collaboration agreements, including a deal worth up to $1.04 billion for the Alzheimer's candidate ADEL-Y01, with an initial payment of $80 million [6] Group 4: Regulatory Changes - The U.S. Congress passed the revised Biosecure Act as part of the annual defense bill, which is expected to raise entry barriers for Chinese life sciences companies into the U.S. market [3]

Financial Data and Key Metrics Changes - The company reported a strong year in 2025, with over 50% of the business transitioning to a growth portfolio that grew by 18% in the most recent quarter [23] - The growth portfolio now includes four products that are annualizing over $1 billion, with Reblozyl annualizing over $2 billion [23][24] - The company achieved a reduction in its expense base from $17.8 billion last year to $16.5 billion this year, with a target of an additional $1 billion in savings for 2026 and 2027 [26][27] Business Line Data and Key Metrics Changes - Cobenfy, a product for schizophrenia, has surpassed 2,700 TRXs weekly and is approaching 3,000 TRXs, significantly exceeding other recent schizophrenia launches [10][11] - Camzyos is annualizing over $1 billion, with expectations for continued significant growth as awareness and diagnosis rates improve [76] - The company is focusing on expanding its pipeline with multiple studies in areas such as Alzheimer's disease, bipolar disorder, and autism irritability [17][21] Market Data and Key Metrics Changes - The company has established a strong access position in Medicaid, Medicare, and commercial settings for Cobenfy, which is critical given the dominance of government payers in this space [10] - The launch of Cuvantic has seen a strong conversion from IV to subcutaneous administration, with expectations that 30%-40% of the IV business will convert by 2028 [44] Company Strategy and Development Direction - The company aims to continue driving its growth portfolio and executing against its pipeline, with a focus on operational efficiencies and cash flow generation [25][27] - The company is leveraging AI to enhance efficiency in drug development and manufacturing processes, which is expected to drive shareholder value [29][30] - The company is actively seeking partnerships and acquisitions in therapeutic areas with high unmet needs, particularly in immunology and oncology [39][40] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth trajectory and operational efficiencies, with a strong cash position of $17 billion at the end of Q3 [28] - The company is optimistic about upcoming data readouts and the potential for new product launches, particularly in the areas of atrial fibrillation and Alzheimer's disease [66][70] Other Important Information - The company is engaging with policymakers on tariff and healthcare policy issues, emphasizing the importance of access to medicines and the normalization of cost differentials [94][95] - The company has implemented direct-to-patient initiatives, significantly reducing costs for patients, which aligns with broader industry trends [97][98] Q&A Session Summary Question: Can you discuss the recent developments in the COVID study? - The company announced that the ADEPT 2 study will continue with additional patient enrollment after addressing irregularities found during clinical trial site reviews [5][6] Question: What is the current status of Cobenfy in the market? - Cobenfy has achieved strong access in Medicaid, Medicare, and commercial settings, with TRXs approaching 3,000 weekly, indicating significant market traction [10][11] Question: How is the company leveraging AI for efficiencies? - AI is being used to enhance drug development processes, improve manufacturing efficiency, and streamline internal operations, which is expected to drive shareholder value [29][30] Question: What are the company's plans for future product development? - The company has multiple studies underway in various therapeutic areas, including Alzheimer's disease and bipolar disorder, and is confident in the potential for positive outcomes [17][21] Question: How is the company addressing the competitive landscape in oncology? - The company is focusing on partnerships and acquisitions in areas with high unmet needs, particularly in immunology and oncology, to strengthen its market position [39][40]

Financial Data and Key Metrics Changes - The company reported a strong year in 2025, with the growth portfolio now comprising over 50% of the business and growing at 18% [30] - The growth portfolio includes four products annualizing over $1 billion, with Reblozyl exceeding $2 billion [31] - The company achieved a reduction in expense base from $17.8 billion last year to $16.5 billion this year, with an additional $1 billion in savings expected for 2026 and 2027 [33] Business Line Data and Key Metrics Changes - Cobenfy has surpassed 2,700 TRXs weekly, approaching 3,000 TRXs, significantly exceeding other recent schizophrenia launches [12] - Camzyos is annualizing over $1 billion, with expectations for continued significant growth as awareness and diagnosis rates improve [87] - The Cuvantic launch has seen strong conversion from IV to subcutaneous administration, with expectations of 30%-40% conversion of IV business by 2028 [51] Market Data and Key Metrics Changes - The company has a strong access position in Medicaid, Medicare, and commercial settings, which is critical in the schizophrenia market [12] - The company is seeing broad utility across various tumor types for Cuvantic, indicating a strong market presence [50] - The company is actively pursuing opportunities in China, recognizing the increasing percentage of INDs coming from that region [75] Company Strategy and Development Direction - The focus for 2026 is to continue driving the growth portfolio and executing against the pipeline, with a strong emphasis on operational efficiencies [32] - The company is leveraging AI to enhance drug development processes and improve operational efficiencies [35] - The company is committed to exploring high unmet needs in therapeutic areas where they have scientific expertise and commercial acumen [42] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the ADEPT program and the broader Cobenfy development program, projecting positive outcomes from ongoing studies [7] - The company is optimistic about the upcoming phase 3 data readouts and the potential for new NMEs by the end of the decade [32] - Management highlighted the importance of direct-to-patient initiatives to improve access and affordability of medications [114] Other Important Information - The company is actively engaging with policymakers regarding tariffs and supply chain flexibility, emphasizing the importance of access to medicines [108] - The company has made significant investments in AI to enhance efficiency in drug development and manufacturing processes [35] - The company is exploring partnerships and acquisitions in areas with high unmet medical needs, particularly in immunology and oncology [45] Q&A Session Summary Question: What is the outlook for the ADEPT studies? - Management is confident in the ADEPT program and has already initiated studies in various indications, including Alzheimer's and bipolar disorder [22][24] Question: How is the company leveraging AI for efficiencies? - AI is being used to accelerate drug development, improve site selection, and enhance manufacturing processes, driving overall efficiency [35][36] Question: What is the strategy for capital deployment moving forward? - The company will continue to focus on high unmet needs within existing therapeutic areas while also exploring new opportunities for partnerships and acquisitions [42][45] Question: How is the Cuvantic launch performing? - The Cuvantic launch has seen strong conversion rates and broad utility across multiple tumor types, with expectations for continued growth [50][51] Question: What are the expectations for Camzyos? - Camzyos is expected to see significant growth as awareness and diagnosis rates improve, with a focus on expanding its use in community cardiology [87][90]

Financial Data and Key Metrics Changes - Total company sales for Q3 2025 were approximately $12.2 billion, reflecting strong demand across the business, with a year-over-year increase of 17% [17][6] - Gross margin was approximately 73%, primarily due to product mix, while operating expenses decreased by approximately $100 million to roughly $4.2 billion compared to the same period last year [22][23] - Overall diluted earnings per share was $1.63, including net charges of approximately $530 million, or $0.20 per share, attributed to acquired in-process R&D and licensing income [22][24] Business Line Data and Key Metrics Changes - The oncology portfolio saw OPDIVO global sales of approximately $2.5 billion, up 6%, driven by demand in various indications [17][18] - REBLOZYL global sales were $615 million, reflecting a 38% increase in the U.S. and a 31% increase outside the U.S. [19] - CAMZYOS global sales increased 88% to $296 million, while Eliquis global sales reached $3.7 billion, growing 23% [20][21] Market Data and Key Metrics Changes - Global sales of the growth portfolio increased 17%, driven by multiple brands including the IO portfolio, REBLOZYL, CAMZYOS, and BREYANZI [6][17] - Sales of COBENFY were $43 million in the quarter, with a year-to-date total of $105 million, indicating steady growth [21][22] Company Strategy and Development Direction - The company is focused on long-term sustainable growth, with plans to introduce 10 new medicines to the market by the end of the decade [14] - Recent acquisitions, such as Orbital Therapeutics, aim to strengthen the cell therapy franchise and enhance the company's capabilities in RNA technology [10][11] - The company is integrating digital technology and AI to drive efficiencies and enhance organizational agility [15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth portfolio's performance and the ability to navigate through the upcoming challenges, emphasizing financial discipline and strategic investments [66][67] - The company anticipates a data-rich period ahead, with multiple pivotal readouts expected in the next 12-24 months [13][14] Other Important Information - The company is maintaining its full-year revenue guidance, increasing it by $750 million at the midpoint to a range of $47.5 billion-$48 billion [24] - The effective tax rate for the quarter was 22.3%, reflecting the earnings mix [22] Q&A Session Summary Question: Updates on ADEPT program and confidence in studies - Management reiterated confidence in the ADEPT program, with results expected by the end of the year, and emphasized the importance of execution across the company [31][32] Question: Commercialization of COBENFY and prescriber engagement - The company is pleased with COBENFY's progress, noting positive physician feedback and a significant number of new trialists being added weekly [40][41] Question: Competitive landscape for PD-1/VEGF bispecifics - Management expressed confidence in the partnership with BioNTech and the potential of pomitomig to become a new standard of care [49][51] Question: Barriers to adoption for COBENFY - Management acknowledged the entrenched market dynamics and emphasized ongoing efforts to educate prescribers and increase adoption [56][58] Question: Cost management and strategic productivity initiatives - The company is on track for $1 billion in cost savings this year and has clear visibility on achieving $2 billion by 2027 [66][67]

Core Insights - Bristol Myers Squibb is expanding its direct-to-consumer offerings by making its blood thinner Eliquis and psoriasis therapy Sotyktu available at significantly discounted prices for cash-paying customers [2] Company Developments - The announcement of the price reduction comes just days before a September 29 deadline set by President [2]

Bristol Myers Squibb said on Thursday it will sell its psoriasis drug Sotyktu directly to cash-paying patients at a more than 80% discount to the drug's list price. ...

Group 1 - Johnson & Johnson's experimental psoriasis drug demonstrated superior skin clearance compared to Bristol Myers Squibb's Sotyktu in two late-stage head-to-head trials [1]