Financial Data and Key Metrics Changes - Revenue for 2025 was $342 million, representing a 3% year-over-year increase, with non-GAAP operating income at $28 million, indicating strong cash generation improvements [5][16] - Operating cash flow for Q4 was $3 million and $27 million for the full year 2025, reflecting improved working capital management [16] - The company ended 2025 with $359 million in ARR and a net debt position reduced from $33 million in 2024 to $11 million in 2025, a decrease of nearly 67% year-over-year [17] Business Line Data and Key Metrics Changes - Subscription ARR from B2B customers grew nearly 20% in 2025, with B2B-oriented customers representing the majority of new platform ARR over the past three quarters [7] - Enterprise customer count increased to 6,648, up 897 accounts sequentially, while average revenue per account (ARPA) decreased by 8% sequentially to $43,200 [18] Market Data and Key Metrics Changes - The platform delivered nearly $32 billion in GMV for 2025, with GMV growth of 12% in 2025 and 11% in 2024 [14][19] - Net revenue retention (NRR) was 95.2% in Q4, up from 95.0% in Q4 2024, indicating a focus on improving customer retention and expansion [20] Company Strategy and Development Direction - The company is focused on three priorities: simplifying the business, realigning investments around high-value initiatives, and building infrastructure to scale as AI and agentic commerce evolve [5][11] - R&D investment is set to increase by nearly 30% in 2026, with a focus on delivering AI capabilities, expanding Feedonomics, rolling out BigCommerce Payments, and launching Makeswift [11][12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the foundation built in 2025 and emphasized a shift from foundation building to execution and monetization in 2026 [15][21] - The guidance for Q1 2026 expects revenue between $82.5 million and $83.5 million, and for the full year 2026, revenue is expected between $347.5 million and $369.5 million, reflecting 2%-8% growth [20][21] Other Important Information - The company is transitioning to new metrics, including total GMV and company-wide NRR, to provide clearer visibility into business performance [19][20] - The partnership with PayPal for BigCommerce Payments is expected to launch around the end of Q1 2026, aimed at simplifying onboarding for merchants and driving higher monetization [10][56] Q&A Session Summary Question: What opportunities does the company see in the agentic commerce landscape? - Management noted strong momentum and alignment with major partners like PayPal and Stripe, emphasizing their readiness to take advantage of evolving opportunities [26] Question: How should the market anticipate changes in take rates? - Management indicated that monetization will come from product shipments and better monetization of the B2B install base, with a focus on improving take rates over time [33][34] Question: What is the rationale behind the wide guidance range for 2026? - The wide range reflects both conservatism due to potential macro issues and optimism about significant innovation and growth opportunities in the pipeline [40][41] Question: What is the core driver for improving NRR? - Management acknowledged that improving NRR is a priority and is linked to better customer engagement and product offerings, with several initiatives aimed at enhancing retention and expansion [67][70]

Financial Data and Key Metrics Changes - In Q4 2025, the company reported group revenue of $228 million, representing a year-over-year growth of 547% and a quarter-over-quarter growth of 56% [10] - The annualized run rate revenue for the core AI cloud business reached $1.2 billion at the end of December, exceeding the high end of the previous guidance [11] - Group adjusted EBITDA margin improved from 19% in Q3 to 24% in Q4, indicating strong operational leverage [11] Business Line Data and Key Metrics Changes - The core AI cloud business revenue grew 830% year-over-year and 63% quarter-over-quarter, driven by high utilization and strong pricing [11] - The average contract duration for new cloud customers increased by 50%, reflecting growing demand for AI solutions [5][25] Market Data and Key Metrics Changes - The company sold out of capacity in Q3 and Q4 of 2025, with demand continuing to exceed available capacity [4][11] - The company is experiencing robust demand from both AI startups transitioning to enterprise-scale and established enterprises adopting AI for critical business processes [5][24] Company Strategy and Development Direction - The main strategic focus is to scale the core AI cloud business through organic growth and targeted acquisitions, such as the recent acquisition of Tavily [7][66] - The company plans to invest between $16 billion and $20 billion in capital expenditures in 2026 to support its growth and capacity expansion [16][29] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving an annualized run rate revenue of $7 billion to $9 billion by the end of 2026, supported by strong demand and capacity expansion [8][12] - The company anticipates that the adjusted EBITDA margin will reach approximately 40% in 2026, driven by the scaling of the core AI business [14][64] Other Important Information - The company ended 2025 with $3.7 billion in cash and cash equivalents, providing a strong financial position to fund growth plans [11] - The company is exploring various funding options, including corporate debt and asset-backed financing, to support its capital needs [17][29] Q&A Session Summary Question: What gives you conviction that the demand for AI will continue to justify these investments? - Management noted that there are strong signals from large clients expanding their capacity needs, and AI startups are transitioning to real enterprises with increasing demand for GPUs [21][24] Question: How are you thinking through to meet the expectations for CapEx? - The COO explained that the majority of CapEx will be financed through cash flows from long-term contracts, with a healthy balance sheet allowing for additional financing options [27][29] Question: Can you help us bridge to the contracted power guidance? - The company is accelerating the build-out of capacity and expects to achieve its goals for 2026 through a mix of smaller and larger projects [36][38] Question: What drove the upside in the December 2025 ARR? - The upside was attributed to solid execution, strong pricing, and utilization, with robust demand trends continuing into Q1 2026 [50][51] Question: How is Nebius handling data center equipment shortages? - Management stated that they are well-positioned to manage risks associated with data center construction and have secured necessary components for major contracts [54][56] Question: What is the strategic rationale behind the acquisition of Tavily? - The acquisition is aimed at enhancing the platform's capabilities and deepening customer engagement, aligning with the company's strategy to be a leading AI cloud provider [66]

Financial Data and Key Metrics Changes - Adjusted operating income increased by 31% year-over-year in Q4 2025, marking the highest level in four years [5][25] - Full-year adjusted income from operations available to common shareholders was over $1.5 billion, a 23% improvement compared to 2024 [25] - Net income available to common stockholders for Q4 was $745 million, or $3.80 per diluted share [26] Business Line Data and Key Metrics Changes - Annuities sales volumes increased by 25% in 2025, with RILA sales up 35% and fixed annuity sales up 11% [11][12] - Group Protection delivered operating earnings of $493 million for the full year, up 16% from 2024, with a margin improvement to 9% [28] - Life Insurance operating earnings improved to $77 million for Q4, compared to an operating loss of $15 million in the prior year [36] Market Data and Key Metrics Changes - Group Protection now accounts for approximately 25% of business unit earnings, up from 18% in 2023 [45] - Spread-based annuity account balances increased to 30%, up from 25% in 2023 [46] - Average account balances in Retirement Plan Services increased nearly 9% year-over-year to $124 billion [35] Company Strategy and Development Direction - The company is focused on increasing risk-adjusted returns, reducing volatility, and growing its franchise through strategic realignment and operational execution [7][10] - There is an emphasis on products with higher risk-adjusted margins and stable cash flows to strengthen business resilience [9][14] - The company aims to maintain expense discipline while investing strategically to support long-term priorities [8][41] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to deliver long-term value despite potential market volatility [10][22] - The company is committed to improving the quality and durability of earnings while focusing on profitable growth [21][36] - The outlook for 2026 includes expectations for continued earnings growth and capital return to shareholders [49] Other Important Information - The investment portfolio delivered an annualized return of nearly 12% for Q4, exceeding targets [24][42] - The company completed the consolidation of several Life Insurance captive entities, which is expected to improve free cash flow [43][69] - Holding company liquidity ended the year at approximately $1.1 billion, providing financial flexibility for future capital returns [44] Q&A Session Summary Question: Capital return guidance and buybacks - Management indicated that capital deployment priorities include maintaining excess capital in operating entities and preparing for optimal handling of preferred securities [52][54] Question: Excess cash and potential uses - The excess cash at the holding company is primarily aimed at managing preferred securities and increasing capital return to shareholders [56] Question: Life Insurance captive consolidation impact - The consolidation of captives is expected to reduce reserve financing costs and improve the free cash flow profile of the legacy Life block [68][69]

Financial Data and Key Metrics Changes - In 2025, the company achieved a core EPS growth of 8% and a core ROE expansion of 30 basis points, reaching a target of 18%+ by 2027 [7][15][24] - The company generated $6.4 billion in remittances and returned nearly $5.5 billion to shareholders, with a LICAT ratio of 136% and a leverage ratio of 23.9% [7][24][25] - A 10% increase in the quarterly common share dividend was announced, alongside a new NCIB program allowing the repurchase of up to 42 million shares [8][24] Business Line Data and Key Metrics Changes - New business CSM growth exceeded 20% in each insurance segment, contributing to double-digit growth in the CSM balance [5][15] - Global WAM reported net outflows of $9.5 billion, primarily due to large retirement plan redemptions, but still delivered strong margins and core earnings growth [6][15][16] - Core earnings in Asia increased by 24% year-over-year, driven by business growth and favorable impacts from previous basis changes [20][21] Market Data and Key Metrics Changes - APE sales in Asia decreased by 3%, with double-digit growth in Japan and Asia Other offset by lower sales in Hong Kong [19][20] - The U.S. segment saw a 9% increase in APE sales, with new business CSM growing by 34%, although core earnings decreased by 22% due to lower investment spreads [22][23] - Canadian APE sales and new business value increased by 2% and 4% respectively, reflecting strong growth in individual insurance and annuity sales [22] Company Strategy and Development Direction - The company introduced a refreshed enterprise strategy focused on growth and customer choice, with strategic investments made in various markets [9][10] - The company aims to become an AI-powered organization, investing in AI to enhance efficiency and customer experiences [12][14] - Strategic acquisitions, including Comvest Credit Partners and a joint venture in India, are part of the company's growth strategy [9][10] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating macroeconomic and geopolitical uncertainties due to the diversified nature of the business [5][6] - The company anticipates continued growth in core earnings and is optimistic about achieving its 2027 targets [15][24] - Management highlighted the importance of maintaining a balanced and diversified business model to mitigate risks [9][10] Other Important Information - The company became the first international life insurer to establish an office in the Dubai International Financial Centre [10] - A significant collaboration in Hong Kong aims to enhance healthcare solutions for customers [11] Q&A Session Summary Question: Clarification on Hong Kong sales and regulatory changes - Management noted that while there was a decline in sales due to regulatory changes, they expect brokers to adjust and sales to increase over time [28][30][31] Question: NBV margin increase in Hong Kong - The increase in NBV margin was attributed to a favorable mix, with a focus on higher-margin channels [34][36] Question: Impact of eMPF on GWAM earnings - Management confirmed that the eMPF transition has had a negative impact, but Comvest is expected to contribute positively to AUM and earnings [37][38] Question: U.S. division's unfavorable mortality experience - Management indicated that the recent unfavorable mortality experience is viewed as normal variability and not indicative of a long-term trend [42][46][48] Question: Legacy book dispositions and EPS neutrality - Management stated that current share price levels do not constrain their ability to pursue future transactions and maintain EPS neutrality [60][61]

Financial Data and Key Metrics Changes - The company reported first quarter revenues of EUR 402 million, representing an 11% increase on a reported basis and an 18% increase in constant currency, exceeding the full year guidance of 13%-15% [12][15] - Adjusted net profit for the first quarter was EUR 49 million, up 47% year-over-year, with adjusted EPS of $0.27, a 50% increase from $0.18 a year ago [18][19] - Gross profit margin for the first quarter was 55.7%, down 460 basis points year-over-year, while adjusted gross profit margin was 57.4%, down 290 basis points [17] Business Line Data and Key Metrics Changes - The B2B segment grew by 24% in constant currency, while DTC (Direct-to-Consumer) grew by 12% [12][18] - The closed-toe share of revenue reached close to 60% during the first quarter, with strong sales in clogs, including the Boston silhouette [14] Market Data and Key Metrics Changes - The Americas segment grew by 14% in constant currency, EMEA by 17%, and APAC by 37% in constant currency [16] - The company is under-penetrated in markets like France, Spain, the UK, and the GCC, indicating strong growth potential in these regions [10] Company Strategy and Development Direction - The company aims for 13%-15% top-line growth in constant currency over the next three years, with a focus on maximizing profitability per pair while protecting brand equity [8][9] - The company plans to double its APAC revenue by 2028, steering growth at double the pace of other segments [10] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the brand's growth potential, citing a total addressable market that includes every human being, with significant room for growth in established markets [9][28] - The company anticipates significant headwinds from foreign exchange and tariffs in the second quarter, projecting a 700 basis point headwind to revenue growth [21][22] Other Important Information - The company plans to repurchase shares for a total consideration of $200 million during fiscal 2026, subject to market conditions [52] - The company ended the quarter with cash and cash equivalents of EUR 229 million and a net leverage of 1.7 times [19][20] Q&A Session Summary Question: Drivers of durable demand momentum for the brand globally - Management highlighted a long runway for growth, with market penetration below 5% in established markets and strong order books for 2026 [28] Question: Allocation of inventory across channels and geographies - Management stated that inventory is allocated to the most profitable channels and regions to optimize brand strength and margin [33] Question: Seasonal progression of margins across quarters - Management indicated that Q1 and Q2 would experience significant FX headwinds, with expected margin pressure from tariffs [41] Question: SG&A and operational leverage - Management acknowledged the impact of tariffs and FX on margins but emphasized the need to balance margin expansion with reinvestment in the business [45] Question: Product trends for the upcoming season - Management noted strong momentum in elevated styles and open-toe silhouettes, particularly in the APAC region [48]

Financial Data and Key Metrics Changes - In Q4 2025, PYRUKYND generated $20 million in net revenue, an 86% increase year-over-year and a 55% sequential increase from $13 million in Q3 2025 [7][10] - Full-year 2025 revenue for PYRUKND reached $54 million, reflecting robust year-on-year growth [7][10] - The company ended 2025 with approximately $1.2 billion in cash, providing flexibility for future investments [8][11] Business Line Data and Key Metrics Changes - U.S. revenue for PYRUKND in Q4 was $16 million, driven by commercial focus in PK deficiency and favorable growth adjustments [10] - Ex-U.S. revenue was $4 million in Q4, primarily due to inventory stocking ahead of demand [11] - Cost of sales for Q4 was $1.9 million, while R&D expenses were $88.1 million, reflecting an increase associated with advancing the pipeline [11] Market Data and Key Metrics Changes - The U.S. launch of ACTIVASE for thalassemia is underway, with expectations for U.S. PK deficiency revenues in 2026 to be between $45-$50 million [10] - The company anticipates a sequential decline in ex-U.S. revenues into Q1 2026 [11] Company Strategy and Development Direction - The company outlined its 2026 strategic priorities, focusing on executing the launch of Pyrukynd, expanding the PK activation franchise, advancing early-stage pipeline programs, and maintaining financial discipline [5][6] - The company aims to leverage its existing commercial presence in thalassemia and PK deficiency to achieve profitability [12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the early market response to ACTIVASE, noting strong engagement from physicians and patients [16] - The company is preparing for a pre-sNDA meeting with the FDA regarding mitapivat for sickle cell disease, which is a critical step in defining the regulatory path [25][44] Other Important Information - The company has completed enrollment in the phase II sickle cell disease trial of tebapivat, with top-line results expected in the second half of 2026 [8][20] - The company is committed to financial discipline, anticipating operating expenses in 2026 to be roughly flat compared to 2025 [12] Q&A Session Summary Question: On the ACTIVASE launch and prescription updates - Management noted that early demand for ACTIVASE is encouraging, with 44 prescriptions written by REMS-certified physicians in the first five weeks of launch [31] - It is expected that prescriptions will grow ahead of revenues due to a 10-12 week conversion time from prescription to treatment initiation [31][32] Question: On sickle cell and tebapivat expectations - Management indicated that the phase II tebapivat trial is a dose-finding trial, and they are excited about the potential hemoglobin response based on previous data [35][36] Question: On payer dynamics and SG&A changes - The payer mix for thalassemia is similar to PK deficiency, with most patients under commercial payers, and initial market access is expected to occur through medical exceptions [93] - SG&A expenses will need to scale up for sickle cell, but the existing infrastructure from PK deficiency and thalassemia will be leveraged [95]

Financial Data and Key Metrics Changes - The company reported first quarter revenues of EUR 402 million, representing an 11% increase on a reported basis and an 18% increase in constant currency, exceeding the full-year guidance of 13%-15% [12][15] - Adjusted net profit for the first quarter was EUR 49 million, up 47% year-over-year, with adjusted EPS of $0.27, a 50% increase from $0.18 a year ago [18][19] - Gross profit margin for the first quarter was 55.7%, down 460 basis points year-over-year, while adjusted gross profit margin was 57.4%, down 290 basis points [17] Business Line Data and Key Metrics Changes - B2B business grew 24% in constant currency, while DTC (Direct-to-Consumer) grew 12% [12][18] - The closed-toe share of revenue reached close to 60% during the first quarter, indicating strong sales in clogs [14] Market Data and Key Metrics Changes - The Americas segment grew 14% in constant currency, EMEA grew 17%, and APAC grew 37% in constant currency [16] - The company is under-penetrated in markets like France, Spain, the U.K., and the GCC, with significant growth potential in these regions [10] Company Strategy and Development Direction - The company aims for 13%-15% top-line growth in constant currency over the next three years, with a focus on maximizing profitability per pair while protecting brand equity [8][9] - The company plans to double its APAC revenue by 2028, steering growth at double the pace of other segments [10] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the brand's growth potential, citing a total addressable market that includes every human being [8] - The company anticipates significant headwinds from foreign exchange and tariffs in the second quarter, projecting a 700 basis point headwind to revenue growth [21][22] Other Important Information - The company plans to repurchase shares for a total consideration of $200 million during fiscal 2026, subject to market conditions [52][54] - The company ended the quarter with cash and cash equivalents of EUR 229 million and a net leverage of 1.7x [19][20] Q&A Session Summary Question: Drivers of durable demand momentum for the brand globally - Management highlighted a long runway for growth, with market penetration below 5% in established markets and strong order books for 2026 [27][28] Question: Allocation of inventory across channels and geographies - Management stated that inventory is allocated to the most profitable channels and regions to optimize brand strength and margin [32][33] Question: Seasonal progression of margins across quarters - Management indicated that Q1 and Q2 would experience significant FX headwinds, with expected margin pressure from tariffs [41][42] Question: SG&A leverage and operational efficiency - Management acknowledged the impact of tariffs and FX on margins but emphasized ongoing operational improvements and investments in D2C [45][46] Question: Product trends for the upcoming season - Management noted strong demand for elevated styles in both closed-toe and open-toe sandals, with a focus on higher price segments [47][48] Question: Balance sheet and cash usage - Management confirmed intentions to execute the $200 million share repurchase, emphasizing that the stock is undervalued [52][53] Question: Performance of own retail stores - Management reported high single-digit same-store sales growth and significant year-over-year growth in retail revenue [59][60]

Financial Data and Key Metrics Changes - For Q4 2025, the company reported net sales of $1.4 billion, a 16% increase year-over-year, with adjusted EBITDA of $269 million, up 7% year-over-year [5][9] - Full-year net sales reached $5.1 billion, with adjusted EBITDA of $1.1 billion, meeting or exceeding previous outlook considerations [5][6] - The adjusted EBITDA margin decreased by approximately 150 basis points compared to last year, influenced by unfavorable foreign exchange and lower specialties margins [9] Business Line Data and Key Metrics Changes - Energy storage segment saw a 14% increase in full-year volumes to 235,000 tons LCE, with Q4 net sales up 23% year-over-year and adjusted EBITDA up 25% [19] - Ketjen's net sales increased by 14% year-over-year, with adjusted EBITDA growing 39%, driven by higher sales volumes [16] - Specialties business experienced a 5% increase in net sales but a 6% decline in adjusted EBITDA due to margin compression [18] Market Data and Key Metrics Changes - Global lithium demand for 2025 was 1.6 million tons, up more than 30% year-over-year, with expectations for 2026 demand to rise to 1.8-2.2 million tons, a 15%-40% increase [23][24] - Stationary storage demand grew over 80% in 2025, with significant increases in shipments across all geographies [25] - European EV demand increased by 34%, while U.S. EV demand slowed due to the removal of consumer tax credits [24] Company Strategy and Development Direction - The company is focusing on cost and productivity improvements, targeting an additional $100 million-$150 million in 2026 [6][33] - Strategic decisions include idling operations at the Kemerton lithium hydroxide plant to improve financial flexibility [7][32] - Investments in top-tier mining resources and exploration interests remain a priority, with a focus on maintaining a competitive position [8][28] Management's Comments on Operating Environment and Future Outlook - Management noted that recent lithium price improvements are insufficient to offset challenges in Western hard rock lithium conversion operations [7] - The company anticipates meaningful positive free cash flow potential if current lithium pricing persists [6][22] - Management expressed confidence in the long-term growth opportunities driven by energy resilience and electric vehicle demand [34] Other Important Information - The company closed the sale of its stake in the Eurocat joint venture and expects to close the sale of a majority stake in Ketjen, generating approximately $660 million in pretax proceeds [7][16] - The company ended 2025 with $1.6 billion in cash and expects to maintain an investment-grade credit profile [26][28] Q&A Session Summary Question: What is the outlook for lithium volumes beyond 2027? - Management indicated that growth opportunities exist at Greenbushes and Wodgina, with a continued growth profile expected after 2027 [38] Question: How does the cost structure of Kemerton compare to Chinese assets? - The cost structure of Kemerton is approximately $4-$5 higher than Chinese conversion assets, influenced by factors such as labor and power costs [41] Question: What is the impact of Chinese lithium capacity closures? - Management noted that about 30,000-50,000 tons of capacity came offline in 2025, influenced by regulatory actions and demand growth [44][46] Question: What factors are driving the decrease in Specialties adjusted EBITDA for 2026? - The decrease is attributed to lack of demand growth in certain markets and a decline in lithium specialties prices following previous peaks [48] Question: How does the company plan to approach investments in the current cycle? - The company plans to be more conservative with capital spending, focusing on smaller, incremental projects with quick returns [52]

Financial Data and Key Metrics Changes - Total revenue for Q4 2025 was $34.1 million, an increase of 11.8% compared to Q4 2024 [51] - For the full year 2025, total revenue was $146.1 million, a slight increase from 2024 [51] - U.S. XPOVIO net product revenue for Q4 2025 was $32.1 million, an increase of 9.6% compared to Q4 2024 [52] - For the full year, U.S. XPOVIO net product revenue was $114.9 million, an increase of 1.9% from 2024 [52] - The company reported a net loss of $102.2 million, or $5.71 per share on a GAAP basis in Q4 2025 [60] - The full year net loss was $196 million, or $17.93 per diluted share for 2025 [60] Business Line Data and Key Metrics Changes - Xpovio net product revenue grew to $32.1 million in Q4 2025 and $114.9 million for the full year 2025 [36] - The company expects to guide towards $115 to $130 million of Xpovio net product revenue in 2026 [36] - License and other revenue was $2 million in Q4 and $31.2 million for the full year 2025 [53] Market Data and Key Metrics Changes - Demand for Xpovio was consistent year-over-year in 2025, with the community setting driving approximately 60% of total U.S. sales [37] - The company is targeting approximately 4,000 newly diagnosed patients with intermediate to high-risk myelofibrosis [45] Company Strategy and Development Direction - Karyopharm is focused on expanding its oncology franchise, particularly in myelofibrosis and endometrial cancer [7][8] - The company is preparing for pivotal data readouts from its late-stage clinical programs, with significant opportunities in myelofibrosis and endometrial cancer [63] - The strategy includes evaluating a range of financing and strategic options to maintain flexibility and align capital decisions with value creation [12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the upcoming data readout from the phase three SENTRY trial in March, which is expected to address an unmet need in myelofibrosis [9][26] - The company is managing its business with discipline, focusing on near-term value-creating milestones while maintaining flexibility [64] - Management emphasized the importance of executing well and generating high-quality data to define the next phase of the company [64] Other Important Information - The company ended the year with $64.1 million in cash, cash equivalents, restricted cash, and investments, compared to $109.1 million as of December 31, 2024 [61] - The full year 2025 included $15 million of R&D reimbursement from Menarini, which will not be received in future years [53] Q&A Session Summary Question: Can you discuss the differences in exposure and activity between the 40 mg and 60 mg doses? - Management indicated that the 60 mg dose showed a clear benefit-risk profile compared to the 40 mg dose, with maximized efficacy in the 60 mg group [70] Question: What are your thoughts on Novartis' recent plans in myelofibrosis? - Management noted that the continued investment in the myelofibrosis space highlights the unmet need and significant market value [74] Question: Can you elaborate on the strategy for eltanexor and other MPNs? - Management stated that eltanexor is a second-generation XPO1 inhibitor with potential applications beyond myelofibrosis, including other MPNs [78] Question: What updates can you provide on the blinded safety data? - Management confirmed that no updates have been made beyond previously disclosed data, and they are looking forward to the upcoming data readout [85] Question: How do you view the potential for symptomatic improvement in your trials? - Management emphasized the goal of achieving statistical significance for both spleen volume reduction and symptomatic improvement [104]

Financial Data and Key Metrics Changes - Total revenue for Q4 2025 reached $225 million, representing a 226% increase year-over-year and a 33% increase sequentially [5][17] - Gross profit totaled $10.6 million, with an adjusted EBITDA of $31.2 million for the quarter [5][21] - Self-mining revenue was $168.6 million, up 306% year-over-year and 28.7% sequentially [17] - Total operating expenses for the quarter were $66.3 million, compared to $42.5 million in Q4 2024 and $60.5 million in Q3 2025 [20] Business Line Data and Key Metrics Changes - Self-mining hash rate increased to over 63 exahash per second by the end of January 2026, up from 55 exahash per second at year-end [13] - SEALMINER sales revenue was $23.4 million, up 105.4% from $11.4 million in Q3 2025 [18] - The overall fleet-wide efficiency improved to 17.5 joules per terahash as of January 31, 2026 [14] Market Data and Key Metrics Changes - The company reported a significant shift in market dynamics around AI data center development, with increased demand for large-scale colocation capacity [6][7] - The average Bitcoin price decreased by 13% quarter-over-quarter, impacting gross margins [18][19] Company Strategy and Development Direction - The company aims to position itself as a vertically integrated Bitcoin and AI infrastructure provider, focusing on Bitcoin mining, ASIC development, and HPC AI [12][28] - The strategy includes prioritizing colocation services in Norway and the U.S. for large-scale AI HPC deployments [7][11] - The company plans to continue investing in self-mining capacity despite current Bitcoin price fluctuations, indicating a long-term belief in Bitcoin [42] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in securing colocation deals in the near future, although predicting exact timelines is challenging [31] - The company anticipates continued growth in self-mining operations and expects the supply-demand imbalance for AI compute to persist into 2027 [12][28] - Management highlighted the importance of maintaining operational flexibility and efficiency in response to market conditions [47] Other Important Information - The company plans to transition from IFRS to GAAP accounting standards starting in Q1 2026 [27] - Capital expenditures for 2025 totaled $176 million, with an anticipated range of $180 million to $200 million for 2026 [24] Q&A Session Summary Question: What are the main items being discussed with potential colocation customers? - Discussions vary by counterparty and include price, duration, and design considerations, with confidence in finalizing deals soon [30][31] Question: What should be expected in terms of debt and cost of capital for colocation projects? - Cost of capital will depend on counterparties and deal terms, making it difficult to predict at this stage [32][35] Question: What is the status of the Tydal site and its customer discussions? - The Tydal site is expected to be completed by the end of the year, with a low PUE of around 1.1 due to its hydropower source [40] Question: How does the company view the growth of its Bitcoin mining business in 2026? - The company remains committed to investing in Bitcoin mining capacity despite current market conditions, with no specific hash rate projections provided yet [42][43] Question: Is there a price point at which mining activity would slow down? - There is a price point where mining could slow, but the company has not reached it yet, and efficiency improvements allow for continued operation [47][48] Question: What is the strategy for GPU rental versus colocation? - The company will pursue colocation for larger sites and GPU rental for smaller sites, reflecting a strategic pivot based on customer needs [83][84]