Core Viewpoint - The launch of China's first 200kV field emission transmission electron microscope by Bozhong Instruments marks a significant breakthrough in high-end scientific instruments, breaking international monopolies and entering a new era of independent research and commercialization in China [1][3]. Group 1 - Bozhong Instruments will hold a grand ceremony for the launch of the first domestic 200kV field emission transmission electron microscope on June 28 [3]. - The development process took five years, relying on fully independent and controllable electronic optical core technology, high stability low ripple power supply, and precise processing and assembly techniques [3]. - The successful integration of core technology breakthroughs into high-end equipment industrialization represents a new milestone in China's high-end scientific instrument autonomy [3].

Core Viewpoint - The article highlights the resilience and innovative vitality of China's scientific instrument industry in the face of global challenges, showcasing significant growth in overseas revenue among domestic listed companies [2][6]. Group 1: Overview of Overseas Revenue - In 2024, the total overseas revenue of 43 domestic listed instrument companies reached 34.707 billion yuan, marking a new high [6][10]. - Over 60% of the companies reported revenue growth, with 21 companies achieving over 100 million yuan in overseas revenue [6][10]. - The top five companies by overseas revenue are Mindray Medical (16.434 billion yuan), Sunny Optical (9.602 billion yuan), Libang Instruments (1.098 billion yuan), BGI Genomics (913 million yuan), and Huashengchang (717 million yuan) [3][6]. Group 2: Performance Analysis - Among the 43 companies, 27 experienced stable or significant growth, with notable examples including Wanyi Technology, which saw a 447.23% increase in overseas revenue [7][12]. - Conversely, 14 companies faced revenue declines, such as Gaode Infrared, which reported a 50.76% drop [7][15]. - Mindray Medical's overseas revenue accounted for 44.75% of its total revenue, reflecting the effectiveness of its globalization strategy [10][17]. Group 3: Market Dynamics - The article indicates a shift in the market, with three companies achieving over 1 billion yuan in overseas revenue, while 18 companies fall within the 100 million to 1 billion yuan range [13]. - Companies with overseas revenue constituting over 10% of total revenue increased to 22, indicating a growing trend in international market engagement [17]. - Wanyi Technology's strategy of "product leadership, quality excellence, competitive pricing, and superior service" has led to substantial growth in overseas markets [13][17]. Group 4: Emerging Companies - New entrants like Titan Technology and Lihua Technology reported 100% growth in overseas revenue, reflecting successful market expansion strategies [14]. - Titan Technology leveraged partnerships with overseas distributors and acquisitions to enhance its competitive brand presence [14]. Group 5: Future Outlook - Despite external uncertainties, the overall trend indicates a robust commitment from Chinese companies to expand in international markets, suggesting a "fast forward" approach to globalization [17].

导读： InfinityBio完成800万美元A轮融资，收购Serimmune资产，推进MIPSA抗体分析平台开发，计划2025年推出新服务。 Infinit y Bio 周三表示，已经完成了 800 万美元的 A 轮融资。并以未披露的金额收购了免疫分析公司 Serimmune 的资产，Serimmune 成立于 2014 年，旨在提供无偏差的抗体反应组服务。包括 Env iroSIGHT 在内的新 MIPSA服务产品也预计将于 2025 年下半年推出。 本轮融资由 I l lumina Ventures 领投，PTX Capital、Blackbird BioVentures 和 Propel Baltimore Fund 参投。此前，该公司曾从包 括马里兰州的 PTX Capital 和 Blackbird BioVentures 在内的投资者那里筹集了 400 万美元的资金。Infinit y 表示，总部位于巴尔的摩 （美国马里兰州最大城市，美国大西洋沿岸重要海港城市），将利用这笔资金扩大其商业足迹，加速其 MIPSA 抗体分析平台的开发，并推出 新的免疫分析服务，收购 Serimmune 的资产是其扩 ...

Core Viewpoint - The article emphasizes the importance of plasmid extraction in life sciences, highlighting its relevance for professionals ranging from students to scientists and its critical role in molecular-level work [1][2]. Summary by Sections Essential Knowledge Points - A qualified plasmid consists of several key components, including the origin of replication (Ori), antibiotic resistance genes, multiple cloning sites (MCS), promoters/enhancers, terminators, and poly(A) signals [5][10][11][12]. - Understanding how to read plasmid maps is crucial, focusing on the location of Ori, selection markers, MCS, and the size of foreign DNA inserts [14][15][19][20]. - The principles of plasmid extraction involve separating plasmid DNA from chromosomal DNA and proteins, utilizing methods like alkaline lysis [21][24][26][28][29]. Common Methods for Plasmid Extraction - Plasmid extraction methods include alkaline lysis, boiling lysis, and silica membrane adsorption, each with specific advantages and disadvantages [37][39][40][45][46]. - Alkaline lysis is the most common method, effective for various E. coli strains, but can damage DNA if not performed correctly [41][43]. - Boiling lysis is quick and simple but may yield lower purity and stability [45]. - Silica membrane adsorption is widely used for its high purity and efficiency, though it can be more costly [46][47]. Considerations for Plasmid Extraction - Proper bacterial culture conditions are essential, including selecting appropriate strains and media, and controlling growth parameters [63][64]. - Careful handling during cell lysis and purification is necessary to avoid contamination and ensure high-quality plasmid DNA [65][66][67]. - Using nuclease-free materials and reagents is critical to prevent DNA degradation [68][69]. Methods to Improve Plasmid Extraction Concentration - Strategies to enhance plasmid DNA concentration include optimizing lysis conditions, ensuring complete enzymatic treatment, and increasing initial cell quantities [70][71][72][74]. - Proper sample storage and equipment maintenance are also important for achieving higher yields [75][77]. Small-Scale Plasmid Preparation - Plasmids are circular DNA molecules that can replicate independently within bacterial cells, making them ideal for gene cloning [78][79]. - The alkaline lysis method is commonly used for small-scale plasmid preparation, allowing for the removal of proteins and RNA [80][81]. - The extraction process typically involves bacterial growth, harvesting, lysis, and purification steps [82][83]. Common Issues and Solutions in Plasmid Extraction - Problems such as excessive bacterial culture volume or inadequate lysis can lead to low yields and purity, requiring adjustments in protocol [97][98].

Core Viewpoint - Bio-Rad has decided to suspend its previously announced tariff surcharge plan, indicating a commitment to support customers amid complex global logistics challenges [2]. Group 1 - Bio-Rad's Senior Vice President of Commercial Operations for the Americas, Ryan Short, stated that the company will not implement the temporary tariff surcharge initially considered on May 21 [2]. - The decision reflects Bio-Rad's ongoing dedication to customer support while closely monitoring the evolving situation [2]. - Analyst Tycho Peterson from Jefferies noted that Bio-Rad's change in stance suggests a lack of broad pricing power for its product portfolio, particularly for standardized reagents [2]. Group 2 - Peterson highlighted that as tariff-related disputes, especially those involving China, begin to ease, the need for additional surcharges may diminish [2]. - He emphasized that implementing a surcharge could lead to a more significant decline in demand than anticipated, making it necessary to cancel the plan to protect revenue and market share [2]. - Following the announcement, Bio-Rad's stock price saw a slight increase of 1%, reaching $231.89 on the New York Stock Exchange [2].

Core Viewpoint - The article highlights various high-paying job opportunities in the scientific instrument sector, emphasizing the demand for skilled professionals in sales and technical roles across different companies in China [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][20][21][22]. Job Opportunities - Shanghai Licheng Instrument Technology Co., Ltd. is seeking an international trade manager with a salary range of 12k-20k, requiring over 5 years of experience in foreign trade and team management [2]. - Jena Analytik is looking for a regional sales representative in Xi'an, offering a salary of 8k-15k, with a preference for candidates with over 3 years of sales experience in chemical analysis instruments [2]. - Shanghai Flash Spectrum Biotechnology Co., Ltd. is hiring an amino acid analyzer sales manager in Taiyuan, with a salary range of 12k-24k [3]. - Beijing Pulit Technology Instrument Co., Ltd. is recruiting a sales manager in Wuhan, offering a salary of 10k-15k, requiring 1-3 years of relevant experience [4]. - Ying Sheng Hengtai is looking for a regional sales manager in the environmental field in Tianjin, with a salary range of 8k-15k, requiring a background in related fields [5]. - Yi Lu Wu You is hiring a medical device sales representative in Wuhan, with a salary range of 5k-20k, requiring at least 2 years of relevant experience [6]. - Haineng Technology is seeking a sales engineer in Haikou, offering a salary of 8k-12k, with a preference for candidates with marketing experience in scientific instruments [7]. - Saikamu is looking for a regional sales manager in Hangzhou, with salary negotiable, open to fresh graduates [8]. - Guangzhou Hexin Instrument Co., Ltd. is hiring a sales engineer for environmental/laboratory direction in Hangzhou, with a salary range of 5k-10k [9]. - Chengbang Haoran Measurement and Control Technology is seeking a regional sales representative for centrifuges in Chengdu, with a salary range of 5k-10k [10]. After-sales Positions - Agilent Technologies (China) Co., Ltd. is hiring an after-sales engineer for laboratory project management in Nanjing, with a salary range of 13k-18k [11]. - Yuanwei Max is looking for an application engineer in multiple cities, offering a salary range of 7k-15k [12]. - Shanghai Kailai Instrument Co., Ltd. is seeking an after-sales assistant in Shanghai, with a salary range of 9k-11k [13]. - Boside Technology Co., Ltd. is hiring a technical engineer in Beijing, with a salary range of 8k-12k [14]. - Beijing Jingke Ruida Technology Co., Ltd. is looking for after-sales engineers in multiple cities, with a salary range of 6k-12k [15]. - Hunan Lingfeng Instrument Equipment Co., Ltd. is hiring after-sales engineers in Changsha, with a salary range of 6k-10k [16].

Core Viewpoint - Chongqing University of Commerce has announced procurement intentions for 28 items of laboratory equipment, with a total budget of 118 million yuan, scheduled for procurement in June to July 2025 [2][5]. Procurement Summary - The procurement includes various advanced instruments such as FFT dual-channel vibration analyzers, modal analyzers, rolling friction and wear comprehensive testing platforms, and field emission scanning electron microscopes [2][4]. - The total budget for the procurement is 118 million yuan, which is approximately 17.1 million USD [5]. Specific Equipment and Requirements - **Intelligent Manufacturing and Green Development Equipment Update Project**: - Includes embodied intelligent robots, industrial large models, and various AI platforms, with a budget of 872,000 yuan, scheduled for June 2025 [4][6]. - **Mechanical Engineering College Equipment Procurement**: - Items include a multi-dimensional connected traffic digital twin and axle coupling vehicle collaborative testing platform, with a budget of 913,000 yuan, scheduled for July 2025 [4][6]. - **Advanced Measurement and Testing Equipment**: - Procurement of FFT dual-channel vibration analyzers and modal analyzers, with a budget of 57,000 yuan, scheduled for July 2025 [9]. - Rolling friction and wear comprehensive testing platform, with a budget of 85,000 yuan, scheduled for July 2025 [9]. - **Field Emission Scanning Electron Microscope**: - Aimed at high-resolution morphology and elemental analysis, with a budget of 430,000 yuan, scheduled for July 2025 [11]. Educational Support and Objectives - The equipment is intended to support undergraduate and graduate education in fields such as computer science, artificial intelligence, mechanical design, and automation [4][6]. - Specific projects aim to enhance practical training and research capabilities in carbon finance, environmental science, and engineering [13][14]. Supplier Requirements - Suppliers must meet national and industry standards, provide comprehensive after-sales service, and ensure timely delivery as per the procurement documents [7][8][17].

Core Insights - The 2024 revenue of the domestic instrument industry shows significant differentiation, with leading companies like Antu Bio achieving counter-cyclical growth while others face challenges due to market contraction and cost pressures [2][4] Group 1: Revenue and Income Disparities - The income of executives in the instrument sector has widened significantly compared to last year, primarily driven by high dividends [4] - Antu Bio's chairman, Miao Yongjun, is the only executive with an income exceeding 100 million yuan, with 99% of his income coming from dividends [4] - The dividend payout ratio for Antu Bio is 60.28% of net profit, while Tailin Bio has an even higher ratio of 91.94%, raising concerns about sustainable development [4] Group 2: Growth Drivers and Market Challenges - The biopharmaceutical supply chain and overseas markets are identified as core growth drivers, with Antu Bio's overseas revenue increasing by 36.25% year-on-year and Wanyi Technology achieving a remarkable 447% growth [4] - Traditional sectors like environmental monitoring and industrial process analysis are under severe pressure, as evidenced by the declining income of Xuedilong's chairman, which fell from 140 million yuan in 2022 to 110 million yuan in 2023 [5] Group 3: Cost Pressures and Profitability - Cost pressures are intensifying, squeezing net profit margins across the industry, with Tailin Bio facing significant profit margin erosion due to raw material price increases and price wars [6] - Despite a 15.01% year-on-year revenue growth, Lihua Technology experienced a decline in net profit due to rising costs and increased expenses [6] - Companies like Nanwei Technology have successfully implemented quality improvement and efficiency enhancement measures, restoring growth in core business areas while controlling expenses [6] Group 4: Executive Compensation Trends - The average pre-tax salary of executives has decreased to approximately 860,000 yuan, down from 1.2 million yuan last year, reflecting cost-cutting measures amid profit pressures [9] - The compensation structure for executives in the instrument industry is evolving, emphasizing the importance of strategic transformation, industry upgrades, and cost management [9]

Core Viewpoint - Waterwood Future (Beijing) Technology Co., Ltd. has successfully won the bid for the procurement project of a high-performance cryo-transmission electron microscope for Hunan Normal University, with a transaction amount of 19.85 million yuan [1][2]. Group 1: Project Details - The project was announced on June 16, 2023, and involves a single-source procurement for a 300kV cryo-transmission electron microscope [2][3]. - The total budget for the procurement was set at 20 million yuan, with the final bid amount being 19.85 million yuan [4][8]. - The project aims to establish a domestic research and application demonstration base for cryo-electron microscopy, promoting the development of domestic high-end scientific instruments [3]. Group 2: Company Information - Waterwood Future holds the largest commercial high-end cryo-electron microscope platform globally, with a total of 9 high-performance electron microscopes as of 2023, including 8 units at 300kV and 1 unit at 120kV [3]. - Waterwood Future's subsidiary, Waterwood Science Instrument (Beijing) Technology Co., Ltd., is the only manufacturer in China capable of developing a complete cryo-transmission electron microscope with an acceleration voltage of 300kV and a structural resolution of 1.4 Å [3]. - The pricing for their products ranges from 35 million to 46.6 million yuan, significantly lower than similar imported products [3].

Core Viewpoint - The article highlights the contrasting trends in employee changes among 44 listed instrument companies in China for 2024, indicating a split between companies expanding their workforce and those reducing it due to revenue pressures [1][5][10]. Group 1: Overall Trends - The overall trend shows a slight increase in employee numbers among listed instrument companies, with 24 companies expanding their workforce compared to 20 companies reducing it [5][6]. - Mindray Medical leads with a total of 21,667 employees, reflecting a 20.08% increase, driven by international expansion and digital transformation [5][6]. - Nanwei Technology shows a significant employee increase of 56.60%, attributed to its acquisition of shares in Fuli Instruments and expansion in high-margin product lines [5][6]. Group 2: Employee Reductions - 20 companies experienced varying degrees of layoffs, with HeXin Instruments seeing a drastic reduction from 684 to 276 employees, a nearly 60% drop [6][10]. - Other companies with significant layoffs include Wanyi Technology, JuGuang Technology, and Blue Shield Technology, indicating a strong correlation between workforce adjustments and revenue pressures [6][10]. Group 3: R&D Investment - Mindray Medical not only leads in total employees but also has a R&D team of 5,259, accounting for nearly 25% of its workforce, with an 18.85% increase in R&D personnel [7][10]. - Nanwei Technology's R&D personnel increased by 37.14%, with R&D investment rising by 25.84%, reflecting its commitment to high-precision material development [7][10]. - Other companies like Puyuan Precision Electric and Sand Technology also reported over 10% increases in R&D personnel, indicating active investment in new technologies [7][10]. Group 4: Industry Cycle Reflection - The changes in personnel structure reflect the development stages of various sub-industries, with life science instrument companies facing downward pressure due to market demand shifts and cost-cutting policies [9][10]. - In contrast, optical instruments and environmental monitoring companies are more active, leveraging new business opportunities and technological breakthroughs [9][10]. - The ongoing competition for high-quality R&D talent is expected to intensify as companies respond to technological innovation and domestic substitution trends [10].