Core Viewpoint - The announcement from the company reflects a strong commitment to its long-term value and future prospects, as demonstrated by the voluntary shareholding commitment from key executives [1] Group 1: Shareholder Commitment - Dr. Wu Jinzi and He Jingdao have voluntarily committed not to sell or pledge any shares they control until the release of three key clinical trial data points [1] - The three clinical data readouts include: (i) top-line data from the U.S. Phase I clinical study of ASC47 combined with semaglutide, expected by the end of September 2025; (ii) top-line data from the U.S. 13-week Phase IIa clinical study of ASC30 oral tablets in overweight or obese subjects, expected by December 2025; and (iii) top-line data from the U.S. Phase I single ascending dose study of ASC50 in healthy subjects, also expected by December 2025 [1] - As of the announcement date, the total number of voluntarily locked-up shares held by Dr. Wu and his wife amounts to 576 million shares, representing approximately 58.03% of the company's existing issued share capital (excluding treasury shares) [1]

Core Viewpoint - The company expresses strong confidence in its long-term value and future prospects through a voluntary commitment by its founder and major shareholders to not sell any shares before the release of three key clinical trial data points [1] Group 1: Clinical Trial Data Commitments - The founder, Dr. Wu, and his spouse, Ms. He, have committed not to sell or pledge any shares they control until the following clinical data readouts: 1. Topline data from the U.S. Phase I clinical study of ASC47 combined with Semaglutide in obese subjects, expected by the end of September 2025 2. Topline data from the U.S. 13-week Phase IIa clinical study of ASC30 oral tablets in obese or overweight subjects, expected by the end of December 2025 3. Topline data from the U.S. Phase I single ascending dose study of ASC50 in healthy subjects, expected by the end of December 2025 [1][1][1] Group 2: Shareholding Information - As of the announcement date, Dr. Wu and Ms. He hold a total of 576 million shares, representing approximately 58.03% of the company's existing issued share capital (excluding treasury shares) [1][1][1]

Core Viewpoint - The company, Gilead Sciences-B (01672.HK), has announced a voluntary commitment by its founder and major shareholders to not sell any shares before the release of three key clinical trial data points, reflecting their confidence in the company's long-term value and future prospects [1] Group 1: Shareholder Commitment - Dr. Wu Jinzi and Ms. He Jingdao have committed to not selling or pledging any shares they control until the release of three specific clinical trial results [1] - The three clinical data readouts include: (i) top-line data from the U.S. Phase I clinical study of ASC47 combined with semaglutide in obese subjects, expected by the end of September 2025; (ii) top-line data from the U.S. 13-week Phase IIa clinical study of ASC30 oral tablets in obese or overweight subjects, expected by the end of December 2025; and (iii) top-line data from the U.S. Phase I single ascending dose study of ASC50 in healthy subjects, also expected by the end of December 2025 [1] - As of the announcement date, the total number of voluntarily locked-up shares held by Dr. Wu and Ms. He is approximately 576 million shares, representing about 58.03% of the company's existing issued share capital (excluding treasury shares) [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容所產生或因依 賴該等內容而引致的任何損失承擔任何責任。 本公告乃歌禮製藥有限公司（「本公司」或「歌禮」，連同其附屬公司稱為「本集 團」）自願作出。 本公司董事（「董事」）會（「董事會」）謹此宣布，其獲告知，為表達對本公司長遠 價值及未來前景的堅定信心，吳勁梓博士（歌禮創始人、董事會主席兼首席執行 官、及本公司控股股東，「吳博士」），與何淨島（本公司執行董事及控股股東、吳 博士之配偶，「吳夫人」）一起，已自願承諾在如下3個臨床數據讀出前，不會出 售（包括但不限於出售或質押）任何由彼等或彼等各自控制的實體直接或間接實益 擁有的本公司股份（「股份」）：(i) ASC47聯合司美格魯肽在肥胖受試者中進行的 美國I期臨床研究頂線數據，預計於2025年9月底獲得；(ii) ASC30口服片在肥胖 或超重受試者中進行的美國13周IIa期臨床研究頂線數據，預計於2025年12月獲 得；及(iii) ASC50在健康受試者中進行的美國I期單劑量遞增研究頂線數據，預 計於202 ...

9月11日，港股三大指数集体下跌，均止步4连涨行情，市场做多情绪趋于谨慎。 截止收盘，恒生指数跌0.43%险守26000点大关，国企指数、恒生科技指数分别下跌0.73%及0.24%。 | 名称 | | 最新价 | 涨跌额 | 涨跌幅 | | --- | --- | --- | --- | --- | | 恒生指数 | 7 | 26086.32 | -113.94 | -0.43% | | 800000 | | | | | | 国企指数 | intrieter | 9260.25 | -67.91 | -0.73% | | 800100 | | | | | | 恒生科技指数 | Mala | 5888.77 | -13.92 | -0.24% | | 800700 | . NY | | | | 具体来看： 盘面上，大型科技股普遍走低，尤其是美团跌6%刷新阶段新低；报道称特朗普政府拟限制中国药品，生物医药股集体重挫，创新药概念股跌幅居前；影视 娱乐股、钢铁股、汽车股、内房股、手游股多数低迷。 半导体芯片股涨幅强势；受美联储降息前景支撑，铜、铝等有色金属股表现活跃，军工、苹果概念、建材水泥、重型机械、高铁基建股走强 ...

Group 1 - The Hong Kong pharmaceutical sector experienced a significant decline, with major stocks dropping sharply [1] - Gilead Sciences-B (01672.HK) fell nearly 15%, indicating a substantial loss in market value [1] - China Biopharmaceutical (01177.HK) saw a decline of over 10%, reflecting broader market trends affecting the industry [1] Group 2 - Other notable declines included CSPC Pharmaceutical Group (01093.HK), BeiGene (06160.HK), Hengrui Medicine (01276.HK), and WuXi AppTec (02359.HK), all of which experienced significant drops [1]

港股创新药概念持续走低，歌礼制药跌超14%，中国生物制药跌超9%，百济神州、石药集团跟跌。 ...

Core Viewpoint - The recent clinical trial results for ASC30, a long-acting GLP-1 receptor agonist developed by the company, indicate its potential as a quarterly administered treatment for weight management in obese patients, showing a 75-day observed half-life [1] Group 1: Company Developments - The company has reported that its ASC30 formulation, designed for weight maintenance, has demonstrated an observed half-life of 75 days in a Phase Ib clinical trial involving obese participants with a BMI of 30 kg/m² or higher [1] - The ASC30 formulation utilizes the company's Ultra-Long-Acting Platform (ULAP) for drug development, highlighting its innovative approach in the pharmaceutical industry [1] - Following a single subcutaneous injection of 100 mg ASC30, the time to reach peak concentration (Cmax) was observed to be 17 days post-administration [1] Group 2: Market Activity - On September 10, shareholders of the company deposited shares into Futu Securities International Hong Kong, with a market value of HKD 1.994 billion, representing 14.11% of the total shares [1]

智通财经APP讯，歌礼制药-B(01672)发布公告，由于合资格参与者根据公司于2019年6月6日采纳的购股 权计划行使购股权，公司于2025年9月10日合计发行9.8万股普通股。 ...

歌礼制药-B(01672)发布公告，由于合资格参与者根据公司于2019年6月6日采纳的购股权计划行使购股 权，公司于2025年9月10日合计发行9.8万股普通股。 ...