Core Viewpoint - The company is focusing on accelerating the development of innovative drugs through its strong oncology research team and strategic global clinical development capabilities, aiming to become a leading innovator in cancer treatment [1]. Group 1: Company Strategy and Development - The company has one of the largest oncology clinical research teams in the industry and is leveraging this to enhance its innovative drug offerings [1]. - In the past 18 months, the company has advanced 15 new molecular entities into clinical development, covering various treatment modalities [1]. - From 2026 onwards, the company expects to introduce 8 to 10 new molecular entities into clinical development each year, signaling a new wave of innovation [1]. Group 2: Pipeline and Future Prospects - Several products in the company's pipeline, including CDK4 inhibitors, B7-H4 ADC, PRMT5 inhibitors, GPC3x41BB bispecific antibodies, and CEA ADC, are expected to enter late-stage clinical development by 2026 [1]. - The company is committed to building a sustainable competitive advantage and will continue to invest in a rich and innovative R&D pipeline [1]. - The company aims to actively seek and execute business expansion opportunities that create long-term value [1].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 內幕消息 二零二六年度醫療健康大會簡報 本公告由WuXi Biologics (Cayman) Inc.藥明生物技術有限公司*（「本公司」）根據 香港聯合交易所有限公司證券上市規則（「上市規則」）第13.09條及香港法例第 571章《證券及期貨條例》第XIVA部項下內幕消息條文（定義見上市規則）而作出。 本公司將於二零二六年一月十四日（美國太平洋時間）出席第44屆年度摩根大 通醫療健康大會（「年度醫療健康大會」），會上將進行包含本公司業務營運的 若干資訊的簡報（「簡報」）。為確保本公司所有股東及潛在投資者能夠公平及 時地取得該等信息，本公司於本公告納入簡報全文。本公司股東及潛在投資者 務請注意，簡報可能包含前瞻性陳述，該等陳述就其性質而言存在風險及不確 定性，簡報中陳述的任何估計及未來建議均基於若干假設及估計以及管理層 僅根據當前可得資料作出的判斷。 – 1 – 誠如簡報中所披露，本集團業務及財務表現依 ...

Core Insights - The global biotechnology industry is at a pivotal turning point in 2026, marked by a significant rebound in merger and acquisition (M&A) activity, with 173 BD transactions in 2025, a notable increase from 136 in 2024, and total transaction values reaching $146.8 billion, up 218% from the previous year [1][2] - The changing regulatory environment, including the implementation of the IRA and the legislative challenges of the Biodefense Act, alongside the Federal Reserve's interest rate cuts, is redefining capital flows and asset pricing logic [1] Industry Transaction Evolution - The biopharmaceutical sector is transitioning from an abnormal to a normal state in terms of transaction activity, following a peak during the COVID-19 pandemic, with a notable decline in 2023-2024 due to valuation discrepancies and multiple uncertainties [1][2] Transaction Trends and Preferences - In 2025, 58% of the total transaction value was attributed to marketed products and late-stage clinical assets, reflecting a clear preference among pharmaceutical companies for lower-risk assets amid a looming $300 billion patent cliff [2][3] Emerging Treatment Areas and Technologies - The focus of investment is shifting, with neurological diseases approaching oncology in transaction value, indicating a significant change in investment priorities [3] - Cardiovascular and metabolic diseases, driven by the GLP-1 drug trend, have become the third-largest investment hotspot, while interest in rare diseases and gene therapy has cooled [4] - New technological platforms such as bispecific antibodies and molecular glue degraders are emerging, while AI applications are rapidly transitioning from concept validation to integration into workflows, enhancing clinical trial success rates [4] China's Market Growth - The Chinese biopharmaceutical market has seen a tenfold increase in Western capital investment, growing from $6 billion in 2020 to $61 billion by Q3 2025, now accounting for 35% of global alliance investment [5] - China's shift from a "fast follower" to an "innovation source" is supported by a flexible regulatory environment and strategic government backing, fostering rapid drug development [5] Future Outlook - The biopharmaceutical industry is at a critical crossroads in 2026, characterized by substantial cash reserves, imminent patent cliffs, evolving technology platforms, and changing geopolitical dynamics, presenting both opportunities and challenges [6] - For Chinese biopharmaceutical companies, this period represents a golden opportunity to engage in the global innovation ecosystem and enhance independent innovation capabilities [6]

Core Viewpoint - The company, Heptares Therapeutics, has entered into a global strategic collaboration and licensing agreement with Bristol-Myers Squibb to discover and develop next-generation bispecific antibodies, which has positively impacted its stock price and trading volume [1]. Group 1: Financial Aspects - Heptares Therapeutics will receive an upfront payment of $90 million as part of the agreement [1]. - The company is eligible for up to $1.035 billion in development and commercial milestone payments, along with tiered royalties, if Bristol-Myers Squibb advances all potential projects [1]. Group 2: Recent Collaborations - Since 2025, Heptares Therapeutics has secured three major contracts with multinational corporations (MNCs), including a significant partnership with AstraZeneca worth 4.575 billion yuan, which involves multiple targets and projects [1]. - In June, the company established a global strategic collaboration with Otsuka Pharmaceutical regarding the BCMAxCD3 bispecific T-cell engager (HBM7020) [1]. - Overall, Heptares Therapeutics has completed seven collaborations with MNCs, with total external cooperation amounts exceeding $10 billion [1].

Core Viewpoint - The announcement of a global strategic collaboration and licensing agreement between the company and Bristol-Myers Squibb is expected to enhance the development of next-generation bispecific antibodies, leading to significant financial benefits for the company [1] Group 1: Financial Aspects - The company will receive an upfront payment of $90 million as part of the agreement with Bristol-Myers Squibb [1] - The company is eligible for up to $1.035 billion in development and commercial milestone payments if all potential projects are advanced by Bristol-Myers Squibb [1] - Cumulatively, the company has secured over $10 billion in total collaboration agreements with multinational corporations (MNCs) [1] Group 2: Recent Collaborations - Since 2025, the company has secured three major deals with MNCs, including a significant collaboration with AstraZeneca worth 4.575 billion yuan, which also involved a $105 million equity investment [1] - In June, the company entered into a global strategic collaboration with Otsuka Pharmaceutical regarding the BCMAxCD3 bispecific T-cell engager (HBM7020) [1] - The total number of collaborations with MNCs has reached seven [1]

Core Viewpoint - The article discusses a strategic global collaboration and licensing agreement between the company and Bristol-Myers Squibb aimed at discovering and developing a new generation of bispecific antibodies [1] Group 1: Agreement Details - The agreement was established on December 17, 2025, and focuses on the discovery and acceleration of bispecific antibodies [1] - The company will receive an upfront payment of $90 million as part of the agreement [1] - If Bristol-Myers Squibb chooses to advance all potential projects, the company could receive up to $1.035 billion in development and commercial milestone payments, along with tiered royalties [1]

Core Viewpoint - The announcement highlights a strategic global collaboration and licensing agreement between the company and Bristol-Myers Squibb aimed at discovering and developing next-generation bispecific antibodies [1] Group 1: Agreement Details - The agreement was signed on December 17, 2025, and focuses on the discovery and acceleration of bispecific antibodies [1] - The company will receive an upfront payment of $90 million as part of the agreement [1] - If Bristol-Myers Squibb chooses to advance all potential projects, the company could receive up to $1.035 billion in development and commercial milestone payments, along with tiered royalties [1]

Core Viewpoint - The announcement highlights a strategic global collaboration and licensing agreement between the company and Bristol-Myers Squibb aimed at discovering and developing next-generation bispecific antibodies [1] Group 1: Agreement Details - The agreement was established on December 17, 2025, and focuses on the discovery and acceleration of bispecific antibodies [1] - The company will receive a total payment of $90 million as part of the agreement [1] - If Bristol-Myers Squibb decides to advance all potential projects, the company could receive up to $1.035 billion in development and commercial milestone payments, along with tiered royalties [1]

Core Viewpoint - The announcement highlights a strategic collaboration between Heptares Therapeutics-B (02142.HK) and Bristol-Myers Squibb aimed at discovering and developing next-generation multispecific antibodies, with significant financial implications for Heptares [1] Group 1: Partnership Details - Heptares Therapeutics has entered into a long-term global strategic collaboration and licensing agreement with Bristol-Myers Squibb [1] - The collaboration focuses on the discovery and acceleration of multispecific antibodies [1] Group 2: Financial Implications - Heptares Therapeutics will receive an upfront payment totaling $90 million [1] - If Bristol-Myers Squibb chooses to advance all potential projects, Heptares could receive up to $1.035 billion in development and commercial milestone payments, along with tiered royalties [1]

Core Viewpoint - The article presents an interview with Yang Yunxia, a partner at Sequoia China, who discusses the value judgment framework for the next stage of the biopharmaceutical industry, emphasizing that Biotech will remain a mainstream investment direction in healthcare, particularly focusing on the iteration of "second-generation technology paradigms" [4][7]. Group 1: Investment Trends and Opportunities - Biotech is highlighted as a key investment direction, with a focus on advancements such as ADC drugs evolving from single-target to dual-target and the development of more complex antibody technologies [7][8]. - The Chinese biopharmaceutical industry is transitioning from being a global observer to a significant participant, characterized by strong iteration capabilities and efficient execution [9][10]. - By 2024, China is expected to account for 18% of the global share of new molecular entities, ranking as the second-largest country for new drug listings [9]. Group 2: Market Dynamics and Challenges - The overall pharmaceutical industry saw a 16.72% increase from early 2025 to November, outperforming the CSI 300 index by 1.68 percentage points, driven by breakthroughs in innovative drugs and active business development (BD) transactions [7]. - The article notes that while there are many opportunities, the industry must also confront challenges, including the need for improved commercialization capabilities and the risk of resource wastage due to blind competition [10][11]. Group 3: Strategic Insights for Investment - Yang Yunxia emphasizes the importance of selecting early-stage projects based on two criteria: the team and the asset, which are crucial for maximizing value returns [15]. - The article discusses the significance of BD transactions as a means to enhance capital, brand, and capabilities, which are essential for the growth of Biotech companies [11][12]. - It is noted that the pricing of Chinese Biotech assets in overseas transactions is often lower, highlighting the need for a shift in perception regarding the value of Chinese assets in global markets [11][12]. Group 4: Future Outlook - Yang Yunxia maintains an optimistic yet cautious outlook on the capital market cycle for 2026, emphasizing that the core standard for assessing enterprise value lies in fundamentals [8][14]. - The article concludes that the Chinese biopharmaceutical industry must focus on quality, differentiate its offerings, and balance speed with value to strengthen its competitive position globally [15].