和元生物技术（上海）股份有限公司 简式权益变动报告书 上市公司：和元生物技术（上海）股份有限公司 股票上市地点：上海证券交易所 股票简称：和元生物 股票代码：688238 信息披露义务人 1：浙江华睿盛银创业投资有限公司 注册地址：浙江省诸暨市岭北镇金山湖村 323 号 通讯地址：杭州市西湖区文二路 391 号西湖国际科技大厦 A 座 19 楼 信息披露义务人 2：诸暨富华产业转型升级基金合伙企业（有限合伙） 注册地址：浙江省诸暨市岭北镇金山湖村 153 号 通讯地址：杭州市西湖区文二路 391 号西湖国际科技大厦 A 座 19 楼 通讯地址：杭州市西湖区文二路 391 号西湖国际科技大厦 A 座 19 楼 信息披露义务人 4：浙江华睿火炬创业投资合伙企业（有限合伙） 注册地址：浙江省杭州市滨江区江南大道 3900 号 1 层 1030 室 通讯地址：杭州市西湖区文二路 391 号西湖国际科技大厦 A 座 19 楼 信息披露义务人 5：杭州华睿嘉银股权投资合伙企业（有限合伙） 注册地址：浙江省杭州市余杭区仓前街道景兴路 999 号 6 幢 209-6-200 通讯地址：杭州市西湖区文二路 391 号西湖国际科 ...

证券代码：688238 证券简称：和元生物 公告编号：2025-059 和元生物技术（上海）股份有限公司 关于持股 5%以上股东权益变动至 5%以下的 ●本次权益变动为持股 5%以上非第一大股东减持，不会导致公司控股股东及 实际控制人的情况发生变化。 公司于近日收到股东华睿盛银及其一致行动人出具的《简式权益变动报告 书》及《关于股份减持计划实施结果的告知函》，现将有关权益变动情况公告如 1 下： 一、本次权益变动基本情况 （一）信息披露义务人基本情况 提示性公告 本公司董事会、全体董事及相关股东保证本公告内容不存在任何虚假记载、 误导性陈述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律 责任。 重要内容提示： ●本次权益变动系和元生物技术（上海）股份有限公司（以下简称"公司"） 股东浙江华睿盛银创业投资有限公司（以下简称"华睿盛银"）、诸暨富华产业 转型升级基金合伙企业（有限合伙）（以下简称"诸暨富华"）、浙江华睿胡庆 余堂健康产业投资基金合伙企业（有限合伙）（以下简称"华睿胡庆余堂"）、 浙江华睿火炬创业投资合伙企业（有限合伙）（以下简称"华睿火炬"）、杭州 华睿嘉银股权投资合伙企业（有限合伙 ...

Core Insights - The company reported a revenue of 120 million yuan for the first half of 2025, representing a year-on-year growth of 6%, while the net profit attributable to shareholders was a loss of 105 million yuan, reducing the loss by 8.78 million yuan compared to the same period last year [1] Group 1: Business Performance - The cell and gene therapy CRO business generated revenue of 40.70 million yuan, an increase of 3.79% year-on-year, with over 14,000 research laboratory clients served, indicating a continuous improvement in market coverage [1] - The CDMO business revenue was 65.62 million yuan, remaining stable compared to the previous year, with 52 IND approvals obtained for clients and over 540 CDMO projects undertaken, including 5 Phase III clinical projects [1] - The company secured over 90 million yuan in new CDMO orders during the year [1] Group 2: Regenerative Medicine and Capacity Expansion - The regenerative medicine segment made significant progress, including the development of processes for stem cells and immune cells, and collaboration with leading companies and research institutions [2] - The company’s subsidiary successfully registered human dermal fibroblast exosomes in the global cosmetic ingredient directory, expanding opportunities in anti-aging and health management [2] - The first phase of the Lingang industrial base has been fully operational, with production capacity and line numbers ranking among the top in the international industry, enhancing delivery efficiency and customer retention [2] Group 3: Technological Innovation - The company is focusing on technological innovation, with R&D investment of 23.21 million yuan, accounting for 19.37% of revenue, and filing for 2 invention patents and 8 utility model patents [2] - The company has developed an intelligent R&D system leveraging AI technology, including a virus yield prediction model based on BERT, which optimizes production efficiency [3] - AI models have been created for adenoviral vector optimization, utilizing deep learning frameworks to enhance research and development efficiency [3]

和元生物2025半年报 ...

Core Viewpoint - The company is facing challenges in its cell and gene therapy CDMO business due to macroeconomic changes, industry conditions, and downstream demand, resulting in low order prices and negative gross margins, although there has been some improvement compared to the previous year [1][2]. Group 1: Company Overview - The company is focused on cell and gene therapy, which is a key development direction in the biopharmaceutical industry, supported by national and local policies [2]. - The company aims to enhance its competitiveness and market penetration by improving R&D efficiency, expanding into new business areas, and optimizing operations [2]. Group 2: Financial Data - The company reported a net loss of RMB 10,515.07 million for the first half of 2025, primarily due to low order prices and the early production stage of its projects [21]. - The company has fully utilized the raised funds for planned investments, with no reported issues in fund management or usage [10][20]. Group 3: Shareholder Information - The company has not disclosed any special arrangements regarding corporate governance or significant changes in major shareholders [3][4]. Group 4: Upcoming Events - The company will hold a performance briefing on August 27, 2025, to discuss its half-year results and address investor questions [5][8].

Core Viewpoint - The report highlights the ongoing challenges faced by the company in its cell and gene therapy CDMO business, including low order prices and high operational costs, while also emphasizing the potential for growth in the industry supported by favorable policies and technological advancements [1][6][11]. Financial Performance - The company reported a revenue of approximately 119.85 million yuan for the first half of 2025, representing a 6.01% increase compared to the same period last year [4]. - The total profit for the period was a loss of approximately 102.77 million yuan, an improvement from a loss of 113.36 million yuan in the previous year [4]. - The net profit attributable to shareholders was approximately -104.57 million yuan, showing a reduction in losses compared to -113.35 million yuan in the same period last year [4][5]. Industry Overview - The cell and gene therapy sector is identified as a key growth area in biomedicine, with significant advancements in technology and increasing clinical applications [7][11]. - The global pipeline for gene therapies has expanded, with over 4,469 gene therapy projects reported as of mid-2025, indicating a robust growth trajectory in the industry [10][11]. - The industry is characterized by a diverse landscape, with both large enterprises and numerous small to medium-sized companies, leading to a competitive environment [7][11]. Technological Advancements - Continuous innovation in gene editing and delivery technologies is crucial for the advancement of cell and gene therapies, with AI playing a significant role in enhancing research efficiency [8][9]. - Recent breakthroughs in stem cell therapy and regenerative medicine are paving the way for new clinical applications, demonstrating the potential for significant market growth [12][13]. Market Dynamics - The investment landscape for cell and gene therapy is showing signs of recovery in China, with a total financing amount of approximately 4.09 billion yuan in the first half of 2025, up from 2.57 billion yuan in the same period of 2024 [11][12]. - Despite the positive trends, the CDMO sector faces challenges due to the complexity and high costs associated with drug development and production, which may hinder rapid revenue growth [11][12]. Regulatory Environment - The government continues to support the cell and gene therapy industry through various policies aimed at promoting innovation and ensuring quality standards in drug development [14].

Core Viewpoint - The report highlights the ongoing challenges faced by He Yuan Biotechnology in its cell and gene therapy CDMO business, including low order prices and high operational costs, despite some improvements compared to the previous year [1][2]. Company Overview - He Yuan Biotechnology is listed on the Shanghai Stock Exchange with the stock code 688238, focusing on cell and gene therapy [2]. - As of the end of the reporting period, the total assets of the company were approximately 2.12 billion RMB, a decrease of 7.23% from the previous year [2]. Financial Performance - The company's revenue for the reporting period was approximately 119.85 million RMB, reflecting a year-on-year increase of 6.01% [3]. - The total profit for the period was a loss of approximately 102.77 million RMB, an improvement from a loss of 113.36 million RMB in the previous year [3]. - The net loss attributable to shareholders was approximately 104.57 million RMB, compared to a loss of 113.35 million RMB in the same period last year [3]. - The cash flow from operating activities showed a loss of approximately 88.50 million RMB, which is an improvement from a loss of 114.63 million RMB in the previous year [3]. - The weighted average return on net assets decreased by 0.69 percentage points to -6.35% [3]. Industry Context - The cell and gene therapy sector is identified as a key development area in the biopharmaceutical industry, supported by various national and local policies [2]. - The company aims to enhance its competitiveness and market penetration by improving R&D efficiency and expanding into new business areas [2].

Core Viewpoint - He Yuan Bio reported a steady growth in revenue and advancements in AI technology to enhance research and development efficiency, positioning itself for rapid industry development [1][2][3] Financial Performance - In the first half of 2025, He Yuan Bio achieved operating revenue of 119.85 million yuan, a year-on-year increase of 6.01% [1] - The net profit attributable to the parent company, excluding non-recurring gains and losses, was -10.45 million yuan, a reduction in losses by 14.89 million yuan compared to the same period last year [1] Business Segments - The company’s CRO business in cell and gene therapy generated sales revenue of 40.70 million yuan, up 3.79% year-on-year [1] - The CDMO business maintained its leading position with sales revenue of 65.62 million yuan, remaining stable compared to the previous year [1] - He Yuan Bio assisted clients in obtaining 52 domestic and international IND approvals and undertook over 540 CDMO projects, including 5 Phase III clinical projects, with new CDMO business orders exceeding 90 million yuan in the year [1] R&D and Innovation - R&D investment for the first half of 2025 was 23.21 million yuan, accounting for 19.37% of operating revenue, with 2 new invention patent applications and 8 utility model patent applications [2] - The company overcame key technical challenges, such as the formation of packaging cell syncytia [2] AI Integration - He Yuan Bio is actively integrating AI technology to build an intelligent research and development system, enhancing efficiency in research and production [2] - The company developed a virus yield prediction model based on BERT, optimizing virus packaging scale and improving overall production efficiency [3] - An AI model for AAV virus vector optimization was created using generative AI, balancing high survival rates with functional mutations [3] Future Outlook - He Yuan Bio anticipates a stable and positive development trend, supported by sufficient order reserves, steady capacity release at the Lingang base, and deep integration of AI technology [3]

Group 1 - The company reported a revenue of 119,854,988.98 yuan for the first half of 2025, representing a year-on-year growth of 6.01% [2] - The net profit attributable to shareholders of the listed company was -104,570,120.70 yuan [2]

Group 1 - The company, He Yuan Biology, announced that it will hold a semi-annual performance briefing on August 27, 2025, from 15:00 to 16:00 [2]