Market Overview - The medical services sector increased by 0.56% on November 25, with ST Zhongzhu leading the gains [1] - The Shanghai Composite Index closed at 3870.02, up 0.87%, while the Shenzhen Component Index closed at 12777.31, up 1.53% [1] Top Gainers in Medical Services - ST Zhongzhu (600568) closed at 2.57, up 4.90% with a trading volume of 53,900 shares and a turnover of 13.85 million yuan [1] - Chengda Pharmaceutical (301201) closed at 47.78, up 2.97% with a trading volume of 112,700 shares and a turnover of 540 million yuan [1] - Boji Pharmaceutical (300404) closed at 10.10, up 2.75% with a trading volume of 108,600 shares and a turnover of 10.9 million yuan [1] Top Losers in Medical Services - Jiuzhou Pharmaceutical (603456) closed at 18.75, down 0.85% with a trading volume of 181,100 shares and a turnover of 343 million yuan [2] - Tongce Medical (600763) closed at 41.95, down 0.66% with a trading volume of 49,600 shares and a turnover of 210 million yuan [2] - Yingkang Life (300143) closed at 10.12, down 0.49% with a trading volume of 44,700 shares and a turnover of 4.56 million yuan [2] Capital Flow Analysis - The medical services sector experienced a net outflow of 113 million yuan from institutional investors, while retail investors saw a net inflow of 30.37 million yuan [2][3] - Major stocks like WuXi AppTec (603259) had a net inflow of 67.13 million yuan from institutional investors, while Sunshine Nuohua (688621) saw a net outflow of 2.29 million yuan from retail investors [3] Summary of Individual Stock Performance - Sunshine Nuohua (688621) had a net inflow of 38.24 million yuan from institutional investors, but a net outflow of 3.59 million yuan from retail investors [3] - Chengda Pharmaceutical (301201) also saw a significant net inflow of 36.45 million yuan from institutional investors, with a net outflow of 13.58 million yuan from retail investors [3] - New Mileage (002219) had a net inflow of 14.15 million yuan from institutional investors, while retail investors experienced a net outflow of 6.70 million yuan [3]

证券日报网讯和元生物11月24日在互动平台回答投资者提问时表示，公司按照交易所的规定将在定期报 告中及时披露相应时点的股东数量。 ...

Market Overview - The medical services sector experienced a decline of 2.71% on November 21, with Baihua Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3834.89, down 2.45%, while the Shenzhen Component Index closed at 12538.07, down 3.41% [1] Stock Performance - Notable gainers included Yangguang Nuohua, which rose by 4.47% to a closing price of 61.21, with a trading volume of 86,300 shares and a transaction value of 530 million [1] - Baihua Pharmaceutical saw a significant decline of 9.67%, closing at 9.06, with a trading volume of 292,400 shares and a transaction value of 275 million [2] - Other notable decliners included Chengda Pharmaceutical (-9.58%), Berry Genomics (-8.67%), and Guangzheng Eye Hospital (-7.26%) [2] Capital Flow - The medical services sector experienced a net outflow of 1.325 billion in institutional funds, while retail investors saw a net inflow of 1.332 billion [2] - The table of capital flow indicates that major stocks like Yangguang Nuohua had a net inflow of 10.986 million from institutional investors, while retail investors had a net inflow of 1.374 million [3]

Core Insights - The company focuses on providing CRO and CDMO services for cell and gene therapy, as well as technical services in regenerative medicine and anti-aging fields [1][5][6] Financial Performance - For the period from January to September 2025, the company achieved a total revenue of 180 million yuan, a decrease of 1.91% year-on-year [1] - The CRO business generated revenue of 61.997 million yuan, reflecting a growth of 2.81% year-on-year, while the CDMO business revenue was 96.7021 million yuan, down 9.72% year-on-year [1] - Other main businesses, including research reagents and cell storage services, saw a revenue increase of 55.99%, totaling 21.3862 million yuan [1][2] Profitability - The company reported a net profit attributable to the parent company of -162 million yuan, which is a reduction in losses by 38.1258 million yuan compared to the same period last year [2] Business Development - The company has established over 14,700 collaborative research laboratories in the CRO sector and has completed over 600 CDMO projects, including five Phase III clinical projects [2] - The company has assisted clients in obtaining 60 clinical trial approvals, including 14 from the FDA [2] International Expansion - The company is expanding its CRO, CDMO, and regenerative medicine services overseas, utilizing online marketing and participation in influential academic conferences to enhance brand visibility [3] - A subsidiary has successfully registered Human Fibroblast Extracellular Vesicles with INCI, marking a significant milestone for global cosmetic market entry [3] Technological Advancements - The company is focusing on two core technology clusters and is exploring the application potential of emerging technologies in client projects [4] - AI technology is being integrated to enhance research efficiency and foster innovation through external collaborations [4] Market Trends - The company views the restructuring of domestic medical enterprises as a necessary step towards high-quality industry development, presenting new growth opportunities [5] - The company aims to leverage its extensive technical expertise and production capacity to meet the evolving market demands [5][6]

Core Viewpoint - He Yuan Biotechnology has signed a strategic cooperation agreement with Changsha Duozheng Biotechnology Co., Ltd. to focus on the cutting-edge field of stem cells and immune cells, aiming to enhance the cell industry in Changsha and the central China region [1] Group 1 - The partnership will create a comprehensive business system covering "technology research and development, quality testing, standardized preparation" to "clinical-grade storage" [1] - The collaboration aims to promote the upgrading and clustering of the cell industry at both regional and national levels [1]

Meeting Overview - The fourth extraordinary general meeting of shareholders was held on November 13, 2025, in Shanghai [5] - The meeting was convened by the board of directors and chaired by Chairman Pan Yudong, utilizing a combination of on-site voting and online voting [2] Attendance - All 8 current directors attended the meeting, along with the board secretary and other senior management personnel [3] - The meeting complied with the relevant regulations of the Company Law and the company's articles of association [2][6] Voting Results - Two resolutions were presented: 1. Election of a non-independent director for the fourth board [4] 2. Change of an independent director for the fourth board [4] - Both resolutions were passed with more than half of the valid voting rights held by attending shareholders or their proxies [4] Legal Verification - The meeting was witnessed by Shanghai Jinmao Law Firm, with lawyers confirming that the meeting's procedures were in accordance with legal and regulatory requirements [6]

证券代码：688238 证券简称：和元生物 公告编号：2025-064 （二） 股东会召开的地点：上海市临港新片区沧海路 3888 号 （三） 出席会议的普通股股东、特别表决权股东、恢复表决权的优先股股东及 其持有表决权数量的情况： | 1、出席会议的股东和代理人人数 | 64 | | --- | --- | | 普通股股东人数 | 64 | | 2、出席会议的股东所持有的表决权数量 | 172,907,660 | | 普通股股东所持有表决权数量 | 172,907,660 | | 3、出席会议的股东所持有表决权数量占公司表决权数量的比 | 27.4322 | | 例（%） | | | 普通股股东所持有表决权数量占公司表决权数量的比例（%） | 27.4322 | 和元生物技术（上海）股份有限公司 2025年第四次临时股东会决议公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 本次会议是否有被否决议案：无 一、 会议召开和出席情况 （一） 股东会召开的时间：2025 年 11 月 13 日 （四） 表决方 ...

Tel/申话:(8621) 6249 6040 Fax/传真:(8621) 6249 56 Website/网址: www.iinmao.com.cn 上海市金茂律师事务所 关于和元生物技术(上海)股份有限公司 2025年第四次临时股东会之法律意见书 致:和元生物技术(上海)股份有限公司 和元生物技术（上海）股份有限公司（以下简称"公司"）2025 年第四次临时 股东会 (以下简称" 本次股东会" ) 于 2025 年 11 月 13 日下午在公司会议室召开 ｡ 上海市金茂律师事务所（以下简称"本所"）经公司聘请并接受公司委托,委派茅 丽婧律师、吴丹琪律师（以下简称"本所律师"）出席本次股东会,并根据《中华 人民共和国公司法》(以下简称"《公司法》")、《中华人民共和国证券法》(以 下简称"《证券法》"）、中国证券监督管理委员会公布的《上市公司股东会规则》 (以下简称"《股东会规则》")等相关法律、法规和规范性文件以及《和元生物 技术(上海)股份有限公司章程》（以下简称"《公司章程》"),就本次股东会 的召集、召开程序、出席会议人员资格、表决程序、表决结果等发表法律意见。 本所律师同意公司将本法律意见书作为本 ...

Group 1 - The immunotherapy sector is experiencing a strong rebound, with companies like Zhongyuan Qihuo and Kaineng Health hitting the daily limit up [1] - Other companies in the sector, such as Jimin Health, Guanhao Bio, Chengda Pharmaceutical, Zexing Pharmaceutical, and Heyuan Bio, are also showing significant gains [1]

Group 1 - The core transaction involved Hehui Optoelectronics, with a total of 1.7165 million shares traded on November 11, resulting in a transaction value of 4.8233 million yuan, which accounted for 1.37% of the total trading volume for that day [1][2] - The transaction price was 2.81 yuan per share, representing a discount of 0.71% compared to the market closing price of 2.83 yuan [1][2]