证券代码：688520 证券简称：神州细胞 公告编号：2025-039 北京神州细胞生物技术集团股份公司 关于参加 2025 年半年度科创板创新药行业 集体业绩说明会的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 三、 参加人员 投资者可于 2025 年 9 月 9 日（星期二）至 9 月 15 日（星期一）16:00 前登 录 上 证 路 演 中 心 网 站 首 页 点 击 " 提 问 预 征 集 " 栏 目 或 通 过 公 司 邮 箱 ir@sinocelltech.com 进行提问。公司将在说明会上对投资者普遍关注的问题进行 回答。 北京神州细胞生物技术集团股份公司（以下简称"公司"）已于 2025 年 8 月 29 日发布公司 2025 年半年度报告。为便于广大投资者更全面深入地了解公司 2025 年半年度经营成果、财务状况，公司计划于 2025 年 9 月 16 日 （星期二） 15:00-17:00 参加由上海证券交易所主办的 2025 年半年度科创板创新药行业集体 业绩说明会，就投资者关心 ...

Company Overview - Shenzhou Cell is located in Beijing Economic and Technological Development Zone and was established on April 23, 2007. The company went public on June 22, 2020. Its main business involves the research and industrialization of biopharmaceutical products for malignant tumors, autoimmune diseases, infectious diseases, and genetic diseases [1][2]. Stock Performance - As of September 8, Shenzhou Cell's stock price was 61.74 CNY per share, with a market capitalization of 27.495 billion CNY. The stock has increased by 70.41% year-to-date but has seen a decline of 6.27% over the last five trading days and 5.65% over the last twenty days [1]. - The company has appeared on the "Dragon and Tiger List" three times this year, with the most recent occurrence on July 4, where it recorded a net buy of 87.5322 million CNY [1]. Financial Performance - For the first half of 2025, Shenzhou Cell reported a revenue of 972 million CNY, a decrease of 25.50% year-on-year. The net profit attributable to the parent company was -33.7711 million CNY, reflecting a significant decline of 126.87% year-on-year [2]. Shareholder Information - As of June 30, 2025, the number of shareholders was 9,754, a decrease of 12.74% from the previous period. The average number of circulating shares per person increased by 14.60% to 45,656 shares [2]. - Notable changes in institutional holdings include the entry of new shareholders such as Southern CSI 500 ETF and China Europe Medical Health Mixed A, while Hong Kong Central Clearing Limited and China Merchants National Bio-Medical Index A exited the top ten circulating shareholders [2]. Industry Classification - Shenzhou Cell belongs to the pharmaceutical and biotechnology sector, specifically in the subcategory of biopharmaceuticals, with a focus on innovative drugs, vaccines, biomedicine, anti-cancer drugs, and cell therapy [2].

Group 1 - The electric power equipment industry has become a favorite among investors in September, with a net buying amount of 1.144 billion yuan, leading the market [1][2] - 26 stocks, including Jianghuai Automobile, saw over 100 million yuan in financing on a single day, indicating significant institutional interest [2] - The current market activity may reflect a strategic maneuver by institutions rather than genuine enthusiasm for the new energy sector [1][9] Group 2 - Historical context shows that market fluctuations often coincide with institutional strategies, such as the significant market movements in the second quarter of 2025 [3][4] - Institutions may engage in "smashing the market" to accumulate shares when they find their positions insufficient, leading to sudden market drops that are misinterpreted as external shocks [4][12] - The electric power equipment sector's current financing activity raises questions about whether it is a genuine value discovery or a prelude to another institutional shakeout [9][12] Group 3 - Case studies of Huadong Medicine and Shenzhou Cell illustrate the difference between genuine market adjustments and strategic institutional actions, with the latter often leading to significant price movements [6][8] - Data analysis reveals that Shenzhou Cell experienced notable institutional buying during its adjustment, while Huadong Medicine did not, resulting in divergent outcomes when the market rebounded [8] - The electric power equipment industry's recent activity may mirror past instances where institutions manipulated market perceptions to their advantage [12]

Group 1 - The core viewpoint of the news is that Shenzhou Cell has experienced significant stock price fluctuations and changes in shareholder structure, reflecting its performance in the biopharmaceutical industry [1][2]. - As of September 5, Shenzhou Cell's stock price increased by 2.04% to 62.62 CNY per share, with a total market capitalization of 27.887 billion CNY [1]. - The company has seen a year-to-date stock price increase of 72.84%, but it has experienced a decline of 1.39% over the last five trading days and 5.55% over the last twenty days [1]. Group 2 - Shenzhou Cell operates in the biopharmaceutical sector, focusing on the research and commercialization of biological drugs for various diseases, including cancer and autoimmune diseases [1][2]. - For the first half of 2025, Shenzhou Cell reported a revenue of 972 million CNY, a year-on-year decrease of 25.50%, and a net profit attributable to shareholders of -33.771 million CNY, a decline of 126.87% [2]. - The number of shareholders decreased by 12.74% to 9,754 as of June 30, 2025, while the average circulating shares per person increased by 14.60% to 45,656 shares [2].

Group 1 - The core viewpoint of the news is that Shenzhou Cell's stock has experienced fluctuations, with a notable year-to-date increase of 71.71%, but recent declines in the short term [1][2] - As of September 4, Shenzhou Cell's stock price was 62.21 yuan per share, with a total market capitalization of 27.704 billion yuan [1] - The company has seen significant trading activity, with a net outflow of main funds amounting to 5.9535 million yuan on September 4, and notable buying and selling volumes from large orders [1] Group 2 - Shenzhou Cell operates in the pharmaceutical and biotechnology sector, focusing on the research and commercialization of biological drugs for various diseases, including cancer and autoimmune diseases [1][2] - For the first half of 2025, Shenzhou Cell reported a revenue of 972 million yuan, a year-on-year decrease of 25.50%, and a net profit attributable to shareholders of -33.7711 million yuan, reflecting a significant decline of 126.87% [2] - The number of shareholders decreased by 12.74% to 9,754 as of June 30, 2025, while the average circulating shares per person increased by 14.60% [2]

Group 1 - The core viewpoint of the news is that Shenzhou Cell's stock has increased by 5.2%, reaching a price of 66.80 yuan per share, with a total market capitalization of 29.748 billion yuan [1] - Shenzhou Cell, established on April 23, 2007, and listed on June 22, 2020, focuses on the research and commercialization of biopharmaceutical products for various diseases, including malignant tumors and autoimmune diseases [1] - The company's main business revenue is entirely derived from product sales, accounting for 100% of its income [1] Group 2 - Among the top circulating shareholders of Shenzhou Cell, a fund under China Europe Fund, specifically the China Europe Medical Health Mixed A (003095), has entered the top ten shareholders, holding 2.3579 million shares, which is 0.53% of the circulating shares [2] - The China Europe Medical Health Mixed A fund has achieved a year-to-date return of 28.82% and a one-year return of 43.11%, ranking 2520 out of 8254 and 3274 out of 8037 respectively [2] Group 3 - The fund manager of China Europe Medical Health Mixed A is Ge Lan, who has a tenure of 10 years and 219 days, with the fund's total asset size at 39.908 billion yuan and a best return of 125.88% during her tenure [3] - Another fund manager, Zhao Lei, has a tenure of 60 days, managing assets worth 30.801 billion yuan, with a best return of 13.75% during his short tenure [3]

Core Insights - The company Shenzhou Cell (688520) reported a significant decline in financial performance for the first half of 2025, with total revenue of 972 million yuan, a year-on-year decrease of 25.5%, and a net profit attributable to shareholders of -33.77 million yuan, down 126.87% [1] - The company's gross margin decreased to 94.79%, a drop of 1.86% year-on-year, while the net margin turned negative at -3.48%, a decline of 136.05% [1] - The total of financial, sales, and management expenses reached 550 million yuan, accounting for 56.63% of total revenue, which is an increase of 68.51% compared to the previous year [1] Financial Performance - Total revenue for 2025 was 972 million yuan, down from 1.305 billion yuan in 2024, representing a 25.5% decline [1] - Net profit attributable to shareholders was -33.77 million yuan, compared to a profit of 12.6 million yuan in 2024, marking a 126.87% decrease [1] - The company's cash flow per share was -0.46 yuan, a significant drop of 257.03% year-on-year [1] Operational Metrics - The company's return on invested capital (ROIC) was 8.8% last year, indicating average capital returns [3] - The historical median ROIC since the company went public is -57.43%, with the worst year being 2019 at -339.66% [3] - The company has reported losses in 8 out of 4 annual reports since its IPO, suggesting poor investment returns [3] Debt and Cash Flow Concerns - The cash flow situation is concerning, with cash and cash equivalents to current liabilities ratio at 15.38%, and the average operating cash flow over the past three years being -9.98% [4] - The interest-bearing debt ratio has reached 81.64%, indicating high leverage [4] - Accounts receivable have increased significantly, with accounts receivable to profit ratio at 750.91% [4] Market and Product Insights - The company's core product, Anjain, has seen a decline in sales due to regional price reductions and healthcare cost controls [7] - Future growth potential for the product may depend on whether adult preventive treatments can be included in health insurance reimbursements [7] Fund Holdings - Several funds have recently increased their holdings in Shenzhou Cell, with the largest being Shenwan Lixin CSI 500 Index Enhanced A, holding 617,000 shares [6] - The fund's recent performance shows a net value increase of 51.36% over the past year [6]

Core Viewpoint - Beijing Sinocell Technology Group Co., Ltd. reported significant declines in revenue and net profit for the first half of 2025, indicating potential challenges in its operational performance [1]. Financial Summary - Total assets increased by 7.38% to CNY 3,526,218,500.07 compared to the end of the previous year [1]. - Net assets attributable to shareholders decreased by 21.33% to CNY 110,838,929.67 [1]. - Revenue for the period was CNY 972,020,482.48, down 25.50% from CNY 1,304,669,628.08 in the same period last year [1]. - Total profit was reported at a loss of CNY 33,858,151.29, a decline of 126.86% compared to a profit of CNY 126,073,272.07 in the previous year [1]. - Net profit attributable to shareholders was a loss of CNY 33,771,096.29, down 126.87% from CNY 125,705,731.32 [1]. - The net profit after deducting non-recurring gains and losses was a loss of CNY 36,108,173.65, a decrease of 110.61% from CNY 340,264,529.53 [1]. - Net cash flow from operating activities was a negative CNY 206,121,389.52, down 257.03% from CNY 131,265,288.50 [1]. - The weighted average return on net assets was -27.24% [1]. - Basic and diluted earnings per share were both -CNY 0.10, a decrease of 135.71% from CNY 0.28 [1]. - Research and development expenses accounted for 39.91% of revenue, an increase of 3.43 percentage points from 36.48% [1]. Shareholder Information - The total number of shareholders at the end of the reporting period was 9,754 [2]. - The largest shareholder, Nanchang Sinocell Anyuan Enterprise Management Consulting Partnership, held 4.86% of shares, amounting to 21,657,406 shares [2]. - Other notable shareholders included Tianjin Yingya Equity Investment Management Co., Ltd. with 0.84% and Beijing Sinocell Technology Group Co., Ltd. with 0.61% [2][3].

Core Viewpoint - The company reported a revenue of 972 million yuan for the first half of 2025 and is actively optimizing its capital structure through a private placement to raise up to 900 million yuan for R&D funding, reflecting confidence in its future prospects and commitment to investor interests [2][5]. Group 1: Financial Performance - The company's revenue for the reporting period was 972 million yuan, influenced by price reductions in its core product Anjain® due to regional alliance procurement and medical insurance cost control [3]. - The company is implementing a private placement plan to raise no more than 900 million yuan, which will enhance its capital structure and support R&D efforts [2][5]. Group 2: R&D and Innovation - The company is focusing on expanding its market presence and ensuring competitive pricing for its products, with new products gradually contributing to revenue growth [3]. - The self-developed antibody drugs Anpingxi®, Anjairun®, and Anbeizhu® have been included in the national medical insurance, covering various indications in autoimmune diseases, hematological malignancies, and solid tumors [3]. - The company has 13 products in clinical stages, targeting multiple disease areas, and is accelerating the transition of more candidates from preclinical to clinical research [4]. Group 3: Operational Efficiency - R&D investment remains around 390 million yuan, supporting 14 major products in clinical stages and optimizing clinical project priorities based on various factors [4]. - The company is enhancing its operational efficiency by controlling costs across various dimensions, including financial management, R&D project management, production processes, and operational management [6]. - A project management computer system has been trialed to improve R&D speed, quality stability, and cost-effectiveness [6].

Core Viewpoint - Shenzhou Cell reported a revenue of 972 million yuan for the first half of 2025, with plans for a private placement to raise up to 900 million yuan for R&D funding and to improve capital structure [1][2] Financial Performance - The company experienced revenue fluctuations primarily due to price reductions from centralized procurement and medical insurance control affecting its core product, Anjia [1] - R&D investment was approximately 390 million yuan, supporting 14 major clinical-stage products and more candidates [2] Capital Structure and Financing - The company has initiated a refinancing plan to issue up to 25 million shares, raising a maximum of 900 million yuan, which has been accepted by the Shanghai Stock Exchange [2][3] - If the maximum shares are issued, total shares will increase to 470 million, with the controlling shareholder's stake rising to 62.98% [2] Product Development and Market Strategy - The company is actively expanding into lower-tier markets to enhance product hospital admission rates and patient coverage [1] - Newly launched products are gradually becoming new revenue growth points, with self-developed antibody drugs included in the national medical insurance [1] Industry Context - The Chinese innovative drug sector is transitioning from R&D-driven to commercial breakthroughs, with recent government measures supporting high-quality development in the industry [3] - The chairman of Shenzhou Cell emphasized the importance of long-term innovation and aligning with national interests to facilitate the final steps of innovative drugs from market entry to clinical application [3]