Core Viewpoint - The article emphasizes the rising importance of biomanufacturing as a strategic and innovative field, which is seen as a new growth point that can drive industrial structure optimization and economic transformation. The release of the "2025 China Synthetic Biomanufacturing Industry Development White Paper" highlights the current state, trends, and challenges of the biomanufacturing industry in China [1]. Group 1: Current State and Trends - The white paper provides an overview of the global biomanufacturing industry, including its development status and trends [5]. - It compares the biomanufacturing sectors of China and the United States, highlighting competitive dynamics [5]. - Future development trends in biomanufacturing are discussed, indicating potential growth areas [5]. Group 2: Policy Landscape - The report outlines major policies affecting biomanufacturing both domestically and internationally for the years 2024-2025 [5]. - It details foreign biomanufacturing industry policies and their implications for the sector [5]. - Domestic policies related to biomanufacturing are also analyzed, providing insights into regulatory frameworks [5]. Group 3: Industry Map and Applications - The white paper presents a comprehensive map of the Chinese biomanufacturing industry, identifying key players and their roles [5]. - It analyzes the biomanufacturing industry chain and key application areas, including pharmaceuticals, food, personal care, agriculture, chemicals, materials, and energy [5][6]. - Specific applications of biomanufacturing in various sectors are highlighted, showcasing its versatility and potential impact [5]. Group 4: Key Enterprises and Investment Landscape - The report identifies ten leading enterprises in the Chinese biomanufacturing industry, providing insights into their operations and market positions [6]. - It summarizes the strategic directions of 15 listed companies in synthetic biology, indicating their focus areas and growth strategies [6]. - The investment landscape for synthetic biology in China is examined, detailing funding trends and opportunities from 2024 to mid-2025 [6]. Group 5: Challenges and Recommendations - The white paper discusses the challenges faced by the biomanufacturing industry in China, including technological, regulatory, and market-related issues [6]. - It offers targeted policy recommendations to address these challenges, aiming to support the sustainable development of the biomanufacturing sector [6].

Core Points - Anhui Huaheng Biological Technology Co., Ltd. has submitted an application for the issuance and listing of H-shares on the Hong Kong Stock Exchange on September 30, 2025 [1][3] - The issuance will be limited to qualified overseas investors and domestic qualified investors under Chinese laws [2] - The application is subject to approval from relevant regulatory bodies, including the China Securities Regulatory Commission and the Hong Kong Stock Exchange, and remains uncertain [3] Group 1 - The company has published the application materials on the Hong Kong Stock Exchange website, which may be updated [1][2] - The announcement serves to inform domestic investors about the issuance and listing process [2] - The company will fulfill its information disclosure obligations based on the progress of the application [3]

Key Points - Fengshan Group clarified that its sales do not involve solid-state battery electrolyte materials [1] - Zhiwei Co., Ltd. plans to invest approximately 1.5 billion yuan in the construction of high-end cast steel pump and valve components manufacturing project [1] - Tianyong Intelligent won a bid for a 58.8 million yuan DHE high-efficiency platform production line engine assembly line project [1] - Hanwei Technology intends to sell 65% of its stake in Hanwei Zhiyuan [1] - Huaxin Environmental plans to repurchase shares worth between 40 million to 80 million yuan [1] - Xin Nuo Wei is planning to issue E-shares and list on the Hong Kong Stock Exchange [1] - Shareholders of Run Da Medical, Zhu Wenyi and Liu Hui, plan to reduce their holdings by no more than 2.99% [1] - Feng Assistant intends to raise no more than 984 million yuan through a private placement to actual controllers [1] - Jiaotong Sino's chairman Li Wei has been placed under detention [1] Investment Projects - Nong Shang Environment's subsidiary plans to invest in the construction of intelligent computing center infrastructure [1] - Sai En Si (Fujian Longli Chemical) plans to invest no more than 300 million yuan in the expansion of the selection agent project [1] - Bin Hua Co. intends to invest 1.421 billion yuan in the construction of an integrated source network load storage project [1] Contracts and Acquisitions - Zhong Wu Drone signed a major contract worth 615 million yuan [1] - Xin Nuo Wei plans to acquire a 29% stake in Ju Shi Bio [1] - Huaheng Biological submitted an application for H-share issuance and listing on the Hong Kong Stock Exchange [1] - Kete Power plans to issue shares overseas (H-shares) and apply for listing on the Hong Kong Stock Exchange [1]

Core Viewpoint - Anhui Huaheng Biotechnology Co., Ltd. (Huaheng Bio) is facing a "revenue growth without profit" dilemma, with its market value having dropped by 57% from its peak [2][7]. Company Overview - Established in 2005, Huaheng Bio focuses on synthetic biology technology, primarily engaged in the research, production, and sales of amino acids, vitamins, and bio-based new material monomers, applicable in personal care, functional foods, and nutrition [5]. - The company was listed on the New Third Board in August 2014 and delisted in February 2018. It subsequently went public on the Shanghai Stock Exchange's Sci-Tech Innovation Board in April 2021, raising 625 million yuan at an initial price of 23.16 yuan per share [6]. Financial Performance - Revenue has shown consistent growth, reaching 14.19 billion yuan in 2022, 19.38 billion yuan in 2023, and 21.78 billion yuan in 2024, with a compound annual growth rate of 31.67% over the first three years [9]. - The company reported a net profit of 4.49 billion yuan in 2023, but this plummeted by 57.8% to 1.9 billion yuan in 2024, with a further decline of 23.26% to 1.15 billion yuan in the first half of 2025 [10]. Cost and Profitability Issues - The decline in net profit is attributed to rising costs, with sales costs increasing by 41.7% in 2024 compared to 2023, alongside heightened competition and increased operational expenses [10]. - The gross profit margin has decreased from 38.7% to 24.8% during the reporting period, with a further drop to 23.5% in the first half of 2025 [11]. Market Position - Amino acid products are the primary revenue source, accounting for 69.3% to 82.2% of total revenue during the reporting period [12]. - Huaheng Bio holds the leading global market share in the L-alanine and L-valine segments, despite being approximately one-third the size of its competitor, Kasei Bio, which reported revenues of 29.58 billion yuan in 2024 [12].

Core Viewpoint - The company, Huaheng Biological (688639.SH), has submitted an application for issuing H-shares and listing on the Hong Kong Stock Exchange as of September 30, 2025 [1] Group 1 - The application was submitted to the Hong Kong Stock Exchange and the relevant documentation was published on the exchange's website [1] - The application materials were prepared in accordance with the requirements of the Hong Kong Securities and Futures Commission and the Hong Kong Stock Exchange [1] - The information contained in the application is a draft version and may be updated or changed over time [1]

Core Viewpoint - Huaheng Biological has submitted an application for issuing H-shares and listing on the main board of the Hong Kong Stock Exchange on September 30 [1] Group 1 - The company filed the application with the Hong Kong Stock Exchange on September 30 [1] - The application materials for the issuance and listing were published on the Hong Kong Stock Exchange's website on the same day [1]

证券代码：688639 证券简称：华恒生物 公告编号：2025-046 安徽华恒生物科技股份有限公司 关于向香港联交所递交 H 股发行并上市的申请并刊发 申请资料的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 安徽华恒生物科技股份有限公司（以下简称"公司"）已于 2025 年 9 月 30 日 向香港联合交易所有限公司（以下简称"香港联交所"）递交了发行 H 股股票并在 香港联交所主板挂牌上市（以下简称"本次发行上市"）的申请，并于同日在香港 联交所网站刊登了本次发行上市的申请资料。该申请资料为公司按照香港证券及 期货事务监察委员会（以下简称"香港证监会"）及香港联交所的要求编制和刊发， 为草拟版本，其所载资料可能会适时作出更新和变动，投资者不应根据其中的资 料作出任何投资决定。 需要特别予以说明的是，本公告仅为境内投资者及时了解本次发行并上市的 相关信息而作出。本公告以及公司刊登于香港联交所网站的申请资料不构成也不 本次发行如果最终实施，发行对象将仅限于符合相关条件的境外投资者及依 据中国相关法律法规有权进行境外证券 ...

华恒生物公告，公司已于2025年9月30日向香港联合交易所有限公司递交了发行H股股票并在香港联交 所主板挂牌上市的申请，并于同日在香港联交所网站刊登了申请资料。本次发行对象将仅限于符合相关 条件的境外投资者及依据中国相关法律法规有权进行境外证券投资的境内合格投资者。 ...

Core Insights - Anhui Huaheng Biotechnology Co., Ltd. has submitted a listing application to the Hong Kong Stock Exchange, with Huatai International as the exclusive sponsor [1] Company Overview - The company is a pioneer in synthetic biology, focusing on the research, large-scale production, and commercialization of bio-based products through biomanufacturing technology [3] - It has established a leading position in the industry over 20 years, with strong R&D capabilities and mature mass production capabilities [3] - According to Frost & Sullivan, the company is one of the most comprehensive producers of bio-based products commercialized through synthetic biology globally [3] Market Position - The company is the first globally to industrialize a series of amino acids (including L-Alanine and L-Valine) through anaerobic fermentation [3] - By 2024, the company holds the largest market share for L-Alanine and L-Valine globally [3] Client Relationships - As of June 30, 2025, the company has established stable long-term partnerships with over 768 clients across 85 countries in Asia, Europe, and America [5] Product Portfolio - The company's bio-based products include: - Amino acid series (mainly alanine series, L-Valine, Tryptophan, Arginine) - Vitamin series (mainly D-Calcium Pantothenate, D-Pantothenol, Inositol) - Other bio-based products (mainly bio-based new material monomers like 1,3-Propanediol and Succinic Acid, Malic Acid, Arbutin) [5] - These products are widely used in various industries, including animal nutrition, personal care, food and beverage, advanced materials, and plant nutrition [5] Manufacturing Technology - The company employs two green manufacturing technology platforms: fermentation and enzyme catalysis, focusing on microbial cell factories and enzyme-based production processes [7] - Its biomanufacturing methods replace traditional chemical synthesis with renewable biological resources, reducing pollution, energy consumption, and carbon footprint [7] Financial Performance - The company's revenue and gross profit for the fiscal years are as follows: - FY2022: Revenue of RMB 1.418 billion, Gross Profit of RMB 548 million, Gross Margin of 38.7% - FY2023: Revenue of RMB 1.938 billion, Gross Profit of RMB 782 million, Gross Margin of 40.4% - FY2024: Revenue of RMB 2.178 billion, Gross Profit of RMB 540 million, Gross Margin of 24.8% - H1 2024: Revenue of RMB 1.016 billion, Gross Profit of RMB 321 million, Gross Margin of 31.6% - H1 2025: Revenue of RMB 1.489 billion, Gross Profit of RMB 350 million, Gross Margin of 23.5% [7] Use of Proceeds - The funds raised from the listing will be used for: - Accelerating global expansion and layout - Development of synthetic biology enabling technologies, new products, and solutions - Capacity upgrades - Working capital supplementation and other general corporate purposes [7]

Core Viewpoint - Anhui Huaheng Biotechnology Co., Ltd. is pursuing an IPO in Hong Kong, revealing significant changes in key financial metrics, including a decline in gross margin from 40.4% in 2023 to 24.8% in 2024 and a drop in net margin from 23.0% to 8.5% [1] Business Model - The company focuses on bio-based products, utilizing biomanufacturing technology to produce amino acids, vitamins, and other bio-based products, which are widely used in various industries [2] - Amino acid products are the primary revenue source, accounting for 69.3% to 82.2% of total revenue from 2022 to the first half of 2025 [2] Financial Performance - Revenue growth is notable, increasing from 1.419 billion to 2.178 billion yuan from 2022 to 2024, with a compound annual growth rate of 23.9% [3] - The net profit decreased from 319 million yuan in 2022 to 185 million yuan in 2024, with a decline in the first half of 2025 compared to the same period in 2024 [4] - Gross margin has been declining, from 38.7% in 2022 to 24.8% in 2024, with further decline in the first half of 2025 [5] - Net margin has also significantly decreased from 22.5% in 2022 to 8.5% in 2024 [6] Revenue Composition - The revenue composition shows a decreasing trend in the share of amino acid products, while the share of vitamin products has fluctuated, and other bio-based products have seen an increase [8] Related Transactions - There is an overlap between major customers and suppliers, which raises concerns about the fairness of pricing and potential risks of interest transfer [9] Financial Challenges - Market price fluctuations and rising costs are significant challenges, with sales costs increasing by 41.7% in 2024 compared to 2023 [10][11] - The company faces risks related to research and development, including high uncertainty and potential delays in product launches [12] Competitive Landscape - The company holds a competitive advantage through technological leadership and a diversified product portfolio, but it faces intense competition that could impact its market share and profitability [13][14] Customer and Supplier Dynamics - Customer concentration remains stable, with major customers accounting for 9.0% to 15.4% of revenue, while supplier concentration is relatively low [15][16] Management and Governance - The company has a concentrated ownership structure, which may influence decision-making and potentially affect minority shareholders [16] - The management team has extensive experience in the biomanufacturing sector, which supports business development and strategic decision-making [18]