2025.09. 04 本文字数：1975，阅读时长大约3分钟 作者 | 第一财经 吴斯旻 进入9月，北京、浙江等多省份陆续启动今年流感疫苗预防接种工作。一则"公费流感疫苗单价降至5.5元"的消息引起业界关注。 9月1、2日，全国公共资源交易平台（北京）先后发布2025年北京流感疫苗免疫类和非免疫类招标采购项目的中标公告，华兰生物、上海生物制品研 究所（下称"上生所"）、北京科兴三家疫苗厂商中标"免疫类"项目。 其中，上生所的三价流感疫苗中标价5.5元/支，创公费流感疫苗市场的价格新低；华兰生物的三价流感疫苗中标价为10元/支。 上述中标价甚至低于部分地区的疫苗接种服务费。第一财经了解到，目前部分地区对二类疫苗收取接种服务费，标准往往为6～25元/剂次。其中，北 京多家医院和社区卫生服务中心反映，对自费疫苗收取25元/剂次服务费。 | ロ、エヌアハリリの | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 供应商 | 商品名称 | 规格型号 | 数量 | 南投 | 常价 | 服务要求 | | 华兰生物疫苗股份有限 公司 | 三价流感疫苗3 | ...

进入9月，北京、浙江等多省份陆续启动今年流感疫苗预防接种工作。一则"公费流感疫苗单价降至5.5 元"的消息引起业界关注。9月1、2日，全国公共资源交易平台（北京）先后发布2025年北京流感疫苗免 疫类和非免疫类招标采购项目的中标公告，华兰生物、上海生物制品研究所、北京科兴三家疫苗厂商中 标"免疫类"项目。其中，上生所的三价流感疫苗中标价5.5元/支，创公费流感疫苗市场的价格新低；华 兰生物的三价流感疫苗中标价为10元/支。上述中标价甚至低于部分地区的疫苗接种服务费。了解到， 目前部分地区对二类疫苗收取接种服务费，标准往往为6～25元/剂次。其中，北京多家医院和社区卫生 服务中心反映，对自费疫苗收取25元/剂次服务费。 (第一财经) ...

Core Viewpoint - The blood products industry is experiencing significant performance differentiation among listed companies due to fluctuating terminal medical demand, ongoing centralized procurement policies, and intensified competition for plasma station resources [1][2]. Revenue Performance - The blood products industry has shown a clear tiered revenue structure, with leading companies benefiting from resource barriers while smaller firms struggle with revenue growth [2][3]. - Shanghai Raist achieved a revenue of 3.952 billion yuan, with a year-on-year plasma collection increase of nearly 12% [2]. - Tian Tan Bio reported a revenue of 3.110 billion yuan, a year-on-year increase of 9.47%, supported by its stable plasma collection capabilities [2]. - Hualan Bio generated a revenue of 1.798 billion yuan, up 8.8% year-on-year, with its blood products segment contributing 1.737 billion yuan, a 7.57% increase [2]. - The top three companies accounted for 74.64% of the total revenue of the eight listed companies in the industry [2]. Profitability Analysis - There is a significant disparity in net profit performance, with only two companies reporting positive year-on-year growth in net profit [4][5]. - Shanghai Raist led with a net profit of 1.03 billion yuan, while Hualan Bio saw a notable increase of 17.19% in net profit to 516 million yuan, driven by improved gross margins [4]. - Tian Tan Bio's net profit decreased by 12.88% to 633 million yuan, impacted by declining product sales prices and reduced interest income [4]. - The profitability of smaller companies is under pressure, with Baiya Bio reporting a net profit of 225 million yuan and a cash dividend plan reflecting shareholder returns [5]. - Bai Lin Bio's net profit fell by 27.89% to 236 million yuan due to capacity expansion efforts, while Wei Guang Bio's net profit slightly decreased by 2.02% to 108 million yuan [5][6]. Industry Challenges - The industry faces challenges such as weak terminal demand, ongoing centralized procurement pressures, and financial and R&D constraints [6]. - The demand for conventional products like human albumin has decreased due to adjustments in treatment rhythms at medical institutions [6]. - Centralized procurement policies continue to exert pressure on pricing, affecting revenue from related business lines [6]. - Companies are experiencing tight funding issues as they invest in expanding plasma stations and advancing new product development [6].

Investment Rating - The report provides a positive outlook on the MASH non-invasive diagnosis technology, suggesting it could accelerate new drug development in the pharmaceutical and biotechnology sector [2]. Core Insights - The pharmaceutical and biotechnology sector experienced a decline of 0.65% from August 25 to August 29, underperforming compared to the Wind All A index (1.9%) and the CSI 300 index (2.71%). Only the medical research outsourcing (4.9%) and other biological products (0.14%) sectors saw gains, while in vitro diagnostics (-4.12%), raw materials (-3.34%), and vaccines (-0.59%) faced significant declines [2][7]. - The FDA has accepted the proposal for using VCTE-LSM as a reasonable alternative endpoint for clinical trials in adults with MASH and moderate to advanced fibrosis. This non-invasive method is expected to enhance patient compliance and could lead to a surge in drug development in the MASH area within the next two to three years [2][13]. - The report emphasizes the potential for domestic companies in China to leverage their cost advantages and forward-looking strategies in the field of non-invasive companion diagnostics, particularly in the MASH drug development competition [2]. Market Weekly Review - The pharmaceutical and biotechnology sector's performance was notably weaker than the broader market indices, with specific sub-sectors like medical research outsourcing and other biological products showing resilience [7][8]. - Individual stocks such as Tianchen Medical (30.1%), Ailis (25.6%), and Maiwei Biotech-U (22.4%) performed well, while stocks like Lifang Pharmaceutical (-13.9%), Yuekang Pharmaceutical (-11.9%), and Kanghua Biotech (-11.1%) faced significant losses [10][12]. Industry News and Key Company Announcements - On August 28, Kangfang Biotech announced that its drug AK112 received approval for treating advanced non-squamous non-small cell lung cancer, with promising clinical trial results expected to be presented at an international conference [12]. - The report highlights various companies' financial performances, with notable revenue changes and profit margins, indicating a mixed outlook across the sector [16][17].

Core Insights - The company reported a total operating revenue of 1.798 billion yuan for H1 2025, representing an 8.8% year-on-year increase, and a net profit attributable to shareholders of 516 million yuan, up 17.19% [1] - The blood products segment showed steady growth with revenue of 1.737 billion yuan in H1 2025, a 7.57% increase, and a gross margin of 51.69% [1][2] - The vaccine segment achieved significant growth with a revenue of 57 million yuan, a 92.63% increase, despite challenges from price reductions and fluctuating vaccination rates [2] - The company demonstrated improved profitability with a net profit margin of 28.69%, up 2.06 percentage points year-on-year, and announced a mid-year dividend plan of 5 yuan per 10 shares, totaling approximately 914 million yuan [3] Financial Performance - H1 2025 total operating revenue: 1.798 billion yuan, up 8.8% [1] - H1 2025 net profit attributable to shareholders: 516 million yuan, up 17.19% [1] - H1 2025 gross margin for blood products: 51.69%, up 1.59 percentage points [1] - H1 2025 net profit margin: 28.69%, up 2.06 percentage points [3] Segment Performance - Blood products revenue: 1.737 billion yuan in H1 2025, up 7.57% [1] - Vaccine revenue: 57 million yuan in H1 2025, up 92.63% [2] - Clinical progress in vaccines includes completion of Phase III for certain products and ongoing clinical trials for others [2] Future Outlook - The company expects steady growth in plasma collection due to the operational commencement of the Fengdu plasma collection station and the upcoming peak collection season [1] - Earnings per share (EPS) projections for 2025-2027 are 0.71 yuan, 0.76 yuan, and 0.80 yuan respectively [4]

Hualan released its 1H25 results on Aug 27, 2025. Both its revenue (Rmb1,798mn, +9% yoy) and net profit (Rmb516mn, +17% yoy) were largely in-line with GSe (Rmb1,905mn/519mn). By product breakdown, revenue from albumin/IVIG/other plasma products/vaccines reached Rmb696mn/453mn/588mn/57mn, with +8% /-1%/+15%/+93% yoy respectively. The company noted that unit prices for its two key plasma products, albumin and IVIG, both declined by c.5%, though management emphasized that this performance is relatively favorab ...

据证券之星公开数据整理，近期华兰生物（002007）发布2025年中报。截至本报告期末，公司营业总收 入17.98亿元，同比上升8.8%，归母净利润5.16亿元，同比上升17.19%。按单季度数据看，第二季度营 业总收入9.31亿元，同比上升7.53%，第二季度归母净利润2.03亿元，同比上升13.62%。本报告期华兰 生物盈利能力上升，毛利率同比增幅3.73%，净利率同比增幅7.05%。 本次财报公布的各项数据指标表现尚佳。其中，毛利率52.58%，同比增3.73%，净利率29.07%，同比增 7.05%，销售费用、管理费用、财务费用总计2.78亿元，三费占营收比15.44%，同比减8.64%，每股净资 产6.57元，同比增6.86%，每股经营性现金流0.13元，同比减28.21%，每股收益0.28元，同比增17.37% | 项目 | 2024年中报 | 2025年中报 | 同比增幅 | | --- | --- | --- | --- | | 营业总收入(元) | 16.53亿 | 17.98亿 | 8.80% | | 归母净利润(元) | 4.4亿 | 5.16/Z | 17.19% | | 扣非净利润( ...

Market Overview - The recombinant protein sector experienced a decline of 1.01%, ranking among the top losers in concept sectors as of the market close on August 28 [1] - Notable declines within the sector included companies such as Aladdin, Bory Pharmaceutical, and Zhongyuan Union, while Chengdu XianDao, Dezhan Health, and Betta Pharmaceuticals saw increases of 7.44%, 2.38%, and 2.02% respectively [1] Concept Sector Performance - The top-performing concept sectors included Copper Cable High-Speed Connection (+5.61%), Co-Packaged Optics (+5.13%), and F5G Concept (+5.12%), while the recombinant protein sector was among the laggards with a decline of 1.01% [2] Capital Flow Analysis - The recombinant protein sector faced a net outflow of 1.348 billion yuan, with 41 stocks experiencing net outflows, and 6 stocks seeing outflows exceeding 50 million yuan [2] - Bory Pharmaceutical led the outflows with a net outflow of 548 million yuan, followed by Zhifei Biological, Hualan Biological, and Zhongyuan Union with net outflows of 149 million yuan, 88.91 million yuan, and 77.72 million yuan respectively [2] Individual Stock Performance - Bory Pharmaceutical reported a decline of 6.63% with a turnover rate of 5.33% and a net outflow of 547.71 million yuan [3] - Chengdu XianDao was the standout performer in the sector, increasing by 7.44% despite a net outflow of 203.74 million yuan [3] - Other notable stocks with significant net inflows included Dezhan Health (+2.38%) with a net inflow of 46.14 million yuan, Haoyuan Pharmaceutical (+1.82%) with a net inflow of 18.75 million yuan, and Maimai Biological (+1.82%) with a net inflow of 18.75 million yuan [4]

Investment Rating - The investment rating for the company is "Outperform" (maintained) [1] Core Views - The company's blood products business is experiencing steady growth, and its gene company is accelerating its development [1] - The company reported a revenue of 1.798 billion yuan in the first half of 2025, representing an 8.8% year-on-year increase, and a net profit attributable to shareholders of 516 million yuan, up 17.19% year-on-year [7] - The company is actively promoting plasma collection, achieving a total collection of 803.66 tons in the first half of 2025, a 5.23% increase compared to the same period last year [7] - The gene company, Hualan Gene, has begun contributing revenue, with sales of Bevacizumab reaching 58.8958 million yuan in the first half of 2025 [7] - The company has adjusted the pricing of its quadrivalent influenza vaccine, which may impact future profit forecasts [7] Financial Data and Profit Forecast - Total revenue forecast for 2025 is 4.867 billion yuan, with a year-on-year growth rate of 11.1% [5] - Net profit attributable to shareholders for 2025 is projected to be 1.203 billion yuan, reflecting a 10.6% year-on-year increase [5] - Earnings per share (EPS) for 2025 is estimated at 0.66 yuan [5] - The company's average industry valuation for 2025 is set at 30X PE, leading to a target market value of 36.1 billion yuan, indicating a 14% upside potential from the current market value [7][8]

Group 1 - Core viewpoint: Hualan Biological (002007.SZ) reported its semi-annual results for 2025, revealing significant institutional investor interest with 29 institutions holding a total of 660 million shares, representing 36.12% of the total share capital [1] - The top ten institutional investors collectively hold 36.05% of Hualan Biological's shares, with a slight decrease of 1.14 percentage points compared to the previous quarter [1] Group 2 - In the public fund sector, one fund, the Biological Vaccine ETF, increased its holdings, while two funds, including the Innovative Medicine and the China Securities Index Fund, saw a reduction in holdings by 0.26% [2] - A total of 14 new public funds were disclosed this period, including Southern CSI 500 ETF and Ping An CSI A500 ETF, while 9 funds were no longer disclosed, such as E Fund CSI 300 Medical ETF and Huatai-PineBridge CSI 300 ETF [2] - Foreign investment sentiment showed an increase in holdings from one foreign fund, Hong Kong Central Clearing Limited, with an increase of 0.32% [2]