关于持股 5%以上股东及其他股东股份减持计划 的预披露公告 持股5%以上股东四川发展证券投资基金管理有限公司－川发精选3号私募 证券投资基金、股东孙晚丰、李声友保证向本公司提供的信息内容真实、准确、 完整，没有虚假记载、误导性陈述或重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 特别提示： 持有成都康华生物制品股份有限公司（以下简称"公司"）8,079,027 股（占 公司总股本的 6.2172%）的股东四川发展证券投资基金管理有限公司－川发精选 3 号私募证券投资基金（以下简称"川发精选 3 号"）计划于本公告披露之日起 15 个交易日后的 3 个月内以集中竞价和大宗交易方式减持公司股份不超过 3,898,405 股（即不超过公司总股本的 3.0000%）。 持有公司 139,635 股（占公司总股本的 0.1075%）的股东孙晚丰先生计划于 本公告披露之日起 3 个交易日后的 3 个月内以集中竞价和/或大宗交易方式减持 公司股份不超过 34,908 股（即不超过公司总股本的 0.0269%）。 持有公司 303,848 股（占公司总股本的 0.2338%）的股东李声友先生计 ...

Investment Rating - The industry investment rating is maintained at "Overweight" [3][10][29] Core Viewpoints - The vaccine industry is experiencing significant innovation breakthroughs both domestically and internationally, with multiple companies achieving clinical trial approvals for new vaccines [2][6][10] - The industry is currently facing performance pressure due to supply-demand imbalances, with high competition leading to price declines for some products [10][29] - Long-term prospects remain positive, driven by policy support, increasing demand due to aging populations, and ongoing technological advancements in vaccine development [11][31] Summary by Sections Recent Developments - Watson Bio's mRNA vaccine for respiratory syncytial virus (RSV) has received clinical trial approval, marking a significant step in domestic vaccine innovation [5][6] - The first phase trial of China's Tian Tan strain HIV vaccine has been successfully completed, indicating progress in HIV vaccine research [5][6] - Pfizer reported a 10% revenue growth in Q2 2025, exceeding market expectations, with significant contributions from its anticoagulant and COVID-19 products [5][6] Market Performance - The vaccine sector saw a slight decline of 0.44% last week, while the overall pharmaceutical sector dropped by 0.84% [7][8] - The vaccine industry has shown a cumulative increase of 0.96% since the beginning of 2025, indicating a recovery trend [7][8] Valuation Metrics - The vaccine sector's price-to-earnings (PE) ratio is 80.76X, with a recent decrease of 0.33X, while the price-to-book (PB) ratio stands at 1.96X [9][10] - The PE ratio is within the 48.20% percentile since 2013, indicating a relatively high valuation compared to historical data [9][10] Investment Recommendations - The report suggests focusing on companies with strong innovation capabilities and differentiated products, recommending companies like CanSino and Kanghua Bio [10][31] - The long-term outlook emphasizes the importance of innovation and international expansion as key drivers for growth in the vaccine industry [10][31]

Core Insights - The animal vaccine sector saw a rise of 1.41%, ranking 8th among concept sectors, with 15 stocks increasing in value, led by Shenlian Bio, Kanghua Bio, and Tiankang Bio, which rose by 9.71%, 8.60%, and 2.02% respectively [1][2] - The sector experienced a net outflow of 6.53 million yuan in capital, with seven stocks receiving net inflows, primarily led by Guoyao Modern, which saw a net inflow of 29.79 million yuan [2][3] - The top three stocks by net inflow ratio were Guoyao Modern at 17.35%, Kexing Pharmaceutical at 9.18%, and Luoniushan at 9.02% [3] Stock Performance - Guoyao Modern had a daily increase of 1.35% with a turnover rate of 1.14% and a net capital flow of 29.79 million yuan [3] - Kexing Pharmaceutical increased by 0.54% with a turnover rate of 2.79% and a net capital flow of 24.08 million yuan [3] - Luoniushan rose by 1.11% with a turnover rate of 2.44% and a net capital flow of 16.07 million yuan [3] Declining Stocks - Xianfeng Holdings, Biotech Shares, and Yongshun Bio were among the stocks with the largest declines, falling by 3.05%, 1.04%, and 0.60% respectively [1][4] - Other notable declines included Tian Kang Bio at 2.02% and Ruipu Bio at 0.56% [4]

Group 1 - The animal vaccine sector experienced a decline of 0.39% as of the market close on August 4, ranking among the top losers in concept sectors [1][2] - Within the animal vaccine sector, notable declines were observed in stocks such as Kexing Pharmaceutical, Shenlian Biological, and Kanghua Biological, while 11 stocks saw price increases, with notable gains from Biological Shares, Jinhai Biological, and Weilan Biological, which rose by 2.70%, 2.51%, and 2.10% respectively [1][2] - The animal vaccine sector faced a net outflow of 45 million yuan in principal funds today, with 14 stocks experiencing net outflows, led by Kanghua Biological with a net outflow of 34.6 million yuan [2][3] Group 2 - The top gainers in the concept sectors today included the military equipment restructuring concept, which rose by 5.68%, and military-civilian integration, which increased by 3.53% [2] - The stocks with the highest net inflows in the animal vaccine sector included Jinhai Biological, Guoyao Modern, and Biological Shares, with net inflows of 53.99 million yuan, 11.44 million yuan, and 9.32 million yuan respectively [2][3] - The stock Kanghua Biological had a trading volume turnover rate of 6.20% and a price drop of 2.67%, indicating significant trading activity despite the decline [3]

Core Viewpoint - Kanghua Biotech has established itself as a comprehensive vaccine enterprise since its founding in 2004, focusing on research, development, and operation in the biopharmaceutical field, and is recognized as the first domestic company to produce and sell human diploid cell rabies vaccines [2] Group 1: Company Overview - The company has accumulated significant advantages in the vaccine industry over more than twenty years [2] - Kanghua Biotech emphasizes the importance of innovative research and development for long-term corporate growth [2] Group 2: Research and Development Platforms - The company has built multiple innovative vaccine platforms, including mRNA vaccine platform, recombinant protein VLP vaccine platform, polysaccharide-protein conjugate vaccine platform, live attenuated vaccine platform, inactivated vaccine platform, and novel vaccine adjuvant platform [2] - Ongoing research projects include a six-valent norovirus vaccine, ACYW135 group meningococcal conjugate vaccine, and herpes simplex virus vaccine [2] Group 3: Future Prospects - The company aims to actively advance the product development process and the realization of research outcomes, with the potential to expand its product pipeline in the future [2]

Core Viewpoint - Kanghua Biological has undergone a change in control, with its major shareholder Wang Zhentao transferring part of his equity and voting rights to Shanghai Wankexin Biological, raising questions about the company's future direction amid declining performance [1][2]. Group 1: Ownership Change - On July 20, Kanghua Biological announced that Wang Zhentao and his associates plan to transfer 21.91% of their shares and voting rights, with a total transaction value of 1.85 billion yuan [1][2]. - Wang Zhentao is expected to gain approximately 960 million yuan from this transaction, with the breakdown showing direct and indirect benefits from the sale [2]. Group 2: Financial Performance - Kanghua Biological has faced declining financial performance, with revenue growth stagnating and a projected revenue drop of 9.23% to 1.432 billion yuan in 2024 [6]. - The company's net profit peaked at 830 million yuan in 2021 but has since halved, with a forecasted net profit of 399 million yuan for 2024 [6][7]. - The first quarter of 2025 showed a significant decline, with revenue down 56% year-on-year and net profit down 86% [7]. Group 3: Market Position and Competition - Kanghua Biological's core product, the freeze-dried rabies vaccine, has been under pressure due to high production costs, leading to a price disadvantage compared to competitors [8][9]. - The market share of Kanghua's rabies vaccine has decreased, with a 43.83% drop in the number of vaccine batches approved for sale in 2024 [9]. Group 4: Management and Governance - Despite a reduction in employee numbers to 620, the chairman's salary has increased to a five-year high of 2.3745 million yuan, raising concerns about management decisions amid financial struggles [7]. - Wang Zhentao has high levels of pledged shares, indicating financial pressure, with 89.20% of his directly held shares in Kanghua Biological pledged [9][10]. Group 5: Future Prospects with State-Owned Enterprises - The acquisition by Shanghai Wankexin Biological, linked to state-owned enterprises, is seen as a potential turning point for Kanghua Biological, providing new resources and governance improvements [15][20]. - The Shanghai Biomedicine M&A Fund, which has a significant stake in Wankexin, aims to support Kanghua Biological's restructuring and integration within the biopharmaceutical industry [19][20].

Group 1 - The animal vaccine sector experienced a rise of 2.22%, leading the concept sectors in terms of growth, with 13 stocks increasing in value, including Shenyuan Biological which hit the daily limit, and Yongshun Biological, Kexing Pharmaceutical, and Jinhai Biological showing notable gains of 6.32%, 4.08%, and 3.32% respectively [1][2] - The main inflow of funds into the animal vaccine sector amounted to a net inflow of 51 million yuan, with Kexing Pharmaceutical receiving the highest net inflow of 72.79 million yuan, followed by Shenyuan Biological, Kanghua Biological, and Xianfeng Holdings with net inflows of 57.81 million yuan, 46.82 million yuan, and 7.03 million yuan respectively [2][3] - The net inflow ratios for Shenyuan Biological, Xianfeng Holdings, and Kexing Pharmaceutical were 23.96%, 11.45%, and 9.02% respectively, indicating strong investor interest in these stocks [3] Group 2 - The animal vaccine sector's performance was contrasted by declines in other sectors, such as the China Shipbuilding System which fell by 2.54%, and the military equipment restructuring concept which decreased by 1.90% [2] - The trading volume and turnover rates for leading stocks in the animal vaccine sector were significant, with Shenyuan Biological showing a turnover rate of 7.26% and Kexing Pharmaceutical at 7.15% [3][4] - Several stocks within the animal vaccine sector experienced negative net inflows, including Guoyao Modern, Biological Shares, and Zhongmu Shares, which saw declines of 0.70%, 0.58%, and 0.52% respectively [1][4]

Core Insights - The report highlights that the total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - A total of 1,144 secretaries earned over 1 million yuan annually, accounting for more than 21% of the total [1] Salary Distribution - The average annual salary for secretaries in the A-share biopharmaceutical sector is 1.01 million yuan [5] - The distribution of salaries is as follows: below 500,000 yuan (15%), 500,000-1,000,000 yuan (41%), 1,000,000-2,000,000 yuan (38%), 2,000,000-3,000,000 yuan (4%), and above 3,000,000 yuan (2%) [5] Age and Education Distribution - The age distribution of secretaries shows that those aged 40-50 constitute 61%, while those over 50 account for 15%, and those aged 30-40 make up 18% [1] - In terms of education, 52% of secretaries hold a bachelor's degree, while 44% have a master's degree, and only 2% possess a doctoral degree [3] Investor Engagement - There is significant variation in the number of investor meetings held by companies, with 43% of companies hosting fewer than 10 meetings annually [7] - The top five companies with the highest number of investor meetings are: Bohui Innovation (1,500 meetings), Jindike (777 meetings), Nearshore Protein (681 meetings), Sailun Biotech (549 meetings), and Kanghua Biotech (504 meetings) [9]

Core Insights - The report highlights that the total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - Over 21% of company secretaries earn more than 1 million yuan annually, indicating a significant portion of high earners in this role [1] Salary Distribution - The average annual salary for company secretaries in the biopharmaceutical sector is 1.01 million yuan, with the distribution of salaries as follows: below 500,000 yuan (15%), 500,000-1,000,000 yuan (41%), 1,000,000-2,000,000 yuan (38%), 2,000,000-3,000,000 yuan (4%), and above 3,000,000 yuan (2%) [5] - The top five highest-paid company secretaries have salaries of 3.2565 million yuan, 2.5345 million yuan, 2.2809 million yuan, 1.9265 million yuan, and 1.89 million yuan, with their tenure at the companies ranging from less than one year to 15 years [7] Age and Educational Background - The age distribution of company secretaries shows that those aged 40-50 constitute 61%, while those over 50 account for 15%, and those under 30 make up 6% [1][3] - The educational background indicates that 52% hold a bachelor's degree, 44% have a master's degree, and only 2% possess a doctoral degree, with the latter represented by just one individual [3] Investor Engagement - There is a significant variance in the number of investor meetings held by companies, with 43% of companies hosting fewer than 10 meetings annually, while only 2% have more than 1,000 meetings [9] - The five companies with the highest number of investor meetings are reported to have 1,500, 777, 681, 549, and 504 meetings, respectively [9]

Core Viewpoint - The A-share market has seen a strong performance in the biopharmaceutical sector, particularly in vaccine stocks, driven by the release of the 2025 treatment plan for Chikungunya virus, highlighting the lack of available vaccines in China [1][2] Group 1: Market Performance - Shenyuan Biological (申联生物) rose by over 10%, with a year-to-date increase of 42.60% and a market capitalization of 3.203 billion [2] - Global Printing (环球印务) increased by 9.96%, with a market cap of 3.252 billion and a year-to-date rise of 34.04% [2] - Guanhao Biological (冠昊生物) saw a 7.70% increase, with a market cap of 4.969 billion and a year-to-date increase of 55.65% [2] - Sealy Medical (塞力医疗) rose by 5.60%, with a market cap of 6.055 billion and an impressive year-to-date increase of 339.06% [2] - Other notable performers include Kanglao Weishi (康乐卫士) up 4.98%, Jinhai Biological (金河生物) up 4.62%, and Weilan Biological (蔚蓝生物) up 4.41% [1][2] Group 2: Regulatory and Health Measures - The 2025 Chikungunya virus treatment plan emphasizes preventive measures such as eliminating mosquito breeding sites and using repellents [1] - Travelers to Chikungunya endemic areas are advised to enhance their preventive awareness to avoid infection [1] - Currently, there is no available vaccine for the Chikungunya virus in China, indicating a potential market opportunity for vaccine development [1]